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INHIBITION STUDIES OF TERPENE BASED NATURAL PRODUCTS WITH CYCLIN-DEPENDENT KINASE 4 (CDK4 MIMIC CDK2)
Cyclin dependent kinases (CDKs) are known as cell cycle regulators in eukaryotic cell cycle. Different CDKs (CDK2, CDK4 etc.) are having structure homology among them. Using computer based molecular modeling tools, interactions between naturally occurring terpene based compounds with crystal structure of CDK4 mimic CDK2 enzyme having PDB ID : 1GII. Using In-silico techniques, the binding energies ...
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ANALYSIS OF ANTIMICROBIAL USAGE PATTERN: A RETROSPECTIVE OBSERVATIONAL STUDY
Objective: Antimicrobials have become one of the most misused therapeutic agents resulting in resistance. Present study was carried out to evaluate the antimicrobial drug utilization pattern. Method: A retrospective, observational record based study was done in hospitalized patients from medicine and surgery department of tertiary care hospital of central India over a period of one year. Result: A...
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FORMULATION, CHARACTERIZATION AND IN-VITRO / EX-VIVO EVALUATION OF TROLAMINE SALICYLATE – LOADED TRANSFERSOMES AS TRANSDERMAL DRUG DELIVERY CARRIERS
The percutaneous delivery of salicylates to muscle and joints via the application of trolamine salicylate including transfersomes is the goal of this study and is beneficial for the treatment of inflammatory muscle, tendon and joint diseases. In this study, Trolamine salicylate permeability parameters through rat skin were evaluated with different trasfersome formulations in comparison with contro...
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CARBON NANOTUBES: AN APPROACH TO NOVEL DRUG DELIVERY SYSTEM
Carbon nanotubes are cylindrical carbon molecules have novel properties, making them potentially useful in many applications in nanotechnology, electronics, optics, and other fields of material science as well as potential uses in architectural fields. They have unique electronic, mechanical, optical and chemical properties that make them good candidates for a wide variety of applications, includi...
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ANTINOCICEPTIVE EFFECTS OF METHANOLIC EXTRACTS OF POTENTILLA ANSERINA IN ANIMAL MODELS
Potentilla anserina (Rosaceae) is a traditional medicinal plant in India, and it is available throughout the Northern hemisphere. This study was intended to evaluate the antinociceptive activity of methanolic extract of Potentilla anserina in acetic acid-induced writhing test in mice and Eddy’s Hot Plate method in Albino rats at the dose level of 75, 150 and 300 mg/kg p.o and the study was compa...
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ANTIBACTERIAL ACTIVITY FROM BARK EXTRACTS OF PTEROSPERMUM ACERIFOLIUM (L.) WILLD.
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro anti...
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STUDIES ON PHTHALIC ACID-PROPANE-1, 2-DIOL-GLYCEROL CO-POLYESTER AS AN ENTERIC COATING MATERIAL
Enteric coating material that, was synthesized in the laboratory and applied to a tablet and also drug release profile was investigated. A polymeric material - Phthalic acid propane-1,2 diol-glycerol co-polyester (PPGC) was synthesized from phthalic acid and propane-1, 2-diol with 5% glycerol of total weight as a crosslinking agent using Dean-Stark apparatus with Ferric Chloride as catalyst and o-...
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HISTORY, MANIFESTATION AND PREVENTIVE MEASURES FOR RUBELLA IN INDIA: A REVIEW
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the in...
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ANTI-INFLAMMATORY, ANTI-ARTHRITIC AND ANALGESIC ACTIVITY OF THE ALCOHOLIC EXTRACT OF THE PLANT URGINEA INDICA KUNTH.
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic meth...
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THE EFFECT OF FORMULA TO PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (ANREDERA CORDIFOLIA (TEN) STEENIS)
Binahong (Anredera cordifolia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine and it is relevant to develop dosage forms of binahong using formulation technology approach. The aim of this research was to find out wound healing gel formula of ethanolic extract of binahong. The factorial design method 3 factors and 2 levels were employed to achieve this study. Three ...
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