Taraxacum officinale (TO) Weber commonly known as dandelion has contained triterepenes-taraxasterol and taraxerol in its roots which are nowadays being recognized as potent anticancer compounds. The main objective behind the present study was to increase the yield of taraxasterol and taraxerol through induction of hairy roots in Taraxacum officinale Weber using two strains of Agrobacterium rhizoge...
IN-VITRO STUDIES ON OIL DEGRADING BACTERIA ISOLATED FROM OIL CONTAMINATED SOIL OF VANIYAMBADI AND AMBUR AREAS OF VELLORE DISTRICT
The oil polluted soil has many hydrocarbons which can be degraded by microbes. These oil degrading microbes were isolated from the oil contaminated soil through plate and dilution technique. The oil contaminated soils were collected from the oil spilled places of Vaniyambadi and Ambur areas of Vellore District, Tamil nadu, India. Through the biochemical tests, the isolated bacterial strains were i...
QSRT STUDIES OF 2-(5-ARYL-1, 3, 4-OXADIAZOL-2-YL)-N-(5-METHYLISOXAZOL-3-YL)-ACETAMIDE DERIVATIVES AS AN ANTIMICROBIAL AGENTS
Quantitative structure relationship techniques (QSRT) is among the most widely used computational technology for analog-based drug design. A molecular modeling approach using theoretical, computational analysis through chem sketch ACD lab online software was done for determination of probable antimicrobial activity. To develop a pharmacophoric model for inhibition, QSRT parameters PCP, ADME, and t...
Cancer is one of the emergings, and best-understood neoplasm’s from a genetic perspective, yet it remains the second most common cause of cancer-related death, indicating that some of its cancer cells are not removing completely by current therapies. Chitosan is a polysaccharide β-linked D-glucosamine and N-acetyl-D-glucosamine were used as conjugate to 5Fluorouracil. 5FU is one of the most com...
Objective: To investigate the patient’s knowledge of hypertension fact with validated Morisky questionnaires and management of drug adherence. Materials and Methods: The aim of one present study was undertaken 100 patients attending the cardiology, outpatient department in various private sector hospitals in southern Tamilnadu and to assess the patient’s medication knowledge and drug adherence...
COMPARATIVE STUDY ON EFFECT OF DIFFERENT CAPPING AGENTS ON THE ANTIMICROBIAL ACTIVITY OF ZNO NANOPARTICLES
The present study focuses on the synthesis of ZnO nanoparticles by chemical method in alcohol base using three different capping agents-Thioglycerol, oleic acid and Triethanol amine (TEA). The effect of concentrations was analyzed for their effectiveness in particle growth and antibacterial activity. The antibacterial activity of ZnO nanoparticles using these capping agents at different concen...
STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TWO SYNTHETIC ANTIBIOTICS, AMOXICILLIN AND ENROFLOXACIN, SIMULTANEOUSLY
This work proposes a precise, accurate, sensitive and selective stability indicating RP-HPLC method for the simultaneous quantification of amoxicillin and enrofloxacin in bulk powder and oral suspension formulations. Chromatographic separation was performed on the reverse phase C18 analytical column using 0.1M potassium dihydrogen orthophosphate–methanol (65:35, v/v) as mobile phase and with det...
A series of some quinolino-benzimidazole/thiazole derivatives (3a-3h) have been synthesized from2-hydroxyquinoline-3-formaldehyde derivatives (1a-1d) and 1, 2-phenylenediamines/2-aminothiophenols (2a-2c). The synthesized compounds were characterized by FTIR, 1H-NMR and Mass Spectrometry. All the compounds were screened in-vitro for their antibacterial activity against Mycobacterium tuberculosis (H...
Objective: Lepidium sativum (Garden cress) is traditionally an important plant with a wide range of activities from the ages. Ample literature about its biological activities, motivate us to evaluate the total flavonoids content and to screen the nootropic activity in mice. Methods: Ethanolic extract was prepared from the seeds of Lepidium sativum using ethanol (70% v/v) and total flavonoids conte...
Background: Acute respiratory distress syndrome (ARDS) is a medical condition occurring in critically ill patients characterized by extensive inflammation in the lungs and associated with several complications. Therefore, the present study aimed to identify the common risk factors associated with ARDS in Hail Region, Northern Saudi Arabia. Methodology: This study investigated retrospectively 68 pa...