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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 10, October

Review Articles

 
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1.

A REVIEW ON ETIOLOGY AND CHALLENGES ASSOCIATED WITH VARIOUS THERAPIES FOR THE TREATMENT OF PSORIASIS

Psoriasis is autoimmune, hyperproliferative skin disease, which is affecting 2-5% of the population. Etiology of psoriasis is multi-factorial. The disease is identified as periodic recycle of events with red-scaly skin plaques. The epidemiology of Psoriasis is still unknown. From medication, this disease can only be prevented. Currently, there are many approaches to cure this disease, but still, n...

N. V. Gupta, K. Kowshik * and S. Kanna

Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagara, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4409-19

4409-4419

1191

656

2.

FLAVONOIDS IMPACT ON PREVENTION AND TREATMENT OF OBESITY AND RELATED METABOLIC RISK FACTORS

Metabolic syndrome, the most prevailing health concern worldwide, and their incidences are increasing at a very high rate, resulting in enormous social costs. Obesity is a measure risk factor for non-communicable disease such as cardiovascular diseases, diabetes, cancer, and inflammation-based diseases. Therapeutic strategies for managing this syndrome include synthetic drugs and surgery, which en...

V. K. Jain *, G. P. Choudhary and G. N. Darwhekar

School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4420-29

4420-4429

750

465

Research Articles

 
Title
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3.

VASORELAXANT AND ANTIHYPERTENSIVE EFFECTS OF RHUS PENTAPHYLLA (SEARSIA PENTAPHYLLA)

Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. Thi...

N. Messaoudi, H. Mekhfi, M. Aziz, A. Legssyer, M. Bnouham and A. Ziyyat *

Laboratory of Physiology, Genetics and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohammed First, Oujda-Morocco.

DOI: 10.13040/IJPSR.0975-8232.10(10).4430-43

4430-4443

750

389

4.

“MITREС” AS AN EFFECTIVE DRUG FOR THE TREATMENT OF COWS WITH CHRONIC ENDOMETRITIS

The leading factor restraining the intensification of herd reproduction is endometritis. The article states that the microflora of cow uterine exudate in chronic purulent-catarrhal endometritis is represented by Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Citrobacter freundii, Streptococcus faecalis, Streptococcus faecium, as well as anaerobes and group С Streptococci. The drug "Mi...

A. Semivolos, V. Agoltsov, O. Popova, T. Rodionova, I. Pankov and N. Solotova *

Department of Veterinary Medicine and Biotechnology, Saratov State Agrarian University named after N. I. Vavilov, Theater Square, 1, Saratov, Russia.

DOI: 10.13040/IJPSR.0975-8232.10(10).4444-50

4444-4450

743

284

5.

COMPARISON OF THE TOXICOLOGICAL EFFECT OF LEAD-BASED HERBO-MINERAL PREPARATIONS AND THEIR CORRESPONDING METAL NANO-PARTICLE ON ENZYMATIC ACTIVITY AND GROWTH OF BAKER’S YEAST

Metallic toxicity associated with Ayurvedic formulations like herbomineral preparation (Bhasma), especially because of heavy metals such as lead, has always been a matter of debate in the scientific community. Instead of that, ancient Ayurvedic literature reveals that sodhana process used for the preparation of such formulations, either decreases or eliminate the toxic effect of such heavy metals ...

S. P. Pandey and M. S. Sudheesh *

V. N. S. Institute of Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4451-61

4451-4461

707

292

6.

TOXICITY STUDIES OF A SAPONIN ISOLATED FROM THE FRUITS OF MOMORDICA DIOICA IN RATS

The objective of this study was to evaluate the toxicity of a saponin isolated from the fruits of the Momordica dioica as per OECD guidelines. Saponin was isolated from the methanolic extract of the fruits of M. dioica, and acute, sub-acute, sub-chronic and chronic toxicity was evaluated. The study of the acute toxicity of saponin M. dioica (SMD) at a single dose of 5000 mg/kg/b.w. by oral route i...

D. K. Jha *, R. Koneri and S. Samaddar

Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4462-76

4462-4476

647

427

7.

STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF EDOXABANTOSYLATE MONOHYDRATE: A COMPREHENSIVE STUDY INVOLVING IMPURITIES ISOLATION, IDENTIFICATION AND DEGRADATION KINETICS DETERMINATION IN VARIOUS CONDITIONS

Objective: State of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Edoxabantosylate (EDO) Methods: Successful RP-HPLC chromatographic method was accomplished on a CHROMBUDGET® 100-5-C18 column (250 mm × 4.6 mm, 5 μ) column using methanol and acetate buffer in the ratio of 53:47 having 2.9 pH and 10mM buffer strength. The deg...

S. Masani, P. Shah, S. Saroj and S. J. Rajput *

Faculty of Pharmacy, G.H. Patel Pharmacy Building, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4477-87

4477-4487

686

321

8.

PHARMACOLOGICAL EVALUATION OF ANTI-ULCER EFFECTS OF COMBINED DOSES OF ALOE VERA AND VITAMIN-E AGAINST INDOMETHACIN INDUCED PEPTIC ULCER MODEL

Peptic Ulcer Disease (PUD) is one of the most prevalent pathogenic conditions which affects around 5-10% of the global population. Helicobacter pylori infection and the use of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are two of the most common etiological causes in the PUD pathogenesis. First line treatment for PUD involves use of drugs which cause acid suppression or target against the erad...

A. Srivastava * and R. Singh

Hygia Institute of Pharmaceutical Education and Research, Faizullaganj, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4488-93

4488-4493

325

161

9.

EFFECTS OF USING DIFFERENT LEVELS OF CHROMIUM PICOLINATE ON PERFORMANCE, SOME BLOOD BIOCHEMICAL AND INTESTINAL MORPHOLOGY AND MICROFLORA IN ROSS 308 BROILER CHICKS EXPOSED TO THE HEAT STRESS CONDITION

This study was aimed to investigate the effects of different levels of dietary chromium picolinate (CrPic) on performance, some blood biochemical and intestinal morphology and microflora in Ross 308 broiler chicks. A total of 240 broiler chickens Ross 308 strain, from 21 to 42 days old were used in a completely randomized design. All chickens consumed a diet based on the corn-soybean meal, and the...

O. Hamidi, M. Chamani, H. Ghahri *, A. A. Sadeghi and H. Malekinejad

Department of Animal Science, College of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.

DOI: 10.13040/IJPSR.0975-8232.10(10).4494-00

4494-4500

271

116

10.

ROLE OF ANDROGRAPHIS PANICULATA ON ALTERED STEROIDOGENESIS AND OXIDATIVE IMPAIRMENT IN OVARY OF MICE SUBJECTED TO ARSENIC INTOXICATION

The present study was designed to determine the role of Andrographis paniculata (AP; 50 mg/kg) against the oxidative stress caused by the arsenic (0.5 and 1.0 mg/kg) for 30 days in adult mice. The results of in-vivo studies demonstrated that arsenic treatment resulted in a significant dose-dependent increase in the ovarian arsenic level and lipid peroxidation (LPO), followed by a marked reduction ...

D. M. Damore * and M. V. Rao

Department of Zoology, Bhavan’s Sheth R. A. College of Science, Gujarat University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4501-06

4501-4506

341

127

11.

FORMULATION AND EVALUATION OF pH TRIGGERED IN-SITU OCULAR GEL OF OFLOXACIN

Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of of...

K. Wadhwa *, C. Sharma, M. Goswami and N. Thakur

University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4507-12

4507-4512

341

151

12.

SYNTHESIS, CHARACTERIZATION, AND DNA- BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES

Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important ...

S. Sudhasankar

Department of Chemistry, SRMIST, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4513-20

4513-4520

292

140

13.

COMPARATIVE DISSOLUTION BEHAVIOUR OF TEN MARKETED CHLORAMPHENICOL CAPSULES IN INDONESIA

Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods: Ten products were selected, consisted of 3 generics (A, B and C) and 7 branded names (D, E, F, G, H, I and J); F was chosen as an innovator. The dissolution test was performed by ...

H. Lucida *, L. G. Fadri and Dachriyanus

Department of Pharmaceutics, Faculty of Pharmacy, Universitas Andalas, Padang, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(10).4521-25

4521-4525

272

115

14.

