Pages Menu
ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

Categories Menu

Volume 14 (2023) - Issue 4, April

Review Articles

 
Title
Views
PDF
Cited
1.

MOLECULAR DOCKING IS AN IDEAL TOOL IN PHARMACEUTICAL DRUG DEVELOPMENT OF ANTI-TUBERCULOSIS MOLECULES

Advancements in X-ray crystallography, Nuclear magnetic resonance (NMR) spectroscopy, and innovation projects like the human genome project left gigantic amounts of biological information accessible to the common public, academicians, and industries. Computer-Aided Drug Design (CADD), such as molecular docking, is an ideal method to exploit this biological information in rapid drug development and...

Fathima Asra, Naresh Dumala *, Fathima Ajra, Shaik Mallika and Kannan Vadivel

Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1534-46

1534-1546

814

757

2.

MAGNETIC NANOPARTICLES FOR THEIR THERAPEUTIC APPLICATIONS

Magnetic nanoparticles are hugely used in hyperthermia, targeted drug delivery processes, diagnosis, extraction, and cellular imaging of biological molecules, which can be widely used in cancer treatment. The focus of attention is on formation, features, types, made work, coating material, and therapeutic application of magnetic nanoparticles. It also pivots in safety and biocompatibility in magne...

Divyani Singh * and Prashant Shukla

Department of Pharmaceutics, Hygia Institute of Pharmaceutical Education and Research Faizullahganj, Prabhandh Nagar, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1547-60

1547-1560

1103

409

3.

RECENT TRENDS IN WOUND CARE HERBAL FORMULATIONS: META ANALYSIS AND SYSTEMATIC REVIEW

Wound healing is a normal and common process that typically involves overlapping roles to increase normal activity by increasing neutrophils. The healing process can be managed by using natural substances that have therapeutic properties. The activity of numerous proteins and their regulation by genes orchestrate a healing performance like no other. The present study is to learn about the recent a...

Satish Dubey, Akanksha Singh, Kundan Kumar Ojha, Barkha Kumari, Priyanka Kumari, Shilpa Vinodia, Mery Aradhna Bara and Ashwini Kumar Dixit *

Department of Botany, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1561-71

1561-1571

775

452

4.

A BRIEF REVIEW ON: PHYTOCHEMICAL AND ANTIULCER PROPERTIES OF PLANTS (FABACEAE FAMILY) USED BY TRIBAL PEOPLE OF GADCHIROLI INDIA.

Medicinal plants play a vital role in human health as these are nature’s gift to human beings to make disease-free, healthy lives. The various families such as Amaranthaceae, Cucurbitaceae, Euphorbaceae, Fabaceae, Malvaceae, Myrtaceae, Orchidaceae, Piperaceae, Solanaceae etc. comprises several medicinal properties distributed in the tropical and subtropical region of India. The medicinal usage o...

Lalchand D. Devhare * and Niharika Gokhale

Oriental College of Pharmacy and Research, Oriental University Indore, Sanwer Road, Jakhya, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1572-93

1572-1593

672

486

5.

PHARMACEUTICAL APPLICATIONS OF LYOPHILIZATION: RECENT UPDATES AND ADVANCEMENTS

For almost five decades, from its application in preserving blood plasma to stabilizing pharmaceuticals and biopharmaceuticals, lyophilization has been used in life sciences. Lyophilization is a popular drying technique for preserving various drugs, formulations and biological materials such as proteins, plasma, and living cells. The researchers have made significant efforts to develop lyophilize...

M. S. Motwani, A. R. Shahu, M. J. Umekar, D. M. Biyani and K. J. Wadher *

Department of Pharmaceutics, Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1594-03

1594-1603

661

504

6.

TREATMENT STRATEGIES FOR NEURODEGENERATIVE DISEASES THROUGH IMPORTANT MEDICINAL PLANTS USED IN UNANI MEDICINE

Neurodegenerative diseases (NDs) that are characterized by progressive loss of functioning and structure of neurons are of great burden to the individuals and the society. With several hypotheses, the existent cause still remains a mystery for various NDs in healthcare. Protein degradation, inflammation, oxidative stress, environmental factor, mitochondrial defects, abnormal protein accumulation i...

Tarana Umar, Rampratap Meena *, Mustehasa, Ghazala Javed and Asim Ali Khan

Central Council for Research in Unani Medicine, 61-65, Institutional Area. Opp. D Block. Janakpuri, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1604-10

1604-1610

533

301

7.

DEPRESSION: UNDERSTANDING THE PATHOPHYSIOLOGY AND TREATMENT MODALITIES

Depression is accepted as a condition of misery and is treated as a disorder that includes mental and emotional disorders. Depression is a deadly disease that affects about 5% of the general population. In addition, depression is a heavy burden on patients and families. Furthermore, many epidemiological studies have shown that the occurrence of depressive disorders in the general population is inc...

