EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERS
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physi...
FORMULATION AND EVALUATION OF IN-SITU NASAL GEL OF MONTELUKAST SODIUM FOR THE EFFECTIVE TREATMENT OF ASTHMA
In this research work an attempt was made to formulate and evaluate in-situ gel for the intranasal delivery of montelukast sodium for the effective treatment of asthma. Thermally gelling in-situ gel formulations for nasal administration were prepared by using polymers such as poloxamer 407 and HPMC K4M in varying concentrations by using cold method. The formulated in-situ gels were evaluated for c...
A PRELIMINARY STUDY ON TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITIES OF CALYCOPTERIS FLORIBUNDA ROOT EXTRACTS
We evaluated the total phenolic acid content and antioxidant activity of methanolic and aqueous extracts of Calycopteris floribunda roots. Antioxidant activity of the extracts was determined using Reducing Power Assay and Total Antioxidant Capacity (TAC) assays. Preliminary phytochemical analysis of the extracts revealed the presence of various phytochemicals. The total phenolic content of the ext...
The antibacterial and antifungal activity of methanolic extract of Asteracantha longifolia Nees has been evaluated against 4 Gram positive bacteria, 7 Gram negative bacteria and 7 fungi. Ciprofloxacin and fluconazole used as standards for bacteria and fungi, respectively. The extract showed varying degrees of antimicrobial activity with zone of inhibition ranging from 15.0 to 26.0 mm. A. longifoli...
FORMULATION, CHARACTERISATION AND IN-VITRO EVALUATION OF NOVEL IONICALLY CROSS LINKED CASEIN NANOPARTICLES FOR MEMANTINE HYDRO-CHLORIDE DELIVERY
The objective of the study was to fabricate protein nanoparticles for better controlled and targeting action of drug, which can also overcome the problems like multidose therapy, poor patient compliance and high cost associated with conventional formulations. Memantine HCl loaded casein nanoparticles (F1 to F6) were prepared by ionically cross-linked method. The formulated nanoparticles were evalu...
Context: Acne vulgaris, a very common malady of adolescents, is well known and easily recognized. Acne is a “polymorphic” disorder which exhibits series of widespread and diverse lesions. Four key factors have been identified in the etiology of acne: increased sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit with Propioni bacterium acnes and the producti...
FORMULATION AND PHYSICOCHEMICAL EVALUATION OF MEDLAR (MESPILUS GERMANICA L.) AND OAK (QUERCUS CASTANEIFOLIA C. A. MEY.) EFFERVESCENT TABLETS
Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea. Medlar and oak, the fruits of M. germanic...
ACUTE DERMAL TOXICITY AND IRRITABILITY STUDIES OF Ag2Ga NANONEEDLE MEDIATED SILVER FORMULATION AS PER OECD 402 AND 404 PROTOCOLS
We have developed Ag2Ga nanoneedles and achieved individual nanoneedles with diameter ranging from 200 to 250 nm with sharp tip and micro scale length required for a drug carrier to deliver drugs to site of application. Nanoneedles are designed to be inserted in human tissue and therefore they have to be compatible with the local environment of both in terms of toxicity and intended function. The ...
CHARACTERISTICS, TREATMENT PATTERNS AND OUTCOMES OF PATIENTS WITH SMALL CELL LUNG CANCER – A RETROSPECTIVE ANALYSIS
PURPOSE: The aim of this retrospective study is to present data of patient characteristics, treatment patterns, and treatment results in an unselected patient population with small cell lung cancer (SCLC) in limited disease (LD) and extensive disease stage (ED). MATERIAL AND METHODS: All patients of carcinoma lung from April 2007 to December 2009 were analyzed for present study, conducted i...
The present study has been designed to investigate the effect of modulation of tumour necrosis α (TNF-α) on naloxone induced opioid withdrawal syndrome. Chronic morphine (5mg/kg,i.p) administration followed by a single injection of naloxone (8mg/kg, i.p) was used to precipitate opioid withdrawal syndrome in mice. Behavioral observations were made immediately after naloxone treatment. Withdrawa...