Volume 16 (2024) - Issue 1, January
Review Articles
EXPLORING MICROBIOTA DYNAMICS: FROM TRADITION TO INNOVATION IN HEALTH
The human microbiota, a complex assembly of microorganisms residing in various bodily niches, plays a critical role in health and disease. Historically, traditional medicine implicitly recognized the importance of the microbiota through the use of fermented foods and herbal remedies, which we now understand can influence the gut microbial composition and contribute to a robust immune system and im...
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SCALE-UP OF EXTRACTION PROCESS FOR DILL SEED OIL
Concentrated preparations called extracts are made from raw materials by isolating specific components through specific methods. Essential oils, tinctures, liquid extracts, and dry extracts are among the different kinds of extracts. The type of input material, the solvent employed, the temperature, and the extraction time are all important variables. Efficiently isolating and condensing particular...
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A BRIEF REVIEW ON STEM CELLS
Despite being hard to define, stem cells have a lot of potential as therapeutic agents and as tools for understanding development. Like any new field, though, blind excitement can sometimes eclipse reality. Nine widespread misunderstandings that we feel have an impact on how we assess stem cells as therapeutic possibilities are outlined in this review. We propose that each of these factors should ...
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A SYSTEMATIC REVIEW ON TRADITIONAL MEDICINAL PLANT: ANOGEISSUS LATIFOLIA
The aim of this paper is to give a systematic overview on the morphology, ethnobotanical uses, phytochemistry and pharmacological activities of Anogeissus latifolia. It focuses to identify the research gap and further proceed to experimental studies. It may also help out the researcher for further detailed studies. A systematic search criterion of literature was carried out by computing Google sch...
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UNLOCKING THE ADAPTOGENIC POWER OF ROSEMARY (ROSMARINUS OFFICINALIS): A COMPREHENSIVE EXPLORATION OF ITS PHARMACOLOGICAL POTENTIAL FOR STRESS RESILIENCE AND HOLISTIC WELL-BEING
Rosmarinic acid, a key component of Rosemary (Rosmarinus officinalis), holds significant promise as an adaptogen in herbal medicine, offering a natural remedy to counteract stress's wide-ranging impacts on health. This abstract explores rosmarinic acid's pharmacological activities, emphasizing its modulation of the hypothalamic-pituitary-adrenal (HPA) axis, regulation of neurotransmitters, antioxi...
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RELEVANCE OF PRESCRIBING INDICATORS, PHARMACOECONOMICS, AND THERAPEUTIC ADHERENCE AMONG PATIENTS OF TYPE 2 DIABETES MELLITUS WITH HYPERTENSION IN INDIA- A REVIEW
The co-occurrence of Type 2 Diabetes Mellitus (T2DM) and hypertension is a growing public health concern in India. Effective management requires careful consideration of prescribing indicators, pharmacoeconomic implications, and therapeutic adherence. This review aims to explore the current landscape of prescribing practices, economic burden, and adherence patterns among Indian patients suffering ...
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HERBAL APPROACHES TO SKIN LIGHTENING: A COMPREHENSIVE REVIEW
Hyperpigmentation is a skin complaint where black patches or spots appear on skin. It affects a large percentage of the human population. Cosmetics that naturally lighten the skin have been shown to be both safe and effective for treating hyperpigmentation. To achieve a lighter skin appearance, skin lightening goods are commercially accessible for cosmetic resolutions. They're also utilised in the...
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POLYMER GRAFTING AND ITS APPLICATIONS: A REVIEW
Grafting polymerization is a process in which polymer chains are covalently bonded (grafted) onto a backbone polymer, leading to the formation of a new material with enhanced properties or functionalities. This process involves the attachment of polymer chains (known as "graft chains" or "grafts") onto the surface or within the bulk of the substrate material. Polysaccharides have numerous applicat...