Anuradha Pannu and Abhilasha Ahlawat *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1611-21

1611-1621

498

333

8.

REVIEW ON NARINGIN: METHOD OF ISOLATION, ANALYTICAL DEVELOPMENT, AND ITS RECENT PHARMACOLOGICAL ACTIVITIES

Naringin is a flavonoid isolated from different citrus fruits like Grapefruit, Orange, Pomelo, Lemon, etc, which are commonly called local fruit. Naringin is found in the white spongy portion of citrus peel. Its content varies from 0.65 mg/gm in the mandarin peel to 14.40mg/gm in the grapefruit peel. Naringin is metabolized to the flavanone naringenin by the enzyme Naringinase present in the liver...

B. Sudarshana, T. Nilotpal, S. Bhupendra and J. Honey *

Department of Pharmaceutical Analysis, Himalayan Pharmacy Institute, Majhitar, Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1622-29

1622-1629

637

224

9.

CURCUMIN DERIVATIVE: AN EMERGING ANTI-INFLAMMATORY AGENT

Numerous disorders are caused by inflammation, and recent epidemics have prompted public health concerns. The fact that there are so many anti-inflammatory medications available doesn't change the fact that they frequently don't work because they pose a severe risk of gastrointestinal toxicity with both acute and chronic use, hematologic toxicity with acute use, and nephrotoxicity with chronic use...

Shalini Awasthi * and Cheenu Bhargava

Department of Pharmacology, Advance Institute of Biotech and Paramedical Sciences, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1630-35

1630-1635

453

221

10.

SELENIUM CONTAINING COMPOUNDS & IT’S BIOLOGICAL APPLICATION

Selenium (Se) is a fundamental micro nutrient of life forms and has significant capacity. It takes part in the elements of seleno protein in a few habits. As of late, this has drawn in much consideration because of its restorative potential against a few illnesses. Numerous natural Se-containing compounds, both natural and artificial, have been identified, studied and used in the treatment of canc...

Ariful Alam Sujon

Department of Pharmacy, School of Pharmaceutical Science, Lovely Professional University, Jalandhar-Delhi G.T Road, Phagwara, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1636-41

1636-1641

472

234

11.

QUALITY BY DESIGN (QbD) BASED APPROACH FOR DEVELOPMENT OF FAST DISSOLVING TABLETS

Background: Oral disintegrating tablets are strong dosage forms comprising medications that disintegrate throughout the oral cavity in less than 1 minute. Quality by designis a modern approach to pharmaceutical quality. Pharmaceutical Quality Design and discusses the use of Quality Design to maintain the quality of Pharmaceuticals. Methods: The frequent screening design, such as 32 factorial desig...

Bhukya Yamuna, Thadipatri Reshma and Nawaz Mahammed *

Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K. R. Palli Cross, Anantapur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1642-48

1642-1648

635

362

12.

AN APPROACH TOWARDS THERAPEUTIC INTERVENTION USING CARBON-BASED NANOMATERIALS AND METAL-BASED NANOPARTICLES: A MECHANISTIC REVIEW

Nanotechnology is an interdisciplinary field of science that refers to the research and technology development at atomic, molecular, and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales that range from 1nm to 100 nm. During the past few decades, a surfeit of nanomaterials (NMs) and nanoparticles (NPs) has evolved and been eval...

Sreelekha Das, Romita Guchhait and Tamalika Chakraborty *

Department of Biotechnology, Gurunanak Institute of Pharmaceutical Sciences and Technology, Kolkata, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1649-59

1649-1659

426

268

13.

THE CURRENT REGISTRATION REGULATIONS OF COSMETIC PRODUCTS IN “BRICS” COUNTRIES

Cosmetic products are produced by the most inventive and technically driven methods to reach more consumers in the developing world. Cosmetic products are also regulated, similar to pharmaceutical products. BRICS countries are emerging markets with a partial regulatory system similar to well-regulated countries. BRICS countries have a registration or notification process for cosmetics based on the...

R. Sathyalakshmi, N. Jaipratap and C. Sowmya *

Department of Pharmaceutical Regulatory Affairs, Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1660-67

1660-1667

548

239

14.

THE CURRENT REGISTRATION REGULATIONS OF COSMETIC PRODUCTS IN “BRICS” COUNTRIES

Omega-3 fatty acids are essential fatty acids present in regular animal and plant food diets. They play a key role in different body functions. Omega-3 fatty acids help to prevent central nervous system diseases. In this paper, we have shown the molecular basis of this effect. There isa number of studies showing the role of omega-3 fatty acids in the prevention of different central nervous system ...

