Volume 5 (2014) - Issue 2, February
Review Articles
REVIEW ON NON-VIRAL DELIVERY SYSTEMS FOR siRNA
The emergence of RNAi, has found new horizons in siRNA as drug molecule. This technology offers a great promise in the achieving efficient treatment. There is a demand for designing efficient siRNA delivery systems/ vehicles that can achieve targeted delivery and replicate the invitro success. The siRNA delivery system selection is based on target cell type. The siRNA delivery systems are catego...
2992
1066
A REVIEW ON: POTENTIAL ANTIDIABETIC HERBAL MEDICINES
Diabetes mellitus (DM) is a metabolic disorder of the endocrine system. This frightful disease is found in all parts of the world and is becoming a serious threat to healthcare providers. Nowadays DM is a most spreading disease in the world. In rapidly growing world a number of treatment options are available for treatment of DM. Long term use of allopathic medicinal agents may cause unwanted side...
9836
3172
PROTEASOME INHIBITORS FOR USE IN MULTIPLE MYELOMA
The approval of first-in-class proteasome inhibitor bortezomib in 2003, made possible the therapeutic validation of proteasome as a target for use in discovery and development of new treatment options in cancer, particularly haematological conditions like Multiple Myeloma. However, this breakthrough drug discovery suffered from a few limitations. As a result, the discovery of bortezomib not only i...
2756
1995
AN UPDATE ON AYURVEDIC HERB HENNA (LAWSONIA INERMIS L.): A REVIEW
Lawsonia inermis L. is a much branched glabrous shrub or small tree, cultured for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. It has been traditionally reported in use of headache, hemicranias, lumbago, bronchitis, boils, ophthalmia, syphilitis, sores, amenorrhea, scabies, diseases of the spleen, dysuria, bleeding disorder, skin diseases, di...
11089
3190
APPROACHES AND SIGNIFICANCE OF TRANSDERMAL DRUG DELIVERY SYSTEMS: A REVIEW
Transdermal Drug Delivery System (TDDS) is the most innovative and Novel drug delivery systems by penetrating through the skin by increasing the scope of molecules that can be delivered. TDDS that traditionally uses a patch containing loaded drug substances pressed on to the skin is convenient, painless and non-invasive, to avoid gastro intestinal (GI) tract toxicity (peptic ulcer disease). Tran...
8393
1887
Research Articles
FORMULATION AND IN VITRO EVALUATION OF PIDOTIMOD DISPERSIBLE TABLETS
The aim of this article was to develop pidotimod dispersible tablet and optimize the ingredients for the tablets. The effect of ingredients (diluents, disintegrants and lubricants) on the characteristics of the tablets was evaluated. The pidotimod dispersible tablets were prepared by wet granulation. The effect of diluents on the tablets was investigated by Carr’s index, dissolution, hardness, f...
4250
1908
PHYTOCHEMICAL SCREENING, IN-VITRO MEMBRANE STABILIZING AND THROMBO-LYTIC ACTIVITIES OF LOPHOPETALUM JAVANICUM
In the present study, different extracts of Lophopetalum javanicum (Zoll) leaves were evaluated for erythrocyte membrane stabilizing and thrombolytic activities. Phytochemical analysis of the plant was also performed to detect presence of different kinds of phytoconstituents. In order to predict anti-inflammatory activity the plant extracts were subjected to check erythrocyte membrane stabilizatio...
3155
1158
INFLUENCE OF THE SEASONAL CHANGES AND OF THE EXTRACTION METHOD ON FLAVONOID CONTENT IN PEPEROMIA PELLUCIDA L. (H.B.K.)
During the obtainment of herbal products, standardization of raw plant materials is ensured by the quality of herbal drugs, of the extraction conditions, followed by the determination of the content of one or more components or of the most representative compounds of their composition, which are adjusted to values previously defined, resulting in greater uniformity of plant derivatives, impo...
