Drug release properties from dosage forms can be modified by using many rate controlling polymers. Such controlled release properties from carrier systems are desirable since efficient drug delivery is achieved. The aim of the present study was to develop efficient chitosan nanoparticles loaded with rosmarinic acid (RA) and evaluate its drug release properties and wound healing efficiency in rats....
FORMULATION, EVALUATION AND CYTOTOXIC POTENTIAL OF METRONIDAZOLE LOADED POLOXAMER 407 HYDROGEL IN SCC-29 CELL LINES
The present research work was planned to formulate poloxamer 407 based hydrogel formulations of metronidazole and the evaluation of various parameters like swelling behavior, drug PH stability, in-vitro and in-vivo drug release, and in-vitro cytotoxic activity. Two different concentrations of metronidazole hydrogel formulations were prepared using poloxamer 407 and were assessed by a validated HPL...
This article reveals a detailed review of important constitutes of herbal drugs which will be useful to treat various types of cancer. Cancer is the second leading cause of death in both developed and developing countries as the number of mortalities is increasing day-by-day and year after year. Herbal drugs have contributed for the discovery of new anticancer drugs due to conventional cancer ther...
The role of liquid membrane hypothesis has been studied in the mechanism of action of Ertapenem. In the present study transport of selected permeants (glucose, p-amino benzoic acid and ions like magnesium, ammonium, phosphate, calcium, sodium, potassium and chloride) through liquid membrane generated by Ertapenem in series with supporting membrane has been studied. The results indicate that the li...
VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAUNORUBICIN AND CYTARABINE IN BULK AND ITS PHARMACEUTICAL DOSAGE FORM
This paper describes a new validated Reverse-Phase High-Performance Liquid Chromatography (HPLC) method for the simultaneous determination of two anti-cancer drugs, Daunorubicin and Cytarabine (Ara-C). A simultaneous determination method saves cost and time as both drugs can be injected into a single HPLC system without the need to change or re-equilibrate with a new mobile phase. The objective of...
Present study explains the cancer nano-therapeutics which is rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability. To improve the bio-distribution of cancer drugs, nanoparticles have been designed with optimal size and surface characteri...
A COMPARISON BETWEEN WELLS’ SCORE AND MODIFIED DOPPLER ULTRASOUND IN THE DIAGNOSIS OF DEEP VENOUS THROMBOSIS OF THE LOWER LIMB
The assessment of the probability of occurrence of deep vein thrombosis played a very important part in making a correct diagnosis and modified Wells’ score is a widely used prediction rule for pre-test probability assessment. We aimed to evaluate the diagnostic accuracy of the modified Wells’ score in the diagnosis of lower extremity deep vein thrombosis compared to Doppler ultrasound study. ...
The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet h...
EVALUATION OF THE ANTI – PROLIFERATIVE EFFECT, ANTIOXIDANT AND PHYTOCHEMICAL CONSTITUENTS OF FICUS PUMILA LINN.
This study sought to evaluate the heavy metal content of the raw powder and extract of the plant, the phytochemical constituents, antioxidant effect by the use of DPPH assay, the total phenolic content using Folin Ciocalteu assay and the cytotoxic effect using the MTT Assay of Ficus pumila ethanolic extract, methanolic and hydro fractions on liver cancer cells (HepG2), Leukemic cells (Jurkat) and ...
INTERACTION OF TETRACYCLINE HYDROCHLORIDE WITH IRON: KINETIC SPECTROPHOTOMETRIC AND CONDUCTOMETRIC INVESTIGATIONS
The interaction of the antibiotic, tetracycline hydrochloride (TC.HCl) has been investigated employing three simple spectrophotometric and conductometric methods. In methods (A and B), a kinetic spectrophotometric procedure based on the oxidation of (TC.HCl) by Fe3+ ion in the presence of 1, 10 - Phenanthroline (o-phen) (A) and 2, 2′- Bipyridyl (bipy) (B) was developed. The formation of the ferr...