ASSESSMENT OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF ETHANOLIC EXTRACT OF LEAVES OF ACALYPHA HISPIDA
The ethanolic extract of leaves of Acalypha hispida was evaluated for phytochemical, cytotoxic and antibacterial activities. Phytochemical studies revealed the presence of flavonoids, saponins, glycosides, reducing sugars and steroids. Cytotoxic activity was investigated by brine shrimp (Artemia salina) lethality assay. The extract showed potent cytotoxic effect (LC50 19.95µg/ml) which is compara...
Simple, fast and economic spectrophotometric methods were developed for determination of Tolterodine in bulk and pharmaceutical dosage forms using water as the solvent. The quantitative determination of the drug was carried out using the zero order derivative measured at 281.5 nm, first order derivative measured at 274 nm and area under curve was measured in wavelength range of 276-286 nm. Calibra...
STUDIES ON ANTIDIARRHOEAL ACTIVITY OF LEAVES OF AMORPHOPHALLUS PAEONIIFOLIUS IN EXPERIMENTAL ANIMALS
Acute diarrhoea is one of the principal causes of death in the infants, particularly in developing countries. An array of medicinal plants with anti-diarrhoeal properties has been widely used by the traditional practitioners; however, the efficacy of many of these anti-diarrhoeal conventional medicines has not been scientifically evaluated. Hence the present study was under taken to explore anti-d...
ESTIMATION OF TOTAL POLYPHENOLIC CONTENT IN AQUEOUS AND METHANOLIC EXTRACTS FROM THE BARK OF ACACIA NILOTICA
Plant polyphenols have been studied largely because of the possibility that they might underlie the protective effects afforded by fruit and vegetable intake against cancer and other chronic diseases. The objective of the present study is to estimate the total polyphenolic content in aqueous and methanolic extract prepared from the bark of Acacia nilotica plant species. Acacia nilotica (L.) Willd....
A variety of Nano-biomaterials are synthesised, characterised and tested to find out their potentialities by global scientific communities, during the last three decades. Among those, nanostructured ceramics, cements and coatings are being considered for major use in orthopaedic, dental and other medical applications. The development of novel biocompatible ceramic materials with improved biomedica...
C-phycocyanin (C-PC) is a biliprotein found in edible blue-green algae. Its anti-cancer, anti-inflammatory, anti-proliferative and anti-oxidant activities has been evidenced by many in vitro and in vivo studies. Anti-inflammatory activity of C-PC demonstrated by free radical scavenging, inhibition of DNA damage, and decreased ROS. Here, the effects of C-PC on cytotoxicity and cell signaling throug...
ASSESSMENT OF DRUG UTILIZATION PATTERN DURING PREGNANCY IN ADAMA RIFERRAL HOSPITAL, OROMIA REGION, ETHIOPIA
Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. ...
IN VITRO ANTIOXIDANT ACTIVITY OF DIFFERENT GASTROPODS, BIVALVES AND ECHINODERM BY SOLVENT EXTRACTION METHOD
Antioxidants can protect the human body from free radicals and ROS effects. They retard the progress of many chronic diseases as well as lipid peroxidation. The commercially used synthetic antioxidants BHA and BHT have been suspected of being responsible for liver damage and carcinogenesis. Hence, a need for identifying alternative natural and safe sources of antioxidants has been created, and the...
FORMULATION DESIGN AND IN-VITRO EVALUATION OF ZOLMITRIPTAN GASTRORETENSIVE FLOATING MATRIX TABLETS FOR MANAGEMENT OF MIGRAINE
Objective: The objective of the present investigation was to formulate and evaluate hydrodynamically balanced floating matrix controlled drug delivery system of Zolmitriptan by increasing its residence time and improves the bioavailability. Methods: Twelve different formulations of floating tablets were prepared using direct compression technique with hydrophilic polymers such as HPMC K4M, K15M, K...
In recent years, a large number of oils and their constituents have been investigated for their antimicrobial properties against bacteria and fungi. The present investigation evaluated the antimicrobial potential of edible medicinal oils of Cocos nucifera, Helianthus annus, Brassica juncea, Ricinus communis, Arachis hypogea, Glycine max, Gossypium hirsutum and Sesamum indicum extracted from differ...