DNA BINDING AND ANTIBACTERIAL ACTIVITY OF TRANSITION METAL COMPLEXES WITH PREORGANIZED HEXADENTATE LIGAND
A new preorganized ligand, benzil bis [2-(2-amino-ethylamino) ethanol)] (H2BAE) has been synthesized and characterized for the first time. Copper (II) and cobalt (II) complexes of H2BAE have been synthesized and characterized based on molar conductivity data IR, UV-Vis spectroscopy. The complexes are found to have general formula M(BAE)2 (where, M = Cu (II) and Co (II). IR spectral data indica...
RP-UPLC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ESTIMATION OF LEVOCETIRIZINE IN LEVOCETIRIZINE DIHYDROCHLORIDE TABLETS
Current analytical research and experiments provide the development of a simple, sensitive, accurate, rapid, and stability indicative RP-UPLC method for estimation of Levocetirizine in Levocetirizine dihydrochloride tablets. This development was achieved using a Waters Acquity UPLC with BEH, C18 column of dimensions of 100 mm × 2.1 mm, 1.7 µm column at 0.3 mL/min flow rate and Acquity TUV detect...
IN-VITRO ANTHELMINTIC EFFECT OF CAPPARIS DECIDUA (KAIR) ON TEGUMENT OF GASTROTHYLAX CRUMENIFER IN GOAT BY LIGHT MICROSCOPY
Paramphistomiasis is the major problems in the yield of goat and human health. This disease causes loss of life of goat, reduce meat and milk production. The medicinal plant Capparis decidua has been used in the treatment of asthma, cough and inflammation. This plant also shows anthelmintic activity. Live amphistome Gastrothylax crumenifer were collected from the rumen of the freshly slaughtered g...
Lupeol (I) is a naturally occurring triterpene that has been isolated from the stem bark of Crataeva nurvala in appreciable amount. Due to the presence of a single hydroxyl group and a large, apolar skeleton, lupeol acts as an amphiphile. The two possible sites for chemical modification present in lupeol are ring-A and isopropenyl side chain. We modified it in three naturally occurring analogous d...
Literature evidence suggests that neuroinflammation plays a key role that activates and propagates the neurodegenerative process associated with many neurological diseases. Different stimuli, such as lipopolysaccharide (LPS) are the endotoxin that activates the immune system to create neuroinflammation associated with neurodegeneration. The peak expression of different cytokines (TNF-α, IL-1β &a...
Tissue specificity is the essential need of the hour to cut down clinical abnormalities. Allowing desired drug concentration to reach the target site is the current trend of the drug delivery system. Laminin is an active component of the basal lamina and present in most cells and organs has shown great utility in this case. It is a heterotrimeric glycoprotein containing an α-chain, a β-chain, an...
Arbuscular mycorrhizal fungi (AMF) enjoy being the cynosure in most agro-ecosystems. These fungi benefit the plant in multiple ways. They improve plant growth by enhancing nutrient uptake and protecting the plant from various plant pathogens, thereby promoting plant diversity. These fungi improve plant tolerance to various abiotic stresses, such as salinity, drought, extreme temperatures, and heav...
QUALITATIVE AND QUANTITATIVE ESTIMATION OF TYROSINE KINASE INHIBITORS IN PHARMACEUTICAL AND BIOLOGICAL MATRICES – AN OVERVIEW
Tyrosine kinase inhibitors generally having a narrow therapeutic window and large inter-patient variability. In order to support its therapeutic drug monitoring, fast and accurate methods are needed to supporting the pharmacokinetic-guided dosing in patients treating with various tyrosine kinase inhibitors (TKIs) either alone or in combination in bulk, formulations or human plasma using HPLC and d...
The bioavailability of conventional ophthalmic solutions is very poor due to efficient protective mechanisms of the eye, blinking, reflex Mental health problems are characterized by in definite persistently depressed mood, low self-esteem, loss of interest in normal life activities. A common problems were the chances to occurs from generation to generation, i.e., genetic in nature, and these may a...
The aim of this review is to provide an extensive overview of the diverse pharmacological activities of quinazoline moiety. Quinazolines are well-known and important nitrogen-containing heterocyclic compounds made chemical formula C8H6N2. For the last few years, the heterocyclic fused nucleus quinazoline has drawn immense attention due to its diversified application in medicinal chemistry research...