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FLOATING MICROSPHERES: A NOVEL EMERGING TREND IN GASTRO RETENTIVE DRUG DELIVERY
Oral Conventional dosage forms offer no control over the release of drug from the dosage form, which leads to variations in plasma drug levels; gastric emptying and gastric resident time are two another important factors that have a significant effect on the therapeutic efficacy of drug and it causes changes in the retention time of the drug. Accordingly, Floating microspheres is one of the most d...
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IN-SILICO MODELLING STUDIES ON RITONAVIR AND LOPINAVIR TO COMBAT COVID-19
The coronavirus is a group of families that cause respiratory problems in mammals, which consists of MERS (Middle East Respiratory Syndrome), SARS (Severe Acute Respiratory Syndrome), and COVID-19. The virus attaches to the ACE-2 receptor present in the epithelial cell of the lungs in the infected patients, and the infection may lead to fibrosis if not treated. The size of the genome may vary from...
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PHARMACOLOGICAL STUDIES OF MEDICINAL PLANT CITRULLUS COLOCYNTHIS: A REVIEW
The medicinal plant Citrullus colocynthis is very significant for indigenous medicine. The pharmacological effects of root, fruits, seeds, leaves, and the whole C. colocynthis have been practices for the treatment of diseases. Phytochemical screening of the fruits of C. colocynthis has observed several bioactive compounds. The glycosides, flavonoids, alkaloids, carbohydrates, fatty acids, and esse...
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PHYTONUTRIENTS AND ANTIMICROBIAL ASSAY OF CAT’S TAIL
Herbal medicine plays an important role in rural areas, and various locally produced drugs are still being used as household remedies for different ailments. Acalypha hispida (Euphorbiaceae) is a plant popularly used in pharmaceutical used and as a commercial product. Hence, the need to explore the potential of this plant, especially in the area of traditional medicine and pharmaceutical industrie...
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SIMULTANEOUS HPTLC METHOD FOR DETERMINATION OF GALLIC ACID, VANILLIC ACID AND SYRINGIC ACID IN AGRO-INDUSTRIAL WASTE OF DATE FRUITS
Phoenix dactylifera is a medicinally important plant. Fruits are traditionally used for the nutritional purpose. Date seeds are the rich sources of phenolic acids which exhibits strong antioxidant property. HPTLC is a simple, versatile method and it provides visualization of separated constituents. The advantage of this method is this method requires a small amount of sample for analysis. The pres...
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HEPATOPROTECTIVE ACTIVITY AND OXIDATIVE STRESS OF THE AQUEOUS EXTRACT OF SEED FROM PINTO BEAN (PHASEOLUS VULGARIS L.) IN STREPTOZOTOCIN INDUCED ALBINO WISTAR RATS
The aim of the study was to evaluate the anti-diabetic and antioxidant effects of aqueous extract of Phaseolus vulgaris L. seeds in normal and streptozotocin (STZ) induced diabetic rats. Female Albino Wistar rats were divided into 6 groups of 6 rats; each was assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ (55 mg/kg body ...
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PREPARATION, EVALUATION AND CHARACTERIZATION OF STARCH AND GRAFTED STARCH
The aim of this study was to synthesize the graft copolymer of starch to obtain materials that profit from the particular properties of both natural and synthetic polymeric material. Thus in the present work, a graft copolymer of methyl acrylate and potato starch has been synthesized under microwave irradiation using K2S2O8-TU redox pair, which generates free radical sites on the starch backbone w...
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SYNTHESIS, CHARACTERIZATION AND ANTICANCER ACTIVITY OF PIPERAZINE AMIDE DERIVATIVE
Piperazine is a nitrogen-containing heterocyclic compound and has fascinating applications in drug discovery and development. In the present study, novel 4-(benzo[1,3]dioxol-5-ylmethyl) piperazine amide derivative was prepared by acid amine coupling of 1-piperonyl piperazine derivative and benzoic acid. Synthesized compound was characterized by IR, NMR and mass spectral studies. Further, in-vitro ...
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IMPROVEMENT IN SOLUBILITY OF CEFIXIME TRIHYDRATE BY HYDROTROPIC METHOD
Background: Solubility is an important boundary to obtaining the needed drug concentrations in systemic circulation for pharmacological response to be shown. In today’s time, poor water solubility is the crucial issue faced with developing new chemical entities. Objective: Cefixime trihydrate (CT) is an oral third-generation cephalosporin antibiotic used to treat bacterial diseases. It has an or...
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IDENTIFICATION AND DOCUMENTATION OF EDIBLE INSECTS OF VESPA AFFINIS IN NAGALAND BY USING DNA BARCODE TECHNIQUES
DNA bar-coding is an ordered strategy that utilizes a little genetic marker in insect DNA to distinguish animal categories, as well as unidentified species. The present investigation manages the utilization of COI gene sequences in the distinguishing proof and documentation of edible insects in Nagaland. More than 2000 types of edible insects are recorded in more than 300 ethnic groups all around ...
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