Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
BELINOSTAT: A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T-CELL LYMPHOMA
Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple cancer types. Belinostat is under global development with Spectrum Pharmaceuticals, currently approved by the U.S. Food and Drug Administration with indications for relapsed or refractory peripheral T-cell lymp...
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GENUS HUNTERIA- A ETHNOPHARMACOLOGICAL, CHEMICAL AND PHARMACOLOGICAL PERSPECTIVES
Hunteria is a genus of plant in family Apocynaceae. It comprises of 12 species but more prevalent are Hunteria umbellata and Hunteria zeylanica. Taditionally H. umbellata have been used in the treatment of yaws and sexually transmitted infections, stomach ache, ulcers, diabetes mellitus and dysmenorrhoea. H. zeylanica is used to cure profile but its prolonged use, particularly, at high doses shoul...
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ZIKA VIRUS – A REVIEW ON PAST, PRESENT AND FUTURE SCENARIO
Zika virus is transmitted to people through aedes mosquito bites. People with Zika virus disease usually have symptoms of mild fever, exanthema (skin rash), joint pain and conjunctivitis that normally last for 2-7 days. There is no specific treatment or vaccine currently available. The best form of prevention is protection against mosquito bites. The virus is known to circulate in Africa, the Amer...
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A CASE CONTROL STUDY OF OXIDATIVE STRESS IN TUNISIAN PATIENTS WITH ISCHEMIC HEART DISEASE
Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. Serum total homocysteine (Hcy) concentration was measured by fluorescence polarization immunoessay. Plasma levels of substances reacting with thiobarbituric acid (TBARS...
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PHARMACOKINETIC DERIVATION OF RATES AND ORDERS OF REACTIONS IN MULTI-COMPARTMENT MODEL USING MATLAB
Pharmacokinetic modeling is the representation of the logarithmic mathematical equations in order to measure the physiologic response of the body to the drug. Absorption, distribution, metabolism and excretion follow drug kinetic principles according to specific reaction mechanisms in which concentration of the drug may either be dependent or independent of drug-body interactions. Michaelis-Menten...
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INFLUENCE OF FLUCONAZOLE PRE-TREATMENT ON ANTIDIABETIC ACTIVITY OF THIAZOLIDINEDIONES IN DIABETIC RATS
The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720µg/kg, p.o) was studied. This study was conducted on diabetic rats of either sex, randomly distributed into two different groups. Diabetes was induced by administering 120mg/kg of alloxan intraperitonially. Then they were pretreated with fluconazole (36 mg/kg) in 2% w/v gum...
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DESIGN AND IN VITRO EVALUATION OF PROCHLORPERAZINE MALEATE BUCCOADHESIVE TABLETS AND COMPARISON OF MONOLAYER, BILAYER AND COMPRESSED COATED TABLETS
Buccoadhesive tablets have long been employed to improve the bioavailability of drugs undergoing significant first pass hepatic metabolism. Prochlorperazine maleate is an anti-emetic drug. It was under goes extensive first pass metabolism resulting in an oral bioavailability of 0 to 16 % and it shows variable absorption from GIT. Hence in the present work Buccoadhesive bilayered tablets of Prochlo...
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CURATIVE EFFECTS OF MALOTILATE ON ETHANOL – INDUCED HEPATIC DYSFUNCTION IN RATS
In chronic alcoholics, continuous heavy drinking leads to progression of alcoholic liver disease (ALD) from alcoholic fatty liver, hepatitis to cirrhosis. Strict abstinence from alcohol has its own limitations and there is paucity of promising drugs available to treat ALD. Malotilate showed promising hepatocyte regenerating capacity and ability to prevent such damage. Aims: The objective of this...
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EVALUATION OF ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF SOME NUTRITIONAL SUPPLEMENTS
The nutritional supplements are the natural food supplements, and other related products used to boost the nutritional content of the diet. These nutritional supplements have been of interest to research because of their antioxidant property by consumption of food and drinks. The present study deals with a comparative evaluation of antioxidant and anti-inflammatory effects of marketed nutritional ...
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FORMULATION AND CHARACTERIZATION OF DILTIAZEM HCL MATRIX TABLETS BY EMPLOYING ELECTROLYTES WITH GUM KONDAGOGU
The objective of the present investigation is to prepare and evaluate the sustained release matrix tablets of Diltiazem HCl using a natural polymer Gum kondagogu. Diltiazem HCl was formulated as sustained release matrix tablet formulations with natural polymer by employing pharmaceutically acceptable electrolytes. Electrolytes such as Sodium carbonate, Magnesium carbonate and Calcium carbonate wer...
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