NANO THERANOSTICS – A BREAKTHROUGH IN CANCER DIAGNOSIS AND TREATMENT AND REGULATIONS OF NANO TECHNOLOGY PRODUCTS
An object with at least one characteristic dimension between 1 and 100 nm can be defined as “nanomaterial”. The unbelievable development of nanotechnology in the last 30 years has allowed the release of new and efficient synthetic routes towards the production and functionalization of different NPs, composed of a variety of materials including noble metals (e.g. gold and silver), semiconductor...
Cyamopsis tetragonoloba is widely used by people and is found to have multiple medicinal utilities. Four (chloroform, ethyl acetate, methanolic and aqueous) extracts of Cyamopsis tetragonoloba fruit were therefore, analysed by Gas Liquid Chromatography and Mass Spectrometry analysis to assess their phytochemical constituents. The chloroform extract of Cyamopsis tetragonoloba fruits showed the pres...
FORMULATION OF GEL KEFIR PRODUCT OF MILK FERMENTATION AND ANTIBACTERIAL ACTIVITY TESTS AGAINST PROPIONIBACTERIUM ACNES
Propionibacterium acnes is one of the bacteria that causes acne. One of the natural ingredients that potentially as anti acne is kefir. Kefir is a product of fermented milk with starter kefir grain. The fermented kefir is incorporated into the gel product for acne treatment. The purpose of this study was to formulate the fermented kefir in the gel product and to test the antibacterial activity aga...
A new drug delivery system for H2 receptor antagonist ranitidine hydrochloride was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of time. Floating mucoadhesive tablets of ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ran...
Introduction: Antiplatelets play a crucial role in improving many metabolic disorders and complications, including dyslipidemia, atherosclerosis, diabetes mellitus and cardiovascular diseases. The most common and effective antiplatelets used widely are aspirin and clopidogrel. The aim of this study is to evaluate the dyslipidemic and protective effects of aspirin and clopidogrel in obese rats. Mat...
QUALITATIVE AND QUANTITATIVE ASSESSMENT OF BIOACTIVE PHYTOCHEMICALS IN GOBINDOBHOG AND BLACK RICE, CULTIVATED IN WEST BENGAL, INDIA
Phytochemicals are bioactive compounds produced by plant through primary and secondary metabolism. Phytochemicals are found to be more effective than conventional synthetic chemicals. Rice is considered as the staple food for most of the people residing in this part of world, i.e., the eastern part of India. There are many varieties of rice cultivated in West Bengal, India and among which Gobindob...
In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacter...
In the present study reports synthesis and development of 3-Chloro – N - ((5-chloro-1-tosyl-1H-benzo [d] imidazol – 2 - yl) methyl) - N arylquinoxalin-2-amines (5a-e) from 3-chloro-N-p-tolyl quinoxalin -2-amine (3) condensed with proporgyl bromide followed by adding 4-chloro-N1-tosylbenzene-1,2-diamine,by adopting simple procedure. All titled compounds were screened for their anti bacterial ac...
IN SILICO EPITOPE PREDICTION AND HOMOLOGY MODELING OF ENVELOPE SURFACE GLYCOPROTEIN GP160, PRECURSOR REGION FROM HUMAN IMMUNO DEFICIENCY VIRUS -1
The development of a highly effective AIDS vaccine will depend on the success of designing immunogens that will elicit immune response against broadly neutralizing antibodies to naturally circulating strains of HIV- can be done by reverse vaccinology. Reverse vaccinology is a good approach for provoking the broadly neutralizing antibody response by identifying the specific epitopes i.e. surface pr...
A NOVEL, SENSITIVE, BIOANALYTICAL METHOD FOR ESTIMATION OF AMLODIPINE BESYLATE IN RAT PLASMA USING FLOURESCENCE DETECTION BY RP-HPLC
The aim of the present work was to develop and validate a novel, rapid, sensitive, accurate and specific RP-HPLC assay with fluorescence detection for the quantification of amlodipine besylate in rat plasma to be applied to preclinical studies. Flourescein was used as internal standard (IS) and the detection was carried out by an online wavelength switching which enabled detection of amlodipine &a...