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DEVELOPMENT, OPTIMISATION, AND CHARACTERISATION OF SNEDDS OF ANTI-LIPASE INHIBITOR
Background: Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been employed extensively by the formulation of scientists to tackle the low solubility issues of various drugs and lift the bioavailability profile. But the potential of SNEDDS is not limited to augment the dissolution profile only. Objective: The objective of the study was to develop, optimization, and characterization of SNEDDS ...
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MICROEMULSION GEL OF IRBESARTAN: A POTENTIAL TRANSDERMAL DELIVERY SYSTEM
The transdermal delivery route is increasingly being used for drug delivery primarily because the route avoids drawbacks encountered with oral and parenteral routes of drug administration. Irbesartan is an angiotensin II receptor antagonist used clinically to treat hypertension. The objective of the present study was to investigate microemulsion gel as a transdermal delivery system of irbesartan w...
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COMPARATIVE SCREENING AND CHARACTERIZATION OF ANTIOSTEOPOROTIC ACTIVITY OF SESBANIA GRANDIFLORA (L) POIR CRUDE LEAF EXTRACT AND ITS NANOPARTICLE FORMULATION ON SAOS-2 CELL LINES
Increasing severity of the disease osteoporosis in postmenopausal women with long term exposure to pharmacotherapy has spurred interest in the development of using food as medicine and phyto-pharmacotherapy. We examined the effect of n-hexane crude leaves extract and its nanoparticle formulation of Sesbania grandiflora in cell proliferation and bone mineralization at different concentrations in Sa...
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COMPARATIVE INVESTIGATION OF TOXICOLOGICAL CHARACTERISTIC AND SPECIFIC BIOLOGICAL ACTIVITY OF THE MEDIUM-CHAIN ALIPHATIC MONO- AND DIPEROXYCARBOXYLIC ACIDS
The comparative toxicological characteristic in-vitro and antimicrobial activity to perform stability tests of several linear medium-chain aliphatic monoperoxyacids (perC8–C12) and aliphatic diperoxyacid (diperC9) were studied. Substances of peroxide acids: perС8, perС10, perС12, diperoxyazelaic acid (diperC9) are in 5.6; 22.8; 64 and 1.6 times less toxic than reference substance - peracetic ...
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IN-SILICO ANALYSIS OF POTENTIAL ANTIMYCOBACTERIAL COMPOUNDS PRESENT IN CYNODON DACTYLON
Tuberculosis is one of the major contagious diseases and a leading cause of death in humans. Current treatment methods suffer from a multitude of problems like long duration of treatment, lack of patient compliance, presence of drug-resistant bacteria, etc. To combat the disease effectively, there is an urgent need for the development of new drugs effective against both drug-sensitive and drug-res...
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ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF MERREMIA TRIDENTATA ON MURINE MODELS
The present study aims to reveal the anti-inflammatory activity of the ethanolic plant extracts of Merremia tridentata against murine models. The Wistar Albino rats of mixed sex were induced inflammation via injecting histamine and formalin. The anti-inflammatory effect of Merremia tridetata was compared with the presence of positive control, Indomethacin. The Paw volume of the control group (grou...
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CLINICAL DIAGNOSIS AND SAFETY OF VILDAGLIPTIN VERSUS GLIMEPIRIDE WITH METFORMIN OVER PATIENTS OF TYPE-2 DIABETES MELLITUS
The aim of the study to compare the efficacy of vildagliptin (50 mg) and glimepiride (2 mg) metformin (500 mg) for type-2 diabetes mellitus. Vildagliptin and glimepiride are found to be regulated the blood plasma glucose by stimulating beta cell in the pancreas. The treatment course duration of 34 weeks comparative observational study was conducted over 160 patients with type-2 diabetes mellitus w...
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COMPREHENSIVE STUDY OF ACACIA LEUCOPHLOEA (ROXB.): TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL SIGNIFICANCE
Herbal remedies have been utilized in medical practice for thousands of years and are recognized notably as a significant and widely available resource for health treatment. Traditional botanicals and herbal supplements have been deemed to be mild, non-toxic and even safe due to their natural nature. Acacia leucophloea (Roxb.) Willd. belongs to the family Mimosaceae, recognized as a diverse reso...
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CONCERNS AND LIMITATIONS OF MATERIALS FOR ORAL DELIVERY OF INSULIN
Insulin is commonly administered to diabetic patients sub-cutaneously and has shown poor patient compliance. The problem lies with the delivery of proteins and peptides to the body, for which oral, transdermal, vaginal, rectal, and pulmonary routes have been explored for proteins like insulin. Still, so far subcutaneous route has delivered the best results. This results in fear of the patients due...
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A COMPREHENSIVE REVIEW OF PHARMACOLOGICAL PROPERTIES OF LITSEA POLYANTHA
Litsea, an outsized genus comprising 400 species of evergreen trees or shrubs, distributed chiefly in tropical and subtropical Asia, Australia, and therefore the Pacific Islands, belongs to the Lauraceae. Litsea polyantha is found throughout North, East, and Central India at an altitude of 1,200 m. It is often planted as an ornamental plant. It is mostly grown as an honest source of fodder for the...
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