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EVALUATION OF THE NEUROPROTECTIVE ACTIVITY AND COGNITIVE ABILITY OF AEGLE MARMELOS ETHANOLIC LEAVES EXTRACT AND ESTROGEN IN ESTROGEN COMPROMISED FEMALE RATS USING SCOPOLAMINE-INDUCED ALZHEIMER’S MODEL
Alzheimer’s disease, the most common form of dementia, is higher in elderly women than men. Escape latency time of Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) is less than group 2 (Scopolamine and letrozole). As shown by the results, the decrease in AChE level in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) indicates restoration of Ach level in the brain. Increased GSH level was...
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FORMULATION AND IN-VIVO EVALUATION OF MESALAMINE MICROSPONGES FOR COLON TARGETING
The present study aims to develop and characterize colon-targeted mesalamine microsponges for treating inflammatory bowel disease, requiring long-term therapy. Mesalamine microsponges were prepared with different ratios of eudragit S100, by quasi-emulsion solvent diffusion method and evaluated. The drug release from in-vitro dissolution for all the prepared microsponges was extended to 12 hrs and ...
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GC-MS ANALYSIS AND IN-SILICO ADMET ANALYSIS OF THE AQUEOUS METHANOL LEAF EXTRACT OF ISODON TERNIFOLIUS (D. DON) KUDO
Medicinal plants contain phytocompounds which are of medicinal value. Scientific evaluation of these compounds that may serve as potential drugs is important in validating the medicinal plants. The leaf extract of the medicinal plant, Isodon ternifolius (D. Don) Kudo was prepared by the maceration method using 80% aqueous methanol as the extraction solvent. The resulting extract was subjected to ...
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CURRENT LANDSCAPE FROM CLINICAL TRIALS AND FUTURE OF COMBINED CHECKPOINTS BLOCKADE IMMUNOTHERAPY IN CANCERS
Immunotherapy is among cancer immunology's fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical ...
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EVALUATION OF ANTI-ALZHEIMER ACTIVITY OF ETHANOLIC EXTRACT OF ORIGANUM VULGARE LEAVES IN WISTAR ALBINO RATS
Alzheimer's disease, the most frequent cause of dementia, is a major global health concern with enormous societal and individual ramifications. Some of the hallmarks linked with AD include a decrease in acetylcholine (ACh) levels in the synapse, the buildup of extracellular beta-amyloid plaques, and tau protein intraneuronal tangles. Low levels of ACh have been linked to memory and reasoning probl...
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DEVELOPMENT AND EVALUATION OF TASTE-MASKED ORALLY DISINTEGRATING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE
Purpose: The goal of this study was to develop taste-masked orally disintegrating tablets of the bitter-tasting levocetirizine dihydrochloride (LCDH) to improve the accessibility and adherence of pediatric, elderly, non-cooperative and paraplegic patients. Methods: In the present study, orally disintegrating Levocetirizine dihydrochloride tablets were formulated by direct compression. Taste maskin...
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PREPARATION AND EVALUATION OF NEW POLYHERBAL FORMULATION THEIR FOR WOUND HEALING ACTIVITY
Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are the basis of traditional medicine. Any damage or break in the surface of the skin is a wound. In Soxhlet extraction, solvent extraction involves extraction with solvents of increasing polarity from a nonpolar to a more polar solvent to ensure that a wide polarity range of compounds can be extr...
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BRIEF OVERVIEW STUDIES ON ENDOCRINE DISRUPTORS POLYCYCLIC AROMATIC HYDROCARBONS WITH SPECIAL REFERENCE TO NEWSPAPER INK
Now a day’s food materials are packaged and wrapped in paper that is the dangerous practice of wrapping, covering or processing foods with newspaper and printed recycled paper materials remains commonplace worldwide, as seen in the plethora of photographs in advertisements online or in magazines showing newspaper wrapped foods. The health hazard of ink contamination to foods and long-term contac...
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A MOLECULAR MODELING STUDY OF PHYTOCONSTITUENTS ANALYSED VIA GC-MS TECHNIQUE IN THE RHIZOME PART OF HEDYCHIUM SPICATUM (ZINGIBERACEAE)
Hedychium spicatum is one of the plant species reported from the northern Himalayan ranges of India, belonging to the family Zingiberaceae, with ethnobotanical values and is well-known for their ethnomedicinal applications. In the present investigation, pet ether and ethanolic rhizome extracts of Hedychium spicatum were Analyzed by gas chromatography-mass spectrometry (GC–MS) to identify the imp...
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SOLUBILITY ENHANCEMENT OF LABETALOL HYDROCHLORIDE BY USING LIQUISOLID TECHNIQUE FOR MANAGEMENT OF HYPERTENSION
Background: Hypertension is the most common disorder affecting different age groups of people. The increased blood pressure creates discomfort in the patients; these cardiovascular diseases are risky which can lead to “mortality and morbidity”. Labetalol hydrochloride is an anti-hypertensive drug used to treat high blood pressure and Angina. These compounds possess less water solubility and lo...
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