A FORMULA OPTIMIZATION OF NIFEDIPINE TABLET COMBINATION WITH FLOATING MUCOADHESIEVE SYSTEM IN A SIMPLEX LATTICE DESIGN
Nifedipine has poor dissolution characteristics due to its poor wetability and dispersibility in body fluits, floating mucoadhesieve system in a Simplex Lattice Design were combined in an attempt to prolong its gastric residence time. This research was aimed to find an optimum formula, through finding effects of adding polymers (Carbopol 934P, gelatin) concentration and optimum gas generating, t...
FORMULATION AND IN-VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF DICYCLOMINE HYDROCHLORIDE BY USING HYDROPHILIC POLYMERS
The objective of the present study was to develop Sustained release matrix tablets of Dicyclomine hydrochloride to reduce the dosing frequency to twice daily thereby increasing patient compliance and therapeutic efficacy. Twelve batches of tablets were fabricated using hydrophilic polymer guar gum alone or in combination with xanthan gum and pectin. All the batches were formulated by wet granulati...
The reaction between 2-naphthol, aryl aldehydes and ammonia or amines yields aminobenzyl naphthols in process known as Betti reaction; this procedure can be interpreted as extension of the Mannich condensation, with formaldehyde replaced by aromatic aldehydes, secondary amine by ammonia and the C – H acid by an electron-rich aromatic compound such as 2-naphthol. 1,3-Disubstituted-2,3-dihydro-1H-...
To evaluate phytochemical constituents and antioxidant potential of aqueous and hydroalcoholic extracts of root of Mentha arvensis L from Kashmir region. The antioxidant activity of aqueous and hydroalcoholic extracts of Mentha arvensis L was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, hydrogen peroxide scavenging and nitrous oxide scave...
INCREASED INSULIN RESISTANCE, DYSLIPIDEMIA, PRO-INFLAMMATORY MARKERS AND ENDOTHELIAL DYSFUNCTION IN CASTRATED MALE RATS: ROLE OF TESTOSTERONE REPLACEMENT
Molecular effects of androgens on cardiovascular system are variable in nature and are concentration dependent. In spite of the evidences favoring possible involvement of reduced endogenous androgens in the pathogenesis of atherosclerotic vascular disease, there is no certain role of exogenous testosterone supplementation in normal or hypogonadal males to slow down the progression of atheroscleros...
WOUND HEALING ACTIVITIES OF FICUS RACEMOSA LEAVES ETHANOLIC EXTRACT ON EXCISION WOUND MODEL OF WISTAR ALBINO RATS
Present study describes wound healing activities of Ficus racemosa (Linn.) leaves extract on excision wound model of wistar albino rats. During the study, fresh plant materials after shade drying was used for the isolation of extract using soxhlet apparatus and percentage yield was obtained (3.50% in ethanol). Then, preliminary phytochemical screening of the extract was done and certain secondary ...
IMMUNOSTIMULATORY POTENTIAL OF N-BUTANOLIC FRACTION OF HYDROALCOHOLIC EXTRACT OF COSTUS SPECIOSUS KOEN. RHIZOME
The immunomodulatory potential of n-butanolic fraction of rhizome extract (hydroalcoholic) of Costus speciosus was evaluated. For this different models like estimation of serum Immunoglobulin level, carbon clearance test, delayed type hypersensitivity reaction and humoral antibody were used. In delayed type hypersensitivity reaction and humoral antibody titer , mice were immunized by injecting 20%...
DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOFLOXACIN BOTH IN BULK AND PHARMACEUTICAL FORMULATION
The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV-Visible spectrophotometric method for the estimation of levofloxacin in bulk and pharmaceutical formulation. The solvent used throughout the experiment was 0.1N NaOH. Absorption maximum (λmax) of the drug was found to be 288 nm. The quantitative determination of the drug was ca...
THE QUALITY ASSESSMENT OF ONCOLOGICAL PAIN MANAGEMENT CLINICAL TRIALS IN THE CONTEXT OF A LIMITED NUMBER OF META-ANALYSIS OF OPIOID FORMULATIONS
Treatment ofcancer painis mainly based on the use of opioidanalgesics.This study includes opioids commonly used in Polish clinical practice, such as: dihydrocodeine, tramadol, buprenorphine, morphine, fentanyl, oxycodone and methadone. The purpose of our research is performing a quality assessment of the available clinical trials concerning opioids efficacy and an evaluation of the cause of the li...
Aim: H1 Antihistamines are classified into first generation and second generation agents. The main differences between the first and second generations of drugs are their propensity to cause central nervous system (CNS) side effects. Therefore, present study was aimed to analyze the effects of different H1 antihistamines (first and second generation) on CNS using different animal experimental mode...