Meghoparna Kundu, Jeenatara Begum *, Tamalika Chakraborty, Surya Shiskha Baidya, Suparba Tribedy and Nabamisha Chatterjee

Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F, Nilgunj Road, Panihati, Kolkata, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1668-78

1668-1678

401

330

15.

ENHANCEMENT OF THERAPEUTIC ACTION OF ANTI-HYPERLIPIDEMIC DRUGS BY USING A NOVEL NANOSUSPENSION-BASED APPROACH

Hyperlipidemia is an elevated condition of lipid levels in the body and is known to speed up a process of atherosclerosis that may prove fatal in the development of various cardiovascular diseases. The figures of the patient with hyperlipidemia are constantly increasing which is rising a serious risk factor for a group of cardiovascular diseases. Although various pharmacotherapy for hyperlipidemia...

Geeta Mahlawat *, Tarun Virmani and Muhammad Arif

School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1679-90

1679-1690

493

303

16.

HERBAL DRUG LOADED NANOGEL FOR EFFECTIVE TREATMENT OF SKIN DISORDERS

Since ancient times, plants have been used for medicinal purposes for their various therapeutic potentials and safest to modern allopathic medicines. Regularly phytochemicals are proving to be modern medicine with novel drug delivery systems by treating different diseases and disorders. Phytochemical compounds need improvement of efficacy and patient's compatibility to deliver in various diseases,...

Shivani Samaiya * and Virendra Kumar Sharma

School of Pharmacy, LNCT University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1691-02

1691-1702

570

462

17.

CODING FOR AN ANTICOAGULANT: SYSTEMATIC REVIEW OF PHARMACOGENETICS-GUIDED WARFARIN THERAPY ON THE THERAPEUTIC AND ADVERSE CLINICAL EVENTS ON PATIENTS WITH ATRIAL FIBRILLATION, PULMONARY EMBOLISM, AND DEEP VEIN THROMBOSIS

Background: Warfarin is an anticoagulant widely used to prevent thromboembolic events (TEs) in patients with various cardiovascular (CV) diseases. Pharmacogenomics (PGx)-guided testing is a growing method suggested to help predict warfarin dosing. A systematic review was performed to compare the incidence of thromboembolic events (TEs), bleeding events (BEs), time in therapeutic range (TTR), the p...

Amy Marie Green, Marcia Brackbill, Arthur F. Harralson and Sean Hyungwoo Kim *

Shenandoah University Bernard J. Dunn School of Pharmacy, 1775 North Sector Ct, Winchester, VA 22601 USA.

DOI: 10.13040/IJPSR.0975-8232.14(4).1703-13

1703-1713

519

222

Research Articles

 
Title
Views
PDF
Cited
18.

COMPUTER-BASED SCREENING OF THE ANTICANCER PROPERTY OF SELECTED PANAX GINSENG PHYTO-LIGANDS

It cannot be overstated that the rate at which cancer uses glucose for proliferation is one of the many variables contributing to the alarmingly high mortality rate of cancer over time. Cancerous cells can survive because of this. However, a significant therapeutic strategy for malignant cells may involve the blockage of several glucose transporters, including glut 4 encoded by the solute carrier ...

Ezekiel A. Olugbogi *, Olaposi I. Omotuyi, Kolawole T. Mesileya, Damilola S. Bodun, Shola D. Omoseeye, Anita O. Onoriode, Favour O. Oluwamoroti, Joshua F. Adedara, Isaac A. Oriyomi, Fatimat O. Bello, Favour O. Olowoyeye, Oluwatomilola G. Laoye, Damilola B. Adebowale, Aanuoluwapo D. Adebisi , Mark-Solomon C. Ogologo, Obinna C. Etukokwu, Ifeanyichukwu O. Onyemaobi, Salim Y. Jibril and Precious C. Onyeka

Molecular Biology and Simulation Center, Ado-Ekiti, Ekiti State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.14(4).1714-27

1714-1727

760

467

19.

EFFECT OF SAMPLE PREPARATION ON PHYTOCHEMICAL CONTENT, SILVER NANOPARTICLES SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF ZINGIBER OFFICINALE AND CURCUMA LONGA SYNERGISTIC COMBINATION

This work compared the effect of hot aqueous extraction and blending on phytochemical content, AgNPs synthesis, antibacterial and antioxidant properties of ginger and turmeric. Qualitative and quantitative phytochemical screening was conducted on a hot aqueous extract of ginger and turmeric combination (CHAE) and blended ginger & turmeric combination (CBLE). An attempt was then made to synthe...

