The antioxidant and anti-inflammatory activities of various solvent extracts of Fomitopsis dochmius, a polypore found in Western Ghats of Kerala, India were investigated. Petroleum ether (PE), ethyl acetate (EA), 70 % aqueous ethanol (ETH) and hot water (AQ) extracts of the fruiting bodies of the mushroom were examined for their antioxidant activities. PE was found to show activity against hyd...
EVALUATION OF LEVOFLOXACIN VS. NORFLOXACIN; EFFECT ON BLOOD GLUCOSE PROFILE IN ALLOXAN INDUCED DIABETIC ALBINO RATS- A COMPARATIVE STUDY
Flouroquinolones (FQ) used commonly for treatment of community and hospital-acquired infections, has been prefixed with multiple adverse effects. Amongst them the glycemic variability has been attention seeking. Drug induced dysglycemia can be acute or persistent and severe too. The present study is designed to evaluate and compare the actions of Levofloxacin vs. Norfloxacin in altering blood gluc...
In the present study,FDDS of Famotidine, a copmpetative inhibitor of histamine H2 receptors were prepared by using natural gums viz. xanthan gum and guar gum at different drug to gum ratio using sodium bicarbonate and citric acid as gas generating agents and lactose as diluent.FDDS tablets were prepared by wet granulation technique using PVP K30 as granulating agent. The prepared FDDS tablets were...
Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. Serum total homocysteine (Hcy) concentration was measured by fluorescence polarization immunoessay. Plasma levels of substances reacting with thiobarbituric acid (TBARS...
COMPARATIVE STUDY OF OVERLAPPING GENES IN THE GENOMES OF MYCOPLASMA HOMINIS AND MYCOPLASMA PENETRANS
Overlapping genes are pairs of adjacent genes whose coding regions are partially or entirely overlapping. Overlapping genes in prokaryotes are a means to minimize genome size and increase the density of genetic information. Overlapping genes play an important role in genome reduction of Mycoplasmas during the course of their degenerative evolution. In this study overlapping genes in the genomes of...
Superporous hydrogels (SPHs) were developed to retain the drug in the gastric medium. These systems swell very rapidly in the stomach and maintain their integrity for longer time even in the acidic environment of stomach, while releasing the pharmaceutical active ingredient. The present work focuses on concept of development of superporous hydrogel tablets of Dexlansoprazole, their comparativeness...
A simple, rapid, sensitive, and accurate high performance liquid chromatography was developed for determination of Idelalisib (IL) in rabbit plasma using Ibrutinib as internal standard (IS). Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lympho...
PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF AQUEOUS AND ORGANICS STEM EXTRACTS OF STROPHANTHUS HISPIDUS DC.
Antibacterial and antioxidant activities of Strophanthus hispidus stem aqueous and organic (cyclohexane, chloroform, ethyl acetate and ethanol) extracts were investigated in order to assess its use in traditional medicine. In vitro antibacterial activity assessed by Disc diffusion and Microdilution methods, was tested against Gram positive bacteria (sensible Staphylococcus aureus) and gram negativ...
IN-VITRO STUDY OF ANTICONVULSANT ACTIVITY ON THE FRUITS EXTRACTS OF COCCINIA INDICA (WIGHT &ARN.) INDUCED MAXIMAL ELECTROSHOCK SEIZURE (MES) MODEL IN RATS
Aim of the study:In-vitro study of Anticonvulsant activity on the fruits extracts of Coccinia indica (Wight &Arn.) induced maximal electroshock seizure (MES) model in rats. Materials & methods: For the assessment of anticonvulsant activity, the animals were divided into five groups of five animals each albino rats. Group I received Normal saline, Group II received Phenytoin, Group III...
Proniosomes based drug delivery systems have potential as a significant drug carrier in a variety of therapeutic applications. The objective of the present study was to investigate in vitro sonophoretic transdermal delivery of Losartan Potassium (LP) across albino rat skin using proniosomal gel and its comparison with aquasonic gel. Proniosomes of LP were fabricated with L-a-lecithin (egg yolk), c...