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VIRTUAL SCREENING, SYNTHESIS OF NEWER HETEROCYCLES AS PPAR γ AGONISTS WITH ANTIDIABETIC ACTIVITY
Recent decades have experienced a sharp increase in the incidence and prevalence of diabetes mellitus. The major therapeutic approach is to diabetes is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α-amylase and α-glucosidase. The agonists of PPAR γ is of great interest to the pharmaceutical industry since they regu...
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ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF THE LEAF EXTRACT OF BRASSICA NIGRA
Crude ethanolic extract of Brassica nigra was studied to detect the chemical compounds as well as to evaluate the antioxidant and anti-inflammatory activities. The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, reducing power, total phenolic content and flavonoid content were studied. Phytochemical screening showed the presence of alkaloids,...
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ASSESSMENT OF β-ADRENORECEPTOR ANTAGONISTIC ACTIVITY OF NS1 AND NS2 ON PERCENTAGE INHIBITION OF ISOPRENALINE INDUCED TACHYCARDIA AND HYPOTENSION IN RATS
The present investigation is carried out for β-adrenoreceptor antagonistic activity of both derivatives by evaluating their effects on the isoprenaline-induced tachycardia and hypotension in rats. Rats were divided into 5 groups (n=6) based on the treatment given to them. Group 1 received saline (0.9 % NaCl) only, groups 2, 3 were treated using test drugs NS1 and NS2 (1 mg/kg, i.v.) and groups 4,...
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OPTIMUM PARAMETERS FOR WINE PRODUCTION FROM POMEGRANATE FRUIT JUICE
Pomegranate fruits are a very rich source of antioxidants, Vitamin B5 (pantothenic acid), potassium, flavonoids and have numerous health benefits. It may help decrease the risk of having a heart disease, heart attacks, and strokes. These characteristics of pomegranate have great impact on the quality of wines. So there might be a scope for large scale manufacturing of the pomegranate wine as it ha...
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FORMULATION AND EVALUATION OF TOPICAL MICROEMULGEL LOADED WITH TERBINAFINE HCL MICROEMULSION
The aim of the present study was to investigate the potential of a micro-emulgel formulation for topical delivery of Terbinafine. Terbinafine showed highest solubility in propylene glycol among the available oil phase. Tween 80 and polyethylene glycol 400 were used as surfactant and co-surfactant respectively. Using pseudo-ternary phase diagram 1:2 ratio of surfactant: co-surfactant was selected. ...
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STUDY OF DISSOLUTION CHARACTERISTICS OF IBUPROFEN BY DIFFERENT POLYMERS AND SOLID DISPERSION TECHNIQUES
Poor water solubility is characterized by low dissolution rate and consequently reduced bioavailability. Formulation of solid dispersion has attracted considerable interest where dispersing a poorly water soluble drug in a water soluble polymer matrix improves the dissolution characteristics and bioavailability of the drug. The aim of the present study was to enhance the dissolution rate and bioav...
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PHYSICOCHEMICAL CHARACTERIZATION OF – CYCLODEXTRIN COMPLEXES OF TAMOXIFEN CITRATE AND PHASE SOLUBILITY STUDIES
The objective of the present investigation is to study the possibilities to improve the aqueous solubility and dissolution rate of Tamoxifen citrate (TC) – an oral anticancer drug, based on inclusion complexes with a– cyclodextrin (α –CD). The inclusion processes are discussed based on absorption, emission, FT-IR, 1H-NMR, SEM and phase solubility study. The α –CD study shows that the dru...
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PRESCRIPTION PATTERN OF DRUGS USED IN THE TREATMENT OF PEPTIC ULCER DISEASE IN THE DEPARTMENT OF GASTROENTEROLOGY IN A TERTIARY CARE HOSPITAL
For more than a century Peptic Ulcer Disease (PUD) has been considered to be a major cause of morbidity and mortality. Most first line treatment for PUD involves use of acid suppressing drugs and target against the eradication of Helicobacter pylori (H. pylori) infection. However, the treatment strategy employed in India is not well studied. Hence, this study aims to provide insight into the presc...
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MEDICINAL SIGNIFICANCE OF LOVASTATIN
Lovastatin is a naturally occurring drug of statin family used for lowering cholesterol. It is found that it can be useful for treatment or management of multiple diseases and has immense medicinal significance. On one side, this drug is used to induce apoptosis in various cancer cells, while other reports indicate that it also promotes cell survival to alleviate certain disease conditions. Antivi...
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TRANSETHOSOMES: A NEW PROSPECT FOR ENHANCED TRANSDERMAL DELIVERY
The skin covers a total surface area of approximately 1.8 m2 and provides the contact between the human body and its external environment. Transdermal route of drug delivery has gained great interest in pharmaceutical research as it overcomes many problems associated with the oral route of administration. Although the skin, particularly the stratum corneum presents a barrier to most drug absorptio...
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