T. I. Adesipe

Department of Science Laboratory Technology, Federal Polytechnic Ilaro, Ogun, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.14(4).1728-36

1728-1736

712

477

20.

DESIGN, DEVELOPMENT AND OPTIMIZATION OF NOVEL NANOVESICLE LOADED SUBGLOSSAL FILMS FOR ENHANCED SYSTEMIC AVAILABILITY OF TACROLIMUS THROUGH SUBLINGUAL ROUTE

Tacrolimus being the drug of choice in prevention of transplanted organ from rejection suffers from low oral bioavailability and dose-dependent side effects. An attempt was made to formulate tacrolimus into subglossal (sublingual) fast dissolving films containing ethosomes using ethanol and soyalecithin to enhance systemic availability of drug with controlled delivery of drug. Ethosomes were prepa...

R. Suma * Preeti V. Karwa and V. Kusum Devi

Al Ameen College of Pharmacy, Hosur Main Road, Opp to Lalbagh Main Gate, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1737-53

1737-1753

622

406

21.

ANTI-TUMOR ACTIVITY OF TARAXACUM OFFICINALE LAM. LEAVES AGAINST DMBA-INDUCED SKIN CANCER IN SWISS ALBINO MICE

Objective: To investigate the antitumor activity of different extracts (petroleum ether, ethanolic and aqueous extracts) of Taraxacum officinale against DMBA-induced skin cancer in mice. Methods: T. officinale leaves were successively extracted using petroleum ether (PTO), ethanol (ETO) and water (ATO). The antitumor activity was evaluated against DMBA-induced skin cancer in swiss albino mice. The...

Madan Lal Kaushik, Manpreet Singh, Deepika Rani * and Ranjit Singh

Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1754-61

1754-1761

557

423

22.

CYCLOPHOSPHAMIDE INDUCED DNA AND TESTICULAR DAMAGE: PROTECTIVE ROLE OF WITHANIA SOMNIFERA

Objectives: Cyclophosphamide is an alkylating agent known for its reproductive toxicity in males. This study evaluates the protective effects of Withania somnifera extract (WSE) on cyclophosphamide (CP) induced testicular toxicity and DNA damage in male rats. Methods: Adult male rats were randomly divided into four groups Group1-Control, Group 2- Cyclophosphamide, Group 3- Withania somnifera extra...

Y. Sunil Kumar, N. Suchetha Kumari, K. P. Sharmila and Divya Bhargavan *

Department of Pharmacology, K. S. Hegde Medical Academy, Derlakatte, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1762-68

1762-1768

593

373

23.

ASPARTAME CONSUMPTION IN DIABETES MALE ALBINO RATS – COMPLICATIONS IN BRAIN ANTIOXIDANT SYSTEM

The present study investigated the effect of intake of aspartame in diabetic rats, a widely used artificial sweetener (aspartame), on antioxidant defence status in the rat brain. Adult male Wistar rats weighed 180 ± 20 gm were randomly divided into 4 groups as follows: The first group was control; the second group was given aspartame (ASP) at a dose of 50 mg/kg body weight; the third group was Di...

Ediga Madhu Goud, Annapureddy Suvarna and Salikineedy Kishore *

Division of Toxicology, Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1769-77

1769-1777

426

281

24.

ISOLATION, SCREENING AND IDENTIFICATION OF PECTINASE-PRODUCING BACTERIAL STRAIN BACILLUS CEREUS FROM MARINE SEDIMENT SAMPLES

Marine environment is an enormous pool of biodiversity resources that cover approximately 70% surface of the earth. Marine microorganisms have unique properties since they have to adapt to extreme marine environmental conditions in deep-sea water. The present study aims to isolate, screen and identify bacterial strains from marine sediment samples that produce an enzyme pectinase with clinical and...

V. Priya Senan *, Aswathy Sasi and A. Sona

Department of Biotechnology, SAS SNDP Yogam College, Konni, Pathanamthitta, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1778-82

1778-1782

449

269

25.

DOCKING STUDY FOR UROLITHIASIS IN SYNADENIUM GRANTII

Urolithiasis, also called kidney stone, was caused by a missense mutation in the adenine phosphoribosyl transferase enzyme encoded by the APRT gene. This gene was present in human chromosome 16. In this paper, a comparative study of the effectiveness of six ligands reported in Synadenium grantii was analyzed by docking approach. For this purpose, the effective six ligands that were present in Syne...

Archna Sahay *, Mashitha Pise and Hemant Bawankar

Department of, Biochemistry, Bharati Vidyapeeth, Deemed to be University, Rajiv Gandhi Institute of Information Technology and Biotechnology, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1783-88

1783-1788

510

293

26.

