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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 1 (2010) - Issue 8, August (Suppl.)

Review Articles

 
Title
Views
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1.

SOLID DISPERSION AS AN EMINENT STRATEGIC APPROACH IN SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS

The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and vari...

Shikha Aggarwal*, G D Gupta, and Sandeep Chaudhary

A S B A S J S M College of Pharmacy, Bela, Ropar, (Punjab), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).1-135

1-13

1926

936

2.

PRESENT INVESTIGATIONS AND FUTURE PROSPECTS OF ORAL DISINTEGRATING TABLETS: A REVIEW

Oral Disintegrating Drug Delivery Systems (ODDDS) have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, or...

Basani Gavaskar*, Subash Vijaya Kumar, Guru Sharan, Nagaraju M and Y Madhusudan Rao

Department of Pharmaceutics, Vaagdevi College of Pharmacy, Warangal (AP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).14-28

14-28

2291

1688

3.

Akt: A NEW APPROACH FOR CANCER TREATMENT

Direct genetic alterations leading to deregulated PI3K/Akt signaling are common in a significant fraction of human malignancies. Both Akt and Aurora A kinase have been shown to be important targets for intervention for cancer therapy. Nuclear Akt1 expression and Akt activation are common in cancer invasion. However, the mechanisms for this association and its causal role in invasion are uncertain....

Devendra Singh Thakur*, Peeyush Kumar, Pramod Kumar and Champa Lal

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur (CG), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).29-36

29-36

1134

577

4.

RECENT TRENDS IN CHALLENGES AND OPPORTUNITIES OF PHARMACOGENOMICS

Pharmacogenomics is the branch of pharmacology and genomics that deals with the influence of genetic variation on drug response in patients by correlating molecular expressions and single-nucleotide polymorphisms with a drug's efficacy or toxicity. Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with mi...

Debjit Bhowmik, Chiranjib, B C Das and K P Sampath Kumar*

Department of Pharmaceutical Sciences, Coimbatore Medical College, Coimbatore (TN), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).37-46

37-46

1249

420

Research Articles

 
Title
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Cited
5.

DESIGN AND EVALUATION OF RIMONABANT LOADED SODIUM ALGINATE-GUAR-GUM MICROSPHERE FORMULATION

Rimonabant is an anti-obesity drug which acts as Cannabinoid-1 receptor antagonist. Its main avenue of effect is reduction in appetite. The drug was formulated in the form of Sodium Alginate – Guar gum microspheres following ionotropic gelation method to reduce its dose related side effects. A detailed study of physical and chemical parameters including percentage drug loading and cumulative dru...

B K Gupta*, Manas Chakraborty, R Debnath, Soumyadip Bose and S Nandy

Department of Pharmaceutical Technology, Jadavpur University, Kolkata (WB), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).47-61

47-61

1449

584

6.

SYNTHESIS OF WATER SOLUBLE CROSSLINKED N- ACYL DERIVATIVE OF CHITOSAN AND ITS ASSESSMENT FOR ANTIMICROBIAL ACTIVITIES IN VITRO

Currently, natural polysaccharides are being utilized increasingly in the markets because they exhibit biodegradability, biocompatibility, versatility, and are found abundant in nature. Chitosan is a natural polysaccharide that possesses excellent biological properties. It has been recognized for its antibacterial activity, in that it is destructive towards the bacterium Escherichia coli (E. coli)...

S B Sonone *, S S Malve, N S Naikwade and P J Shirote

Appasaheb Birnale College of Pharmacy, Shivaji University, Sangli (MS), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).62-65

62-65

1216

401

7.

PHYTOCHEMICAL EVALUATION AND TLC PROTOCOL OF VARIOUS EXTRACTS OF BOMBAX CEIBA LINN.

Natural products are an important source of new structures leading to drugs in all major disease areas. They represent a pool of privileged structures that are optimized by evolution to interact with proteins and other molecules. Bombax ceiba is an important medicinal plant of tropical and subtropical India. Its medicinal usage has been reported in the traditional systems of medicine such as Ayurv...

D D Chakraborty *, V Ravi and P Chakraborty

Department of Pharmaceutical Sciences, Sardar Bhagwan Singh Post Graduate Institute of Biomedical Science and Research, Balawala, Dehradun, (UK), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).66-73

66-73

2525

740

8.

