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FORMULATION DEVELOPMENT AND EVALUATION OF ORAL THIN FILMS- DIPHEN HYDRAMINE HCl
The aim of this study was to develop a fast releasing oral polymeric thin film, prepared by solvent casting method, with good mechanical properties, instant disintegration and dissolution. Diphenhydramine hydrochloride, an antihistamine drug belonging to BCS class I was used for oral thin film preparation. The formulations from the preliminary trial were analyzed which was applied to optimize the ...
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2993
ANTIMICROBIAL AND TOXICITY STUDY OF DIFFERENT FRACTIONS OF DILLENIA INDICA LINN. BARK EXTRACT
The methanolic extract along with some organic soluble fractions of the bark of Dillenia indica Linn. were tested against four Gram-positive and seven Gram-negative bacteria and against three pathogenic fungi. n-Hexane and dichloromethane fractions showed remarkable activities against all the tested bacteria but n-Hexane fraction showed highest activity against Shigella dysenteriae and its zone of...
10323
2019
ASSESSING THE EFFECT OF PROCESSED NIGELLA SATIVA ON OLIGOMENORRHEA AND AMENORRHEA IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A PILOT STUDY
Objective: The aim of this pilot study was to assess the effect of processed Nigella Sativa (N. Sativa) on oligomenorrhea and amenorrhea in patients with Polycystic Ovarian Syndrome (PCOS). Materials and Methods: Ten women diagnosed with PCOS, having oligo-amenorrhea, participated in this study. The National Institutes of Health (NIH)’s criteria were used for the diagnosis. The patients, between...
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2655
A COMPLETE GUIDE ON THE PHARMACOLOGIC AND PHARMACOTHERAPEUTIC ASPECTS OF CALCIUM CHANNEL BLOCKERS: AN EXTENSIVE REVIEW
The calcium channel blockers, a diverse group of cardiovascular drugs, exert their action by inhibiting the L-type calcium channels and cause vasodilatation in the heart and the smooth muscles. They also block the action potential at the SA and AV node, thus prolonging the duration of the action potential (Verapamil and Diltiazem). Although, the calcium channel blockers have the same anti-hyperten...
10314
3909
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS DETERMINATION OF MINOXIDIL AND FINASTERIDE IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
A simple, precise, rapid, accurate RP-HPLC method has been developed and validated for the simultaneous determination of Minoxidil and Finasteride in pharmaceutical dosage form. The chromatographic separation was achieved on ODS C18 column (25 cm × 4.6 mm, 5 µ particle size) using a mobile phase comprising methanol: water along with 0.5 % triethyl amine (TEA), pH 6.38 adjusted with ortho phospho...
10311
2890
FACILE METHODS FOR THE EXTRACTION OF ESSENTIAL OIL FROM THE PLANT SPECIES – A REVIEW
Essential oils are a diverse group of natural products. Oils are the important source of aromatic and flavoring chemicals in food, industrial, and pharmaceutical products. Essential oil is a concentrated hydrophobic liquid containing volatile aroma compounds derived from the different parts of the plants. Various extraction methods are used in the manufacture and extraction of essential oils from ...
10306
5995
ACTINIDIA DELICIOSA: A REVIEW
Actinidia deliciosa (A. Chev.) C. F. Liang et A. R. Ferguson is a sub-family of the genus Actinidia, which is also known as Chinese gooseberry, kiwifruit, yangtao, etc. in China, and consists of 55–60 species. The genus Actinidia is a dioecious plant and is widely distributed on the Asian continent. It is also native to China and most of the species are cultured in the southwest of China. Out of...
10298
3906
ANTIOXIDANT, CYTOTOXIC AND PHYTOCHEMICAL PROPERTIES OF THE ETHANOL EXTRACT OF PIPER BETLE LEAF
The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picr...
10297
3556
IN-VITRO ANTIFUNGAL ACTIVITY OF LEAF EXTRACTS OF LEUCAS ASPERA AND LEUCAS ZEYLANICA
The aim of the present study is to probe the antimicrobial activities of methanol leaf extract of Leucas sp. Antifungal susceptibilities of certain clinically isolated dermatophytes to methanol extracts of Leucas aspera and Leucas zeylanica leaves were performed using agar well diffusion method. The result obtained shows that all the extracts expressed remarkable antifungal activity with zone of i...
10273
3140
DEVELOPMENT OF ORALLY ADMINISTERED FIXED DOSE COMBINATION (FDC) PRODUCTS: PHARMACOKINETIC AND BIOPHARMACEUTICAL CONSIDERATIONS
Combination drug therapy has been shown to be beneficial in chronic multifactorial diseases, infectious diseases and in the treatment of comorbid conditions. Some drug combinations have also been developed to improve the bioavailability of the active components by combining with drug metabolizing enzyme inhibitors. Fixed dose combinations (FDC) offer advantages of better efficacy, ease of administ...
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3681