Volume 10 (2019) - Issue 10, October
A REVIEW ON ETIOLOGY AND CHALLENGES ASSOCIATED WITH VARIOUS THERAPIES FOR THE TREATMENT OF PSORIASIS
Psoriasis is autoimmune, hyperproliferative skin disease, which is affecting 2-5% of the population. Etiology of psoriasis is multi-factorial. The disease is identified as periodic recycle of events with red-scaly skin plaques. The epidemiology of Psoriasis is still unknown. From medication, this disease can only be prevented. Currently, there are many approaches to cure this disease, but still, n...
Metabolic syndrome, the most prevailing health concern worldwide, and their incidences are increasing at a very high rate, resulting in enormous social costs. Obesity is a measure risk factor for non-communicable disease such as cardiovascular diseases, diabetes, cancer, and inflammation-based diseases. Therapeutic strategies for managing this syndrome include synthetic drugs and surgery, which en...
Rhus pentaphylla (Jacq.) Desf. (Searsia pentaphylla (Jacq.) FA. Barkley) is used for its colorant and tanning properties by the local population. The bark, leaves, roots, and fruits are employed in Moroccan traditional medicine to treat gastrointestinal disorders and diarrhea. Nevertheless, the pharmacological properties of R. pentaphylla on cardiovascular diseases have not yet been presented. Thi...
The leading factor restraining the intensification of herd reproduction is endometritis. The article states that the microflora of cow uterine exudate in chronic purulent-catarrhal endometritis is represented by Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Citrobacter freundii, Streptococcus faecalis, Streptococcus faecium, as well as anaerobes and group С Streptococci. The drug "Mi...
COMPARISON OF THE TOXICOLOGICAL EFFECT OF LEAD-BASED HERBO-MINERAL PREPARATIONS AND THEIR CORRESPONDING METAL NANO-PARTICLE ON ENZYMATIC ACTIVITY AND GROWTH OF BAKER’S YEAST
Metallic toxicity associated with Ayurvedic formulations like herbomineral preparation (Bhasma), especially because of heavy metals such as lead, has always been a matter of debate in the scientific community. Instead of that, ancient Ayurvedic literature reveals that sodhana process used for the preparation of such formulations, either decreases or eliminate the toxic effect of such heavy metals ...
The objective of this study was to evaluate the toxicity of a saponin isolated from the fruits of the Momordica dioica as per OECD guidelines. Saponin was isolated from the methanolic extract of the fruits of M. dioica, and acute, sub-acute, sub-chronic and chronic toxicity was evaluated. The study of the acute toxicity of saponin M. dioica (SMD) at a single dose of 5000 mg/kg/b.w. by oral route i...
STABILITY INDICATING ASSAY METHOD DEVELOPMENT AND VALIDATION OF EDOXABANTOSYLATE MONOHYDRATE: A COMPREHENSIVE STUDY INVOLVING IMPURITIES ISOLATION, IDENTIFICATION AND DEGRADATION KINETICS DETERMINATION IN VARIOUS CONDITIONS
Objective: State of the art, robust and environmentally benign stability indicating assay method (SIAM) has been developed for model drug Edoxabantosylate (EDO) Methods: Successful RP-HPLC chromatographic method was accomplished on a CHROMBUDGET® 100-5-C18 column (250 mm × 4.6 mm, 5 μ) column using methanol and acetate buffer in the ratio of 53:47 having 2.9 pH and 10mM buffer strength. The deg...
PHARMACOLOGICAL EVALUATION OF ANTI-ULCER EFFECTS OF COMBINED DOSES OF ALOE VERA AND VITAMIN-E AGAINST INDOMETHACIN INDUCED PEPTIC ULCER MODEL
Peptic Ulcer Disease (PUD) is one of the most prevalent pathogenic conditions which affects around 5-10% of the global population. Helicobacter pylori infection and the use of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are two of the most common etiological causes in the PUD pathogenesis. First line treatment for PUD involves use of drugs which cause acid suppression or target against the erad...
EFFECTS OF USING DIFFERENT LEVELS OF CHROMIUM PICOLINATE ON PERFORMANCE, SOME BLOOD BIOCHEMICAL AND INTESTINAL MORPHOLOGY AND MICROFLORA IN ROSS 308 BROILER CHICKS EXPOSED TO THE HEAT STRESS CONDITION
This study was aimed to investigate the effects of different levels of dietary chromium picolinate (CrPic) on performance, some blood biochemical and intestinal morphology and microflora in Ross 308 broiler chicks. A total of 240 broiler chickens Ross 308 strain, from 21 to 42 days old were used in a completely randomized design. All chickens consumed a diet based on the corn-soybean meal, and the...
