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THE HEPATIC CYP3A4 UPREGULATED INCREASED METABOLISM IN RESPONSE TO PHYSICAL ACTIVITY AT HIGH ALTITUDE
The present study was designed to assess the pharmacokinetics of drug metabolized by hepatic cytochrome 3A4 (CYP3A4) in human volunteers with physical activity at the high altitude hypobaric hypoxic environment. The International Physical Activity Questionnaire short form 7 (IPAQ SF-7) was used to measure the physical activity. The total of 24 healthy male volunteers participated in this study; fo...
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A COMPARATIVE EVALUATION OF EFFICACY OF OBETICHOLIC ACID VS. URSODEOXYCHOLIC ACID IN PATIENTS WITH ACUTE VIRAL HEPATITIS
Background: Acute viral hepatitis (AVH) is a major public health problem. There is no specific treatment to attenuate AVH. The potential for adding bile acid in the treatment of AVH is consistently increasing. The objective of this study was to assess the effect of obeticholic acid (OCA) in treating AVH patients and also to compare its efficacy with ursodeoxycholic acid (UDCA). Methods: A prospect...
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DESIGN AND OPTIMIZATION OF EXPANDABLE GASTRORETENTIVE PATCH OF METRONIDAZOLE FOR HELICOBACTER PYLORI INFECTION MANAGEMENT
The aim of the present research was to develop and optimize novel expandable gastro retentive formulation of metronidazole to give local action for the management of Helicobacter pylori infection. The formulation contained a drug-loaded sandwich patch prepared by solvent casting method folded into a hard gelatin capsule. Metronidazole being needle shape crystals soluble in 0.1 N HCl, but after dry...
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IN-VITRO ANTI-INFLAMMATORY ACTIVITY, ACUTE TOXICITY TO ZEBRAFISH EMBRYOS AND NUTRITIONAL ANALYSIS OF BOHADSCHIA VITIENSIS WATER EXTRACT
Anti-inflammatory activity and the toxicity of Bohadschia vitiensis water extract were investigated by in-vitro models to evaluate the consumption of the extract by the local community to reduce arthritic-related pain. Specimens of B. vitiensis were collected from Mannar, Sri Lanka, and the water extract (WE) was prepared by removing visceral organs and incubating diced samples in distilled water,...
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DEVELOPMENT AND VALIDATION OF THE KINETIC-SPECTROPHOTOMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF MEZLOCILLIN IN PURE SUBSTANCE AND MEDICAL PREPARATION
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Mezlocillin (Mezl) with potassium caroate in alkaline medium is studied by the increase of forming product light absorbance at 290 nm. Baypen® – powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙K2SO4 (Oxone...
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INHIBITION OF ISLET AMYLOID POLYPEPTIDE FIBRILLATION BY OKRA SEED EXTRACT-COATED GOLD-NANOPARTICLES
In recent work, an ethanolic extract of okra seeds was successfully conjugated onto gold nanoparticles (AuNPs) via a reduction reaction that has been developed by our laboratory. Because of eliciting antioxidant activity and the presence of g-sitosterol in the extract, such synthesis methodology could be applied. The resulting okra-AuNPs were physically characterized by different methods, includin...
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DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES OF LINAGLIPTIN
The main objective of the present research work was to formulate and characterize the linagliptin-loaded solid lipid nanoparticles (SLNs). SLNs possess distinctive characteristics like small and spherical shapes with an average diameter between 1to 100 nm. Linagliptin is used for the treatment of type II diabetes and it is a dipeptidyl peptidase 4-inhibitor and its oral bioavailability is 30%. The...
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A CRITICAL REVIEW ON NIDIGDHIKADI LEHA IN THE MANAGEMENT OF RECURRENT UPPER RESPIRATORY TRACT INFECTION IN CHILDREN
Upper respiratory tract infections are the major cause of childhood morbidity leading to limit the day to day activities and school absenteeism. Diseases like tonsillitis, cough, and cold account for the maximum respiratory tract morbidities. Studies document that, in developing countries, on average, every child has five episodes of acute respiratory infections per year accounting for 30%-50% of ...
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PRESENT SCENARIO OF HEPATOPROTECTIVE POTENTIAL OF MEDICINAL PLANTS: AN UPDATED REVIEW
The liver is the principal site for metabolism and excretion in the body. The human liver metabolizes substances by various biochemical pathways, including oxidation, reduction, hydration, condensation, hydrolysis, conjugation or isomerization. Disorder of any of therefore mentioned process may lead to liver cell injury, what we call as hepatotoxicity, which in turn leads to many diseases. Such di...
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ALPHA-AMYLASE INHIBITORY ACTIVITY OF KATANKATERYADI KWATHA (K. KWATHA) IN MANAGEMENT OF TYPE 2 DIABETES
Objectives: The objective of the study is to find out the alpha-amylase inhibitory activity of Katankateryadi Kwatha. The alpha-amylase enzyme is the key source for postprandial hyperglycaemia, which is responsible for Type 2 Diabetes. Methodology: The crude drugs of Katankateryadi Kwatha (K. Kwatha) were collected from a local market. The Kwatha was prepared and dried with rotatory evaporator, un...
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