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QSAR STUDIES, SYNTHESIS AND BIOLOGICAL EVALUATION OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS: AN APPROACH TO DESIGN ANTICANCER AGENTS
A series of pyrazole derivatives designing for potential EGFR kinase inhibitors have been discovered. Some of them exhibited significant EGFR inhibitory activity. Compound 3-(4-Amino-phenyl)-5-(3-nitro-phenyl)-4, 5-dihydro-pyrazole-1-carbothioic acid amide (AP-2) displayed the most potent EGFR inhibitory activity. The QSAR analysis of a set of these compounds tested for growth inhibitory activity ...
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COMPARATIVE GROWTH ANALYSIS OF CYANOBACTERIA FROM DIVERSE HABITATS WITH REFERENCE TO PIGMENTS
Cyanobacteria are a gram-negative group of microorganisms with unique features and found in diverse conditions of the environment. These tiny bio-factories are rich in pigment molecules like chlorophylls, carotenoids and phycobiliproteins. Studies on physiological and biochemical characteristics of different cyanobacterial strains will not only help to determine their biotechnological potential bu...
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CHEMICAL COMPOSITION OF ESSENTIAL OIL OF EQUISETUM DIFFUSUM: A NOBLE SOURCE OF PHYTOL
Plants as a source of medicine have been inherited and are an important component of the health care system in India. Equisetum diffusum D. Don (Equisetaceae) is one of the medicinally important plants, which is a native species to the Himalayan Mountains. It is popularly known as Himalayan horsetail. The present endeavor deals with the exploration of the chemical composition of Himalayan E. diffu...
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TRIGONELLA FOENUM-GRAECUM L. SEED MUCILAGE-BASE MUCOADHESIVE MICROSPHERES OF DICLOFENAC SODIUM
The study was aimed to discover the properties of Trigonella foenum-graecum L. seed mucilage (TFGSM) in the formulation of mucoadhesive microspheres of diclofenac sodium to prolong the residence time at the site of absorption. Diclofenac sodium microspheres were formulated by ion gelation technique. Different polymer ratios of TFGSM and sodium alginate were used to formulate eight formulations (F1...
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IN-SILICO SCREENING AND MODELING OF DELETERIOUS nsSNPs IN HUMAN GENE FBN1 FOR MARFAN SYNDROME
Marfan syndrome (MFS) is a common dominant inherited disorder that affects connective tissue, which is associated with mutation of the gene FBN1. The protein encoded by this gene contributes to the final structure of microfibrils. Single nucleotide polymorphisms (SNPs) of this gene links to variations in gene expression phenotypically among patients. Therefore SNPs would be the main target for ide...
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THE ANTICANCER ACTIVITY OF BIOACTIVE COMPOUNDS FROM MEDICINAL PLANTS: AN REVIEW
Cancer is a serious health concern in both developed and developing nations. Cancer causes due to unwanted growth of cells and irregular cell division. Medicinal plants have been used by village folk from ancient times. The plants contain various bioactive compounds that can be used for treating cancer. Some of the phyto compounds isolated from plants have shown promising results; these include ...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF LORNOXICAM AND THIOCOLCHICOSIDE IN BULK FORM AND MARKETED PHARMACEUTICAL DOSAGE FORM BY USING RP-HPLC
A simple, reproducible, and efficient reverse phase high performance liquid chromatographic method was developed for simultaneous determination of Lornoxicam and Thiocolchicoside in pure form and marketed combined pharmaceutical dosage forms. A column having Symmetry (C18) (150mm × 4.6mm, 5µm) in isocratic mode with mobile phase containing Methanol: Phosphate Buffer (pH-3.8) (28:72 v/v) was used...
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QUANTITATIVE DETERMINATION OF LACOSAMIDE IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY AND ITS APPLICATION TO PHARMACOKINETIC STUDY
A simple, reliable, and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for the determination of lacosamide, an antiepileptic drug, in human plasma. The lacosamide and internal standard (IS) have been extracted by a simple liquid-liquid extraction method and separated on C18 (50 × 4.6 mm, 5μm) column with the mobile phase of 5mM ammoniu...
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ANTIOXIDANT AND BRINE SHRIMP LETHALITY BIOASSAY OF PECTIN FROM GRAPE FRUIT (CITRUS PARADISI) AND LEMON (CITRUS LIMON)
Pectin is a complex polysaccharide and has been used in food and pharmaceutical industries. The current study aimed to determine antioxidant and cytotoxic activities of pectin from peels of grape fruit (GP) and lemon (LP) by ferric reducing power (FRP) assay and brine shrimp lethality bioassay respectively. In addition, antioxidant and cytotoxic activities of GP and LP were compared with food-grad...
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NANOEMULSION: A PROMISING AND NOVEL NANOTHERAPEUTIC VEHICLE FOR TRANSDERMAL DRUG DELIVERY
Transdermal delivery of therapeutics has been identified by scientific researchers as an alternative choice of drug administration, owing to its unique and tremendous benefit over conventional and oral administrations, but its exploration has been limited because of the “skin barricade” as its major challenge. A special formulation that is capable of meeting up and overcoming its associated ch...
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