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SOLUBILITY ENHANCEMENT AND OPTIMIZATION OF VARIOUS VARIABLES OF FAST DISINTEGRATING TABLETS OF LERCANIDIPINE HYDROCHLORIDE USING CENTRAL COMPOSITE DESIGN
The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion, but it is problematic if the drug is poorly soluble. Sufficient drug absorption, reproducible bioavailability and pharmacokinetic profile of orally administered drug substances are highly dependent on the solubility of that compound in an aqueous medium. Also, the the...
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REVIEW ON MICROSPONGE LEADING MICROPOROUS PARTICULATE TECHNOLOGY WITH CONTROLLED RELEASE, IMPROVE STABILITY TO PROVIDE OPTIMUM SKIN DISORDERS MANAGEMENT ENVIRONMENT FOR THERAPEUTIC APPLICATION
Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduc...
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NANOTHERAPEUTIC APPROACHES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROSPECTS OF PLANT MUSSAENDA FRONDOSA LINN: A HOLISTIC INVESTIGATION
Medicinal plants provide numerous benefits to human health. Mussaenda frondosa Linn belongs to the Rubiaceae family, which has 500 genera and 5300 medicinal plant species. Mussaenda is a flowering plant genus with many beautiful species. Ayurveda, an ancient Indian healing system, describes many herbs, oils, and minerals. People have known about plants' medicinal value since prehistoric times. Mus...
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CANCER-ASSOCIATED THROMBOSIS: AN OVERVIEW OF THROMBOSIS MECHANISMS AND ITS RISK FACTORS IN CANCER
Thrombosis is one of the major causes of death and disability worldwide. Cancer patients are commonly thrombophilia or prothrombotic since they have abnormalities in all three factors of Virchow's triad, which lead to thromboembolism. Venous thrombosis (VT) is a chronic disorder that has the potential to be fatal and cause considerable complications. Venous thromboembolism (VTE) may potentially be...
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OPTIMIZATION OF PROCESS PARAMETERS FOR IMPROVED PRODUCTION OF BIO-ACTIVE METABOLITES BY ENDOPHYTIC FUNGUS CLADOSPORIUM CLADOSPORIOIDES ISOLATED FROM MANGROVE PLANT LUMNITZERA RACEMOSA LINN.
A study has been undertaken with an aim to isolate potent endophytic fungi from mangrove plant Lumnitzera racemosa Linn. Among the 10 different fungal strains isolated, one potent strain with broad-spectrum antagonistic activity was found. Basing on the morphological, cultural and molecular characteristics, the potent fungal strain was identified as Cladosporium cladosporioides. Production of bioa...
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IN-VITRO EVALUATION OF ANTI-HELICOBACTER PYLORI ACTIVITY OF COMMERCIALLY AVAILABLE PROBIOTICS
Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warran...
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CARDIOPROTECTIVE EFFECT OF ARBUTIN ON LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
The present study was designed to investigate the cardioprotective effect of Arbutin (ARB) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac and hepatic markers, antioxidant defense system, lipid peroxidation products and histopathological changes. Rats were pretreated with ARB (25 and 50 mg/kg BW) for 21 days. After pretreatment, ISO (60 mg/kg BW) was admi...
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NANOEMULSION: A PROMISING AND NOVEL NANOTHERAPEUTIC VEHICLE FOR TRANSDERMAL DRUG DELIVERY
Transdermal delivery of therapeutics has been identified by scientific researchers as an alternative choice of drug administration, owing to its unique and tremendous benefit over conventional and oral administrations, but its exploration has been limited because of the “skin barricade” as its major challenge. A special formulation that is capable of meeting up and overcoming its associated ch...
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AN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE
In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacologica...
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QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDIES OF SUBSTITUTED BENZIMIDAZOLE ANALOGUES WITH POTENT ANTIBACTERIAL ACTIVITY
Computational chemistry is a robust and economical tool for designing and developing potent therapeutic molecules. Benzimidazole and its analogues are compounds with a unique pharmacophore that derives its application as broad-spectrum antimicrobial agents. A quantitative structure-activity relationship (QSAR) study was performed using a data set of 28 benzimidazole analogues with antimicrobial ac...
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