MOLECULAR MODELLING AND MOLECULAR DYNAMICS STUDIES OF SPECT PROTEIN OF PLASMODIUM FALCIPARUM AND IN SILICO SCREENING OF LEAD COMPOUNDS
Malaria has been a major life threatening mosquito borne disease. Unavailability of any effective vaccine and recent emergence of multi drug resistant strains of malarial pathogen Plasmodium falciparum continues to cause persistent deaths in the tropical and sub-tropical region. As a result, there is a growing demand for new targets for more effective anti-malarial drugs. A novel microneme prot...
Objectives: The study aimed to isolate coumarin compound from Bauhinia purpurea bark. Method: The bark was extracted successively with methanol in a soxhlet apparatus. The crude mass was subjected to HPLC, as well as column chromatography and eluted with methylene dichloride – methanol system with increasing methanol ratio to isolate compound BP. The structure of compound BP was identified by va...
COMPARATIVE STUDY OF HEPATOPROTECTIVE EFFECT PRODUCED BY CUMINUM CYMINUM AND NIGELLA SATIVA AGAINST CISPLATIN-INDUCED HEPATOTOXICITY; WITH HISTOPATHOLOGICAL STUDIES
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective ef...
Objective: Gestational diabetes mellitus is defined as “carbohydrate intolerance resulting in hyperglycemia of variable severity with onset or first recognition during pregnancy, whether or not insulin is used and regardless of whether diabetes persists after pregnancy. There is evidence that asymptomatic hyperglycemia during pregnancy leads to important morbidity in the mother and foetus. Hence...
COMPARATIVE ANTIOXIDANT POTENTIAL OF AQUEOUS AND ACETONE / WATER EXTRACTS OF GRAINS AND BRANS OF GRANIFEROUS SORGHUM [SORGHUM BICOLOR (L.) MOENCH] HYBRID GUANIPA 71 IN VITRO
Sorghum is an important food source with substantial nutritional value. An in vitro antioxidant evaluation of different extractions of graniferous sorghum [Sorghum bicolor (L.) Moench] hybrid Guanipa 71 was proposed here. Acetone / water extracts of both grains and brans revealed strong antioxidant properties by reducing Fe3+ (22.9% and 42.3%) and chelating Fe2+ (47.3% and 32.4%), respectively. Mo...
Seaweeds form economically important component of marine ecosystems worldwide. A wide range of beneficial and detrimental interactions exists between seaweeds and epiphytic as well as endophytic bacteria. Diversity study can be used to retrieve ecological information about community partner that relates the degree of stability of that community. The present work deals with the study the microbial ...
DESIGN AND EVALUATION OF AMOXICILIN TRIHYDRATE FLOATING GRANULES PREPARED BY MELT GRANULATION TECHNIQUE
The purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability...
In this work, an attempt was made to synthesize new chalcones by Claisen - Schmidt condensation of substituted benzaldehydes with 4-aminoacetanilide in the presence of base catalyst. The synthesized chalcone derivatives was characterized by FT-IR, 1H-NMR, and 13C-NMR and also tested for their antimicrobial activity and compared with the standard drugs....
COMPARATIVE STUDY OF ROPIVACAINE WITH CLONIDINE AND ROPIVACAINE ALONE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK
Background: Brachial plexus block provides minimal systemic impairment and excellent localized postoperative analgesia for upper extremity surgery. LA’s such as lignocaine, bupivacaine and ropivacaine are widely used along with adjuvant to improve the quality, onset and duration of block and to decrease postoperative analgesic requirement and systemic side effects. Adjuvant like α-2 agonist (Cl...
A diet rich in marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve overall health and wellbeing. An association between consumption of fish and seafood and beneficial effects on a variety of health outcomes has been reported in epidemiologic studies and clinical trials. These effects are mainly attributed to...