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SYNTHESIS AND SPECTROSCOPIC CHARACTERISATION OF Cr(III) COMPLEXES DERIVED FROM 2-BENZOYLPYRIDINE AND 2-BENZOYLTHIOPHENE WITH THIOSEMICARBAZONE AND SEMICARBAZONE
The complexes of chromium(III) are synthesised with thiosemicarbazone (L1&L3) and semicarbazone (L2) derived from 2-benzoylpyridine and 2-benzoylthiophene having general composition [CrL2X2]X (Where L=L1&L3(L1&L3= thiosemicarbazone ligand and L2= semicarbazone ligand) and X= NO3- and OAc-) have been synthesised. The complexes and ligand under study are characterised by elemental analys...
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ANTICOCCIDIAL AND ANTIOXIDANT ACTIVITY OF GASTRO’IMMUNE -POLYHERBAL FORMULATION ON COCCI OOCYSTS INFECTED MICE JEJUNUM
Herbal drugs are prescribed widely as an anti-coccidial agent even when their biologically active compounds are unknown, because of their effectiveness, lesser side effects, and relatively low cost. So, in the current study, a poly-herbal formulation was used to find out its effect as an anti-coccidial effect. In the present study, the parameters evaluated were the WBC count, Glutathione levels, m...
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FOUR MOST LIFE THREATENING UROGENITAL CANCER AND ITS MANAGEMENT
Now a day’s urogenital cancer is the life threatening disease in worldwide, among them most four life threatening urogenital cancers are kidney cancer, bladder cancer, prostate cancer and testicular cancer. Kidney cancer or renal cell carcinoma (also called adenocarcinoma) is a disease in which malignant cancer cells are found in the living of tubules (renal epithelium). The kidney cancer has th...
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IDENTIFICATION AND QUANTIFICATION OF OLEANOLIC ACID FROM CYCLEA PELTATA BY HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY (HPTLC) METHOD
Objective: To identify and quantify oleanolic acid from the roots of cyclea peltata by HPTLC method. Methods: The Plant cyclea peltata is a perennial herb from Menispermacae family. The powdered roots of plant cyclea peltata were extracted with methanol. Methanolic extract prepared separated with n-butanol, chloroform, and ethyl acetate as total saponin, total alkaloid and phenolic compound fracti...
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ACCURACY OF STANDARDS IN CHOLESTROL DIAGNOSTIC KITS
The percentage error observed in the claimed standard concentration of cholesterol 200 mg/dl for kits A to D is found to be 0.6, 12.3, 8.96 and 3.76 respectively. As per the guidelines of CLIA 8 allowable error is +10% for cholesterol estimation. Similarly as per the NCEP 9 guidelines + 9 % error is allowable. Therefore, it is noted that kit A is the best kit with an error of just 0.6% followed by...
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MITOCHONDRIA: INSIGHT TARGET OF DRUG DEVELOPMENT IN CANCER CELLS
Mitochondria are involved in different physiological and pathological processes that are crucial for tumor cell physiology, growth and survival and its dysfunction leads to many human abnormalities, including cardiovascular diseases, neurodegenerative diseases, autoimmune disorders and cancer. The present review is focused on the different experimental and therapeutic cancer strategies addressed t...
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ISOLATION, IDENTIFICATION AND QUANTIFICATION OF BIOACTIVE COMPOUNDS FROM AMARANTHUS HYPOCHONDRIACUS LEAF EXTRACT: A VITAL SOURCE OF POTENT NATURAL ANTIOXIDANTS
In this study we aimed at isolation, identification, and quantification of two phenolic compounds reported for the first time in leaves of Amaranthus hypochondriacus. A non targeted GC-MS metabolite profiling of hexane extracts of amaranth leaves was done which indicated the presence of major phenolic compounds. Two alkylated phenols namely 2,4-di-tert-butyl phenol (A) and 3-(3,5-di-tert-butyl-4-h...
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POLY (LACTIC-CO-GLYCOLIC ACID) BASED DOUBLE EMULSION NANOPARTICLE AS ACARRIER SYSTEM TO DELIVER GLUTATHIONE SUBLINGUALLY
The sublingual delivery of drugs represents a continuing challenge, as well as an opportunity. In this study, a poly (lactic-co-glycolic acid) (PLGA) based Water-in-Oil-in-Water (w/o/w) double emulsion of nanoparticles was developed as potential platform technology, to generate sustained drug release profile and maximize the bioavailability of the glutathione (GSH). Two-level full factorial design...
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IN-VITRO ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF DIOSPYROS MELANOXYLON ROXB.
The present research focuses on the screening of phytochemicals from an Indian medicinal plant Diospyros melanoxylon Roxb. by both qualitative and quantitatively and biological activities. Different solvent extracts were prepared and used for this study such as hexane, chloroform, methanol, ethyl acetate and aqueous. Preliminary screening of phytochemicals revealed that the methanolic extract comp...
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STORAGE OF WORKING STANDARDS IN POLYPROPYLENE CONTAINERS, ITS EFFECT, CONTAMINANTS AND IMPACT ON ANALYSIS ON LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROSCOPY
Authorspropose a method to determine the contamination caused during the storage of colchicine stock solution, which will be helpful for the bioanalytical scientists. The process of identification of impurities, exceptionally in this case, started from the point of optimization of the compound, where in the parent ion was not detected and instead an unknown mass is being interpreted by the detecto...
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