ANTIANXIETY AND ANTIDEPRESSANT ACTIVITY OF VALERIANA PYROLAEFOLIA

Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral rout...

A. Kumar *, M. Karan and K. Vasisht

University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4526-30

4526-4530

228

101

15.

DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF DASATINIB IN TABLET DOSAGE FORM

The objective of the present study was to develop and validate a novel RP-HPLC method for the determination of Dasatinib in the pharmaceutical dosage form. Chromatographic separation was conducted on agilent technologies-1260 series with the G1311C quaternary pump, Thermo Scientific C18 column (4.6 mm i.d. × 250 mm, 5 µm particle size) and equipped with photodiode array detector G1315D. The mobi...

P. R. Sankar * and S. Anusha

Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4531-37

4531-4537

324

311

16.

SPAN 40/TWEEN 80-BASED SOYBEAN OLEOGELS: MODELING OF GELATION KINETICS AND DRUG RELEASE

Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical appli...

D. Ash *, S. B. Majee and G. R. Biswas

Department of Pharmacy, NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4538-45

4538-4545

279

109

17.

IN-SILICO MOLECULAR SCREENING OF NATURAL PLANT PRODUCTS FOR THE IDENTIFICATION OF NOVEL POTENTIAL CHEMOTHERAPEUTIC AGENTS AGAINST BREAST CANCER

In-silico computational approaches help in ascertaining drug targets via bioinformatics tools. HER2 is the most valuable therapeutic target for breast cancer therapy. The overexpression of HER2 protein plays a very critical role in the progression of breast cancer. Plant-derived natural products have received increasing attention over the past 20-30 years for their potential as novel therapeutic a...

K. S. N. M. Megana and Y. Suneetha *

Department of Zoology, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4546-51

4546-4551

257

127

18.

SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL GLYCOSYL THIOCARBAMIDES

Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during recent years because of their potential pharmacological properties. Thiourea and their derivatives are important versatile reagent in organic synthesis and show strong antibacteria...

A. D. Mangte *, S. J. Munshi and R. P. Nayak

P. G. Department of Chemistry, Shri P. M. Patel Institute of P. G. Studies & Research in Science, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4552-56

4552-4556

232

192

19.

CHARACTERIZATION AND EVALUATION OF NIZATIDINE FLOATING MICROSPHERES BASED DRUG DELIVERY SYSTEM FOR ANTI-ULCER ACTIVITY

Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floati...

S. K. Mishra * and M. K. Gupta

Oriental College of Pharmacy & Research, Oriental University, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4557-67

4557-4567

323

118

20.

CITRULLUS COLOCYNTHIS PHYTOSOMES: DEVELOPMENT AND PHYSIOCHEMICAL CHARACTERIZATION

Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate extract of Citrullus colocynthis to meet the need for better effectiveness and safety. Required phytosomal formulations were developed using different extracts of Citrullus colocynt...

A. Rani *, S. Arora, A. Goyal and A. Sharma

Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4568-73

4568-4573

228

100

21.

FORMULATION AND EVALUATION OF GASTRO RETENTIVE NOVEL FLOATING IN-SITU GELLING SYSTEM OF CURCUMIN

The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 º...

A. Padhan *, B. K. Nanda and B. C. Behera

PG Department of Pharmaceutics, The Pharmaceutical College, Barpali, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4574-86

4574-4586

314

121

22.

ASSESSMENT OF IN-VITRO ANTICANCER AND ANTIBACTERIAL ACTIVITIES OF CARCHORUS HIRSUTUS PHYTOMEDIATED OPTIMIZED NANOSILVER

The elected work reports for the first time successfully synthesized nanosilver from the aqueous leaf extract of the Carchorus hirsutus plant. Because the phytochemicals within the leaf extract were creditworthy for the reduction of silver ions as the active nanosilver particles, in addition to this, they act as the capping agents who had been environed at the surface of the particles. UV-Vis spec...

D. Ashok *, S. Raju and K. Rama

Green and Medicinal Chemistry Laboratory, Department of Chemistry, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4587-97

4587-4597

217

107

23.