ROLE OF ANDROGRAPHIS PANICULATA ON ALTERED STEROIDOGENESIS AND OXIDATIVE IMPAIRMENT IN OVARY OF MICE SUBJECTED TO ARSENIC INTOXICATION
The present study was designed to determine the role of Andrographis paniculata (AP; 50 mg/kg) against the oxidative stress caused by the arsenic (0.5 and 1.0 mg/kg) for 30 days in adult mice. The results of in-vivo studies demonstrated that arsenic treatment resulted in a significant dose-dependent increase in the ovarian arsenic level and lipid peroxidation (LPO), followed by a marked reduction ...
Rapid precorneal elimination of the drug in conventional ophthalmic solution leads to poor bioavailability and less therapeutic response, which can be overcome by the use of in-situ gel forming system that is instilled into the eye and undergoes a sol-gel transition in the cul-de-sac. The aim of the present study was to formulate and evaluate pH-triggered in-situ gels for ophthalmic delivery of of...
SYNTHESIS, CHARACTERIZATION, AND DNA- BINDING INTERACTION STUDIES OF A NEW MANNICH BASE AND IT’S METAL COMPLEXES
Cyclic imides such as succinimides, maleimides, phthalimide and their derivatives contain an imide ring and a general structure –CO-N(R)-CO- that confers hydrophobicity and neutral nature. Succinimide (pyrolidine 2,5-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Derivatives of succinimide are of important ...
Background: Chloramphenicol capsules are found in several brands with different prices in the market. This study aimed to obtain in-vitro biopharmaceutics quality data from the generic and branded name products. Methods: Ten products were selected, consisted of 3 generics (A, B and C) and 7 branded names (D, E, F, G, H, I and J); F was chosen as an innovator. The dissolution test was performed by ...
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral rout...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF DASATINIB IN TABLET DOSAGE FORM
The objective of the present study was to develop and validate a novel RP-HPLC method for the determination of Dasatinib in the pharmaceutical dosage form. Chromatographic separation was conducted on agilent technologies-1260 series with the G1311C quaternary pump, Thermo Scientific C18 column (4.6 mm i.d. × 250 mm, 5 µm particle size) and equipped with photodiode array detector G1315D. The mobi...
Background: Oleogel is a thermo-reversible, viscoelastic, semi-solid self-assembled preparation in which an apolar phase gets immobilized within a 3-D networked structure formed via physical or chemical interaction with different organogelators. Objective: The objective of the present investigation was to develop drug-loaded (paracetamol) Span 40 / Tween 80-based soybean oleogels for topical appli...
IN-SILICO MOLECULAR SCREENING OF NATURAL PLANT PRODUCTS FOR THE IDENTIFICATION OF NOVEL POTENTIAL CHEMOTHERAPEUTIC AGENTS AGAINST BREAST CANCER
In-silico computational approaches help in ascertaining drug targets via bioinformatics tools. HER2 is the most valuable therapeutic target for breast cancer therapy. The overexpression of HER2 protein plays a very critical role in the progression of breast cancer. Plant-derived natural products have received increasing attention over the past 20-30 years for their potential as novel therapeutic a...
Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during recent years because of their potential pharmacological properties. Thiourea and their derivatives are important versatile reagent in organic synthesis and show strong antibacteria...
CHARACTERIZATION AND EVALUATION OF NIZATIDINE FLOATING MICROSPHERES BASED DRUG DELIVERY SYSTEM FOR ANTI-ULCER ACTIVITY
Objective: The purpose of the present study to develop gastro-retentive drug delivery formulation for enhancing GRT, including the physiological and formulation variables affecting gastric retention. It is a widely employed approach to retain the dosage form in the stomach for an extended period and release the drug slowly that can address many challenges like poor bioavailability. Methods: Floati...
Present work is aimed at development and characterization of phytosomes, novel drug delivery dosage form used to improve the bioavailability of the drug, containing ethanolic, aqueous, dichloromethane and ethyl acetate extract of Citrullus colocynthis to meet the need for better effectiveness and safety. Required phytosomal formulations were developed using different extracts of Citrullus colocynt...
