Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
PRODUCTION OF REACTIVE OXYGEN SPECIES, ITS EFFECT, DRUGS AND PLANT EXTRACT USED AS AN ANTIOXIDANT, CHELATOR ON THALASSEMIC PATIENT: A REVIEW
β- Thalassemia is an inherited genetic disorder which is caused by different kinds of mutations in the HBB gene in chromosome 11. Due to several types of mutation in β- gene, globin chains cannot synthesise completely and free α-globin is highly unstable and readily precipitates bound heme and iron. In β- thalassemia these precipitated iron, repeated blood transfusion and increased gastroint...
4356
1787
COMPARATIVE ASSESSMENT OF THE PHYSICOCHEMICAL AND IN-VITRO BIOAVAILABILITY EQUIVALENCE OF CO-TRIMOXAZOLE TABLETS MARKETED IN TIGRAY, ETHIOPIA
The availability of numerous brands of co-trimoxazole in our local market today places health professionals in a difficult situation of choice of a suitable brand or the possibility of alternative use. The aim of the study was to predict the physicochemical and in-vitro bioavailability equivalence of six brands of co-trimoxazole tablets marketed in Tigray, Ethiopia. Weight uniformity, friability, ...
6548
2808
DEVELOPMENT AND OPTIMIZATION OF ITOPRIDE HYDROCHLORIDE FAST DISINTEGRATING TABLETS USING FACTORIAL DESIGN AND RESPONSE SURFACE METHODOLOGY
The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and in-vitro release. In addition, the optimum formulat...
5010
1910
POTENTIAL ANTI CANCER ACTIVITY OF SNAKE VENOM, BEE VENOM AND THEIR COMPONENTS IN LIVER AND BREAST CARCINOMA
The present study aimed to evaluate the antitumor efficacy of Snake venom (SV), bee venom (BV), combinations of their components and their apoptotic, cell death mechanisms in liver (HepG2) and breast (MCF7) cell lines. Cytotoxic effects of venoms, L-Amino acid oxidase (svLAAO), phospholipase A2(svPLA2), Melittin ( MEL) were tested against HepG2 and MCF-7 cell lines and IC50 was calculated . mRNA e...
8706
2581
PRODUCTION AND CHARACTERIZATION OF L-GLUTAMINASE BY BACILLUS SP.
L-Glutaminase (EC.3.5.1.2) is an amidohydrolase which catalyses the hydrolytical deamination of L-glutamine resulting in the production of L-glutamic acid and ammonia. L-Glutaminase is gaining marked importance due to its application potential in cancer therapy, food industry and of high value chemicals like theronine. A variety of microorganisms, including bacteria, yeast, and filamentous fungi, ...
8864
3309
QUALITY BY DESIGN APPROACH FOR THE DEVELOPMENT AND VALIDATION OF SAXAGLIPTIN BY RP-HPLC WITH APPLICATION TO FORMULATED FORMS
Quality by Design (QbD) is a philosophy that refines the level of knowledge associated with a product that uses process understanding to deliver a product with the desired critical quality attributes. The objective of this present study was to develop and demonstrate an integrated multivariate approach to develop and quantify the constituent concentrations of saxagliptin drug in its pure and formu...
5851
2084
OFF-LABEL USE OF MEDICINES IN CHILDREN
Although plenty of information relating to drug utilization among adults is available, the literature pertaining to children is scarce. The majority of drugs prescribed have not been tested in children and safety and efficacy of children’s medicines are frequently supported by low quality of evidence. This is explained by the lack of clinical research in this population, caused by ethical, sci...
37905
6143
PHYTOCHEMICAL CONSTITUENTS AND ANTIDIABETIC PROPERTIES OF SYZYGIUM CUMINI LINN. SEED
The present study was undertaken to investigate some organic phytochemicals, fatty acids, toxic metals and evaluate lipidemic and antidiabetic activity of a herbal medicine and its one constituent Syzygium cumini seed. Antidiabetic and lipidemic activity of this medicine and seed extract was studied on streptozotocin induced type 2 diabetic model rats. From chemical investigation carbohydrates and...
8260
1932
SYZYGIUM CUMINI (LINN.) – AN OVERVIEW ON MORPHOLOGY, CULTIVATION, TRADITIONAL USES AND PHARMACOLOGY
Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like anti- diabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotectiv...
11302
3083
PRECLINICAL ACUTE AND REPEATED DOSE TOXICITY OF PUERARIA TUBEROSA (PTWE) ON CHARLES FOSTER RATS
Here we have carried out the acute and repeated dose toxicity study on tubers of Pueraria tuberosa water extract (PTWE). For acute toxicity study, rats were orally administered a single dose of 2000 and 5000 mg/kg body weight of PTWE. For repeated dose toxicity study on rats in one set, the different doses were given daily up to 28 days to make general observation and mortality rate. In another se...
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1801