Most Popular
IN-VITRO ASSESSMENT, ISOLATION AND SPECTRAL ANALYSIS OF THE PETROLEUM ETHER EXTRACT OF PUMPKIN SEED
Cucurbita Maxima, commonly known as pumpkin, which belongs to the family Cucurbitaceae, have numerous bio-active compounds such as polyphenols, dietary fibers, carotenoids, and minerals. This seed possesses anti-inflammatory and anti-oxidant properties and can be used in the neuro regenerative effects. In the present paper, an attempt has been made to reveal the phytochemical screening, anti-oxida...
2396
1281
THE HEPATIC CYP3A4 UPREGULATED INCREASED METABOLISM IN RESPONSE TO PHYSICAL ACTIVITY AT HIGH ALTITUDE
The present study was designed to assess the pharmacokinetics of drug metabolized by hepatic cytochrome 3A4 (CYP3A4) in human volunteers with physical activity at the high altitude hypobaric hypoxic environment. The International Physical Activity Questionnaire short form 7 (IPAQ SF-7) was used to measure the physical activity. The total of 24 healthy male volunteers participated in this study; fo...
2393
1201
STATISTICAL OPTIMIZATION OF ORALLY DISINTEGRATING TABLETS OF MEMANTINE HYDROCHLORIDE
Objective: The present work deals with the statistical optimization of memantine hydrochloride orally disintegrating tablets by the design of experimentation. The study was aimed at the development of a stable and robust formulation for the well-being of society for the treatment of Alzheimer’s disease, which is the most common form of dementia. Methods: Binder (X1), disintegrant (X2), and dilue...
2392
1112
PHYTOCHEMICAL ANALYSIS AND MYCOBACTERICIDAL STUDIES OF THE LEAVES OF C. MUCRONATUM SCHUMACH. & THONN.
Combretum mucronatum Schumach & Thonn is a scandent shrub whose leaves are widely used by Ghanaians and other West-African herbalists for the treatment of various infectious and non-infectious diseases. It is used to treat wounds, coughs, dysentery, worm infestation, neurological disorders and bacterial infections. Some coughs are as a result of mycobacterial infection. Despite the success gai...
2392
1362
EVALUATION OF THE SERUM LEVELS OF SOME TRACE ELEMENTS AND ANTIOXIDANT LEVELS IN APPARENTLY HEALTHY INDIVIDUALS WITH FAMILY HISTORY OF TYPE 2 DIABETES IN NNEWI, NIGERIA
There is a paucity of data on studies evaluating trace elements and antioxidant levels and susceptibility of offspring of diabetic parents to type 2 diabetes in Nigerian population. This study evaluated the serum level of some trace elements and antioxidants among apparently healthy individuals with a family history of type2 diabetes mellitus (FH-T2DM). This was a cross-sectional study involving 1...
2391
1048
BIOAVAILABILITY ENHANCEMENT OF ACYCLOVIR USING HIGH-DENSITY GASTRO-RETENTIVE PELLETS
The objective of the present study was to improve the oral bioavailability using high-density gastro-retentive pellets containing solid dispersion of acyclovir. Solid dispersion prepared with polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) using different ratios 1:1, 1:2, 1:3, 1:4, and 1:5 by solvent evaporation method and characterized for solubility study, dissolution stu...
2391
1334
DEVELOPMENT AND VALIDATION OF THE KINETIC-SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF MEZLOCILLIN IN PURE SUBSTANCE AND MEDICAL PREPARATION
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Mezlocillin (Mezl) with potassium caroate in alkaline medium is studied by the increase of forming product light absorbance at 290 nm. Baypen® – powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone...
2390
1527
A COMPLETE RECAPITULATION OF A DRUG DELIVERY BASED ON OSMOTIC PRESSURE: AN OSMOTIC DRUG DELIVERY SYSTEM
Conventional dosage forms are the systems that don't have complete control on their drug release, and also there is no control over the effective concentration at the target site. So in order to overcome this problem the osmotic drug delivery system was developed for the controlled delivery of drugs. This osmotic drug delivery system includes dosage forms for oral administration and implantable sy...
2390
2217
APPLICATION OF PLACKETT–BURMAN DESIGN OF EXPERIMENTS IN THE IDENTIFICATION OF “MAIN FACTORS” IN THE FORMULATION OF DABIGATRAN ETEXILATE MESYLATE IMMEDIATE-RELEASE TABLETS
The current research paper was focused on exploiting Plackett-Burman design to screen the effect of eight factors Pregelatinised Starch (A), Crospovidone (B), Microcrystalline Cellulose PH 101 (C), Talc (D), Magnesium Stearate (E), Hydroxy Propyl Methyl Cellulose (F), Hydroxy Propyl Cellulose (G) and Lactose Monohydrate (H) on the release of drugs from the Immediate release DEM Cocrystal tablets p...
2390
1120
EVALUATION OF PHARMACOGNOSTICAL AND PHYSICOCHEMICAL PARAMETERS OF STEM OF ACACIA ARABICA WILLD.
Acacia Arabica Willd.(syn: Acacia nilotica) is a thorny tree belonging to the family Fabaceae and subfamily Mimosoideae. Gum acacia, an exudation obtained from this plant, is included in the GRAS category and used widely as pharmaceutical aid. The plant contains flavonoids, tannins, and phenolic compounds as its phytoconstituents. The plant possesses antioxidant, antipyretic, antimicrobial, antivi...
2390
891