2707
1121
ADAPTIVE REACTIONS INVESTIGATION UNDER EXPERIMENTAL HYPOXIA CONDITIONS WITH THE PRIOR TREATMENT OF THE 4-THIAZOLIDINONE DERIVATIVE
The effects of 4-thiazolidinone-derivative – Les-589 as perspective anti-hypoxic agent under the experimental hypoxic hypoxia actions were studied. The values of peripheral blood and hematological indexes as well as parameters of cellular oxidative metabolism (level of lipoperoxidation products, activity superoxide dismutase and catalase, levels and ratio of lactic and pyruvic acids in the blood...
2303
949
ADVERSE DRUG REACTION MONITORING AND REPORTING: KNOWLEDGE, ATTITUDE AND BELIEF OF PHYSICIANS & PHARMACISTS OF RAS AL KHAIMAH, UNITED ARAB EMIRATES (UAE)
Adverse drug reactions (ADR) contribute significantly in health care cost through increased patient morbidity and mortality. Thus, there is an urgent need to create awareness among health care professionals towards ADR monitoring and reporting. The aim of our study is to assess the knowledge, attitude and belief of physicians and pharmacists towards ADR. This is a prospective cross-sectional surve...
5695
1293
CHEMICAL COMPOSITION AND ANTIFUNGAL ACTIVITY OF ESSENTIAL OILS FROM SOME MEDICINAL PLANTS OF IRAN
Infectious diseases are the second leading cause of death worldwide. The use and search for drugs and dietary supplements derived from plants have accelerated in recent years. The aim of this study was to evaluate the antifungal activities of the essential oils derived from some species of medicinal plants:Stachys pubescens, Coriandrum sativum, Cinnamomum zelanicum and Bupleurum falcatum against F...
3263
1066
DETERMINANTS OF HEALTH CARE EXPENDITURE IN GREECE: CAN PRIMARY HEALTH CARE IMPACT ON THEIR EVOLUTION?
This paper identifies and analyzes the determinants of public and private health care expenditure in Greece over the period 1970-2004 to assess its relationship with the lack of an integrated Primary Health Care System. The determinants assessed are those commonly stated in international literature as influencing health expenditure growth, i.e. per capita GDP-Gross Domestic Product- (income), demo...
2954
1035
COMPARATIVE ANTIBACTERIAL STUDY OF DIFFERENT EXTRACT OF CLAVERIA ROSEA FRIES AGAINST GRAM NEGATIVE AND GRAM POSITIVE PATHOGENS
Objective: To compare the antibacterial activity of different solvent extract of Clavaria rosea. Method: Different solvent extract of Claveria rosea was prepared. Standard cultures of Escherichia coli (MTCC-1698), Klebsiella pneumoniae (MTCC-7028), Pseudomonas aeuroginosa (MTCC-1934), Salmonella typhi (MTCC-733), Xanthomonas campestris (MTCC-2286), Pseudomonas syringae (MTCC-1604) and Agrobacte...
3113
902
CHANGES IN CHOLESTEROL CONTENT OF THE FRESHWATER FISH, LABEO ROHITA DUE TO THE EFFECT OF AN INSECTICIDE ‘ENCOUNTER’ (HERBAL PLANT EXTRACT)
Recent evidence indicates that fish, an extremely valuable resource, are quickly becoming scarce. One consequence of this scarcity is the increasing concern for fish survival and a growing interest in identifying the levels of various chemical pollutants, which are safe for fish and other aquatic life. Pesticides are among the most hazardous chemicals to men and ambient. Insecticides are extensive...
3774
1206
SYNTHESIS, CHARACTERIZATION, THERMAL AND KINETIC STUDIES OF LANTHANUM (III), THORIUM (IV) AND DIOXOURANIUM (VI) CHELATES WITH MULTIDENTATE LIGAND AND ITS IN VITRO ANTIBACTERIAL ANALYSIS
Metal Complexes of lanthanum (III), Thorium (IV) and dioxouranium (VI) with Schiff base ligand ethyl 2-{[(2E, 3Z)-4-hydroxypent-3-en-2-ylidene] amino}-4, 5, 6, 7-tetrahydro-1-benzothio-phene-3-carboxylate were prepared. All synthesized complexes were identified and confirmed by elemental analysis, molar conductance measurements and spectral analysis (UV-visible, IR and 1H NMR). The conductance mea...
