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DEVELOPMENT AND VALIDATION OF THE KINETIC-SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF MEZLOCILLIN IN PURE SUBSTANCE AND MEDICAL PREPARATION
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Mezlocillin (Mezl) with potassium caroate in alkaline medium is studied by the increase of forming product light absorbance at 290 nm. Baypen® – powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone...
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EVALUATION OF PHARMACOGNOSTICAL AND PHYSICOCHEMICAL PARAMETERS OF STEM OF ACACIA ARABICA WILLD.
Acacia Arabica Willd.(syn: Acacia nilotica) is a thorny tree belonging to the family Fabaceae and subfamily Mimosoideae. Gum acacia, an exudation obtained from this plant, is included in the GRAS category and used widely as pharmaceutical aid. The plant contains flavonoids, tannins, and phenolic compounds as its phytoconstituents. The plant possesses antioxidant, antipyretic, antimicrobial, antivi...
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PREPARATION AND EVALUATION OF EXTENDED-RELEASE MICROSPHERES OF QUETIAPINE FUMARATE
The objective of present study was to develop extended release microspheres of quetiapine fumarate using Eudragit RS 100 and Eudragit RL100 to reduce the dosing frequency. The quetiapine fumarate-loaded Eudragit microspheres were formulated by a solvent evaporation method. A 32 factorial design was employed to study the effect of concentration of sodium lauryl sulfate (SLS) and drug: polymer ratio...
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IN-VITRO ANTI-INFLAMMATORY ACTIVITY, ACUTE TOXICITY TO ZEBRAFISH EMBRYOS AND NUTRITIONAL ANALYSIS OF BOHADSCHIA VITIENSIS WATER EXTRACT
Anti-inflammatory activity and the toxicity of Bohadschia vitiensis water extract were investigated by in-vitro models to evaluate the consumption of the extract by the local community to reduce arthritic-related pain. Specimens of B. vitiensis were collected from Mannar, Sri Lanka, and the water extract (WE) was prepared by removing visceral organs and incubating diced samples in distilled water,...
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EFFECT OF ABIOTIC STRESSES ON THE MARKER CONTENT AND THE ACTIVITY OF CENTELLA ASIATICA
Centella asiatica (CA; family Apiaceae) is extensively used in traditional medicine. A regular supply of this plant is required by the herbal drug industry. Hence, the cultivation of this plant is required. The emphasis of the available cultivation practices is on biomass yield. The activity of the plant, however, depends on the amount of bioactive constituents. The production of these secondary m...
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A COMPLETE RECAPITULATION OF A DRUG DELIVERY BASED ON OSMOTIC PRESSURE: AN OSMOTIC DRUG DELIVERY SYSTEM
Conventional dosage forms are the systems that don't have complete control on their drug release, and also there is no control over the effective concentration at the target site. So in order to overcome this problem the osmotic drug delivery system was developed for the controlled delivery of drugs. This osmotic drug delivery system includes dosage forms for oral administration and implantable sy...
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ADVERSE DRUG REACTION MONITORING IN A TERTIARY CARE HOSPITAL: A PRELIMINARY APPROACH TO ENHANCE REPORTING
Background: Adverse drug reaction (ADR) evaluation and monitoring is key for safe medication use. This study aimed to initiate, enhance reporting and support the Pharmacovigilance program of India. Methodology: This prospective observational study on the evaluation of adverse drug reactions was carried out for 6 months with the approval of ethics committee. Using standard tools, data was collected...
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IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM RHIZOPHORA MUCRONATA METHANOLIC LEAF EXTRACT BY GC-MS ANALYSIS
Herbal medicines play an important role in cancer prevention. Mangroves have been used worldwide due to the presence of various bioactive metabolites in it. The specific medicinal properties of Rhizophora mucronata have been an interest in preventing breast cancer. Mangroves Rhizophora mucronata belongs to family Rhizophoraceae. The leaf extract reveals various roles in folk remedies to treat vari...
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EFFECT OF VERMIWASH AND PLANT GROWTH REGULATORS ON GROWTH AND STEM ANATOMY OF HIBISCUS CANNABINUS L.
Growth and development events in plants are controlled by growth regulators and Phytohormones. These are found naturally in plants. Environmental Pollution is one of the major problems and reactions caused by artificial growth regulators and their low biodegradability has urged us to search for new biofertilizers with growth-regulating activity. Vermiwash is a liquid fertilizer that has been shown...
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COMPARATIVE MODELLING AND DOCKING STUDIES OF CYTOCHROME C OXIDASE SUBUNIT 1 PROTEIN
Cytochrome c oxidase, a mitochondrial metalloenzyme acting as the terminal enzyme of the mitochondrial respiratory chain. It provides a critical function in cellular respiration in both eukaryotes and prokaryotes. The recent development in technology has enabled researchers to understand the genetic, molecular, structural, and functional properties of proteins to identify appropriate targets again...
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