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EVALUATION OF THE SERUM LEVELS OF SOME TRACE ELEMENTS AND ANTIOXIDANT LEVELS IN APPARENTLY HEALTHY INDIVIDUALS WITH FAMILY HISTORY OF TYPE 2 DIABETES IN NNEWI, NIGERIA
There is a paucity of data on studies evaluating trace elements and antioxidant levels and susceptibility of offspring of diabetic parents to type 2 diabetes in Nigerian population. This study evaluated the serum level of some trace elements and antioxidants among apparently healthy individuals with a family history of type2 diabetes mellitus (FH-T2DM). This was a cross-sectional study involving 1...
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FLASH RELEASE ORAL FILM OF CANDESARTAN CILEXETIL FORMULATION AND IN-VITRO EVALUATION
In the present study, to develop a novel flash release fast dissolving oral film of candesartan cilexetil to achieve rapid dissolution and further improve the bioavailability of the drug. Also, to resolve the swallowing problems in pediatrics, geriatric patients by rapid dissolution in saliva and improve the patient compliance. Fast dissolving flash release oral flim of candesartan cilexetil was f...
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DESIGN AND CHARACTERIZATION OF POLYHERBAL FORMULATION FOR HAIR GROWTH CONTAINING ECLIPTA ALBA, HIBISCUS ROSA-SIENSIS, TRIGONELLA FOENUM-GRAECUM LINN.
Gelling agents such as Carbopol 934 and HPMC K 100 were used in different concentrations for the preparation of Topical polyherbal extract gel formulations containing (%w/w) Eclipta alba, Hibiscus rosa-siensis, Trigonella foenum-graecum Linn. Prepared gel extract of various herbal ingredients were characterized by different parameters like gelling capacity, pH, Homogeneity, Grittiness, Extrudabili...
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PHYTOCHEMICAL ANALYSIS OF ETHANOLIC EXTRACT OF PROSOPIS CINERARIA PODS BY GC-MS
This study was aimed to identify the possible bioactive chemical constituents of the state tree of Rajasthan, i.e., Prosopis cineraria L. (locally called Khejri) by GC-MS analysis using the GC-MS equipment (Shimadzu GCMSQP2010). For this purpose, the ethanolic extract of P. cineraria pods were used. Experimental conditions of the GC-MS system were as follows: Rtx-5MS capillary standard non-polar c...
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PHARMACOLOGICAL EVALUATION OF POLYHERBAL SUSPENSION AS ANTI-DEPRESSANT IN RAT
The ethanolic extract of Moringa oleifera leaves & methanolic extract of rose hips of Rosa damascena were first subjected to various phytochemical tests and further assessed for their antioxidant activity by DPPH method. Different ratio of two drugs in the polyherbal formulation were based on antioxidant activity in albino Wistar rats. Thirty rats (180 -250 g) of either sex were randomly divid...
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A VALIDATED STABILITY-INDICATING RP-LC METHOD FOR PROPYLTHIOURACIL WITH LC-MS STUDIES OF FORCED DEGRADATION PRODUCTS AND SIMULTANEOUS ESTIMATION OF ITS IMPURITY
A simple, precise, accurate, sensitive and robust stability-indicating HPLC method for simultaneous estimation of propylthiouracil and its impurity thiourea has been proposed. The separation was achieved on a C18 column (4.6 mm × 150 mm, particle size 5.0 μm) maintained at 45 ºC with a mobile phase composed of water: methanol: acetonitrile (50:35:15 v/v/v) with 0.1% acetic acid and detection wa...
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PHARMACEUTICAL APPLICATIONS OF NEXT GENERATION PRINTING TECHNOLOGIES: A BRIEF LITERATURE REVIEW
Next-generation printing or commonly known as three-dimensional (3D) printing (3DP), is a fabrication process of construction of a 3D object using a computer-aided design or digital 3D model. The 3D object is created layer by layer by depositing, joining, or solidifying a feedstock material such as thermoplastic polymer under the control of a computer-designed program. It is considered the latest ...
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A REVIEW ON MECHANISTIC ASSESSMENT OF HEPATOTOXICITY AND MEDICINAL PLANTS WITH HEPATOPROTECTIVE POTENTIAL
The liver is the most important organ in the body that plays a central role in the detoxification and excretion of many exogenous and endogenous compounds. Due to these functions, hepatic diseases continue to be among the main threats to public health, and that challenges health care professionals. Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic...
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SCREENING OF PHYTOCONSTITUENTS, HPTLC AND FT-IR ANALYSIS IN LUFFA CYLINDRICA (L.) M. ROEM FRUITS
The present investigation deals with the preliminary phytochemical, High Performance Thin Layer Chromatography and Fourier Transform Infrared Spectral analysis of Luffa cylidrica (L.) Roem (Cucurbitaceae) fruits. The results revealed that most of the phytochemicals evaluated were present in ethanolic extract as compared to the petroleum ether extract. Quantitative analysis revealed that the fruits...
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FORMULATION DEVELOPMENT AND EVALUATION OF FLOATING BIOADHESIVE TABLET OF ANTIRETROVIRAL DRUG
Oral route has been commonly adopted and the most convenient route for drug administration. It has been received more attention in the pharmaceutical field because of the more flexibility in the designing of dosage form than drug delivery design for other routes. Gastroretensive systems can remain in the gastric region for several hours and hence significantly prolong the gastric residence time of...
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