The objective of the present study was to formulate and evaluate a gastro-retentive stomach specific novel floating in-situ gelling system of curcumin for potentially treating gastric ulcer, associated with Helicobacter pylori. The in-situ gel of curcumin was prepared by dissolving different concentrations of gelling polymer like sodium alginate in distilled water at 60 ºC. After cooling to 40 º...
ASSESSMENT OF IN-VITRO ANTICANCER AND ANTIBACTERIAL ACTIVITIES OF CARCHORUS HIRSUTUS PHYTOMEDIATED OPTIMIZED NANOSILVER
The elected work reports for the first time successfully synthesized nanosilver from the aqueous leaf extract of the Carchorus hirsutus plant. Because the phytochemicals within the leaf extract were creditworthy for the reduction of silver ions as the active nanosilver particles, in addition to this, they act as the capping agents who had been environed at the surface of the particles. UV-Vis spec...
HPTLC METHOD DEVELOPMENT AND VALIDATION FOR IDENTIFICATION AND QUANTIFICATION OF LUPEOL IN THE LEAVES OF ALSTONIA SCHOLARIS
In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavono...
ESTIMATION OF IPRATROPIUM BROMIDE BY EXTRACTION FREE SPECTRO-PHOTOMETRIC METHOD USING SULPHONAPTHALEIN DYE
The present paper portrays a simple, rapid, nonextractive spectrophotometric method for the estimation of an anticholinergic drug, Ipratropium Bromide. The method is based on the formation of an instantaneous stable yellow colored ion pair complex of drug with a chloroformic solution of reagent Bromophenol Blue (BPB) which shows absorption maxima at 416 nm. Job’s plot of continuous variation aff...
Modified Benzoxazocine moiety of Nefopam with N-Protected-ethanolamine, fluorobenzene benzylbromide, 2,3-dimethyl-benzene, naphthalene, fluro-naphthalene. In these modification Friedel Craft alkylation plays vital role with using grignard reagent and aluminum chloride with the starting phthalic anhydride to form acid compound and was converted to amide compound with using of thionyl chloride, N-Pr...
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY BASED URINARY METABOLIC PROFILING IN POST TRAUMATIC STRESS DISORDER RATS
Though at present, Post-Traumatic Stress Disorder (PTSD) stands to be one of the major mental debilitating psychiatric disorders, however, its clinical diagnosis remains unachieved due to the absence of any biological marker. Hence, this study is aimed at the identification of putative biological underpinnings of PTSD through the metabonomic approach. For this purpose, the animal model based NMR s...
ANTIBACTERIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITY OF BACTERIAL CAROTENOIDS ISOLATED FROM RHODOPSEUDOMONAS PALUSTRIS KRPR01 AND KRPR02
The microbial pigments have more applications than synthetic pigments and are easily biodegradable and safe to use. Among all bacteria, the anoxygenic phototrophic purple non-sulfur bacteria have more applications and can synthesize different pigments. In this present study, bacterial carotenoids were isolated from the two novel strains of Rhodopseudomonas palustris and evaluated its applications....
Epilepsy is a disorder of the central nervous system. A seizure occurs when the brain’s nerve cells misfire and generate a sudden uncontrolled surge of electrical activity in the brain. Seizures can be controlled with modern medicines and surgical techniques and are found to have so many side effects. Natural products from folk remedies are an alternative source of anti-epileptic drugs with bett...
In this study, in-situ raft forming Levofloxacin Suspension formulation was developed. In-vitro conditions like temperature, pH, and RPM simulating the in-vivo conditions like gastric pH, body temperature, and gastric motility respectively were identified as critical process parameters in system scale-up studies. Challenging and characterization were performed in-vitro. The working limits were ide...
FORMULATION AND EVALUATION OF ENTERIC COATED ASPIRIN TABLET BY USING BIOEPOXY RESIN AS COATING MATERIAL
An enteric coating is a polymer barrier applied to oral tablets; it prevents dissolution and disintegration of tablet in the gastric environment. Some drugs like aspirin that have an irritant effect on the GI Track after administration, can be prepared as enteric-coated tablet. Aspirin is used to reduce fever and to relieve pain from various conditions. By coating aspirin tablet with polymer it pr...
Inflammation is part of the body's immune response. There can be four primary indicators of inflammation: pain, redness, heat or warmness and swelling. Plants have the ability to synthesize a wide verity of phytochemical compounds as secondary metabolites which shows anti-inflammatory activity. The anti-inflammatory activity of ethanol extract of Tiliacora acuminata stem and leaf was evaluated usi...