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR IDENTIFICATION AND QUANTIFICATION OF LUPEOL IN THE LEAVES OF ALSTONIA SCHOLARIS

In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavono...

M. M. Sanaye * and S. Zehra

Prin. K. M. Kundnani College of Pharmacy, Cuffe Parade, Colaba, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4598-04

4598-4604

239

112

24.

ESTIMATION OF IPRATROPIUM BROMIDE BY EXTRACTION FREE SPECTRO-PHOTOMETRIC METHOD USING SULPHONAPTHALEIN DYE

The present paper portrays a simple, rapid, nonextractive spectrophotometric method for the estimation of an anticholinergic drug, Ipratropium Bromide. The method is based on the formation of an instantaneous stable yellow colored ion pair complex of drug with a chloroformic solution of reagent Bromophenol Blue (BPB) which shows absorption maxima at 416 nm. Job’s plot of continuous variation aff...

S. M. Raj and V. G. Jamakandi *

KLE University’s College of Pharmacy, Vidyanagar, Hubballi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4605-12

4605-4612

237

115

0

25.

SYNTHESIS OF NEFOPAM ANALOGUES AND CHARACTERISATION

Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role with using grignard reagent and aluminum chloride with the starting phthalic anhydride to form acid compound and was converted to amide compound with using of thionyl chloride, N-Pr...

K. Srinivasachary *, S. Tiwari, Y. S. Somannavar and B. Ramadevi

Chemical Research and Development, APL Research Centre-II, Aurobindo Pharma Ltd., Indrakaran, Sangareddy, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4613-35

4613-4635

236

97

26.

NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY BASED URINARY METABOLIC PROFILING IN POST TRAUMATIC STRESS DISORDER RATS

Though at present, Post-Traumatic Stress Disorder (PTSD) stands to be one of the major mental debilitating psychiatric disorders, however, its clinical diagnosis remains unachieved due to the absence of any biological marker. Hence, this study is aimed at the identification of putative biological underpinnings of PTSD through the metabonomic approach. For this purpose, the animal model based NMR s...

P. Singh

Department of Zoology, University of Delhi, Delhi, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4636-43

4636-4643

233

92

27.

ANTIBACTERIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF BACTERIAL CAROTENOIDS ISOLATED FROM RHODOPSEUDOMONAS PALUSTRIS KRPR01 AND KRPR02

The microbial pigments have more applications than synthetic pigments and are easily biodegradable and safe to use. Among all bacteria, the anoxygenic phototrophic purple non-sulfur bacteria have more applications and can synthesize different pigments. In this present study, bacterial carotenoids were isolated from the two novel strains of Rhodopseudomonas palustris and evaluated its applications....

R. Koyyati, K. R. Kudle and P. R. M. Padigya *

Department of Biochemistry, University College of Science, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4644-49

4644-4649

273

125

28.

ANTIEPILEPTIC ACTIVITY OF RUBIADIN ISOLATED FROM THE ROOTS OF RUBIA CORDIFOLIA IN MICE

Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...

A. Verma *, V. Singh and B. Kumar

Sanskar College of Pharmacy & Research, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4650-56

4650-4656

236

96

29.

AN ATTEMPT TO UNDERSTAND AND VALIDATE THE FACTORS CONTROLLING IN-SITU RAFT FORMATION PROCESS

In this study, in-situ raft forming Levofloxacin Suspension formulation was developed. In-vitro conditions like temperature, pH, and RPM simulating the in-vivo conditions like gastric pH, body temperature, and gastric motility respectively were identified as critical process parameters in system scale-up studies. Challenging and characterization were performed in-vitro. The working limits were ide...

G. S. Deokar *, S. S. Raut and S. J. Kshirsagar

MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4657-67

4657-4667

231

90

30.

FORMULATION AND EVALUATION OF ENTERIC COATED ASPIRIN TABLET BY USING BIOEPOXY RESIN AS COATING MATERIAL

An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it pr...

S. S. Tiwari *, S. J. Wadher and O. S. Yemul

Department of Pharmaceutics, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4668-72

4668-4672

374

109

31.

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF TILIACORA ACUMINATA EXTRACT IN RATS

Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated usi...