SYNTHESIS, CHARACTERIZATION OF BENZOXAZOLE DERIVATIVES FOR IN-VITRO ANTI-TUBERCULAR AND ANTI-BACTERIAL ACTIVITY – A RESEARCH ARTICLE

Different-different modification of Benz-oxazole moiety gives various numbers of novel compounds which shows various biological activities. Some new derivatives (G7-G10) containing Benzoxazole moiety were prepared by the use of different methods and reagents. O- Phenylenediamine treated with Chloroacetic acid to form 2(chloro methyl) benzimidazole (compound B) and 4- methyl, 2- amino phenol with m...

Bhupendra Chauhan *, Gaurav Kumar, Sanjay Singh and Manisha Negi

Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Saharanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1789-94

1789-1794

395

240

27.

DNA BARCODING, DETERMINATION OF BIOACTIVE COMPOUNDS, ANTIOXIDANT AND ANTI-DIABETIC PROPERTY IN EDIBLE GASTROPOD BROTIA COSTULA (RAFINESQUE, 1833) OF DIMAPUR DISTRICT, NAGALAND

The present study evaluated the bioactive components, antioxidant and anti-diabetic potential in the methanolic extract of edible Brotia costula. The identification of the sample was confirmed with the help of the DNA barcoding technique. The COI gene sequence was submitted in NCBI and obtained the accession number OM056887. Bioactive compounds present in the sample were evaluated and identified w...

Lanusangla Imsong and M. Murali *

Department of Zoology, St. Joseph University, Dimapur, Nagaland, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1795-04

1795-1804

386

277

28.

STABILITY INDICATING ANALYTICAL METHOD VALIDATION FOR SIMULTANEOUS ESTIMATION OF FENTICONAZOLE NITRATE, TINIDAZOLE AND LIDOCAINE BY REVERSED PHASE-HPLC

The current study aims to develop a reversed-phase HPLC method for quantifying the active substances of Fenticonazole Nitrate (FENTI), Tinidazole (TINI) and Lidocaine base (LIDO) simultaneously and to validate the proposed method for the intended analytical application in the bulk and pharmaceutical dosage form by ICH guidelines. In this work, the behaviour of f FENTI, TINI and LIDO was studied un...

Gülay Yelken Demirel, Hande Çelebi Yatkın * and Burcu Engin

Exeltis Türkiye, Gazi Osman PaşaOsb. Fatih Bulvari No: 19/2 Çerkezköy/Tekirdağ.

DOI: 10.13040/IJPSR.0975-8232.14(4).1805-10

1805-1810

533

291

29.

AN EXPERIMENTAL STUDY TO ASSESS THE MEMORY-ENHANCING PROPERTY OF PITAVASTATIN AND GEMFIBROZIL IN MICE USING THE MORRIS-WATER MAZE MODEL. EVIDENCE TO CATEGORIZE THEM AS SMART DRUGS

Introduction: Discovery of smart drugs is part of advancing the science of molecular and biochemical mechanisms of memory. Smart drugs are not just memory boosters; they also act as memory enhancers that help quick decision-making. Pitavastatin and gemfibrozil both cause lipid-lowering effects by different mechanisms of action. A few studies show they can act on CREB (c-AMP response elemental bind...

Shoebul Haque *, Ajit Mishra, Farah Asif, Rishi Pal, Narendra Kumar, Rajendra Nath, Amod Kumar Sachan and Rakesh Kumar Dixit

Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1811-18

1811-1818

743

232

30.

MANGIFERIN LOADED NANOPARTICLES FOR CANCER THERAPY: AN APPROACH FOR IMPROVEMENT OF BIO-EFFICACY USING NANOTECHNOLOGY

Cancer is the malignant form of uncontrolled growth of cells and tissues. The drugs currently used for treating cancer can only increase the lifespan of a patient but cannot cure the disease due to their high toxicity and poor targeting of specific sites. Drugs developed from natural compounds are believed to combat those problems due to their ability to stimulate various physiological pathways wi...

Anima Debbarma *, Probin K. R. Roy, T. C. Lalhriatpuii and Hauzel Lalhlenmawia

Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences, Zemabawk, Aizawl, Mizoram, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1819-27

1819-1827

420

231

31.

IN-VITRO ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITY OF WHOLE PLANT EXTRACT OF BIOPHYTUM SPECIES

The whole plant of Biophytum reinwardtii (Zucc.) Klotzsch (BR) and Biophytum veldkampii A.E.S. Khan & et al. (BV) were evaluated for their antioxidant activities, total phenolic content (TPC), and total flavonoid content (TFC). The plants were successfully extracted with varying polarity solvents like pet ether, chloroform, ethyl acetate, and ethanol. Phytochemical evaluation of various extrac...