2887
1277
SIMULTANEOUS ESTIMATION OF PARACETAMOL, GUAIPHENSIN, PHENYLEPHRINE HCl, CHLORPHENIRAMINE MALEATE AND BROMOHEXINE HCl IN COMBINED TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATO-GRAPHY
A reverse phase high performance liquid chromatographic method was developed for the estimation of paracetamol, guaiphenesin, phenylephrine HCl, chlorpheniramine maleate and bromhexine HCL in a single tablet dosage form. This method was proved to be simple, accurate, precise and robust. The chromatographic separation was achieved on a symmetry C-8 column with dimensions of 150 X 4.6mm, 3.5µm. All...
6525
3758
FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF TERAZOSIN HYDRO-CHLORIDE
The objective of the current study was to develop and optimize sublingual tablets of Terazosin Hydrochloride, which is an effective drug in the treatment of Benign Prostate Hyperplasia, Hypertension. Sublingual tablets of Terazosin Hydrochloride were prepared by direct compression method using different superdisintegrating agents such as Crosspovidone, Sodium starch glycolate and Crosscarmellose s...
6568
1830
EXTRACTION AND SCREENING OF BIOACTIVE METABOLITES FROM VIGNA MUNGO AGAINST VARIOUS PATHOGENS
In the present study, Vigna mungo (blackgram) have been used to investigate bioactive compounds through soxhlet extraction. The obtained methanol extract was evaluated for antimicrobial activity by Kirby-Bauer method against bacterial strains (Enterococci sp., Pseudomonas aeruginosa, Klebsiella sp., Bacillus sp., Staphylococcus aueres)and fungal strains (Aspergillus niger, Candida albicans) on Mul...
3293
1286
IN VITRO ANTIBACTERIAL, ANTIOXIDANT, HAEMOLYTIC, THROMBOLYTIC ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF SIMAROUBA GLAUCA LEAVES EXTRACTS
Objective: To study the leaves of Simarouba glauca for their antibacterial, antioxidant, haemolytic, thrombolytic activities and to perform phytochemical evaluation. Methods: The three extracts (chloroform, methanol, ethyl acetate) of Simarouba glauca were screened for antibacterial activity against five pathogenic microorganisms by well diffusion method. In vitro antioxidant activity of extract w...
5372
2908
FABRICATION AND EVALUATION OF CHITOSAN-GELATIN COMPOSITE FILM AS A DRUG CARRIER FOR IN VITRO TRANSDERMAL DELIVERY
Natural polymer composite films from a mixture of chitosan and gelatin of various compositions were solution casted using acetic acid with and without theophylline. The films were characterized by FT-IR, TG, differential scanning calorimetry, SEM, XRD and swellability in phosphate buffer. SEM micrographs indicated uniform dispersion of the drug in the polymer blend and drug crystals were seen at h...
4106
1555
EVALUATION OF OCULOHYPOTENSIVE EFFECT OF ENALAPRILAT USING INTRAOCULAR PRESSURE (IOP) RECOVERY MODEL IN RABBITS
The present study was designed to evaluate the oculohypotensive effect of enalaprilat in comparison to timolol using an intraocular pressure (IOP) recovery model. The study was carried out in 18 adult albino rabbits of 2.5-3.0 kg which were divided into 3 groups.Group Ireceivednormal saline,group II received enalaprilat (0.1%) and timolol (0.5%) was administered in group III. IOP recovery model wa...
4271
1006
SYNTHESIS OF NOVEL 1, 5-DIHYDROBENZOTHIAZEPINE DERIVATIVES BY CONVENTIONAL AND MICROWAVE IRRADIATION METHODS AND THEIR PHARMACOLOGICAL ACTIVITIES
1, 5-Dihydrobenzothiazepines are synthesized by conventional and microwave assisted synthesis methods. By microwave assisted synthesis, a considerable increase in the reaction rate has been observed and that too, with better yields. The compounds have been screened for antimicrobial and cytotoxic activity. 1, 5-Dihydrobenzothiazepines are prepared by the reaction of 1, 3-diarylprop-2-enones with o...
