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FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN SENILITY INDUCED STERILITY OF MALE WISTAR RATS – A HISTOMORPHOMETRIC STUDY
Ageing is associated with the diminished function of various tissues in the body. The gonadal function declines with age. In male, there is progressive atrophy of the sperm producing elements of the testes, resulting in diminished spermatogenesis. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium ...
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IN-VITRO EVALUATION OF EFFECT OF HYDROALCOHOLIC MEDIA ON DRUG RELEASE FROM SUSTAINED RELEASE FORMULATION
In the recent development, worldwide consumption of alcohol has shot up in the past decade as a part of lavish and Gen next lifestyle changes. There have been innumerable instances of people consuming alcoholic beverages and drugs at the same time. Hence in our study, Diclofenac and Metformin were selected as representatives of highly prescribed and overused drugs. Hence, the present study was pla...
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR ESTIMATION OF FLUTICASONE PROPIONATE AND MUPIROCIN IN A COMBINED TOPICAL DOSAGE FORM
The objective of the present study was to develop and validate a precise and accurate reversed-phase high-performance liquid chromate-graphy for simultaneous estimation of for Fluticasone Propionate (FUP) and Mupirocin (MUP) in combined topical dosage form as per ICH guidelines. Chromatographic separation was achieved using HPLC Shimadzu, Japan, with column syncronis C18 (250 × 4.6 mm, 5 μm). Th...
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MIR AND NIR SPECTROSCOPY AS RAPID METHOD TO QUANTIFY MOLSIDOMIN IN GENERIC TABLET
This work investigates the potential of Partial Least Square (PLS) regression using two vibrational spectroscopies as mid infrared (MIR) and near infrared (NIR) spectroscopies for the quantification of molsidomin in tablets. Two very simple, rapid, inexpensive and green strategies were applied for this determination. Powder blends containing molsidomin and excipients were prepared. The excipients ...
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SYNTHESIS, ELECTROCHEMICAL AND ANTIMICROBIAL ACTIVITY OF SCHIFF BASE AND ITS NICKEL (II) COMPLEX
The present study is focused on the electrochemical behavior of glycine 4-bromo acetophenonimine (GBAPI) and its Ni(II) complex. In buffer solutions (Britton-Robinson universal buffer and phosphate buffer) of pH 3 - 9 range, using cyclic voltammetric technique. GBAPI is synthesized by the condensation of 4-bromo acetophenone and glycine amino acid (1:1 molar ratio). The complex is generated by the...
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LYOPHILIZATION- A PROCESS OF OPTIMIZATION OF DOSAGE FORMS
Freeze-drying is a method of removing water by sublimation of ice crystals from frozen material. Suitable parameters of process application allow us to obtain the best quality products compared to products dried with traditional methods. In the pharmaceutical field, lyophilization has become an important subject to ongoing development and its expansion. In this 21st century, Lyophilization emerges...
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ANTIMICROBIAL AND ANTIPLASMODIAL ACTIVITY DISPLAYED BY ACTINOMYCETES ISOLATED FROM SOILS FROM KAVANGO AND HARDAP REGIONS IN NAMIBIA
Plasmodium falciparum and multidrug resistant bacteria such as Mycobacterium avium, Staphylococcus aureus and Escherichia coli are among the top causes of morbidity and mortality especially in developing countries. These pathogens are responsible for the reported antibiotic resistance incidents globally. Due to the increase in antibiotic resistance worldwide, there is an urgent need for new bioact...
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IN-VITRO ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF DIOSPYROS MELANOXYLON ROXB.
The present research focuses on the screening of phytochemicals from an Indian medicinal plant Diospyros melanoxylon Roxb. by both qualitative and quantitatively and biological activities. Different solvent extracts were prepared and used for this study such as hexane, chloroform, methanol, ethyl acetate and aqueous. Preliminary screening of phytochemicals revealed that the methanolic extract comp...
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TO ESTABLISH THE ULCEROGENIC POTENTIAL IF ANY, OF GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) ON IMPORTANT PARAMETERS OF GASTRIC ULCERATION
The aim of this study was to investigate the possibility of gastric-ulceration by ginger-juice (Zingiber officinale Roscoe) in rat. (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done for possible gastric lesion. Effect of treatment with G.J acutely and chro...
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ANTICONVULSANT ACTIVITY OF AQUEOUS EXTRACT OF EUPATORIUM BIRMANICUM DC. LEAVES ON SEIZURE INDUCED BY PTZ IN ALBINO MICE, ALONE AND IN COMBINATION WITH ETHOSUXIMIDE
Objective: To evaluate the anticonvulsant activity of aqueous extract of Eupatorium birmanicum DC. leave (EB) alone and in combination with ethosuximide against seizure induced by PTZ in albino mice. Method: Aqueous extract of EB leaves was prepared using Soxhlet apparatus. The albino mice were fed with EB at 3 doses (200, 400 & 800 mg/kg). One hour after feeding, pentylenetetrazole (PTZ) was ...
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