Chitra C. Nair *, C. S. Hima and A. Asheeta

Department of Pharmacy Practice, Ezhuthachan College of Pharmaceutical Sciences, Marayamuttom, Neyyattinkara, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1828-37

1828-1837

420

337

32.

BAYESIAN OPTIMIZATION-BASED DIAGNOSIS OF COVID-19 CHEST X-RAYS -AI PERSPECTIVE

Coronavirus is the deadliest disease globally, and no efficient treatment has been established. The prognosis of illnesses caused by virus outbreaks is a severe medical process that demands a large amount of accurate data comprised of many factors to produce an appropriate analysis. We have researched and analyzed the factors that might affect humans and increase the chances of infection with Cov...

V. Kakulapati

Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1838-50

1838-1850

343

195

33.

EPIDURAL VOLUME EXTENSION SALINE TECHNIQUE FOR ANESTHETIC MANAGEMENT OF PERIPARTUM CARDIOMYOPATHY CASES FOR EMERGENCY CAESAREAN SECTION- A CASE SERIES

Peripartum cardiomyopathy (PPCM), a rare condition affecting women in late pregnancy and early puerperium, has high morbidity and mortality. It is characterized by impaired contractility with a low ejection fraction. Compensation occurs through the enlargement of the left ventricle with increasing end-diastolic and stroke volumes. As the compensation of the dilated ventricle fails, it leads to sys...

B. R. Kiran * and G. K. Vishwas

Department of Anesthesiology and Critical Care, SS Institute of Medical Sciences, Davangere, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1851-54

1851-1854

491

309

34.

IN-VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF MEDICINAL PLANT BAUHINIA VAHLII

The present study evaluated the antibacterial and antifungal activities of the medicinal plant Bauhinia vahlii. The antibacterial and antifungal activities of vacuum dried ethanol extract of the stem and leaves of Bauhinia vahlii (EEBVS and EEBVL) were performed using the Disc diffusion method. The antibacterial and antifungal activities recorded significant effects against five bacterial strains,...

Divaker Shukla *, Munesh Mani and Navneet Verma

Department of Pharmacognosy and Phytochemistry, Pharmacy Academy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1855-60

1855-1860

479

252

35.

MOLECULAR DOCKING AND BIOLOGICAL EVALUATION OF ACACIA FERRUGINEA AND ITS ACTIVE PRINCIPLE, SEVERIN, AGAINST CHROMOBACTERIUM VIOLACEUM

Misuse and overuse of antibiotics, multi drug resistance bacterial strains have emerged as silent pandemic. Lately, antibiofilm treatment approach using natural compounds have ascended as an alternate strategy to overcome the issue. In this study, the inhibitory effect of bark and leaf extracts of Acacia ferruginea against a model bacterium, Chromobacterium violaceum was evaluated. Results reveale...

M. Jeevitha *, Vinothkannan Ravichandran and Shubashini K. Sripathi

Department of Chemistry, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1861-71

1861-1871

391

247

36.

ANTIDIABETIC, ANTIHYPERLIPIDEMIC, ANTIOXIDANT, HEPATOPROTECTIVE AND RENAL PROTECTIVE EFFECT OF LUFFA CYLINDRICA EXTRACT AGAINST THE STREPTOZOTOCIN-INDUCED DIABETES MELLITUS IN RATS

The main objective of the current study was to see whether SG peel methanolic extract had antidiabetic and hepatoprotective results in streptozotocin-induced diabetic rats. Streptozotocin was administered intraperitoneally to rats to trigger diabetes. When rats had an elevated blood sugar level three days after acquiring streptozotocin, it was determined that they were diabetic. Diabetic rats were...

Vastvikta Sahai and Vikas Kumar *

Department of Pharmaceutical Sciences, Shaloam Institute of Health Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1872-86

1872-1886

390

248

37.

KNOWLEDGE, ATTITUDE, AND PRACTICE OF TYPE 2 DIABETES MELLITUS PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL IN SOUTHERN ASSAM, INDIA

Background: Type 2 diabetes mellitus is increasing very rapidly in India, yet studies regarding knowledge, attitude and practices in diabetes in various Indian communities, especially in the Northeastern region, are limited. It is essential to understand the current gaps in knowledge and problems with the attitude and perceptions of the general population regarding diabetes to effectively plan pub...

N. Thakuria, N. Sinha *, S. Roy and A. Chakraborty

Department of Pharmacology, Silchar Medical College & Hospital, Silchar, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1887-92

1887-1892

435

264

38.

