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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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48.

SOLUBILITY ENHANCEMENT AND OPTIMIZATION OF VARIOUS VARIABLES OF FAST DISINTEGRATING TABLETS OF LERCANIDIPINE HYDROCHLORIDE USING CENTRAL COMPOSITE DESIGN

The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion, but it is problematic if the drug is poorly soluble. Sufficient drug absorption, reproducible bioavailability and pharmacokinetic profile of orally administered drug substances are highly dependent on the solubility of that compound in an aqueous medium. Also, the the...

S. Saini * and R. Garg

IKG Punjab Technical University, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3474-82

3474-3482

2644

1425

8.

REVIEW ON MICROSPONGE LEADING MICROPOROUS PARTICULATE TECHNOLOGY WITH CONTROLLED RELEASE, IMPROVE STABILITY TO PROVIDE OPTIMUM SKIN DISORDERS MANAGEMENT ENVIRONMENT FOR THERAPEUTIC APPLICATION

Although serious systemic and cutaneous side effects need a novel delivery system that provides prolonged and controlled drug release, minimum systemic drug absorption with reduced side effects. Microsponge, a drug delivery system, possesses the versatility to load a wide range of active ingredients to facilitate the controlled release of active ingredients to reduce systemic exposure and to reduc...

N. Tomar, N. Pawar * and K. Bahmani

Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5360-75

5360-5375

2644

2187

2.

NANOTHERAPEUTIC APPROACHES, PHYTOCHEMISTRY AND PHARMACOLOGICAL PROSPECTS OF PLANT MUSSAENDA FRONDOSA LINN: A HOLISTIC INVESTIGATION

Medicinal plants provide numerous benefits to human health. Mussaenda frondosa Linn belongs to the Rubiaceae family, which has 500 genera and 5300 medicinal plant species. Mussaenda is a flowering plant genus with many beautiful species. Ayurveda, an ancient Indian healing system, describes many herbs, oils, and minerals. People have known about plants' medicinal value since prehistoric times. Mus...

Aseem Setia, Sanjay Nagdev, Mrinal Sharma, Shashi Alok, Sandip Tiwari, Megha Verma, Pradeep Golani, Devendra Singh Lodhi and Sankha Bhattacharya *

School of Pharmacy & Technology Management Shirpur, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(7).2562-74

2562-2574

2643

3202

2.

CANCER-ASSOCIATED THROMBOSIS: AN OVERVIEW OF THROMBOSIS MECHANISMS AND ITS RISK FACTORS IN CANCER

Thrombosis is one of the major causes of death and disability worldwide. Cancer patients are commonly thrombophilia or prothrombotic since they have abnormalities in all three factors of Virchow's triad, which lead to thromboembolism. Venous thrombosis (VT) is a chronic disorder that has the potential to be fatal and cause considerable complications. Venous thromboembolism (VTE) may potentially be...

Prashu Yadav, Ashok Kumar Gupta, Rakesh K. Sindhu, Shashi Alok and Vinod Kumar Gupta *

Rapture Biotech International Pvt. Ltd 1, D-201, Sector-10, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(9).4225-36

4225-4236

2643

1256

21.

OPTIMIZATION OF PROCESS PARAMETERS FOR IMPROVED PRODUCTION OF BIO-ACTIVE METABOLITES BY ENDOPHYTIC FUNGUS CLADOSPORIUM CLADOSPORIOIDES ISOLATED FROM MANGROVE PLANT LUMNITZERA RACEMOSA LINN.

A study has been undertaken with an aim to isolate potent endophytic fungi from mangrove plant Lumnitzera racemosa Linn. Among the 10 different fungal strains isolated, one potent strain with broad-spectrum antagonistic activity was found. Basing on the morphological, cultural and molecular characteristics, the potent fungal strain was identified as Cladosporium cladosporioides. Production of bioa...

G. V. L. Bhavani and V. Muvva *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(7).3260-67

3260-3267

2640

1302

67.

IN-VITRO EVALUATION OF ANTI-HELICOBACTER PYLORI ACTIVITY OF COMMERCIALLY AVAILABLE PROBIOTICS

Helicobacter pylori is a major etiological agent responsible for several gastric diseases such as gastritis, peptic ulcer disease, and gastric cancer. From the last two decades, standard triple therapy is mostly recommended for H. pylori eradication; however, its efficacy is restricted by antibiotic resistance. Hence, the present study aimed at exploration for novel therapeutic agents being warran...

G. Gupta, D. Bansal, A. Sharma, T. Ahmad, A. Sachdev and B. Kaur *

Department of Biotechnology, Punjabi University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5890-97

5890-5897

2639

1261

52.

CARDIOPROTECTIVE EFFECT OF ARBUTIN ON LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS

The present study was designed to investigate the cardioprotective effect of Arbutin (ARB) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac and hepatic markers, antioxidant defense system, lipid peroxidation products and histopathological changes. Rats were pretreated with ARB (25 and 50 mg/kg BW) for 21 days. After pretreatment, ISO (60 mg/kg BW) was admi...

S. Sivasangari, L. Asaikumar and L. Vennila *

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.11(3).1433-43

1433-1443

2638

1428

13.

NANOEMULSION: A PROMISING AND NOVEL NANOTHERAPEUTIC VEHICLE FOR TRANSDERMAL DRUG DELIVERY

Transdermal delivery of therapeutics has been identified by scientific researchers as an alternative choice of drug administration, owing to its unique and tremendous benefit over conventional and oral administrations, but its exploration has been limited because of the “skin barricade” as its major challenge. A special formulation that is capable of meeting up and overcoming its associated ch...

O. B. Oyelaja, E. O. Dare, D. P. Katare * and F. O. Oladoyinbo

Centre for Medical Biotechnology, Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(6).2636-48

2636-2648

2638

1350

04.

AN OVERVIEW: MEDICINALLY IMPORTANT HETEROCYCLIC MOIETY BENZOTRIAZOLE

In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacologica...

Hasit V. Vaghani *, Sarika P. Patel and Shweta A. Patel

Mehsana Urban Institute of Sciences, Ganpat Unversity, Kherva, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.13(1).33-41

33-41

2637

1227

16.

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP (QSAR) STUDIES OF SUBSTITUTED BENZIMIDAZOLE ANALOGUES WITH POTENT ANTIBACTERIAL ACTIVITY

Computational chemistry is a robust and economical tool for designing and developing potent therapeutic molecules. Benzimidazole and its analogues are compounds with a unique pharmacophore that derives its application as broad-spectrum antimicrobial agents. A quantitative structure-activity relationship (QSAR) study was performed using a data set of 28 benzimidazole analogues with antimicrobial ac...

Shambhavi Parab, Chandani Muleva, Jinal Shah, Bhairavi Murkute and Madhura Vaidya *

Department of Pharmaceutical Chemistry, MET Institute of Pharmacy, Bhujbal Knowledge City, Bandra Reclamation, Bandra West, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(6).2358-66

2358-2366

2637

1105