STUDY OF ANTIDIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS) AQUEOUS ROOTS AND FLOWER EXTRACTS ON ALBINO MICE
Dexamethasone drug induced the hyperglycemia in the Albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of dexamethasone raised the level of blood sugar in the mice. Administration of aqueous extract of C. citratus root and flower extract reduced the fasting and postprandial blood sugar levels, bringing them towards normal. We were observed anti-diabetic effect...
The purpose of present study was to formulate the gastro-retentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w1/o/w2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro dru...
DETERMINATION OF PALBOCICLIB IN HUMAN PLASMA USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY – ULTRAVIOLET DETECTION
A simple, sensitive, and high-performance liquid chromatography ultraviolet detection (HPLC-UV) method was developed and validated for the quantification of palbociclib in human plasma. Plasma samples were processed by solid phase extraction using an Oasis hydrophilic-lipophilic balance extraction cartridge (1 mL, 30 mg). Commercial imatinib was used as an internal standard. Palbociclib and imatin...
Biopolymers are gaining more importance in our day-to-day life, due to the hazardous effect of synthetic plastics in our environment. Curdlan is one of the biopolymers, which has a broad field of applications in the food, pharmaceutical and medical industries. It is a polymer of glucose, produced by the family members of Rhizobiaceae. Curdlan [(1→3)-β-D-glucan] production takes place under the ...
A REVIEW OF CLASSICAL, PROPRIETARY AND PATENTED AYURVED PRODUCTS AND THEIR INGREDIENTS IN LIVER / SPLEEN DISEASES
Liver disease is the tenth most common cause of death in India as per the World Health Organization and may affect every one in Five Indians. In spite of consistent human effort and drug discovery, modern drug has very little to offer. Nonetheless, Ayurved classical proprietary and patented formulations have shown promising results. The present study provides a general review of the Ayurved produc...
A COMPARATIVE STUDY OF LEDIPASVIR SOLID DISPERSION TECHNIQUE USING SPRAY DRYING AND HOT-MELT EXTRUSION
Ledipasvir is an inhibitor of the HCV NS5A protein, which is required for viral replication used in the treatment of hepatitis C. Ledipasvir is practically insoluble (less than 0.1 mg/mL) across the pH range of 3.0-7.5 Due to low solubility, it results into poor bioavailability after oral administration. Therefore, solid dispersions (SDs) of Ledipasvir were prepared by two methods, i.e. spray dryi...
The present study deals with the Pharmacognostical and preliminary phytochemical studies of fruit pulp of Aegle marmelos. Macroscopy, organoleptic characters, microscopic features, physiochemical standardization parameters such as total ash, acid insoluble ash, water soluble ash, alcohol, water and other organic solvent extractives, preliminary phytochemical assay, fluorescence analysis and microb...
IMPAIRMENT OF OVARIAN BIOCHEMICAL CONTENTS AND ENZYMES ACTIVITIES DURING POTASSIUM BROMATE (KBRO3-) INTOXICATION IN ALBINO MICE MUS MUSCULUS
Potassium bromate (KBrO3-) is a chemical compound commonly used as a oxidizing agent that has been used as a food additive for baking of white bread, bun, pav and pizza bread. Potassium bromate (KBrO3-) is mainly known to generate free radicals, which cause oxidative damage to essential cellular macro molecules, leading to cause nephrotoxicity in experimental animals. In this part of experiment bi...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ZALTOPROFEN AND PARACETAMOL IN COMBINED DOSAGE FORM BY ULTRAVIOLET SPECTROPHOTOMETRY
Two spectrophotometric methods are presented for the simultaneous estimation of Zaltoprofen (ZLT) and Paracetamol (PAR) in laboratory prepared mixture and pharmaceutical dosage form without prior separation. Method (1) is simultaneous equation method (Vierodt’s method); which depends on the fact that absorbance of a mixture is the sum of the individual absorbance of the components. Method (2) is...
Crocus pallasii subsp. haussknechtii grows in the west of Iran where local people consume the corm. It belongs to a saffron family (Iridaceae), which has shown several biological activities including cytotoxic and anti-angiogenesis properties. The corm (the nut and the surrounding fibers) and aerial parts of the species have shown anti-angiogenesis properties in HUV-EC-C cells previously; in the p...