IDENTIFICATION AND CHARACTERIZATION OF NOVEL PHYTOCONSTITUENTS FROM THE FERMENTED EXTRACT OF LEAVES OF MORINGA OLEIFERA BY GC-MS ANALYSIS

Moringa oleiferais a well-known plant that can be used for the treatment of various disorders or nutritional deficiencies; all parts of this plant possess various activities such as antitumor, antipyretic, antiepileptic, anti-inflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol-lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities...

Avneesh Kumar and Akash Ved *

Goel Institute of Pharmaceutical Sciences, Near Indra Canal, Ayodhya (Faizabad) Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1893-98

1893-1898

401

263

39.

A COMPARATIVE STUDY ON THE ANTI-CANCER POTENTIAL OF ENICOSTEMA AXILLARE ON CANINE AND HUMAN BREAST CANCER BY TARGETING RUNX AS A PROGNOSTIC MARKER

The main objective of this study is to find a cure for Human Breast Cancer having Canine Mammary Tumor as a model using the ethyl acetate extract of Enicostema axillare targeting Runt-Related Transcription factor, which plays a vital role in Hippo Signaling Pathway. The preliminary phytochemical analysis and GC-MS analysis were used to determine the plant extract's bioactive compounds. The in-vitr...

S. Pavithra and A. Praveena *

Department of Biotechnology, Prathyusha Engineering College, Tiruvallur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1899-06

1899-1906

432

205

40.

PREPARATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF BERBERINE LOADED NANOEMULSION FOR ENHANCED ANTIMICROBIAL EFFICACY

Aim: The current research aimed to formulate and evaluate herbal nanoemulsion of poorly soluble Berberine hydrochloride, which can provide a realistic alternative for treating microbial infections. Materials and Methods: The drug was characterized using various analytical techniques such as Ultraviolet Spectroscopy, Fourier transform infrared spectroscopy, and Differential Scanning Calorimetry s...

Mohit Nagar *, Sanjar Alam and Mohammad Rashid

Department of Pharmaceutics, R.V. Northland Institute, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1907-20

1907-1920

431

331

41.

DEVELOPMENT OF PARKINSON’S DISEASE RAT MODEL IN TWO WEEKS USING CORN OIL AND ROTENONE INDUCTION

Parkinson's disease has been a challenging neurodegenerative disorder for researchers and clinicians alike for decades. Though L-dopa has changed the management of PD to a considerable extent, effective solutions remain elusive since L-dopa, after a few years, partly loses its efficacy and develops dyskinesias as a complication, incapacitating the patient. Also, existing PD animal models using MPT...

Devika S. Kumar *, Senthilkumar Sivanesan, Vijayaraghavan Rajagopalan and Lal D. V. Nair

Department of Research and Development, Saveetha Institute of Medical & Technical Sciences, Thandalam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1921-33

1921-1933

460

262

42.

PRIMER DESIGNING AND STANDARDIZATION OF PRIMER ANNEALING TEMPERATURE FOR BETA-3-ADRENERGIC RECEPTOR IN MUS MUSCULUS

Adrenergic receptors (ADRs) are implemented in important pharmacological responses. The β3adrenergic receptors have been proposed as a suitable drug target for treating diabetes and obesity. However, very little information is available regarding the expression profile of β3 receptors. We have designed primers for studying the β3adrenergic receptors in C57BL/6J mice using various bioinformati...

Vijayalakshmi Gangadhara and Asha Abraham *

Department of Post Graduate Studies & Research in Biotechnology, St Aloysius College (Autonomous) - Affiliated to Mangalore University, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1934-39

1934-1939

883

330

43.

PHARMACEUTICAL PROCESSING AND ANALYTICAL CHARACTERIZATION OF METAL-BASED AYURVEDIC DRUG “TAMRA BHASMA”

The preparation of metal-based Indian traditional drugs involves the conversion of pure metal into its therapeutically effective form. “Tamra Bhasma” (calcined copper) is one such herbometallic preparation used for various medical conditions like anaemia, obesity, and skin disease, disorders of the liver and spleen, hyper-acidity, rhinitis, hemorrhoids. A detailed evaluation of the changes occ...

Saumya Gulati *, Namrata Joshi and Remya Jayakumar

Department of RasaShastra and Bhaishajya Kalpana, Babu Yugraj Singh Ayurvedic Medical College and Hospital, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1940-53

1940-1953

538

445

44.

FORMULATION AND EVALUATION OF TOPICAL ITRACONAZOLE NANOGEL

Itraconazole is a triazole antifungal category drug used for the treatment of local &Systemic fungal infections. Itraconazole is not recommended to neutropenic and other immune-compromised patients who have difficulty swallowing the oral capsule formulation, and it has many side effects. Commercially, Itraconazole topical gel preparation is not available in the market; thus, this formulation i...

