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ACU-TENS STIMULATION AT BILATERAL ZUSANLI (ST36) ACUPOINT IN STREPTOZOTOCIN INDUCED DIABETIC RATS
The ancient medicine acupuncture was used to treat the diabetes and its complications. Our study was aimed to find out the hypoglycemic effect of Acu-TENS electrical stimulation at bilateral Zusanli (ST36) acupoint in streptozotocin (45 mg/kg/body weight/IP) induced diabetic rats. Diabetes was induced in male albino wistar rats with the administration of single dose of streptozotocin(45mg/kg/body ...
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POLYETHYLENE GLYCOL (PEG) SUPPORTED AMINO DENDRIMERS (DENDRITIC TRIBLOCK COPOLYMER) FOR DELIVERY OF METHOTREXATE (MTX)
Dendrimers are synthetic, highly branched, nanosized, monodisperse macromolecule which proving their applicability in different areas like diagnosis, drug delivery, gene delivery, molecular encapsulation etc. Due to their widespread applications, scientific community is continually engaged in developing newer dendrimers with advanced properties. In the present study, amino dendrimers are synthesiz...
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ADVERSE DRUG INTERACTIONS IN ELDERLY HOSPITALIZED PATIENTS: A PROSPECTIVE ANALYSIS
Objective: To determine the incidence, characteristics, predictors and cost associated with the management of adverse drug interactions (ADIs) in elderly population. Methods: The prospective, intensive and interventional study included all patients taking at least two medications who were elderly admitted to medicine or surgery wards of a tertiary care hospital and were followed untill discharge. ...
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SELF RATED SYMPTOM MEASURE OF VARIOUS MENTAL HEALTH DOMAINS OF UNDERGRADUATE MEDICAL STUDENTS OF TERTIARY CARE TEACHING HOSPITAL
Introduction: Mental disorders account for nearly 12% of the global burden of disease. They are expected to become the second most important cause of disability in the near future. Medical students remain under great academic pressure to pass internal and external exams which continuously keep them under pressure. It is also very important to know how students feel rather than to treat only those ...
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POSTMENOPAUSAL OSTEOPOROSIS- AN UPDATED REVIEW
Osteoporosis is a major growing public health problem with impact that crosses medical, social, and economic lines. Osteoporosis in older women is the 2nd most cause of death in America thus it is one of the essential area to be understand in medical science and need to update time to time. The objective of the present review is to update all aspect of osteoporosis in postmenopausal women, includi...
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DNA BINDING AND CYTOTOXICITY STUDIES OF TERNARY COPPER(II) COMPLEXES CONTAINING HETEROCYCLIC BASES AND THIOUREA
This article describes the Cu(II) complexes including [Cu(phen)(L-val)TU)] 1 & [Cu(bpy)(L-val)TU)] 2 (phen = 1, 10-phenanthroline; bpy = 2,2’-bipyridyl, L-val = L-valine and TU = Thiourea). The complexes were synthesized by ligand substitution method and characterized by various physicochemical techniques. The intense UV band around 270 nm was due to n-π* transition. The binding behaviors o...
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FORMULATION AND OPTIMIZATION OF OSMOTICALLY CONTROLLED, MICROBIALLY TRIGGERED COLON TARGETED SYSTEM USING FACE CENTERED CENTRAL COMPOSITE DESIGN
The purpose of present investigation was to achieve successful delivery especially to colon using microbially triggered, osmotically controlled approach. Prednisolone was chosen model drug for treatment of inflammatory bowel disease (IBD). Prednisolone-β-cyclodextrin complex were prepared and phase solubility study was carried out. Cellulose acetate solution containing chitosan was used to prepar...
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EFFECTS OF PORPHYRA VIETNAMENSIS EXTRACT ON TNBS-INDUCED COLITIS IN RATS
Objective: This study aimed to investigate the intestinal anti-inflammatory activity of a methanolic extract of Porphyra vietnamensis in the TNBS model of intestinal inflammation in rats. Methods: The study included (i) Identification and quantification of Porphyra-334 in P. vietnamensis, (ii) investigation of the effect of methanolic extract on DNA cleavage induced by H2O2 UV-photolysis, (iii) 50...
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STUDIES ON STRUCTURAL PROPERTIES OF THE BINARY MIXTURES OF PHARMACEUTICAL INTERMEDIATES THROUGH DIELECTRIC INVESTIGATIONS
The homo and hetero interaction in the binary mixtures of Ethyl acetate + n-Butylamine, Ethyl acetate + Cyclohexylamine and Ethyl acetate + Diethylamine has been investigated through the orientation of dipoles using dielectric polarization method. The dielectric and thermodynamic parameters such as Kirkwood correlation factor, Excess permittivity, Bruggemann factor and Dipolar excess free energy f...
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A NOVEL APPROACHES FOR DRUG DEVELOPMENT AND PHARMACOLOGICAL STUDY OF HERBAL PLANT
From ancient times, herbal medicines are in use to cure the diseases due to their impending and less side effects. But complications in identification, processing, standardizing, extracting of herbal drugs, it seldom attracts scientists towards the development of novel delivery systems for herbal drugs. During drug development, the complete knowledge of novel scientific approaches like toxicity st...
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