Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
ACCURACY OF STANDARDS IN CHOLESTROL DIAGNOSTIC KITS
The percentage error observed in the claimed standard concentration of cholesterol 200 mg/dl for kits A to D is found to be 0.6, 12.3, 8.96 and 3.76 respectively. As per the guidelines of CLIA 8 allowable error is +10% for cholesterol estimation. Similarly as per the NCEP 9 guidelines + 9 % error is allowable. Therefore, it is noted that kit A is the best kit with an error of just 0.6% followed by...
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AN OVERVIEW ON MICROBIAL FIBRINOLYTIC PROTEASES
Microbial fibrinolytic proteases are of considerable interest in view of their specific activity and stability at biological pH. This review describes different isolation methods which enable the screening and selection of promising organisms for industrial production. Further, strain improvement using mutagenesis and/or recombinant DNA technology can be applied to augment the efficiency of the pr...
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BUCCAL MIDAZOLAM: COULD IT BE AN ALTERNATIVE FOR I/V DIAZEPAM FOR ACUTE SEIZURES IN MALNOURISHED CHILDREN
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intra...
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IMPACT OF ALCOHOL ON RAT HEART AND AORTIC TISSUE ACETYLCHOLINE CONTENT LEVELS IN VITRO AND IN VIVO
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of senso...
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SIMULTANEOUS ESTIMATION OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE, ITOPRIDE HYDROCHLORIDE AND MOSAPRIDE CITRATE BY RP-HPLC METHOD: OPTIMIZATION, DEVELOPMENT, VALIDATION AND APPLICATION TO LABORATORY SAMPLE.
A simple, rapid, accurate, precise and economical RP- HPLC method with UV detection was optimized, developed and validated as per ICH-Q2 guideline for the simultaneous estimation of Esomeprazole magnesium trihydrate (ESO), Itopride hydrochloride (ITO) and Mosapride citrate (MOSA) in laboratory sample. An optimum condition of separation and detection was developed on a reverse-phase Supelco 516 C18...
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INFLUENCE OF INCREASING CONCENTRATIONS OF MAGNESIUM STEARATE AND TALCUM ON DISSOLUTION PROFILE AND PHYSICAL PARAMETERS OF METOPROLOL TARTRATE EXTENDED RELEASE MATRIX TABLETS
Metoprolol tartrate (MT) is cardio-selective β1 receptor antagonist used primarily in the management of chronic heart diseases like in the management of hypertension, angina pectoris, cardiac arrhythmias, myocardial infarction and heart failure. It is only available as prescription drug. The objective of this study was to prepare sustained release matrix tablets of MT using hydrophilic polymer an...
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ROLE OF SERUM BILIRUBIN IN CLINICALLY ADMITTED PATIENTS TO PREVENT THE RISK OF CARDIAC DISEASES
ABSTRACT: Background: Coronary artery disease /coronary vascular disease (CAD/CVD) remains the first killer and common silent disease in the world. The lipid profile plays the essential role in CAD development with lipid oxidation. Lipid oxidation, which accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the patho physiology of CVD. Bilirubin...
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ROLE OF N-ACETYLCYSTEINE IN RESCUE OF MICE HEART
An imbalance between oxidants and antioxidants generates the oxidative stress. Oxidative stress is the major cause of many diseases like cardiovascular, respiratory disease, renal diseases, neurological diseases, cancer, and aging. Cardiovascular complications are the leading cause of mortality in patients so the purpose of this review is to evaluate the effectiveness of N-acetylcysteine (NAC) in ...
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ENHANCEMENT OF DISSOLUTION OF CLOPIDOGREL MINI-TABLETS IN INTESTINAL FLUIDS WITH THE AID OF IN-SITU ACIDIFYING AGENT
The main objective of the present study is to enhance the dissolution of clopidogrel bisulphate in intestinal fluids by formulating into mini-tablets with in-situ acidifying agent mini-tablets. The solubility data reveals, Clopidogrel bisulphate is freely soluble in pH 2.0 and the solubility decreases with increase in pH. Whereas, with weak acid, the solubility of clopidogrel is increased at pH 5....
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MOLECULAR DOCKING STUDIES OF BMS-378806 ANALOGS AS NOVEL HIV-1 GP120/CD4 INHIBITORS
AIDS, a pandemic disease caused by HIV has a high mortality rate. Therapeutic failures have risen due to the emergence of resistant viral strains and adverse side-effects of Anti-HIV drugs. Thus, there arises a need to develop novel and promising anti-HIV drugs. BMS-378806 (BMS-806) inhibits the initial stages of HIV-1 infection by blocking the binding of viral gp120 protein to host-cell CD4 recep...
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