A. Rajesh, A. Doss, P. S. Tresina and V. R. Mohan *

Department of Biomedical Sciences and Technology, Noorul Islam Center for Higher Education, Kumaracoil, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4673-76

4673-4676

218

96

32.

IMPACT OF HYDROTHERMAL ISOLATION METHOD ON THE RECOVERY OF FENUGREEK SEED HEMI-CELLULOSE ANALYZED THROUGH FTIR-DSC-SEM INTERPRETATIONS

Natural Herbal components like seeds mucilages, exudates, gums, polysaccharides, celluloses, hemicelluloses, starch, etc. are now a day’s exploited as excipients. Literature reveals medicinal, nutraceutical and pharmaceutical uses of fenugreek seed hemicelluloses in dosage form design. Hemicelluloses like galactomannans are water-soluble polysaccharides highly susceptible to hydrolysis either by...

G. S. Deokar *, S. S. Shewale, S. J. Kshirsagar and P. D. Ahire

MET’s Institute of Pharmacy, Bhujbal Knowledge City, Adgaon, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4677-84

4677-4684

207

93

33.

TLC BIOAUTOGRAPHY AND LCMS-MS ANALYSIS FOR IDENTIFICATION OF COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS IN ABIES WEBBIANA LEAVES EXTRACT

This study was performed to identify the antimicrobial compounds in Abies webbiana leaves. The antimicrobial compounds were identified by LCMS-MS. The microbial inhibitory activity was evaluated on Staphylococcus aureus ATCC 6538 using REMA technique and Agar-overlay TLC bioautography. The chloroform extract of Abies webbiana leaves was used for the study. The MIC against Staphylococcus aureus was...

A. Ambre, M. Bulbule, V. Shirsat *, D. R. Kandula, A. Singh and M. Pillai

Bombay College of Pharmacy, Kolivery Village, Mathuradas Colony, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4685-93

4685-4693

281

98

34.

COMPARATIVE ACUTE AND SUB-ACUTE TOXICITY STUDY OF HYDRO-ALCOHOLIC EXTRACTS OF CENTELLA ASIATICA AND EVOLVULUS ALSINOIDES IN SWISS ALBINO MICE

In this study, the in-vivo toxicity of Centella asiatica & Evolvulus alsinoides were evaluated by acute and sub-acute toxicity assays according to the guidelines of OECD 423 & 407 respectively. For LD50 evaluation, a single dose of hydro-alcoholic extracts of both plants was orally administered to Swiss albino mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were obse...

M. K. Yadav *, S. K. Singh, M. Singh, S. S. Mishra, A. K. Singh, J. S. Tripathi and Y. B. Tripathi

Department of Kayachikitsa, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4694-99

4694-4699

249

98

35.

WOUND HEALING ACTIVITY OF ETHANOLIC EXTRACT OF LUFFA ACUTANGULA (FRUIT)

The present study investigates the wound healing activity of ethanolic extract of the fruit of Luffa acutangula. The medicinal values of the Luffa acutangula have been mentioned ancient literature as useful in disorders of wound. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using soxhlation method. Ethanolic extract of Luffa acutangula was evaluated for its wound heali...

B. Verma, S. Dwivedi *, S. Raghuwanshi, N. Vyas, S. Malviya and A. Kharia

Department of Pharmacology, Modern Institute of Pharmaceutical Sciences, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4700-04

4700-4704

257

108

36.

PHARMACOKINETICS AND BIOEQUIVALENCE ASSESSMENT OF ORAL RIVAROXABAN TABLET IN IRANIAN HEALTHY VOLUNTEERS

Rivaroxaban is utilized as a direct factor Xa inhibitor for the prevention and remedy of thromboembolic disorders. This study aimed to evaluate a generic version of rivaroxaban 10 mg tablet. Considering previous reports of safety and tolerability of a single dose (1.25-80 mg) of rivaroxaban, this study used a randomized, single-dose two-way crossover of rivaroxaban in 28 healthy volunteers, with a...

M. Dibaei, A. Haghighi, A. A. Golabchifar, K. Sadeghi, N. Pourghasem, A. Tavassoli and M. R. Rouini *

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.10(10).4705-10

4705-4710

302

122

37.