2841
1202
METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF FLUPIRTINE MALEATE AND PARACETAMOL BY RP – HPLC TECHNIQUE
The present study describes a simple, accurate and precise RP-HPLC Technique for the simultaneous determination of Flupirtine maleate and Paracetamol in pharmaceutical dosage form. The method involves an isocratic elution of drug in a stationary phase of Phenomenex, C18 (150mm × 4.6mm, 5µm) column using a mobile phase composition of methanol and 0.1% (v/v) orthophosphoric acid in the composition...
3712
1287
FORMULATION AND EVALUATION OF CLOPIDOGREL BISULPHATE TRANSDERMAL PATCHES USING VEGETABLE OILS AS PERMEATION ENHANCER
OrallyClopidogrel bisulphate has a short elimination half-life (7-8 hrs.), low oral bioavailability (50%) undergoes extensive first pass metabolism (85%) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result, dose development toxic effect. The purpose of this research work was formulation and evaluation of transdermal drug delivery system of Clopidogrel bisulph...
3837
1497
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF RILPIVIRINE IN BULK AND PHARMACEUTICAL FORMULATION
In the present research work, four simple, precise, accurate and economical methods of UV spectroscopy have been developed for the estimation of Rilpivirine in bulk and pharmaceutical formulation. Method A involves estimation of Rilpivirine using low cost solvent, 0.01N HCl by zero order spectroscopy at an absorption maximum of 280nm. Method B involves Area under Curve method which involved calcul...
4407
1899
BIOCONTROL OF β – HAEMOLYTIC AEROMONAS HYDROPHILA INFECTION IN LABEO ROHITA USING ANTAGONISTIC BACTERIUM PSEUDOMONAS AERUGINOSA FARP72
Pseudomonas aeruginosa FARP72 was isolated from the skin mucus of freshwater catfish (Clarias batrachus) as a potent antagonistic bacterium. Efforts have made to assess the antagonistic activity against potential fish and human bacterial pathogens in vitro. Antagonistic effects were confirmed by cross-streaking method against pathogenic bacteria such as Aeromonas hydrophila, Bacillus subtilis, Bac...
6700
1340
STUDY OF ANTIULCER ACTIVITY OF ANGIOTENSIN RECEPTOR ANTAGONISTS IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS
Background: Peptic ulcer is one of the common diseases affecting the mankind. Many studies reveal co-occurrence of both peptic ulcer and hypertension in humans. So, it might be beneficial to choose an optimal drug that will target both these conditions. The role of renin-angiotensin system in the pathogenesis of peptic ulcer is well known. AT receptor antagonists which prevent binding of AT-II to ...
2713
1124
POLYSACCHARIDE AS A POTENTIAL CARRIER FOR MULTIUNIT COLON SPECIFIC DRUG DELIVERY SYSTEM
In the present study maltose a polysaccharide was investigated as a promising carrier for colon specific drug delivery system. It was evaluated for pH change study, by using in-vitro and In-Vivo testing in Wistar rats. In-Vitro study shows that there is drop in the pH from 7.00 to 5.5 when incubated with ceacal content in the controlled condition. The In-Vivo experiment was carried out by admini...
2649
1063
DESIGN AND EVALUATION OF ONCE DAILY LOSARTAN POTASSIUM SUSTAINED RELEASE MATRIX TABLET
The aim of the study was to develop sustained release matrix tablet of Losartan potassium and to evaluate its efficacy in reducing hypertension. In this experiment, sustained release matrix tablets were prepared by direct compression method and Methocel K4M CR and Methocel K100M CR were used as polymer. The evaluation involves three stages: the micromeritic properties evaluation of powder blend, p...
3718
1290
SCREENING OF BEHAVIOURAL, MUSCLE CO-ORDINATION & ANXIOLYTIC ACTIVITIES OF METHANOLIC EXTRACT OF SOPHORA INTERRUPTA (BEDD)
The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Sophora interrupta (papilionaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were adminis...
2713
987
STUDIES ON PHENOTYPIC CHARACTERIZATION AND SELECTIVE VIRULENCE FACTORS OF CANDIDA SPP. AND CRYPTOCOCCUS NEOFORMANS AND IN VITRO SUSCEPTIBILITY OF THESE ORGANISMS TO THE CONVENTIONAL AMPHOTERICIN B AND FUNGISOMETM
The human fungal infections have increased tremendously in our country, especially candidal infections. Cryptococcus neoformans is encapsulated yeast, causes life-threatening infections in immuno-compromised individuals such as AIDS. Meningoencephalitis is the serious consequence of C. neoformans infection. Studies are therefore, required for identification of these fungal...