IMPACT OF HYDROTHERMAL ISOLATION METHOD ON THE RECOVERY OF FENUGREEK SEED HEMI-CELLULOSE ANALYZED THROUGH FTIR-DSC-SEM INTERPRETATIONS
Natural Herbal components like seeds mucilages, exudates, gums, polysaccharides, celluloses, hemicelluloses, starch, etc. are now a day’s exploited as excipients. Literature reveals medicinal, nutraceutical and pharmaceutical uses of fenugreek seed hemicelluloses in dosage form design. Hemicelluloses like galactomannans are water-soluble polysaccharides highly susceptible to hydrolysis either by...
TLC BIOAUTOGRAPHY AND LCMS-MS ANALYSIS FOR IDENTIFICATION OF COMPOUNDS HAVING INHIBITORY ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS IN ABIES WEBBIANA LEAVES EXTRACT
This study was performed to identify the antimicrobial compounds in Abies webbiana leaves. The antimicrobial compounds were identified by LCMS-MS. The microbial inhibitory activity was evaluated on Staphylococcus aureus ATCC 6538 using REMA technique and Agar-overlay TLC bioautography. The chloroform extract of Abies webbiana leaves was used for the study. The MIC against Staphylococcus aureus was...
COMPARATIVE ACUTE AND SUB-ACUTE TOXICITY STUDY OF HYDRO-ALCOHOLIC EXTRACTS OF CENTELLA ASIATICA AND EVOLVULUS ALSINOIDES IN SWISS ALBINO MICE
In this study, the in-vivo toxicity of Centella asiatica & Evolvulus alsinoides were evaluated by acute and sub-acute toxicity assays according to the guidelines of OECD 423 & 407 respectively. For LD50 evaluation, a single dose of hydro-alcoholic extracts of both plants was orally administered to Swiss albino mice at doses of 200, 400, 800, 1600 and 2000 mg/kg. Then the animals were obse...
The present study investigates the wound healing activity of ethanolic extract of the fruit of Luffa acutangula. The medicinal values of the Luffa acutangula have been mentioned ancient literature as useful in disorders of wound. Dried fruits of Luffa acutangula were powdered and extracted with ethanol using soxhlation method. Ethanolic extract of Luffa acutangula was evaluated for its wound heali...
PHARMACOKINETICS AND BIOEQUIVALENCE ASSESSMENT OF ORAL RIVAROXABAN TABLET IN IRANIAN HEALTHY VOLUNTEERS
Rivaroxaban is utilized as a direct factor Xa inhibitor for the prevention and remedy of thromboembolic disorders. This study aimed to evaluate a generic version of rivaroxaban 10 mg tablet. Considering previous reports of safety and tolerability of a single dose (1.25-80 mg) of rivaroxaban, this study used a randomized, single-dose two-way crossover of rivaroxaban in 28 healthy volunteers, with a...
GC-MS INVESTIGATION OF PHYTOCOMPONENTS PRESENT IN ETHANOLIC EXTRACT OF PLANT ICHNOCARPUS FRUTESCENS (L.) W. T. AITON AERIAL PART
Ichnocarpus frutescens (Apocynaceae) generally renowned as Kali Sariva in Sanskrit, Krishna Sariva in Hindi which is a large, evergreen, red woody climber, native to India, Java, China, Southeast Asia, Ceylon, Northern Australia and found ascending to an altitude of 4,000 ft. Different tribes of India are used this plant as a substitute of Indian Sarsaparilla (Hemidesmus indicus). It has been used...
Background: Garlic has been used in world culinary art as well as in herbal medicine since long back. Allicin, an active moiety in garlic, is truly recognized as heart of garlic. But allicin is highly unstable and undergoes formation of numbers of sulfur-containing compounds with reduced allicin content. The major problem associated with dosage form development is instability of allicin. Objective...
PHARMACEUTICAL VALIDATION & PROCESS CONCEPTUALISATION OF ANCIENT INDIAN CALCIUM PREPARATION: SHANKHA BHASMA
In the present study, the pharmaceutical and therapeutic dimensions of Shankha Bhasma (Classical Ayurvedic marine medicine) is explored as a substitute for calcium supplements available in the market. Shankha Bhasma was prepared & standardized by Ayurvedic pharmaceutical procedure accordingly in Rasa Tarangini (a classical 20th-century book on Ayurvedic pharmaceutical medicine). Conch shell (S...
