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ANTIDIABETIC, ANTIHYPERLIPIDEMIC, ANTIOXIDANT, HEPATOPROTECTIVE AND RENAL PROTECTIVE EFFECT OF LUFFA CYLINDRICA EXTRACT AGAINST THE STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS
The main objective of the current study was to see whether SG peel methanolic extract had antidiabetic and hepatoprotective results in streptozotocin-induced diabetic rats. Streptozotocin was administered intraperitoneally to rats to trigger diabetes. When rats had an elevated blood sugar level three days after acquiring streptozotocin, it was determined that they were diabetic. Diabetic rats were...
1868
968
THE QUANTITATIVE ANALYSIS OF METABOLITES FROM SELECTED CHENOPODIUM SPECIES
Chenopodium album L., Chenopodium murale L., and Chenopodium giganteum L. are annual herbs with ethno-medicinal value. The present study investigates the primary and secondary metabolites quantification of Chenopodium species. The quantitative estimation of bioactive molecules from the root, stem, and leaves showed the presence of proteins, carbohydrates, starch, phenols, and flavonoids. However, ...
1868
1090
GLIMPSE OF PHARMACEUTICAL COATING PROCESSES
Manuscript aims to furnish glimpse on coating processes (CoPr). The coating is the process of applying coating materials (CoMa) onto the substrate surface (S-S). With time and space dimension of CoPr, that upraised as sugar-coating (S-C) expanded to film-coating (F-C) and specialized one. Lengthy and wearisome processing and skilled operators issues inherited to S-C spring-up F-C and its improveme...
1867
981
NANOCOSMECEUTICALS: AN IMMERGING TREND IN PHARMACY
The global market size was valued at $ 380.2 billion in 2019 and is projected to reach $463.5 billion by 2027, registering a CAGR of 5.3% from 2021 to 2027. Cosmetics have become an in-dispersible feature of the modern lifestyle. The use of cosmetics has increased in males and women in daily routine, which complements the growth of global cosmetic market demand. The skin care industries are trying...
1867
978
CHRONOTHERAPEUTIC SYSTEMS: NOVEL SYSTEMS OF DRUG DELIVERY
Chronotherapeutic systems are meant for the treatment of most of the diseases that occurred and found till date, which are proved to be in association with the biological/circadian rhythms of our body with respect to disease symptoms and their severity. Such diseases use this treatment as it involves in-vivo drug availability with distinctive release patterns so as to match the rhythms of disease ...
1865
1137
IN-VITRO ALPHA-AMYLASE AND ALPHA-GLUCOSIDASE INHIBITORY ACTIVITIES OF POLYHERBAL FORMULATION
Diabetes mellitus is a chronic disease identified as hyperglycemia that occurs either when the pancreas does not produce enough insulin or when the body cannot metabolize its insulin. Insulin is a hormone that regulates blood sugar levels. Hyperglycemia, or raised blood sugar, is a common effect of uncontrolled diabetes and, over time, leads to serious damage to many of the body's systems. Alpha-a...
1865
975
FORMULATION AND IN-VITRO CHARACTERIZATION OF METFORMIN MICROSPHERE FOR ENHANCED DRUG DELIVERY VIA SPRAY DRYING IN TYPE 2 DIABETES MANAGEMENT
This study focuses on developing and characterizing metformin microspheres using spray drying with hydroxypropyl methylcellulose (HPMC) as a polymer, aiming to enhance gastrointestinal drug delivery, reduce gastric irritation, and lower dosage requirements for type 2 diabetes management. Metformin hydrochloride and HPMC concentrations are varied to generate microspheres with1 to1000µm diameter. T...
1865
1248
ISOLATION AND CHEMICAL CHARACTERIZATION OF POTENTIAL BIOACTIVE COMPOUNDS FROM ALBIZIA STIPULATA BARK
The present research effort was undertaken to isolate phytoconstituents from pharmacologically active extracts of stem bark of Albizia stipulata based on in-vitro pharmacological screening and their subsequent characterization. Methods: Crude extracts of bark of Albizia stipulata were prepared using various solvents such as methanol, hydro alcohol, and water. These extracts were screened for in-vi...
1865
1255
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTRO-PHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TACROLIMUS AND BERBERINE HYDROCHLORIDE
A simple UV spectrophotometric method using the first order derivative technique was developed for the simultaneous estimation of tacrolimus and berberine hydrochloride in nanoparticles. The tacrolimus and berberine hydrochloride stock solutions were prepared methanol and scanned in UV- region for first-order derivative spectrum. The zero-crossing point for tacrolimus and berberine hydrochloride w...
1863
1582
HISTORICAL PERSPECTIVE OF LEAD POISONING AND THERAPEUTIC APPROACH OF GARLIC (ALLIUM SATIVUM) AGAINST VARIOUS HUMAN ALIMENTS
Lead comes in a category of toxic heavy metal which acts as a pollutant when present in high concentration in the environment and cause severe effects on the human body. Due to its continuous use its level increases and serves as a serious threat for the society. Lungs and skin are the first organs which get affected by Lead toxicity. Lungs are the most important and sensitive part of human ther...
1863
1988