Ashwini P. Potulwar * and Shraddha S. Tiwari

School of Pharmacy, SRTM University, Vishnupuri, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1954-61

1954-1961

663

451

45.

QUANTIFICATION OF SPIRONOLACTONE AND ITS IMPURITIES PRESENT IN PHARMACEUTICAL DOSAGE FORMS BY STABILITY-INDICATING HPLC METHOD

Spironolactone belongs to a group of medicine known as aldosterone antagonist used as sparing diuretic, Spironolactone (aldactone) is potassium -aspiring diuretic agent and has half-life of about 16 hours. Spironolactone one diuretics agents which increases renal excretion of water and solutes (mainly sodium salt). It is used mainly in the treatment of refractory edema in patients with congestive ...

Amit S. Tapkir *, Harshal S. Loharkar and Santaji Nalawade

PES Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1962-69

1962-1969

420

241

46.

PREPARATION AND EVALUATION OF NEW POLYHERBAL FORMULATION THEIR FOR WOUND HEALING ACTIVITY

Herbal medicine (also herbalism) is the study of pharmacognosy and the use of medicinal plants, which are the basis of traditional medicine. Any damage or break in the surface of the skin is a wound. In Soxhlet extraction, solvent extraction involves extraction with solvents of increasing polarity from a nonpolar to a more polar solvent to ensure that a wide polarity range of compounds can be extr...

Aditi Rastogi *, Priyanka Yadav and Manoj Kumar Mishra

Shambhunath Institute of Pharmacy, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1970-77

1970-1977

564

329

47.

COST EFFECTIVE, ROBUST PRECISE & STABILITY INDICATING ANALYTICAL METHOD VALIDATION OF RELATED SUBSTANCES FOR PIMECROLIMUS CREAM BYRP-HPLC

A new, precise, economical and gradient reverse-phase high-performance liquid chromatography (RP-HPLC) method has been validated for the relative substance determination in pimecrolimus cream. The chromatographic separation was achieved with phenomenax luna, C18, 150 x 4.6mm and 3 µm particle size column. The flow rate was 1.5 mL/min and eluents were detected at 210 nm using PDA detector. The ret...

Neha Sharma * and Mukesh Kumar Gupta

Faculty of Pharmaceutical Sciences, Lords University, Alwar, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1978-85

1978-1985

472

384

48.

DESIGN AND SYNTHESIS OF SOME NOVEL THIAZOLE MOLECULES

A series of novel (Z)-3-((5-(2-((E)-arylidene) hydrazine-1-carbonyl)-4-methylthiazol-2-yl)amino)-2-cyano-3-(methylthio) acrylate 4a-t molecules have been synthesized and characterized by 1H NMR, 13C NMRand mass spectral analysis. Starting from ethyl 2-amino-4-methylthiazole-5-carboxylate 1 was reacted with hydrazine hydrate to obtain carbohydrazide molecule 2. Furthermore, reaction of molecule 2 w...

Jaysinh I. Jadeja and Mahesh M. Savant *

Department of Chemistry, Atmiya University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1986-91

1986-1991

412

230

49.

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL CARBAZOLE BORONIC ACID DERIVATIVES IN THE TREATMENT OF BREAST CANCER

The present study aimed to synthesize Carbazole boronic acid derivatives and determine their efficacy in treating breast cancer using the MCF-7 cell line. Nine different derivatives (C1-C12) of boronic acid were prepared i.e. 9-ethyl-(9H-carbazol-3-yl)-boronic acid (C1); (9-benzyl-9H-carbazol-3-yl)-boronic acid (C2); [9-(4-fluorobenzyl)-9H-carbazol-3-yl]-boronic acid (C3); [9-(sec-butyl)-9H-carbaz...

Seema Chahar Beniwal and Tarun Virmani *

School of Pharmaceutical Sciences, M. V. N. University, Palwal, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).1992-01

1992-2001

426

222

50.

EVALUATION OF ANTIDIABETIC ACTIVITY OF POLYHERBAL FORMULATION AGAINST STREPTOZOCIN –NICOTINAMIDE INDUCED DIABETES IN RATS

The present work was executed to evaluate the anti-diabetic potency of a polyherbal preparation. The objective of this study is to induce experimental diabetes mellitus using Streptozocin -nicotinamide in normal Albino wistar rats and study the antidiabetic activity of polyherbal formulation by comparison of changes in body weight and levels of glucose between normal and diabetic rats. Hypoglycemi...

Monika Pandey * and Mahesh Kumar Gupta

School of Pharmacy, Career Point University, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(4).2002-10

2002-2010

371

291