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IN VIVO TOXICOLOGICAL EVALUATION OF ORGANOPHOSPHATE PESTICIDE ON FEMALE ALBINO MICE: THERAPEUTIC EFFECTS OF CURCUMIN
Chlorpyrifos (CPF) an Organophosphate insecticide was evaluated for its potential to produce reproductive toxicity in rats following oral exposure. In the present study mice were given CPF at the dose level of 10 mg/kg body weight by Gavage method for 14 and 21 days. Morphological alterations of ovary were examined under LM. Its oxidative stress levels were also evaluated by Lipid peroxidation lev...
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BROAD SPECTRUM ANTIBIOFILM AND ANTIQUORUM SENSING POTENTIAL OF CRUDE SECONDARY METABOLITE EXTRACTS OF MICROBIAL ISOLATES OBTAINED FROM POLLUTED WALDHUNI RIVER
Bacterial biofilms due to antibacterial resistance are causing serious health issues with respect to infection control, its prognosis and treatment of disease. The current scenario demands need of new and alternative antibacterial compounds for treatment of such infections. The current study highlights the use of polluted river, Waldhuni, as a source of potent microorganisms with antibiofilm prope...
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TRANSGENIC LYCOPERSICUM ESCULENTUM MILL (TOMATO) PLANT AS BIOREACTOR FOR THE PRODUCTION OF HUMAN NEUTROPHIL PEPTIDE-1 (HNP-1): A USEFUL PROTEIN BASED PHARMACEUTICAL
The term ‘transgenic plant’ is defined as the plants that are produced in the lab by artificial insertion of genes sometimes from the same species and sometimes entirely from the different kingdom. A major advantage of transgenic plant because of which it gains a lot of importance in today’s world is developing it for producing pharmaceutically useful compounds. Hence, they are act...
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ISOLATION AND CHARACTERISATION OF A NEW ALLELOCHEMICAL FROM PARTHENIUM HYSTEROPHORUS L.
Parthenium hysterophorus L. is commonly known as “Gajar ghas" in Hindi and belongs to family Composite. It is an annual herb erect up to 1.5 m in hight. Its stems is branched and covered with trichomes. Its leaves are pale green, branched and covered with soft fine hairs. In Homoeopathy system, allergies caused by Parthenium can be treated by a drug prepared from Parthenium. Root decoction ...
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DENDRIMERS FOR DRUG SOLUBILITY ENHANCEMENT– A REVIEW
Sufficient fluid solvency has been one in everything about required properties while choosing drug particles and completely uncommon bio-actives for advancement. Here and there dissolvability of a medication decides its pharmaceutical and remedial execution. Most of these days organized medicine IOTAS miss the mark or are rejected for the length of the main times of drug disclosure and improvement...
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EFFICACY AND MECHANISM OF ACTION OF MORINGA OLEIFERA IN DIABETES
Diabetes mellitus (DM) is a globally spreading metabolic disorder with a high incidence rate. About 425 million cases took place in 2017 and expected to rise up to 693 million by 2045. In diabetes, the patient elevation of blood glucose level occurs due to the deformation of insulin receptor action/secretion or both. Long term increases in blood glucose level causes chronic effects such as dysfunc...
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SYNTHESIS OF NOVEL SERIES OF 2-AMINO-1, 2-DIHYDROISOQUINOLINE-3(4H)-ONE DERIVATIVES USED AS ANTIMICROBIAL AND ANTIOXIDANT AGENTS
A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, ...
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EVALUATION OF ANTIBACTERIAL ACTIVITY AND PHYTOCHEMICAL ACTIVITY OF GARCINIA LANCIFOLIA ROXB.
Flavonoids have been reported to have many pharmacological activities, antimicrobial, antioxidant, cytotoxic, chemoprevention activities along with strong antiproliferative effects. The fruits of Garcinia lancaefolia Roxb., family Cluseaceae , a plant endemic to Assam has been used in locally to treat many diseases for which it was selected for investigationg its antimicrobial properties. No sci...
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STUDY OF THE ENZYME-SUBSTRATE BY MOLECULAR MODELING INTERACTION; CASES OF THE DISEASE OF CANCER
This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibi...
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ANTIFUNGAL ACTIVITIES OF PANGIUM EDULE REINW SEED EXTRACTS INHIBIT THE GROWTH OF ASPERGILLUS FLAVUS, PRODUCER OF AFLATOXINS, THROUGH THE IN-VITRO TEST
Aspergillus flavus is a famous fungus that produces aflatoxins. Aflatoxins are the most well known toxic and carcinogenic chemical prominent produced in nature. The fungus and aflatoxins are the main concern of the corn consumer. Pangi (Pangium edule Reinw) is a potential native plant to reduce infestation of the fungus A. flavus to prevent fungal contamination of food or feed. The research was un...
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