Background: The relation between Chronic Kidney Disease (CKD) and cognitive impairment is an important public health issue because the prevalence of CKD is increased worldwide. In recent years, chronic kidney disease has been proposed as an independent risk factor for cognitive decline but the available data are conflicting. In the present study, we examined the relations of CKD and lower renal fi...
IMPACT OF DIFFERENT CARBON SUPPLEMENT ON EXTRACTION OF C-PHYCOCYANIN (C-PC) FOLLOWED BY POLY-β-HYDROXYBUTYRATE (PHB) FROM NOSTOC MUSCORUM
The extraction of poly-β-hydroxybutyrate (PHB) and C-phycocyanin (C-PC) from Nostoc muscorum revealed that PHB yield after C-PC extraction was not found differ significantly as without C-PC extraction. Under photoautotrophic growth condition, the test cyanobacterium accumulates PHB and C-PC with a maximum yield of 40 and 57 mg l-1 respectively at the stationary phase, i.e. on day 21 of incubation...
Background: Antiaris toxicaria is a tree in the mulberry and fig family of Moraceae. The leaf is used to remedy various ailments but the preparation depends on individuals. There is a need to set a standard for its preparation that would ensure optimum therapeutic benefits. Medicinal plants are generally reputed as cheaper and safer alternatives to synthetic drugs but these are often adulterated...
OPTIMIZATION OF TETRABENAZINE TABLET FORMULATION TO MEET THE REQUIRED DISSOLUTION PROFILE AND CONTENT UNIFORMITY
An approach to determine the relationship between independent process variables and their two level four factor partial factorial design was adopted, composite of experiment design was applied to optimize a tablet formulation of Tetrabenazine (TBZ) Tablets 25mg containing high percentage of Lactose Anhydrous, Sodium starch Glycolate, Magnesium Stearate and Starch / Lactose Ratio. The particle size...
ANTIBACTERIAL ACTIVITY OF NIGELLA SATIVA L. SEED OIL IN WATER EMULSION AGAINST DENTAL CARIOGENIC BACTERIA
Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO2) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcu...
Cyclic adenosine monophosphate (cAMP) dependent protein kinase plays a major role in cell signaling pathway. Over expression of extracellular cAMP dependent protein kinase catalytic subunit caused tumorgenesis in prostate. This protein may provide a base for the design of clinically applicable therapeutic strategies. In order to develop potential inhibitor of cAMP dependent protein kinase catalyti...
SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM IN ENVIRONMENTAL AND FOOD SAMPLES USING SOLVENT EXTRACTION
2, 6-dithiol-4-methylphenol (DTMP) is proposed as an analytical reagent for the extractive spectrophotometric determination of molybdenum (V). DTMP in the presence 2, 6- bis (N, N-dimethylaminomethyl)-4-methylphenol (AP) forms red colored complex with molybdenum (V) in the pH range 4.8 - 5.8. The Beer’s law was applicable in the range 0.4-22μg mL−1. The dark red Mo-DTMP-AP complex shows...
ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS
Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...
DESIGN, FORMULATION AND IN VITRO EVALUATION OF MICROSPONGES BASED GEL FOR TOPICAL DELIVERY OF KETOCONAZOLE
The aim of the present study was to formulate topical microsponge-based delivery system containing ketoconazole for controlled release of the drug for proficient treatment of fungal infections. Ketoconazole loaded microsponges were prepared by quasi emulsion solvent diffusion method using ethyl cellulose N22 polymer with varied drug polymer ratios. The prepared microsponges were characterized by S...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC ASSAY METHOD FOR ESTIMATION OF SITAGLIPTIN PHOSPHATE
An Accurate, sensitive, precise and stability indicating high performance thin layer chromatographic (HPTLC) method has been developed and validated for the estimation of SITA-P. The method was developed using TLC aluminium plates precoated with silica gel 60F254 as the stationary phase using ethyl acetate: methanol: formic acid (8.5:1:0.5 v/v/v) as mobile phase. Densitometric analysis of SITA-P w...