GC-MS INVESTIGATION OF PHYTOCOMPONENTS PRESENT IN ETHANOLIC EXTRACT OF PLANT ICHNOCARPUS FRUTESCENS (L.) W. T. AITON AERIAL PART

Ichnocarpus frutescens (Apocynaceae) generally renowned as Kali Sariva in Sanskrit, Krishna Sariva in Hindi which is a large, evergreen, red woody climber, native to India, Java, China, Southeast Asia, Ceylon, Northern Australia and found ascending to an altitude of 4,000 ft. Different tribes of India are used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus). It has been used...

A. Meher *, B. Behera and B. K. Nanda

Department of Pharmacognosy, The Pharmaceutical College, Bargarh, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4711-16

4711-4716

222

104

38.

GARLIC POWDER PREPARATION METHODOLOGY TO IMPROVE ALLICIN CONTENT

Background: Garlic has been used in world culinary art as well as in herbal medicine since long back. Allicin, an active moiety in garlic, is truly recognized as heart of garlic. But allicin is highly unstable and undergoes formation of numbers of sulfur-containing compounds with reduced allicin content. The major problem associated with dosage form development is instability of allicin. Objective...

K. B. Erande * and R. S. Bhambar

Department of Quality Assurance, Mahatma Gandhi Vidyamandir’s Pharmacy College, Panchavati, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4717-23

4717-4723

248

102

39.

PHARMACEUTICAL VALIDATION & PROCESS CONCEPTUALISATION OF ANCIENT INDIAN CALCIUM PREPARATION: SHANKHA BHASMA

In the present study, the pharmaceutical and therapeutic dimensions of Shankha Bhasma (Classical Ayurvedic marine medicine) is explored as a substitute for calcium supplements available in the market. Shankha Bhasma was prepared & standardized by Ayurvedic pharmaceutical procedure accordingly in Rasa Tarangini (a classical 20th-century book on Ayurvedic pharmaceutical medicine). Conch shell (S...

V. Meena *, S. Bhushan and A. Chaudhary

Department of Rasa Shastra & Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4724-30

4724-4730

275

117

40.

SYNTHESIS OF PURE AND BIO MODIFIED CALCIUM OXIDE (CaO) NANOPARTICLES USING WASTE CHICKEN EGG SHELLS AND EVALUATION OF ITS ANTIBACTERIAL ACTIVITY

Calcium oxide nanoparticles (CaO NPs) gain great value in the areas of energy storage and drug delivery systems. Due to good porosity, it finds its part in storage systems and its biocompatibility earns it a good value in drug delivery and gene transfection. Synthesis of nanoparticles by waste materials and plants of metal oxide is gaining considerable interest due to environmentally friendly reac...

S. Pasupathy * and M. Rajamanickam

Department of Chemistry, Government Arts College (Autonomous), Kumbakonam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4731-37

4731-4737

399

130

41.

DEVELOPMENT AND INVESTIGATION OF THERMO-SENSITIVE ORGANOGEL OF DICLOFENAC SODIUM FOR IN-SITU IMPLANTATION

The aim of the present study was to develop and evaluate thermo-sensitive in-situ implant forming injectable organogel systems of diclofenac sodium for prolonged drug effects. The formulations were prepared by separately dissolving fatty acids such as arachidic acid, stearic acid or palmitic acid in injectable soybean oil. The organogels were evaluated for physicochemical parameters as well as for...

A. Muralidhara and M. Koland *

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Deralakatte, Mangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4738-47

4738-4747

217

92

42.

LOW COST AND RAPID BIOSYNTHESIS OF SILVER NANOPARTICLES USING CASSIA TORA LEAF EXTRACT

Chemical, physical, and biological methods have been developed to synthesis nanoparticles but chemical and physical methods are involved in the production of toxic by-products which are hazardous moreover the methods are very expensive. To synthesis stable metal nanoparticles with controlled size and shape, there have been searched for inexpensive, safe, and reliable and “green” approach. The ...

N. S. Ghosh *, R. M. Giilhotra and A. Banerjee

School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4748-52

4748-4752

237

99

43.