HYPOGLYCEMIC AND ANTIHYPERGLYCEMIC EFFECT OF ETHANOLIC EXTRACT OF WHOLE PLANT OF LAWSONIA INERMIS (HENNA) IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Diabetes, a global burden, is characterized by fast elevation of blood sugar level. The incidence of diabetes mellitus is rising all over the world, especially in Asia. Many oral hypoglycemic agents, such as biguanides and sulphonylurea are available along with insulin for the treatment of diabetes mellitus but they have significant side effects and sometimes they are found to be ineffective in ch...

Ankur Choubey*, Mukesh Ojha, Ashish Mishra, Shilpi Mishra and U K Patil

VNS Institute of Pharmacy, Neelbud, Bhopal (MP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).74-77

74-77

1869

742

9.

COMPARATIVE STUDY ON EFFECT OF DIFFERENT SUBLIMING AGENTS ON FAST DISSOLVING TABLETS OF CHLORTHALIDONE BY VACUUM DRYING TECHNIQUE

Chlorthalidone is a phthalamide derivative of benzene sulphonamide and is designated as 2- chloro- 5- (1- hydroxy- 3- oxo- 1- isoindolinyl) benzene sulphanilamide. It is white to yellowish crystalline powder. It is practically insoluble in water, slightly soluble in alcohol. In the present study fast disintegrating tablets of chlorthalidone were prepared by adopting vacuum drying technique to stud...

N G Raghavendra Rao *, Upendra Kulkarni and K Ravi Kumar

Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga (Karnataka), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).78-87

78-87

1598

2418

10.

FORMULATION AND EVALUATION OF DICLOFENAC POTASSIUM MATRIX TABLETS

The objective of the study was to develop HPMC matrix tablets for oral controlled/ sustained release of water soluble Diclofenac Potassium. Sustained release matrix tablets containing 100 mg of Diclofenac Potassium were developed using different drug polymer ratio of HPMC. Tablets were prepared by direct compression. Compressed tablets were evaluated for uniformity of weight, content of active ing...

Basawaraj S Patil*, Upendra Kulkarni and Parikh Bhavik

R.M.E.S’s College of Pharmacy, Gulbarga, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).88-92

88-92

1811

723

11.

FORMULATION AND DEVELOPMENT OF FAST DISINTEGRATING FELODIPINE TABLETS: FUNCTIONALITY OF SUPERDISINTEGRANTS

Felodipine, a calcium channel blocker, is used for hypertension and angina pectoris. Felodipine fast- disintegrating tablets (FDT) have been prepared by direct compression method. Effect of superdisintegrants (like crosspovidone, croscarmellose sodium and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release and stability parameter has been studied. Disinteg...

Hariprasanna RC, Upendra Kulkarni*, Basawaraj S Patil Vipul Karkar and Parikh Bhavik

R.M.E.S’s College of Pharmacy, Gulbarga, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).93-99

93-99

1288

441

12.

IN-VITRO ANTIOXIDANT ACTIVITY OF THE SUCCESSIVE EXTRACTS OF RICINUS COMMUNIS STEMS

There is increasing evidence to support the involvement of free radical reactions in several human diseases. n recent years, it has become increasingly apparent that in man, free radicals play a role in a variety of normal regulatory systems, the de-regulation of which may play an important role in inflammation. Active oxygen species and other free radicals have long been known to be mutagenic. Fu...

Ramesh Kumar Singh *, M K Gupta, Deepti Katiyar, Anshul Srivastava and Parul Singh

Department of Pharmacy, Rameshwaram Institute of Technology & Management, Lucknow (UP) India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).100-03

100-103

1620

542

13.

DESIGN AND EVALUATION OF BUCCOADHESIVE BILAYER TABLETS OF GRANISETRON HYDROCHLORIDE

Purpose of Study: In the present study, an attempt was made to design and evaluate buccoadhesive bilayer tablets of granisetron hydrochloride (an anti-emetic drug), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Method: Bilayer buccal tablets containing the drug were prepared by direct compression method using combination of...

Swamy P V*, Kinagi M B, Biradar S S, Gada S N and Shilpa H

Department of Pharmaceutical Technology, HKE Society’s College of Pharmacy, Sedam Road, Gulbarga (Karnataka), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).104-10

104-110

1704

650

14.

RELEASE PROFILE OF EXTRACTS OF BRIDELIA FERRUGINEA LEAF AND CANTHIUM GLABRIFLORUM STEM BARK FROM DIFFERENT ABSORBENTS

The aqueous decoctions of Bridelia ferruginea leaf and Canthium glabriflorum stem bark were converted into granules by absorbing into different types of absorbents in different quantities. In vitro dissolution studies were then used to assess the release of the extracts from the granules. Comparative and ranking studies of the effects of different weights of the different absorbents on the release...

