PRELIMINARY DEVELOPMENT STUDIES OF HALOBETASOL PROPIONATE ORGANOGEL FOR MANAGEMENT OF ATOPIC DERMATITIS
Halobetasol propionate (HP) is an ultra-potent corticosteroid used in management of severe and recurrent cases of Atopic Dermatitis (AD). The marketed cream formulations are based on synthetic surfactants which often aggravate AD. The present studies investigate biocompatible pluronic lecithin organogel (PLO) of Halobetasol propionate in management of AD. Organogels were prepared by aqueous titr...
EVALUATION OF RATIONAL USAGE OF ANTIMICROBIAL AGENTS IN THE PAEDIATRIC DEPARTMENT AT TERTIARY TEACHING CARE HOSPITAL, GUJRAT
Background: Prescription of drugs which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also know the pathophysiology of diseases and attitude towards rational prescribing. Methods: Retrospective study was carried out by collecting 350 prescriptions containing antimicrobial agents of the indoor patie...
IN-VITRO AND IN-VIVO EVALUATION OF GLYCERIN AS A SOLVENT FOR THE IONTOPHORETIC DELIVERY OF DIPHENHYDRAMINE HYDROCHLORIDE
Diphenhydramine hydrochloride (DPH) is an antihistamine used topically to relieve skin itching and, at higher doses, DPH also has the capability to induce local skin anesthesia. The present study investigates the possibility to deliver DPH via iontophoresis using a stainless steel electrode. In-vitro iontophoresis was performed using 1% (w/v) DPH dissolved in glycerin (100%), deionized (DI) wate...
The purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction was investigated by FTIR and their results directed...
Depression is a well-defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easil...
DESIGN OF SYNTHETIC ANTIMICROBIAL PEPTIDES AGAINST RESISTANT ACINETOBACTER BAUMANNII USING COMPUTATIONAL APPROACH
Acinetobacter baumanniiis typically coccobacillus Gram-Negative bacterium, resists almost all antibiotics in use. Synthetic antimicrobial peptides (AMPs) against this bacterium were designed with the aid of computational software and databases to be with the accepted models. Antimicrobial peptides (AMPs) might be the candidate solution for the this problems. Four peptides designated MY1, MY2, MY3 ...
IN-VITRO EVALUATION OF THE ANTIDIABETIC & CYTOTOXIC ACTIVITIES OF EARTHWORM (LUMBRICUS RUBELLUS) EXTRACTS
This in-vitro antidiabetic and cytotoxic activity of earthworm Lumbricus rubellus extracts were investigated. In the present study, three types of solvent (petroleum ether, 95% ethanol and phosphate buffer) extracts of earthworm paste were prepare and subjected to preliminary screening. The antidiabetic activity was determined in terms of its ability to inhibit the α-amylase activity. Different c...
Typhoid fever and paratyphoid fever (also known as enteric fever, but collectively referred here as typhoid Fevers) are severe systemic illnesses characterized by sustained fever and abdominal symptoms. Treatment of typhoid fever becomes difficult by the development of multi-drug resistant of typhoid organisms especially to ampicillin, trimethoprim-sulfamethoxazole and chloramphenicol. In recent y...
EFFECT OF HIGH LIPID DIET IN SHRINKING THE AMPICILLIN-INDUCED NEUROTOXICITY IN RAT PUPS, INTER-RELATED TO AUTISM ETIOLOGY
Improper diet can affects the brain and can increase the risk for mental disorders and neurodegenerative diseases like autism. Dietary modification can sometime be helpful to children with autism. The present study examined the effects of a high lipid diet on orally administered ampicillin -induced neurotoxic rats and compared with propionic acid models of autism. Forty young male western albino r...
ANTICANCER, ANTIOXIDANT ACTIVITY AND GC-MS ANALYSIS OF SELECTED MICRO ALGAL MEMBERS OF CHLOROPHYCEAE
Microalgae have been widely used as novel source of bioactive substances. These substances exhibit various biological actions including, antioxidant, antimicrobial, antiviral, antitumoral, anti-inflammatory and anti-allergy effects. In the present investigation algal biomass in methanol extracts of chlorophyceae member of three micro algae of Chlorella vulgaris, Desmococcus olivaceous and Chloroco...