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EXPLORING ANTIFUNGAL POTENTIAL OF ESSENTIAL COMPOUNDS IN FISH OILS FOR TREATING SKIN INFECTIONS
Skin fungal infections are a significant global public health concern due to growing resistance to traditional antifungal treatments. This study explores the fungicidal properties of key components in fish oils and their potential use in treating cutaneous fungal diseases. Fish oils contain bioactive substances like omega-3 fatty acids (EPA and DHA), vitamins, sterols, and antioxidants, which can ...
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THE HYDROTROPIC EFFECT: A NOVEL STRATEGY FOR ENHANCED BIOAVAILABILITY
Several techniques were applicable to increase the aqueous solubility’s of poorly water-soluble drugs. Hydrotropy technique is one of them. In the present study, the hydrotropic agent has been used as a Solubilizing agent to solubilize BCS Class-II drugs that is poorly water-soluble drugs. Hydrotropy is an increase in the solubility of a solute in water by adding an agent termed hydrotrope. Incr...
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NON-CODING RNAs AND LUNG CANCER
Lung cancer (LC) represents a significant global contributor to mortality, particularly for those between the ages of 40 and 50. Additional evidence for this predicament comes from the yearly rise in new LC cases and the disease's dismal 5-year survival rate of fewer than 15%. Even though smoking has been linked to a significant portion of Lung Cancer cases, a sizable number of non-smokers also co...
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Research Articles
PROTECTIVE ROLE OF ESCULETIN ON ETHANOL AND LIPOPOLYSACCHARIDE-INDUCED HEPATOTOXICITY IN MALE WISTAR RATS
Alcohol-related liver diseases and their associated damage pose significant health concerns globally. Among potential remedies, esculetin, a saturated dicarboxylic acid known for its anti-inflammatory and antioxidant attributes, stands out. This study aims to explore the hepatoprotective effects of esculetin in rat models afflicted by liver damage induced by ethanol+ lipopolysaccharide (LPS). To e...
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EFFECTIVENESS OF A STRUCTURED EDUCATIONAL INTERVENTION ON KNOWLEDGE, ATTITUDE AND PRACTICE OF PHARMACOVIGILANCE AMONG NURSES
Background: Globally used modern medicines cause various adverse drug reactions (ADR). In order to improve patient safety and welfare, and to reduce patient morbidity and mortality, spontaneous ADR reporting is the need of the hour. Nurses are the first point of contact with patients in any hospital, so their awareness is important to improve the practice of pharmacovigilance. Objectives: To asses...
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ROLE OF DIFFUSION-WEIGHTED IMAGING IN THE EVALUATION OF INTRACRANIAL LESIONS
This study investigates the diagnostic utility of Diffusion Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) values in evaluating intracranial lesions. A cross-sectional analysis of 44 patients was conducted, examining age and gender distribution, histopathological types, and grades of brain tumors. The highest proportion of individuals (22.7%) was within the 0-10 age range, with ma...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SCHIFF BASE AND ITS METAL COMPLEXES
The biological effects of transition metal complexes that include a wide range of ligands are distinguishable from one another. In an effort to produce a novel metal (II) complexes the conventional reflux method has been used to the interaction of two ligands, N-(2H-benzo[d] [1,2,3] triazol-2-yl)-1-(4-nitrophenyl) ethanimine as L1 and an amino acid Alanine as L2 with freshly produced Zinc, Nickel,...
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CHEMICAL CHARACTERIZATION AND ANTIOXIDANT EVALUATION OF OLDENLANDIA PUMILA (L.F.) DC: A COMPREHENSIVE STUDY
Medicinal plants are presently viewed as being of great value because of their unique qualities as a significant source of medicinal phytochemicals that might result in the creation of new medications. Oldenlandia pumila (L.f.) DC. belong to Rubiaceae family and found as a weed throughout India. Oldenlandia pumila (L.f.) DC. has antibacterial, antiviral, antioxidant, anticancer, anti-inflammatory,...
