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EVALUATION OF IN-VITRO ANTI-OXIDANT ACTIVITY OF SOME SYNTHESIZED NOVEL L-ARGININE ANALOGUES
A series of novel L-arginine analogues were synthesized and screened for in-vitro anti-oxidant activity by Nitric oxide (NO) scavenging and 1-1-diphenyl-2-picrylhydrazyl (DPPH) scavenging methods. The purity of the synthesized compounds has been characterized by various analytical techniques such as UV, FTIR and TLC. The synthesized compounds were evaluated for in-vitro anti-oxidant activity by NO...
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POLYETHYLENE GLYCOL (PEG) SUPPORTED AMINO DENDRIMERS (DENDRITIC TRIBLOCK COPOLYMER) FOR DELIVERY OF METHOTREXATE (MTX)
Dendrimers are synthetic, highly branched, nanosized, monodisperse macromolecule which proving their applicability in different areas like diagnosis, drug delivery, gene delivery, molecular encapsulation etc. Due to their widespread applications, scientific community is continually engaged in developing newer dendrimers with advanced properties. In the present study, amino dendrimers are synthesiz...
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SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NOVEL 3, 6- DISUBSTITUTED IMIDAZO [2, 1-B] [1, 3] THIAZOLES
Cyclocondensation of α-bromo ketones with thiourea afforded 4-substituted 1, 3-thiazole-2-amines. These compounds on further treatment with α-bromo ketones afforded 3, 6-disubstituted imidazo[2, 1-b][1, 3]thiazole (1a-1j). All the synthesized compounds were confirmed for their structure by FTIR, 1H NMR and GSMS spectra and tested in vitro for their anti-microbial activity by cup plate method aga...
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EFFECT OF PLACEBO ON DEPRESSION
Depression is a well defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easil...
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PRODUCTION OF BIODIESEL FROM AGRO-INDUSTRIAL WASTE
Fossil fuels are significantly depleted nowadays due to excess utilization. Therefore, it is always better to find alternatives to produce eco-friendly fuels. This paper deals with the production of biodiesel from agro-industrial waste such as young coconut husk, custard apple seeds and broiler chicken skin. Lipids were isolated from the substrates using the modified Bligh and Dyer method and tran...
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STANDARDIZATION WITH HPTLC ANALYSIS OF POLYHERBAL POWDER FORMULATION: SAFOOF-E-MUSAKKIN
Background & Objectives: Standardization of polyherbal Unani formulations is essential to assess the quality of drugs, based on their active principles, physical and chemical standards. This work reports on standardization of a polyherbal Unani powder formulation Safoofe- Musakkin (SM) consist of Rauwolfia serpentina Benth. Ex kurz root, Coriandrum sativum Linn. seed and Piper nigrum Linn. fru...
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VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS
The voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetr...
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SYNTHESIS AND ANTIMICROBIAL STUDIES OF SOME NEW HALOGENATED ISOXAZOLINE DERIVATIVES
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this rea...
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IDENTIFICATION OF E.COLI NISSLE 1917 PROTEINS BY USING 2-D GEL ELECTROPHORESIS UNDER THE INFLUENCE OF COCOS NUCIFERA SAP AND WINE
Proteomics is the large scale study of proteins. Before going to analyse the differentially expressed proteins, through 2-D gel electrophoresis the proteins were extracted in a sample under stress. In the present study, we were isolated the protein samples of E. coli Nissle 1917 treated with cocoti sap and wine stress. The isolated proteins washed with 2-D clean up kit because it was very sensit...
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A PROSPECTIVE STUDY TO COMPARE THE EFFECT OF DIFFERENT HAART REGIMENS ON CD4 COUNTS OF HIV PATIENTS WITH TUBERCULOSIS
Introduction: AIDS is one the most dreaded diseases of human race in the present times. More than two- third of HIV infected individuals have an associated infectious pulmonary disease. Mycobacterium tuberculosis is considered as more virulent compared to other opportunistic pathogen causing latent infection. Cure of AIDS is still an unsolved mystery but some of the drugs have been developed to de...
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