The objective of this study was to evaluate the possible antimicrobial properties of water, methanol, chloroform and Petroleum ether extracts of leaves of different Indian medicinal plants including Mangifera indica Linn, Ixora parviflora Vahl, Psydium guajava Linn, Calotropis procera Ait. The extracts were investigated individually for in vitro antibacterial activity by cup plate (well diffusion)...
ANTITUMOR POTENTIAL OF STANDARDIZED EXTRACT FROM AEGLE MARMELOS ROOT ON DALTON’S LYMPHOMA INDUCED MICE MODEL
The antitumor property of the successive, standardized methanolic (MeOH) extract of Aegle marmelos roots (MAM) was investigated in Dalton’s ascites lymphoma mice model. Materials and methods: Flavonoid present in MAM was quantitatively estimated using high performance thin layer chromatography. MAM (100, 300 mg/kg) was administered orally for 15 days to assess antitumor activity. The tumor was i...
FORMULATION AND EVALUATION OF GASTRORETENTIVE DELIVERY OF TIZANIDINE HYDROCHLORIDE USING NATURAL POLYMERS
The present investigation concerns the design and evaluation of floating tablets of Tizanidine hydrochloride, which after oral administration are designed to prolong the gastric residence time and increased drug bioavailability. It is a centrally acting α2 adrenergic agonist. It is used in the treatment of migraine headaches, spasms and anticonvulsant. The dosage was designed by using natural pol...
ASSESSMENT OF β-ADRENORECEPTOR ANTAGONISTIC ACTIVITY OF NS1 AND NS2 ON PERCENTAGE INHIBITION OF ISOPRENALINE INDUCED TACHYCARDIA AND HYPOTENSION IN RATS
The present investigation is carried out for β-adrenoreceptor antagonistic activity of both derivatives by evaluating their effects on the isoprenaline induced tachycardia and hypotension in rats. Rats were divided into 5 groups (n=6) on the basis of treatment given to them. Group 1 received saline (0.9 % NaCl) only, groups 2, 3 were treated using test drugs NS1 and NS2 (1 mg/kg, i.v.) and groups...
ANTIFUNGAL GLYCEROGELATIN: ATTEMPT AT FORMULATION AND EVALUATION OF A POTENTIAL TRANSUNGUAL DRUG DELIVERY SYSTEM
Onychomycosis representing about 30% of mycotic cutaneous infections is the fungal infection that affects the nails. Although not life threatening, it adversely affects the psychology of the patient whose nails become yellow, discolored, brittle and unsightly. It may also pose serious problems in immunocompromised individuals. The current market of products for treatment of onychomycosis includes ...
A CLINICAL STUDY ON THE IMPACT OF DIFFERENT TREATMENT MODALITIES ON IMPROVING THE CLINICAL OUTCOMES IN CHRONIC PERIODONTITIS PATIENTS
Background: Periodontal disease is one of the two main and most prevalent oral diseases all over the world. Treatment strategies are diverse. To date, scaling and root planing (SRP) is still the gold standard non-surgical therapy for periodontitis. Systemically administered antibiotics can be used as an adjunct to SRP to improve the treatment outcome of periodontitis. Purpose: To compare clinical ...
Objective: The objectives are to assess the drug dose administration and reduce the dose toxicity in geriatric patients. Method: A Prospective interventional study has been carried out on drug dose administration in geriatric patients with respect to creatinine clearance rate at a tertiary care hospital for about 6 months. A total number of 204(47 baseline+157study) geriatric patients are included...
HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...
This article mainly focuses on the approval process of drug import and export from India. Now a day’s foreign pharmaceutical companies have a better legal foundation for releasing new drugs in India. The Indian medical regulatory system has become more complicated, and new drugs can take a year or more to be approved for marketing. Ever-changing laws and regulations are driving demand for regula...
The pH-sensitive microcapsules were prepared by interfacial polymerization, in which caffeine was used as a modeldrug and hyperbranched poly L-lysine (HBPL) and terephthaloyl chloride as wall-forming materials. The microcapsules were characterized by Malvern particle size analysis, scanning electron microscopy, Fourier transform infrared spectrophotometry (FTIR) and UV-vis spectrophotometer. Trito...