3124
1461
UV-SPECTROSCOPIC METHOD FOR ESTIMATION OF TIEMONIUM METHYLSULFATE 50 MG TABLET IN BULK AND PHARMACEUTICAL PREPARATIONS
Tiemonium Methylsulfate is an antispasmodic drug. It strengthens calcium bonding with phospholipids and proteins. A simple, sensitive and highly accurate UV spectroscopic method has been developed for the determination of Tiemonium Methylsulfate in bulk and its tablet dosage form. Tiemonium Methylsulfate in its distilled water solutions was determined at the wavelength range of 200-400 nm by the s...
5260
3128
DESIGN AND EVALUATION OF DILTIAZEM HYDROCHLORIDE LOADED BUCCAL PATCH
The purpose of this study was to develop and optimise the formulation of mucoadhesive patches of Diltiazem hydrochloride using chitosan as base matrix. The patches were prepared by solvent casting method. PVP (K30) and propylene glycol were introduced into the patches formulae to improve the filming properties. The patches were found to be smooth in appearance, uniform in thickness, weight, and ...
2796
976
DEVELOPMENT AND VALIDATION OF A RAPID RP-HPLC METHOD FOR ESTIMATION OF SPARFLOXACIN IN TABLET DOSAGE FORM
The study describes development and subsequent validation of a reverse phase (RP) high-performance liquid chromatography (HPLC) method for the estimation of sparfloxacin (SPR) in tablet dosage form. The liquid chromatographic separation was achieved isocratically using a mobile phase composed of phosphate buffer (5.3 mM) and acetonitrile in the ratio of 60:40 (v/v) adjusted to pH 3.5 using dilute ...
4284
1259
EFFECT OF STEM BARK EXTRACTS OF OROXYLUM INDICUM; AN ETHNOMEDICINAL FOREST TREE ON SILK PRODUCTION OF BOMBYX MORI
The present investigation was under taken to find out the effect of stem bark extracts of medicinally important forest tree Oroxylum indicum (L) Kurz on silk production of Bombyx mori. Silk worms were fed with the leaves of mulberry fortified with stem bark extracts of O. indicum. The silk worms were reared up to the end of fifth instar. As the concentration of stem bark extract of O. indicum incr...
3474
1202
TOXICOLOGICAL ASSESSMENT OF CONSUMPTION OF BENZENE-POLLUTED WATER ON THE HEART AND BLOOD OF ALBINO RATS
The long-term effects of daily consumption of benzene-contaminated water over a period of Sixty-five days on rats’ cellular system were inspected. Haematological parameters such as haemoglobin, packed cell volume etc were determined. Standard enzyme assays were conducted on some enzymes (alkaline phosphatase, acid phosphatase and lactate dehydrogenase) activities of the heart and serum. Signific...
2619
975
DEVELOPMENT OF AN HERBAL ENERGY DRINK USING MEDICINAL PLANT EXTRACTS AND FURTHER STATISTICALLY ANALYSING THE SENSORY PROPERTIES BY ANALYSIS OF VARIANCE (ANOVA)
Energy drinks (EDs) are caffeine-based beverages that commonly contains large amount of carbohydrates, sugar, health supplements and various energy stimulants, such as ginseng and vitamin B, to name a few. These drinks are marketed for young people actively involved in sports or overworking hours, as natural alternatives that increases fun and improve physical and cognitive performances such as...
4315
1241
PHYTOCHEMICAL INVESTIGATION AND BIOLOGICAL ASSESSMENT OF 12-HYDROXY-OCTADEC-CIS-9-ENOIC ACID ISOLATED FROM SWIETENIA HUMILIS ZUCC. SEED OIL
The genus Swietenia belongs to Meliaceae family which consists of 37 genera and about 300 species which is found in most of the parts of India. In present investigation we made an efficient effort to extract ricinoleic acid from the seed oil of Swietenia humilis, Zucc. They are used in medicine folklore to cure various diseases in Mexico, Africa and India. Physicochemical properties of Swietenia h...
