Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
ANTIMICROBIAL ACTIVITY OF BURSERA PENICILLATA LEAF EXTRACTS ON HUMAN INFECTIOUS PATHOGENS
The purpose of this study was to evaluate antimicrobial activity of Bursera penicillata leaf extract against human infected bacteria. Antimicrobial activity of Petrolium ether, Methanolic and Aqueous extracts from leaves of Bursera penicillata were tested against pathogenic bacteria Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, Staphylococcus saprophyticus, Ente...
4680
1890
FABRICATION AND CHARACTERIZATION OF MICROEMULSION BASED ORAL SOLID DOSAGE FORM OF GLIMEPIRIDE
The aim of this investigation was to develop a solid microemulsion of Glimepiride for enhancing its solubility, and its dissolution rate. For this purpose, solubility of Glimepiride was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility. Pseudo-ternary phase diagrams were constructed to identify the microemulsion existing zone. The optimized micr...
4935
2826
SOME COMMON PLANTS USED BY THE PEOPLE OF KOVILPATTI, TAMIL NADU, INDIA TO TREAT RHEUMATISM
An ethnobotanical survey was carried out in Kovilpatti, Thoothukudi District, Tamil Nadu, India, for the documentation of important medicinal plants used for the treatment of rheumatism. The plants were collected according to their family, local name, vernacular name and useful parts and medicinal uses. There are eight plants are mostly used in this area to treat rheumatism...
6220
1685
ROLE OF SESAMUM ALATUM L. ON NEPHROPATHY IN DIABETIC RATS
Background: Type 2 Diabetes is a metabolic disorder, characterized by chronic hyperglycemia. It results from insulin resistance, a condition in which the body cells fail to use insulin properly. In Ayurveda Sesamum alatum L. (Pedaliaceae) has been used for the treatment of Diabetes. In this study, the antidiabetic activity of the Methanolic leaf extract of S. alatum was investigated, and the ren...
4296
1696
MICRODOSING: A NEW STRATEGY FOR DRUG DEVELOPMENT PROCESS
New drugs are a great need for clinical conditions but unfortunately development costs are rising and number of drugs receiving marketing approval has fallen. Microdosing is a new experimental approach that offers a faster and potentially less expensive approach for obtaining human in vivo pharmacokinetic (PK) data in early stages of drug development. The concept of microdosing involves the use of...
4149
1963
COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS- REVIEW
Artemisinin and its derivatives have successfully been used in treatment of falciparum malaria infections in various parts of the world. More importantly, they have proved effective against strains resistant to conventional antimalarials such as chloroquine and mefloquine in those parts of the world where malaria is endemic. Only one clinically relevant artemisinin-resistant human malaria has been...
4236
1454
SYNTHESIS OF CEFOTAXIME FROM DAMA (DIETHYL THIOPHOSPHORYL [(Z)-(2-AMINOTHIAZOL-4-YL)-2-(METHOXYIMINO) AND 7-ACA (7-AMINO CEPHALOSPORINIC ACID)
A simple procedure is reported for the synthesis of Cefotaxime Sodium from an isolable activated ester, diethyl thiophosphoryl [(Z)-(2-aminothiazol-4-yl)-2-(methoxyimino) acetate (DAMA) and 7-ACA (7-Aminocephalosporinic acid). DAMA was synthesized from ATMA [(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetic acid] and DHP [O, O-diethyl O-hydrogen phosphorothioate], which was treated with 7-ACA and ...
5245
2592
PELLETIZATION OF LAMOTRIGINE SOLID DISPERSION FOR IMPROVED SOLUBILIZATION
Poorly solubility in water of many newly developed high-potential drugs is an obstacle in formulation development. The aim of this study was to increase the solubility of Lamotrigine which is a poorly soluble drug and comes under BCS class-II by using solid dispersion technique. Lamotrigine, PEG 4000 and PVPK-30 solid dispersion was prepared by solvent evaporation method and the formulation was ch...
3752
1683
PHYTOCHEMICAL SCREENING ON THE AERIAL PART OF THE LUFFA ECHINATA LINN.
The present work deals with development and standardization of phytochemical screening for quantification of ethanolic extract of aerial part of the Luffa echinata Linn. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various, physical evaluation and preliminary phytochemical screening of various successive...
3809
1589
ROLE OF BIOINFORMATICS, CHEMOINFORMATICS AND PROTEOMIC IN BIOMARKER IDENTIFICATION AND DRUG TARGET VALIDATION IN DRUG DISCOVERY PROCESSES
Novel biomarker identification and drug target validation are highly complex and resource-intensive processes, requiring an integral use of various tools, approaches and information. The recently developed proteomic technology features high-throughput parallel analysis of thousands of proteins in individual patients and amount populations and thus opens up the possibility of providing more details...
8041
2385