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CONTAINMENT OF HUMAN GASTROINTESTINAL PARASITES BY HERBAL DRUGS: AN IN-VITRO STUDY
Parasitic worms live in and feed in living hosts. They receive nourishment and protection while disrupting their hosts ability to absorb nutrients. The macroparasites called helminths, causes Helminthiasis. In India, the overall prevalence rates range from 12.5% to 66%. About 50% of the urban population and 68% of the rural population in India is affected. According to WHO, just few medications...
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A STUDY OF BIOFILM FORMATION AND METHICILLIN RESISTANCE IN COAGULASE NEGATIVE STAPHYLOCOCCUS IN VARIOUS CLINICAL SAMPLES
Coagulase negative Staphylococcus, always regarded as nonpathogenic common commensal of skin and mucous membrane, are emerging as ubiquitous endemic nosocomial and oppurtunistic pathogens in recent times. They usually are considered as culture contaminants, thus left untreated which lead to their increased pathogenic potential. Methicillin resistance in Coagulase negative Staphylococcus is of sign...
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FOURIER TRANSFORM INFRA-RED SPECTROSCOPY (FTIR) ANALYSIS AND IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF ALMOND GUM
Objectives: The anti-inflammatory activity of powdered almond gum (Prunus dulcis) was studied by using HRBC membrane stabilizing method and the bioactive compounds which are responsible for anti-inflammatory activity was analyzed by using FTIR analysis. Methods: To study the in-vitro anti-inflammatory activity Human red blood cell (HRBC) membrane stabilization method has been used and for identifi...
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QUANTITATIVE ESTIMATION OF QUERCETIN FROM PHOENIX SYLVESTRIS USING VALIDATED HPTLC METHOD
Introduction: Phoenix Sylvestris (L.) Roxb also known as date palm or Indian sugar palm, belongs to the Arecaceae family. In our present study, we used the fruit part (epicarp, endocarp). The fruit is very delicious in taste worldwide. It’s flavonoid part is reported with quercetin but its quantification has not yet been reported. Aim: The study aimed to carried out the Quantitative estimation o...
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A SINGLE-CENTRIC, SINGLE-ARM PILOT STUDY TO EVALUATE THE SAFETY AND EFFECTIVENESS OF SWASA KUDORI CHOORANAM (SKC) IN THE MANAGEMENT OF SWASA KAASAM (BRONCHIAL ASTHMA) – A STUDY PROTOCOL
Background: Cuvācakācam (SwasaKaasam) is one of the twelve types of Kācam in Siddha System of Medicine and is clinically correlated with Bronchial Asthma. Asthma is a Non-Communicable Disease that affects global health invariably by affecting all age groups with 5th global rank in terms of Daly’s. According to GBD, 13.09% of the population in India suffered from asthma and the prevalence in P...
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KNOWLEDGE, ATTITUDE AND PRACTICE (KAP) OF HUMAN PAPILLOMA VIRUS (HPV)—INFECTION AND ACCEPTABILITY OF HPV VACCINE AMONG MEDICAL STUDENTS IN A TERTIARY CARE CENTRE, KARUR, INDIA
Background: Human Papilloma Virus (HPV) is a common sexually transmitted infection, and its persistence can lead to cervical cancer. It can be prevented by vaccines. Objectives: The study was conducted with the objective of analyzing knowledge, attitude, and practice towards HPV infection and the acceptability of vaccination among medical students. Methodology: Around 405 students in a tertiary ca...
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VALIDATED ANALYTICAL METHOD DEVELOPMENT AND CHARACTERIZATION OF FORCED DEGRADATIVE PRODUCTS OF MITAPIVAT AND THEIR TOXICITY PREDICTION BY IN-SILICO STUDIES
The current study reports to validate a stability indicating RP-HPLC method for estimation of mitapivat in bulk, pharmaceutical formulations and FD characterization by using MS method. The chromatographic separation was accomplished on Waters X-Bridge phenyl column (150× 4.6mm, 3.5µm). With the mobile phase consisting of acetonitrile and 0.1% OPA (80ː20v/v) at a flow rate of 1ml/min. The eluent...
