Prostaglandin endoperoxide synthases, usually known as cyclooxygenases (cyclooxygenase-1 and cyclooxygenase-2), catalyze a key step in the formation of biologically effective prostaglandins. In recent times, a cyclooxygenase-1 variant protein, called cyclooxygenase-3 used to be found and characterized. COX-3 is studied recent along with significant margin for the formation of anti-inflammatory, an...
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method aga...
MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NEWLY SYNTHESIZED 1, 3, 4-THIADIAZOLE DERIVATIVE OF GUAR GUM
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 N...
THE EFFECT OF INTAKE DUCK EGG YOLK ON BODY WEIGHT, LIPIDS PROFILE AND ATHEROSCLEROSIS DISEASES IN MALE WISTAR RATS
Duck egg yolks contained fat and higher cholesterol than chicken eggs. A high-fat diet has caused obesity to impact for the development of diseases such as type II diabetes, stroke, atherosclerosis, hypertension, cardiovascular disease and certain forms of cancer. The purpose of using laboratory animals determined the effects of duck egg yolk to body weight, lipids profile, and atherosclerosis dis...
Childhood is characterized by periods of rapid growth, maturation, and development. There is a change in the magnitude of the dose required during childhood and adolescence. Thus, Paediatric practice requires a range of dosage forms that are acceptable at different ages and abilities and a range of strengths or concentrations allowing administration of the correct age-related dose. Literature show...
DEVELOPMENT AND VALIDATION OF A HPLC ANALYTICAL METHOD FOR DETERMINATION OF ELLAGIC ACID IN EPILOBIUM ANGUSTIFOLIUM EXTRACT
Development of quality assessment parameters for natural products is a prominence necessity to justify their acceptability and activity. Establishment of authentic and reliable analytical methods which profile the quantitative phytochemical composition of marker constituents in multicomponent composition like extract is a challenging task. A simple, rapid, precise, and reliable HPLC method was dev...
Heterocyclic chemistry plays a very most important role in medicinal chemistry as well as in organic chemistry. Most of the drug molecule formed and possesses therapeutic activity due to the heterocyclic scaffold. A slight change in heterocyclic moiety leads to the major therapeutic change in the drug molecule. Benzothiazole can serve as a unique and versatile moiety for experimental drug design. ...
IN-VITRO ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF DIOSPYROS MELANOXYLON ROXB.
The present research focuses on the screening of phytochemicals from an Indian medicinal plant Diospyros melanoxylon Roxb. by both qualitative and quantitatively and biological activities. Different solvent extracts were prepared and used for this study such as hexane, chloroform, methanol, ethyl acetate and aqueous. Preliminary screening of phytochemicals revealed that the methanolic extract comp...
A COMPARATIVE STUDY OF THE IN VITRO ANTIBACTERIAL ACTIVITY OF ENDOCARP, DATE PALM TISSUE AND DATE PALM TISSUE WITH ENDOCARP TOGETHER AGAINST SOME GRAM NEGATIVE AND GRAM POSITIVE PATHOGENIC BACTERIA
The antibacterial activities of water extracts of the three major parts of the date palm fruit were compared against Eschereshia coli; Klebsiella pneumonia; Salmonella enteritidis; Pseudomonas aeruginosa; Staphylococcus aureus using the agar well diffusion method. Endocarp extract showed a wide range of activity against all Gram negative bacteria while it exhibited a low activity against Gram posi...
Losartan potassium is used to treat hypertension, and it protects the kidneys from diabetic nephropathy. The drug has a short plasma half-life, inadequate bioavailability, removed rapidly from the blood circulation. These problems can be eliminated by formulating a novel dosage form of a drug in the form of floating oral in-situ gel. Present research performed on losartan potassium drug deals w...