The aim of this research was to formulate and evaluate microspheres of Fluoxetine Hydrochloride. It is a selective inhibitor of serotonin reuptake type of drug used in the treatment of depression. It is practically soluble in water belongs to BCS class I with a bioavailability approximately 72%. Fluoxetine HCl mucoadhesive microspheres were prepared by using chitosan polymer and emulsion solvent e...
Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical C...
Algae are extensively used in cosmetics, supplements and pharmaceutical industries. Researches support their hypotensive, cytotoxic, anti-inflammatory and many other biologic effects. In the present study, the cytotoxic, antioxidant and acetylcholinesterase inhibitory activities of two brown algae, Padina tetrastromatica and P. australis, have been evaluated. Total extract was prepared using metha...
Lagerstroemia speciosa is commonly known as crape myrtle belonging to the Lythraceae family. Lagerstroemia speciosa or Banaba is a medicinal tree traditionally used to lower blood sugar in the body. Its high content of corosolic acid makes it an effective anti-diabetic drug. Banaba is also recommended for kidney, bladder problems and hypertension. Leaves of the species have been traditionally used...
A rapid reverse phase high performance liquid chromatographic method was developed for the estimation of Manidipine dihydrochloride in its pure form as well as in tablet dosage forms. Chromatography was carried out on an phenomenex C18 column (250´4.6mm, 5 µm), using a mixture of acetonitrile and water (80: 20 v/v) with pH adjusted to 3.5 with ortho phosphoric acid (0.1 % v/v) as the mobile ph...
ETHNOBOTANICAL AND ETHNOPHARMACOLOGICAL ACTIVITIES OF ARTEMISIA NILAGIRICA, LYONIA OVALIFOLIA, SARCOCOCCA SALIGNA AND TARAXACUM OFFICINALE
Indian medicinal plants and traditional knowledge have been an integral part of our lifestyle since ages and now became an important source for natural product research (NPR) and development. Due to its knowing ability and applications, this knowledge has long been used as a thriving source for discovery of new drug molecules. This study was conducted under the routine drug development program of ...
In recent years, in silico approaches have been predicting novel drug targets. The objective of this study was to analyze the inhibitory action of canthin-6-one alkaloid by computational docking studies. For this study, natural metabolite canthin-6-one isolated from Simarouba glauca was used as ligand for molecular interaction. The crystallographic structure of molecular target Epidermal Growth Fa...
ETHNOPHARMACOBOTANICAL INFORMATIONS OF SOME HERBACEOUS MEDICINAL PLANTS USED BY TODA TRIBES OF THIASHOLA, MANJOOR, NILGIRIS, WESTERN GHATS, TAMILNADU, INDIA
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and ni...
A topological index is a numeric quantity associated with a graph which characterizes the topology of the graph and is invariant under graph automorphism. Topological indices such Randić, atom-bond connectivity (ABC) and geometric (GA) indices are used to predict the bioactivity of different chemical compounds. Recently, the edge version of atom-bond connectivity and geometric arithmetic indices ...
AN IMMUNOMODULATORY PROFILE OF AQUEOUS EXTRACT OF OXALIS CORNICULATA LINN IN ALBINO WISTAR RATS AND SWISS ALBINO MICE
Objective and Background: To study the immunological activity of aqueous extract of Oxalis corniculata in Albino wistar rats and Swiss Albino mice. The Oxalis corniculata is an edible and a medicinal plant which is important to the food industry and may also have a significant role to play in health care. Material and Methods: The aqueous extract of whole plant of Oxalis corniculata was adminstere...