2537
1186
FORMULATION AND EVALUATION OF NIFEDIPINE LIQUISOLID TABLET
The liquisolid technique is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dried powder by simple physical blending with selected carrier and coating material. The in vitro dissolution property of poorly water soluble Nifedipine was improved by exploring the potential of liquisolid technique. Different liquisolid tablets were prepared by...
4213
1454
DEVELOPMENT AND VALIDATION OF NEW RP-HPLC ASSAY METHOD FOR VALSARTAN IN PURE AND IN FORMULATIONS
An isocratic, reversed phase HPLC method was developed, using an Inertsil ODS C8 (100 x 4.6) mm,5u column and the mobile phase containing an homogenous mixture of buffer and acetonitrile (65:35,v/v). The flow rate of the mobile phase was maintained at 1.0ml/min and the detection was carried out at wavelength 250 nm. The developed method was validated with respect to linearity, accuracy (recovery),...
2775
945
ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF CLITORIA TERNATEA LINN. LEAVES EXTRACT ON RAT MODEL
Clitoria ternatea Linn is used both in traditional system and folk medicine to treat various inflammatory diseases such as arthritis and burns. The aim of the present study was to evaluate the analgesic and anti-inflammatory activity on scientific basis of different extracts of Clitoria ternatea Linnusing carrageenan-induced paw edema and tail flick method in rats respectively at various dose leve...
5710
1934
ANTIBIOTIC SUSCEPTIBILITY PATTERN OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS IN TERTIARY CARE CENTER AT SOUTHERN RAJASTHAN
The objective of this study was to determine antibiotic susceptibility pattern of methicillin resistance Staphylococcus aureus in tertiary care center at Southern Rajasthan. Modified Kirby Baurer disc diffusion method was used for antimicrobial sensitivity testing of all samples. Maximum resistance among Staphylococcus aureus isolates (n=400) was observed against Methicillin (59%), Amikacin (53%...
3086
1088
ASSESSMENT OF C.S.J.M. UNIVERSITY CAMPUS STUDENTS AWARENESS AND ATTITUDE TOWARDS ANALGESICS (NSAIDs)
The present study was performed with an objective to assess knowledge, awareness, frequency indication and pattern of uses and attitude towards Non-Steroidal anti-inflammatory drugs (NSAIDs) among the scholars. In this survey based qualitative research, 591 respondents from the C.S.J.M. University campus, Kanpur, were screened out during the changing weather of north India (January–February 2013...
3248
1078
ACCURACY OF STANDARDS IN CHOLESTROL DIAGNOSTIC KITS
The percentage error observed in the claimed standard concentration of cholesterol 200 mg/dl for kits A to D is found to be 0.6, 12.3, 8.96 and 3.76 respectively. As per the guidelines of CLIA 8 allowable error is +10% for cholesterol estimation. Similarly as per the NCEP 9 guidelines + 9 % error is allowable. Therefore, it is noted that kit A is the best kit with an error of just 0.6% followed by...
2445
1035
DEVELOPMENT AND VALIDATION OF DIFFERENT SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE FROM BULK DRUG AND TABLETS
Simple, sensitive and accurate UV- spectrophotometric methods have been developed for the determination of an anti-HIV drug, Tenofovir Disoproxil fumarate (TDF), in raw material and in tablets. The drug shows maximum absorbance at 259 nm in selected four different media namely gastric fluid simulated (HCl) pH 1.5, vaginal fluid simulated (VFS) pH 4.2, phosphate buffer (PB) pH 6.8 and double distil...
3062
927
FORMULATION AND IN-VITRO EVALUATION OF GEL CONTAINING ETHOSOMES ENTRAPPED WITH ETODOLAC
Etodolac is an indole acetic acid derivative having half-life of 4 to 7 h and used for the treatment Rheumatoid arthritis. The oral use of Etodolac is not much recommended as it has many systemic side effects. The entrapment of drug in a vesicle has shown improved delivery of drug at the targeted site and has also reduced the dose and thus, has shown better patient compliance. Ethosomes are lipid ...
4647
1957