SIMULTANEOUS ESTIMATION OF MOXIFLOXACIN HCl AND BROMFENAC SODIUM IN EYE DROPS BY SPECTROPHOTOMETRIC METHODS
Moxifloxacin Hydrochloride is a fluorinated quinolone antibacterial and Bromfenac Sodium is a non-steroidal anti-inflammatory. The combination formulation is used for the treatment of the reduction of post operative inflammatory conditions of the eye. Three new, simple, accurate and precise UV spectrophotometric methods have been developed and validated for the simultaneous determination of Moxifl...
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF BRINZOLAMIDE AND TIMOLOL BY HPLC FROM OPHTHALMIC PREPARATION
A fast, sensitive and accurate reverse phase liquid chromatographic method has been developed and validated for the simultaneous determination of Brinzolamide and Timolol maleate from ophthalmic preparation. Chromatographic separation of these two drugs were achieved on Zorbax Eclipse Plus, Agilent Technology (150mm x 4.6mm, 5μm) as stationary phase with a mobile phase comprising of triethylamine...
The current scenario was to study Polyelectrolyte complex. Polyelectrolyte complexes (PECs) represent a special class of polymeric compounds consisting of oppositely charged polyions that can have either cationic or anionic charges. Due to their charges they are hydrophilic, and normally water soluble, and can be used in a variety of applications, such as drug delivery, coatings, shampoos, or as f...
Mimusops elengi Linn. (Family: Sapotaceae) is a tree which is traditionally used against a number of diseases including ulcers, headache, dental diseases, wound and fever. In the present study crude methanolic extract of Mimusops elengi Linn. leaf was investigated for possible antioxidant, analgesic and cytotoxic activity. The extract exhibited statistically significant antioxidant activity in DPP...
Pyogenic infection refers to bacterial infection that leads to the production of pus. Antibiotics to treat these pyogenic bacterial infections are routinely prescribed, toxicity of which is serious threat and makes chemotherapy more difficult. Management of pyogenic infections consists of aspiration or surgical drainage followed by appropriate antibiotics. A total of 50 samples were examined, 36...
Air pollution tolerance index was assessed with plant species located at ChinnaTirupathi, Salem, Tamil Nadu, India. This study was conducted during March, 2013. Since, all the lands are converted to buildings, it is essential to know more about plants and its benefits offered to the environment and the dangers, risks caused by cutting trees. In this study, our aim is to evaluate, whether the plant...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS DETERMINATION OF ATORVASTATIN CALCIUM AND AMLODIPINE BESILATE IN TABLET DOSAGE FORM BY RP-HPLC
A high performance liquid chromatography method was developed for the simultaneous separation and quantization of Atorvastatin calcium and Amlodipine besilate in combined pharmaceutical tablet dosage form. The chromatographic estimation was achieved by using mobile phase consisting of a mixture of phosphate buffer (1ml ortho phosphoric acid in 1000 ml 0f water) acetonitrile and methanol (53:43:4, ...
EVALUATION OF ANTIVENOM ACTIVITY OF CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST VIPERA RUSSELLI SNAKE VENOM
Ethnopharmacological relevance: Calotropis gigantea is usedtraditionally to treat common diseases such as fever, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting and diarrhoea, either alone or with other medicines Aim of the study: To evaluate the antivenom activity of Calotropis gigantea plantextract against Vipera russelli snake venom Mate...
The task of achieving efficient delivery of drugs that have poor bioavailability or narrow absorption windows have plagued the pharmaceutically industry for decades. Thus, much research has been dedicated to the development of novel polymeric-based gastro retentive drug delivery technologies that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs. Several technical ...
Buccal controlled drug delivery system has been developed since the environment of the oral cavity provides potential sites for drug delivery. The acid hydrolysis and first pass effects can be avoided. The release of drug can be affected by continuous secretion of saliva. The mucin film exists in oral mucosa offers an opportunity to develop mucoadhesive system, which retain at absorption site for ...