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ANTIOXIDANT, CYTOTOXIC AND PHYTOCHEMICAL PROPERTIES OF THE ETHANOL EXTRACT OF PIPER BETLE LEAF
The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picr...
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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS DETERMINATION OF MINOXIDIL AND FINASTERIDE IN PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD
A simple, precise, rapid, accurate RP-HPLC method has been developed and validated for the simultaneous determination of Minoxidil and Finasteride in pharmaceutical dosage form. The chromatographic separation was achieved on ODS C18 column (25 cm × 4.6 mm, 5 µ particle size) using a mobile phase comprising methanol: water along with 0.5 % triethyl amine (TEA), pH 6.38 adjusted with ortho phospho...
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EFFECT OF DIFFERENT CARBON AND NITROGEN SOURCES ON α- AMYLASE PRODUCTION FROM BACILLUS AMYLOLIQUEFACIENS
Amylases are among the most important enzymes in present-day biotechnology. The effects of various carbon and nitrogen sources on α-amylase production by submerged fermentation (smF) from Bacillus amyloliquefaciens was investigated. The study revealed that the levels of the α- amylase production varied greatly with the type and concentration of carbon and nitrogen sources used. The highest α-am...
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ASSESSING THE EFFECT OF PROCESSED NIGELLA SATIVA ON OLIGOMENORRHEA AND AMENORRHEA IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME: A PILOT STUDY
Objective: The aim of this pilot study was to assess the effect of processed Nigella Sativa (N. Sativa) on oligomenorrhea and amenorrhea in patients with Polycystic Ovarian Syndrome (PCOS). Materials and Methods: Ten women diagnosed with PCOS, having oligo-amenorrhea, participated in this study. The National Institutes of Health (NIH)’s criteria were used for the diagnosis. The patients, between...
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DEVELOPMENT OF ORALLY ADMINISTERED FIXED DOSE COMBINATION (FDC) PRODUCTS: PHARMACOKINETIC AND BIOPHARMACEUTICAL CONSIDERATIONS
Combination drug therapy has been shown to be beneficial in chronic multifactorial diseases, infectious diseases and in the treatment of comorbid conditions. Some drug combinations have also been developed to improve the bioavailability of the active components by combining with drug metabolizing enzyme inhibitors. Fixed dose combinations (FDC) offer advantages of better efficacy, ease of administ...
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ACTINIDIA DELICIOSA: A REVIEW
Actinidia deliciosa (A. Chev.) C. F. Liang et A. R. Ferguson is a sub-family of the genus Actinidia, which is also known as Chinese gooseberry, kiwifruit, yangtao, etc. in China, and consists of 55–60 species. The genus Actinidia is a dioecious plant and is widely distributed on the Asian continent. It is also native to China and most of the species are cultured in the southwest of China. Out of...
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FACILE METHODS FOR THE EXTRACTION OF ESSENTIAL OIL FROM THE PLANT SPECIES – A REVIEW
Essential oils are a diverse group of natural products. Oils are the important source of aromatic and flavoring chemicals in food, industrial, and pharmaceutical products. Essential oil is a concentrated hydrophobic liquid containing volatile aroma compounds derived from the different parts of the plants. Various extraction methods are used in the manufacture and extraction of essential oils from ...
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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF TELMISARTAN
The patients with sudden increase blood pressure have markedly reduced function ability and extremely restless, in such cases rapid onset of action is of prime importance. So the patients would be benefited from acute treatment by using Fast dissolving drug delivery system. Telmisartan is an Anti-hypertensive drug which is insoluble in water; hence the drug may be slowly or incompletely dissolves ...
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IN-VITRO ANTIFUNGAL ACTIVITY OF LEAF EXTRACTS OF LEUCAS ASPERA AND LEUCAS ZEYLANICA
The aim of the present study is to probe the antimicrobial activities of methanol leaf extract of Leucas sp. Antifungal susceptibilities of certain clinically isolated dermatophytes to methanol extracts of Leucas aspera and Leucas zeylanica leaves were performed using agar well diffusion method. The result obtained shows that all the extracts expressed remarkable antifungal activity with zone of i...
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AN OVERVIEW ON SOLUBILITY ENHANCEMENT TECHNIQUES FOR POORLY SOLUBLE DRUGS AND SOLID DISPERSION AS AN EMINENT STRATEGIC APPROACH
Solubility is an important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Among all newly discovered chemical entities most of the drugs are lipophillic and fail to reach market due to their poor water solubility. The solubility behavior remains one of the most challenging aspect informational development. Hence various techni...
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