SYNTHESIS OF PURE AND BIO MODIFIED CALCIUM OXIDE (CaO) NANOPARTICLES USING WASTE CHICKEN EGG SHELLS AND EVALUATION OF ITS ANTIBACTERIAL ACTIVITY
Calcium oxide nanoparticles (CaO NPs) gain great value in the areas of energy storage and drug delivery systems. Due to good porosity, it finds its part in storage systems and its biocompatibility earns it a good value in drug delivery and gene transfection. Synthesis of nanoparticles by waste materials and plants of metal oxide is gaining considerable interest due to environmentally friendly reac...
DEVELOPMENT AND INVESTIGATION OF THERMO-SENSITIVE ORGANOGEL OF DICLOFENAC SODIUM FOR IN-SITU IMPLANTATION
The aim of the present study was to develop and evaluate thermo-sensitive in-situ implant forming injectable organogel systems of diclofenac sodium for prolonged drug effects. The formulations were prepared by separately dissolving fatty acids such as arachidic acid, stearic acid or palmitic acid in injectable soybean oil. The organogels were evaluated for physicochemical parameters as well as for...
Chemical, physical, and biological methods have been developed to synthesis nanoparticles but chemical and physical methods are involved in the production of toxic by-products which are hazardous moreover the methods are very expensive. To synthesis stable metal nanoparticles with controlled size and shape, there have been searched for inexpensive, safe, and reliable and “green” approach. The ...
The solar UV radiation is the major trigger factor that causes skin cancer. Nearly 65% of cases of melanoma occurs dues to high exposure to the UV radiation. It also accounts for 90% of the nonmelanoma skin cancers also referred to as NMSC also including the cases of basal cell carcinoma (BCC) and the squamous cell carcinoma (SCC). The rate of malignancy in other cases has seemed to get reduced bu...
The present research work was carried out to Formulate and evaluation of bilayer tablet dosage form for the treatment of Hypertension. The objective of this study to compare the specific characteristics of Olmesartan Midoxomil [Angiotensin II receptor antagonist] and Hydrochlorothiazide [Thiazide Diuretics] in order to design stable formulation. It can be concluded that Olmesartan Midoxomil [Angio...
Background: The irrational uses of antibiotics play a crucial role in emerging of antimicrobial resistance. So regular review of the prescribing patterns represents an effective monitoring study that enhances rational prescription of antibiotics. This study evaluated the prescribing pattern of antibiotics at Al-Rass hospital in Qassim region. Methodology: A retrospective cross-sectional study was ...
Metabolic syndrome is a group of several clinical conditions which is related to the prevalence of another disease such as cardiovascular disease, diabetes mellitus (DM) or increased fasting blood glucose level, visceral obesity, hypertension, etc. The major factor that affects the metabolic syndrome occurrence is diet composition.This research aimed to determine the influence of diet composition ...
GENDER WISE PREVALENCE OF COMORBIDITIES AND MEDICATION ADHERENCE AMONG TYPE 2 DIABETICS IN MALAPPURAM
Background: Type 2 diabetes is a major lifestyle disease often seen with comorbidities or complications. This study is conducted to find out the gender-wise prevalence of comorbidities and medication adherence among the diabetics in Malappuram. Methods: A cross-sectional study was conducted among the 179 diabetics selected for the study. A pre-tested interview schedule was used to collect informat...
AN ANALYTICAL STUDY ON THE CLINICAL EFFICACY OF PEENISA PUGAI TOWARDS THE MANAGEMENT OF PEENISAM (SINUSITIS)
Pugai (fumigation) is one among the external medicines in treating a variety of diseases with the fumes of herbs or aromatic substance. Peenisa pugai is an external therapeutic measure that has been indicated in Siddha literature for the effective management of Peenisam that can be symptomatically correlated with that of Sinusitis. The aim of the present Pilot study was to compare the efficacy of ...
SCREENING OF 4-([1,3,4]OXADIAZINO[6,5-b] INDOLE-3-YL)ANILINE DERIVATIVES FOR ANTI-BACTERIAL ACTIVITY BY IN-SILICO AND IN-VITRO METHODS
Schiff bases of isatin are investigated overtime for their pharmaceutical properties and have been found to have various activities such as anti-viral, anti-bacterial, anti-inflammatory, analgesic, anti-HIV, anti-depressant, anti-convulsant, fungicidal, etc. Isatins are treated with hydrazine derivatives and cyclized by sulfuric acid. These compounds are alkylated by di alkyl aminoalkyl halides in...