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PREVALENCE AND FACTORS ASSOCIATED WITH KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS SELF-MEDICATION AMONG UNDERGRADUATE MEDICAL STUDENTS IN GOVERNMENT MEDICAL COLLEGE, ALMORA, UTTARAKHAND
Background: The rapid development of new technology, and especially the Internet and other related communication systems, has provided new possibilities for searching any information that can be used for self-medication, also it seems that medical students having proper knowledge of medicine are very much involve in self-medication. This study therefore, intended to evaluate the knowledge, attitud...
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VACCINE HESITANCY-MEASURING THE MAGNITUDE AND PROVIDING POSSIBLE SOLUTIONS TO ADDRESS THE ISSUE IN MEWAT DISTRICT OF THE NORTHERN INDIAN STATE HARYANA
Objective: To understand the magnitude of vaccine hesitancy, its proximal determinants, and recommend specific interventions to address it in Mewat district (also known as Nuh), Haryana. Design: A mixed-method study design was adopted which involved: Household survey (479 households) and key informant interviews with healthcare providers (10 service providers). Setting: Four blocks namely, Nuh, Fe...
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EFFECT OF COMBINATION OF METHANOLIC EXTRACT OF GLYCYRRHIZA GLABRA ROOTS AND CITRUS LIMON LEAVES AGAINST SIO2 INDUCED SILICOSIS IN MALE WISTAR RATS
Aim & Background: Silicosis is a prevalent occupational lung disease caused by inhalation of Respirable Crystalline Silica (RCS), leading to irreversible pulmonary fibrosis and restrictive lung disease. This study investigates the therapeutic potential of a combination of methanolic extracts from Glycyrrhiza glabra (licorice) root and Citrus limon (lemon) leaf (CMEGC) against silica-induced si...
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ESTIMATE THE SEROPREVALENCE OF TTI IN BLOOD DONORS AND COLLATE THE RISK OF TTI BETWEEN VOLUNTARY DONORS AND REPLACEMENT DONORS
Introduction: The goal of BTS (Blood Transfusion Service) is to provide safe and quality blood and blood products to needy patients. In developing and underdeveloped countries, there exists a gap between the demands and supply of blood products. Since 100% voluntary blood donation is not achieved, we rely on replacement donors also. Hence this study was attempted to assess the seroprevalence of TT...
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AN EFFICIENT SYNTHESIS, CHARACTERIZATION AND BIOACTIVITY OF BENZIMIDA-ZOLE LINKED TRIAZOLES
A series of benzimidazole-linked triazoles hybrids (4a-4u) have been synthesized by simple cyclization, followed by amide coupling and click reaction starting from o-phenylene diamines as substrates with 4-formylbenzioc acid, propargylamine and followed by treatment with aryl azides. The structure of synthesized compounds (4a-4u) was confirmed by spectral techniques. The prepared compounds were sc...
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QUALITY ASSESSMENT AND COMPARATIVE STUDY OF DIFFERENT MARKETED BRANDS OF SIMVASTATIN IN MALAYSIA
Introduction: Simvastatin is one of the cholesterol-reducing agents, in the class of statins which is an HMG-CoA reductase inhibitors, used in the treatment of hyperlipidemia. It was categorized in biopharmaceutics classification system (BCS) class II drug, which has low solubility in aqueous media. It is a white-to-off white crystalline and non-hygroscopic powder, insoluble in water, but soluble ...
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PROCESS VALIDATION OF EXTENDED-RELEASE BI-LAYERED TABLET CONTAINING DAPAGLIFLOZIN, SITAGLIPTIN & METFORMIN HYDROCHLORIDE
The Purpose of research was to study process validation for Dapagliflozin 10 mg, Sitagliptin 100 mg and Metformin Hydrochloride 500 mg (Extended Release) Bilayered Tablets. The critical process parameters were identified with the help of process capability and evaluated by challenging its lower & upper release specifications. Three initial process validation batches (I, II, III) of the same si...
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