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ROLE OF NANOMEDICINE TO COMBAT COVID-19- A REVIEW
COVID-19 has been proved to create a pandemic over the world within a few years. All scientists and health workers are trying to develop an effective treatment with collaboration. Various strategies such as antiviral, antibacterial, and antimalarial drugs have been employed to treat COVID- 19, but they were found to relieve the symptoms only. The formation of various variants of the virus in vario...
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EVALUATION OF ADULTERATION OF HERBAL MEDICINE USED FOR TREATMENT OF ERECTILE DYSFUNCTION IN NAIROBI COUNTY, KENYA:
In the recent past, adulteration of herbal products has increased rapidly, and today it is a global problem. Synthetic Phosphodiesterase type 5 inhibitors are the main adulterants in herbal medicine used for erectile dysfunction. The present study evaluated the herbal medicines used as sex enhancers in Nairobi County, Kenya, for adulteration with Phosphodiesterase type 5 inhibitors (sildenafil, ta...
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CASE REPORT ON GUILLAIN BARRE SYNDROME – ACUTE MOTOR AXONAL NEUROPATHY (AMAN)
Guillain-Barre syndrome occurs when the body's immune system targets a portion of the peripheral nervous system. In addition to the nerves that convey pain, temperature, and touch sensations, the condition can also impair the nerves that regulate muscular movement. This may lead to muscular weakness and/or loss of feeling in the arms and/or legs. A 12-year-old boy was taken to the hospital with ch...
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SYNTHESIS, CHARACTERIZATION AND PERSISTENT DNA BINDING, ANTI-MICROBIAL AND CYTOTOXICITY STUDIES OF NOVEL COPPER (II) COMPLEXES CONTAINING L-TRYPTOPHAN AND HETEROCYCLIC BASE
The copper (II) complexes, [Cu(phen)(tryp)I] (1), [Cu(phen)(tryp)Cl], (2) [Cu(phen)(tryp)SCN] (where phen = 1,10-phenanthroline and tryp = tryptophan ) has been synthesized and characterized by Infra-red Spectra, UV–Visible Spectra, EPR Spectra and elemental analysis methods. Binding interactions mode of the complexes with calf thymus DNA (CT-DNA) were investigated by UV–Vis absorp-tion titrat...
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DESIGN AND SYNTHESIS OF BIOLOGICAL ACTIVE N-(5-P-TOLYL-1,3,4-THIADIAZOL-2-YL) BENZAMIDEANDITS DERIVATIVES WITH EVALUATION OF THEIR ANTI-BACTERIAL ACTIVITY
A number of N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives were synthesized from aromatic acid. The antibacterial activity of these newly synthesized N-(5-p-tolyl-1,3,4-thiadiazole-2-yl) benzamide derivatives against Gram-positive bacteria and Gram-negative bacteria was also studied using the minimum inhibition concentration method. The synthesized compounds were showed better results ...
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ALPHA-AMYLASE INHIBITORY ACTIVITY OF KATANKATERYADI KWATHA (K. KWATHA) IN MANAGEMENT OF TYPE 2 DIABETES
Objectives: The objective of the study is to find out the alpha-amylase inhibitory activity of Katankateryadi Kwatha. The alpha-amylase enzyme is the key source for postprandial hyperglycaemia, which is responsible for Type 2 Diabetes. Methodology: The crude drugs of Katankateryadi Kwatha (K. Kwatha) were collected from a local market. The Kwatha was prepared and dried with rotatory evaporator, un...
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DESIGN AND CHARACTERIZATION OF SILVER NANOPARTICLES OF MOMORDICA CHARANTIA LINN. BY GREEN SYNTHESIS
Objective: Present research work describes an eco-friendly and quick method for the development of silver nanoparticles (AgNP) using Momordica charantia Linn. extract and silver nitrate solution. Our investigation reports the antimicrobial activity of developed nanoparticles against Staphylococcus aureus, Escherichia coli. Method: Silver nanoparticle developed by reduction of silver nitrate soluti...
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SIMULTANEOUS VOLTAMMETRIC DETERMINATION OF PERACETIC ACID AND THE COEXISTENT HYDROGEN PEROXIDE USING CARBOSITALL ROTATION ELECTRODE
The aim of the present work is to determine the feasibility of peracetic acid (PAA) and the coexistent hydrogen peroxide (HP) simultaneous quantitative determination in disinfectant solution by voltammetry using carbositall rotation electrode (CE) as indicating electrode. It has been experimentally proved that the optimum pH for analysis is approximately 3.6. The linear relationship has been obse...
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COMPARATIVE SOLUBILITY STUDY OF CYCLODEXTRINS (Β- CD AND HPΒ- CD) AND ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF LORNOXICAM BY USING TERNARY COMPLEXATION
The present investigation aimed to provide an approach for the solubility and bioavailability enhancement by Comparative solubility of cyclodextrins with Lornoxicam (LXM) by forming ternary Inclusion complexation (TIC). The phase-solubility and saturation solubility studies were executed in the existence of β-CD, HP-βCD and polymers. The drug/CD complexes were formulated and characterized furthe...
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SCREENING OF 4-([1,3,4]OXADIAZINO[6,5-b] INDOLE-3-YL)ANILINE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY BY IN-SILICO AND IN-VITRO METHODS
Schiff bases of isatin are investigated overtime for their pharmaceutical properties and have been found to have various activities such as anti-viral, anti-bacterial, anti-inflammatory, analgesic, anti-HIV, anti-depressant, anti-convulsant, fungicidal, etc. Isatins are treated with hydrazine derivatives and cyclized by sulfuric acid. These compounds are alkylated by di alkyl aminoalkyl halides in...
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