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IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM RHIZOPHORA MUCRONATA METHANOLIC LEAF EXTRACT BY GC-MS ANALYSIS
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat vari...
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CARDIOPROTECTIVE EFFECT OF SANDAL WOOD (SANTALUM ALBUM LINN.): AN EXPERIMENTAL TRAIL
Background: In the Unani System of Medicine, Sandal safed (Sandalwood) is used in many cardiac problems as it possesses Mufarreh (exhilarant) and Muqawwi Qalb (cardiotonic) activities. The present study was designed to evaluate the cardioprotective effect of Sandal safed in Isoproterenol-induced Myocardial Infarction. Methods: Male Wistar rats, weighing 150-200gm, divided into five groups of ten i...
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VARIOUS HERBAL PLANTS ARE USED AS ANTICANCER AGENTS
Cancer is the world's second-largest cause of death. Although substantial progress has been made in treating and controlling cancer progression, there are still significant flaws and space for improvement. During chemotherapy, several unfavourable side effects might arise. Natural-derived substances are attracting scientific and academic attention since they are thought to have fewer hazardous sid...
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IN-VITRO ANTICANCER ACTIVITY OF CASSIA FISTULA FRUIT AND LEAF EXTRACT ON LIVER CANCER CELL LINE
Among different neoplastic lesions, hepatocellular carcinoma plays a pivotal role due to the extreme difficulty of treating it in advanced conditions. Research shows that there is a high intractability towards chemotherapy for this disease. Therefore, using medicinal plants can be another approach to fend off this grim scenario and pave a new way to prolong survival time. For this purpose, the eth...
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FORMULATION AND IN-VITRO CHARACTERISATION OF CONTROLLED RELEASE LAFUTIDINE SUPER PORUS HYDROGEL TABLETS
The aim is to design, develop & characterize a desired gastro retentive super porous hydrogel (SPH) formulations containing lafutidine is histamine H2-receptor antagonist that may be used alone or with other agents to treat inhibits stomach acid production. SPH‘s synthesized employing various composite agents viz., sodium alginate, pectin, Carbopol, and chitosan were subjected to density and...
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BIOAVAILABILITY ENHANCEMENT OF ACYCLOVIR USING HIGH-DENSITY GASTRO-RETENTIVE PELLETS
The objective of the present study was to improve the oral bioavailability using high-density gastro-retentive pellets containing solid dispersion of acyclovir. Solid dispersion prepared with polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) using different ratios 1:1, 1:2, 1:3, 1:4, and 1:5 by solvent evaporation method and characterized for solubility study, dissolution stu...
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PHYTOCHEMICAL ANALYSIS AND MYCOBACTERICIDAL STUDIES OF THE LEAVES OF C. MUCRONATUM SCHUMACH. & THONN.
Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gai...
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STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DARUNAVIR, COBICISTAT, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE IN BULK AND PHARMACEUTICAL FORMULATION
A simple, accurate & precise method was developed for the simultaneous estimation of Darunavir (DAR), Cobicistat (COB), Emtricitabine (EMT), and Tenofovir alafenamide (TEN) in their bulk and pharmaceutical formulation. The chromatogram was run through Agilent C18 (150 × 4.6 mm, 5 m) column. Mobile phase containing 0.1% Ortho Phosphoric acid (OPA) (pH 2.4) and Acetonitrile in the ratio of 55:4...
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ADVERSE DRUG REACTION MONITORING IN A TERTIARY CARE HOSPITAL: A PRELIMINARY APPROACH TO ENHANCE REPORTING
Background: Adverse drug reaction (ADR) evaluation and monitoring is key for safe medication use. This study aimed to initiate, enhance reporting and support the Pharmacovigilance program of India. Methodology: This prospective observational study on the evaluation of adverse drug reactions was carried out for 6 months with the approval of ethics committee. Using standard tools, data was collected...
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EFFECT OF ABIOTIC STRESSES ON THE MARKER CONTENT AND THE ACTIVITY OF CENTELLA ASIATICA
Centella asiatica (CA; family Apiaceae) is extensively used in traditional medicine. A regular supply of this plant is required by the herbal drug industry. Hence, the cultivation of this plant is required. The emphasis of the available cultivation practices is on biomass yield. The activity of the plant, however, depends on the amount of bioactive constituents. The production of these secondary m...
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