R Johnson*, J Adotey/, M T Bayor and K Annan

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).111-17

111-117

1245

496

15.

ISOLATION AND EVALUATION OF CASSIA AUNGOSTIFOLIA SEED MUCILAGE AS GRANULATING AGENT

Cassia aungostifolia is a common herbaceous belongs to the family of Caesalpiniaceae. Seeds of plant contain gluco-mannose hence attempt to evaluate the seeds for suitability as tablet binder is considered and the present exploration repots the isolation of mucilage of Cassia aungostifolia seed. The DSC and FTIR thermograms of drug and mucilage indicated no chemical interaction. Phytochemical and ...

Sudarshan Singh* and SangeetaSingh

Shree HNS Institute of Pharmaceutical Education and Research, Rajkot, (Gujarat), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).118-25

118-125

1305

499

16.

PHYTOCHEMICAL SCREENING AND GUT MOTILITY ACTIVITY OF ETHANOLIC EXTRACT OF WHOLE PLANT OF SCUTIA MYRTINA KURZ.

Phytochemical and Gut motility activity of Ethanolic Extract of whole plant of Scutia Myrtina Kurz collected from Kolli Hills, Tamil Nadu was studied. Phytochemical studies revealed the presence of Alkaloids, Glycosides (Anthraquinone), Flavonoids and Tannins. For Gut Motility activity Extracts in concentration of 200mg/Kg and 400mg/Kg were studied in three animal models in comparison to Caster Oi...

N Goutam*, R Goutam, S Jain, S Deb Roy, K K Nayak, G Tomar and D N Sharma

Abhilashi College of Pharmacy, Ner Chowk, Dist: Mandi, (HP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).126-32

126-132

1346

517

17.

FORMULATION AND OPTIMIZATION OF FAST DISSOLVING MELOXICAM TABLETS BY VACUUM DRYING TECHNIQUE

Despite recent success, many fast-dissolving tablets (FDTs) still face problems of low mechanical strength, poor mouth-feel, higher wetting and disintegration times. This research work aimed to overcome from these drawbacks. Attempts were made to prepare fast dissolving tablets by employing vacuum drying technique utilizing single and multi-volatile components. Analysis revealed that, formulation ...

Upendra Kulkarni, Vipul Karkar*, Parikh Bhavik and Qamar Jamal Ahmad

RMES’S College of Pharmacy Gulbarga (Karnataka), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).133-38

133-138

1706

494

18.

STUDIES ON THE ANTI- INFLAMMATORY PROPERTIES OF CURCULIGO ORCHIOIDES GAERTN. ROOT TUBERS

In this study, the anti-inflammatory effect of methanolic extract obtained from root tubers of plant Curculigo orchioides Gaertn. (Amaryllidaceae) was investigated. The effect of extract was studied in Carrageenan induced rat paw oedema. The extract at a dose of 200mg/kg and 400mg/kg was carried out for the investigation. The results indicate that methanolic extract, at the dose of 200mg/kg & ...

Anuj Kumar Agrahari*, Sanjaya Kumar Panda, Ashutosh Meher and Amiya Ranjan Padhan

The Pharmaceutical College, Department of Pharmacognosy, Samaleswari Vihar, Tingipali, Barpali, Bargarh, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).139-43

139-143

1953

668

19.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF DIPHENHYDRAMINE HYDROCHLORIDE IN SOFT GELATIN CAPSULE

A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Diphenhydramine Hydrochloride in soft gelatin capsule dosage form. For UV spectrophotometric method, maximum absorption was found at λmax 258nm.The percentage recovery of Diphenhydramine Hydrochloride ranged from (98.97 ± 0.2989) in capsule dosage form. The developed method was ...

Arun Kumar Mishra *, Arvind Kumar and Amrita Mishra

Central Facility of Instrumentation, College of Pharmacy, IFTM, Moradabad, (UP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).144-48

144-148

2023

1496

20.

FORMULATION DEVELOPMENT AND EVALUATION OF BUCCAL FILMS OF CARVEDILOL

Carvedilol is used for hypertension, angina pectoris and in symptomatic heart failure. It has a short half life of 2h and bioavailability of 25%. Therefore the present investigation is concerned with the development of the buco-mucoadhesive films, which were designed to prolong the buccal residence time, to increase penetration through buccal mucosa and thus increase the bioavailability and its ha...

Parmar Viram J*, Lumbhani A N., Vijayalakshmi P and Sajal Jha

Shree Samanvay Institute of Pharmaceutical Education & Research, Bhambhan (BOTAD), Bhavnagar, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).149-56

149-156

1923

598