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STUDY OF ANTIDIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS) AQUEOUS ROOTS AND FLOWER EXTRACTS ON ALBINO MICE
Dexamethasone drug induced the hyperglycemia in the Albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of dexamethasone raised the level of blood sugar in the mice. Administration of aqueous extract of C. citratus root and flower extract reduced the fasting and postprandial blood sugar levels, bringing them towards normal. We were observed anti-diabetic effect...
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EMERGING USE OF GREEN SYNTHESIS SILVER NANOPARTICLE: AN UPDATED REVIEW
The aim of this review article is to reflect the current availed study on green synthesis of silver nanoparticle and its future prospects to treat chronic diseases. The development of eco-friendly and reliable techniques for synthesis of silver nanoparticles is a vital step in the area of nanotechnology. The researchers have shown more interest and attention on this because of its unique propertie...
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CHITOSAN: A NOVEL EXCIPIENT IN PHARMACEUTICAL FORMULATION: A REVIEW
Chitosan is a cationic natural polysaccharide which is derived from the chitin of crustaceans, with crabs and shrimp-shell wastes as its principal source. Its properties includes extent of deacetylation and the average molecular weight of polymer as well as low toxicity and good bioavailability make it a novel excipient in pharmaceutical formulation as a relatively new development. Together with c...
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ANTIOXIDANT, CYTOTOXIC AND PHYTOCHEMICAL PROPERTIES OF THE ETHANOL EXTRACT OF PIPER BETLE LEAF
The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picr...
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STABLE FORMULATION OF ACECLOFENAC AND THIOCOLCHICOSIDE TABLETS
The present study relates to the stable fixed dose combination comprising of Aceclofenac as a glycolic acid ester of Diclofenac is having analgesic and anti-inflammatory action and Thiocolchicoside, as a glycosulfurated analogue of colchicine which is well known centrally acting muscle relaxant in unit dosage form and to the preparation method thereof. Aceclofenac is very susceptible to decomposit...
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¬POST-STROKE DEPRESSION: PATHOLOGLOGY, DIAGNOSIS AND TREATMENT STRATEGY
Post stroke depression is most commonly faced psychiatric challenge, causing severe disability. Post stroke depression (PSD) occurs in nearly one-third patients either during acute/chronic stroke period. It’s often under-diagnosed. A good diagnosis must be done within one month after stroke, based on self-reporting tools, followed by observer-rated interview. Mechanism is multifactorial, present...
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AN OVERVIEW ON COVID-19 OUTBREAK: EPIDEMIC TO PANDEMIC
COVID-19 is a disease caused by the novel coronavirus, which was initially called 2019-nCoV, consequently termed as SARS-CoV-2 by the experts of the International Committee on Taxonomy of Viruses (ICTV) as it is exceptionally alike to the virus that caused the SARS outbreak in 2002 to 2003. World Health Organization already had declared COVID-19 as an international emergency as the disease is spre...
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POTENTIAL BIOMEDICAL APPLICATIONS OF METALLIC NANOBIOMATERIALS: A REVIEW
Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, durin...
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BIOEQUIVALENCE STUDY OF TWO ORAL FORMULATIONS OF METAMIZOLE 500 MG IN HEALTHY VOLUNTEERS
Background: Metamizole (Dipyrone) is widely used and has effective analgesic, antipyretic, and antispasmodic properties. After oral or intravenous administration, dipyrone is rapidly hydrolyzed to the active moiety 4-methylaminoantipyrine. Aim: The aim of this study was to assess the bioequivalence of 2 oral formulations of Metamizole 500 mg. Methods: This double blind, randomized, single-do...
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COMPARATIVE QUALITY EVALUATION OF PARACETAMOL TABLET MARKETED IN SOMALI REGION OF ETHIOPIA.
The safety and efficacy of a pharmaceutical dosage form can be guaranteed when its quality is reliable. The efficacy of pharmaceutical dosage forms generally depends on their formulation properties, and manufacturing methods, hence it is likely that the quality of dosage form may vary. The aim was to evaluate the quality of paracetamol tablet marketed in Somali region of Ethiopia. The study was ex...
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