DEVELOPMENT AND CHARACTERIZATION OF MANNOSYLATED QUERCETIN LOADED LIPOSOMES FOR SKIN CARCINOMA

The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced bu...

N. Verma and S. Saraf *

University Institute of Pharmacy, Pt. Ravishankar Shukla University Raipur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4753-59

4753-4759

229

125

44.

FORMULATION AND EVALUATION OF ANTIHYPERTENSIVE BILAYER TABLET

The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension. The objective of this study to compare the specific characteristics of Olmesartan Midoxomil [Angiotensin II receptor antagonist] and Hydrochlorothiazide [Thiazide Diuretics] in order to design stable formulation. It can be concluded that Olmesartan Midoxomil [Angio...

D. G. Dnyaneshwar *, M. T. Deshmukh, R. S. Solunke and R. V. Shete

Rajgad Dnyanpeeth’s College of Pharmacy Bhor, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4760-75

4760-4775

302

96

45.

THE PATTERN OF ANTIBIOTICS PRESCRIPTION AT AL-RASS HOSPITAL

Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was ...

M. A. Mobark *, H. S. Al-Harbi, E. S. Ahmed and Y. N. Al-Harbi

Department of Pharmacy Practice, College of Pharmacy, Qassim University, KSA.

DOI: 10.13040/IJPSR.0975-8232.10(10).4776-81

4776-4781

391

134

46.

THE INFLUENCE OF DIETARY COMPOSITION TO METABOLIC SYNDROME INCIDENCE

Metabolic syndrome is a group of several clinical conditions which is related to the prevalence of another disease such as cardiovascular disease, diabetes mellitus (DM) or increased fasting blood glucose level, visceral obesity, hypertension, etc. The major factor that affects the metabolic syndrome occurrence is diet composition.This research aimed to determine the influence of diet composition ...

W. Aligita *, A. Sumanjaya and I. K. Sukmawati

Department of Pharmacology, Bandung School of Pharmacy, Jl. Soekarno Hatta, Bandung, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(10).4782-86

4782-4786

261

97

47.

GENDER WISE PREVALENCE OF COMORBIDITIES AND MEDICATION ADHERENCE AMONG TYPE 2 DIABETICS IN MALAPPURAM

Background: Type 2 diabetes is a major lifestyle disease often seen with comorbidities or complications. This study is conducted to find out the gender-wise prevalence of comorbidities and medication adherence among the diabetics in Malappuram. Methods: A cross-sectional study was conducted among the 179 diabetics selected for the study. A pre-tested interview schedule was used to collect informat...

N. V. F. Zuhara *, A. T. Banu and N. Chokli

Department of Home Science, KAHM Unity Women’s College, Manjeri, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4787-93

4787-4793

192

88

48.

AN ANALYTICAL STUDY ON THE CLINICAL EFFICACY OF PEENISA PUGAI TOWARDS THE MANAGEMENT OF PEENISAM (SINUSITIS)

Pugai (fumigation) is one among the external medicines in treating a variety of diseases with the fumes of herbs or aromatic substance. Peenisa pugai is an external therapeutic measure that has been indicated in Siddha literature for the effective management of Peenisam that can be symptomatically correlated with that of Sinusitis. The aim of the present Pilot study was to compare the efficacy of ...

R. Gnanasundari, P. Shanmugapriya *, J. I. Kumar, R. Jeevagladys and V. Banumathi

Department of Nanju Noolum Maruthuva Neethi Noolum, National Institute of Siddha, Tambaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4794-98

4794-4798

222

76

49.

SCREENING OF 4-([1,3,4]OXADIAZINO[6,5-b] INDOLE-3-YL)ANILINE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY BY IN-SILICO AND IN-VITRO METHODS

Schiff bases of isatin are investigated overtime for their pharmaceutical properties and have been found to have various activities such as anti-viral, anti-bacterial, anti-inflammatory, analgesic, anti-HIV, anti-depressant, anti-convulsant, fungicidal, etc. Isatins are treated with hydrazine derivatives and cyclized by sulfuric acid. These compounds are alkylated by di alkyl aminoalkyl halides in...

M. Bhamidipati and K. Swathi *

Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(10).4799-05

4799-4805

205

124