Volume 15 (2024) - Issue 8, August
Review Articles
THE ROLE OF GRANULOCYTE-COLONY STIMULATING FACTOR FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NEUTROPENIA IN ACUTE LYMPHOBLASTIC LEUKEMIA
Chemotherapy-induced neutropenia (CIN) is a common and sometimes fatal side effect of treatment for acute lymphoblastic leukemia (ALL), the most common malignancy in individuals over 40. Antibiotics are used in addition to supportive care as a current treatment. Granulocyte-colony stimulating factor (G-CSF) has been tested in clinical studies as a supplementary treatment to reduce febrile neutrop...
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A REVIEW ARTICLE ON ANTIOXIDANT PROFILE OF BLUE TEA POLYPHENOLS IN THE TREATMENT OF VARIOUS DISEASES
Clitoria ternatea (Blue tea) is a traditional medicinal plant belonging to family Fabaceae having generous amount of anthocyanins which possess majorly antioxidant properties. It contains wide range of phytoconstituents such as triterpenoids, flavanol glycosides, tannins, alkaloids, amino acids, proteins, ternatins (poly acylated anthocyanins) and carbohydrates etc. According to the data obtained ...
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BIOMARKER LANDSCAPE OF MYCOSIS, WITH SPECIAL EMPHASIS ON MUCORMYCOSIS
Systemic fungal infections, including opportunistic and endemic mycoses, pose a significant threat to immunocompromised individuals. Mucormycosis, caused by zygomycetes, is particularly devastating, characterized by tissue necrosis and diverse clinical manifestations. Risk factors such as immunodeficiency and underlying diseases contribute to its incidence. Through a comprehensive literature analy...
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A NOVEL APPROACH TO TREAT NEUROLOGICAL DISORDER BY USING LIPID-BASED DRUG DELIVERY SYSTEM
One in every three people suffers from some kind of neurological disorder. Considering the huge burden of the disease, it is imperative to develop and treat such conditions. Because of time constraints and obstacles, treating neurological disorders remains challenging for medical professionals. The number of new pharmacologically active lipid compounds discovered using current drug development met...
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NUTRIMILLET INSIGHTS: A REVIEW OF MILLET VARIETIES AND ADVANCED PROCESSING TECHNIQUES FOR ENHANCED NUTRITIONAL IMPACT
Millets are a group of small-seeded, grains that have gained renewed attention in recent years due to their high nutritional value and sustainable agricultural practices. This abstract provides an overview of millets, their processing methods, and their remarkable nutritional benefits, highlighting their potential to address global food and nutrition challenges. Millets have been cultivated for th...
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A COMPREHENSIVE REVIEW: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UTERINE ANTIFIBRINOLYTICS BY HPLC
The estimation of pharmaceutical and biological materials typically uses the key qualitative and quantitative technique known as high performance liquid chromatography (HPLC). It is the most adaptable, secure, trustworthy, and quick chromatographic approach for drug component quality control. Uterine fibroids are non-malignant developments that create in the uterus. They are otherwise called leiom...
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NETWORK PHARMACOLOGY AND TELEMEDICINE-A DIGITAL PARADIGM
Attempts are made in understanding drug action and its molecular interaction with multiple target in living cell using computational power as a tool leading to the emergence of Network Pharmacology (NP) and Telemedicine (TM). Network Pharmacology (NP) has been appearing as an important tool in underlining the complex relationship between the pharmacokinetic and pharmacodynamics of drug, aids in th...
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GREEN REMEDIATION: A CRITICAL EXAMINATION OF BIOCHAR’S HEAVY METAL ADSORPTION ABILITIES
Biochar can be used as an efficient and low-cost adsorbent for wastewater treatment as heavy metal pollution has become the serious issue for environmental pollution today. A number of studies have demonstrated effective removal of heavy metals from water by biochar. Several factors affecting the sorption tendency of biochar, feedstocks materials play a significant role. Depending on the biochar t...
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THE ROLE POLYMERIC NANOPARTICLES IN CANCER CHEMOTHERAPY: A NARRATIVE SYNTHESIS OF THE EVIDENCE
Chemotherapy is a familiar treatment technique that uses chemical drugs to kill cancer cells. This technique affects normal healthy tissues because it is unspecific and has toxic side effects. Now a days, nano technology application in chemotherapy have helped to solve uncontrolled problems of drug delivery and other side effects. Nanoparticles (NPs) can provide outstanding advantages over convent...
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IMPORTANCE OF ADHATODA VASICA NEES IN TRADITIONAL SYSTEM OF MEDICINES: A REVIEW
Adhatoda vasica Nees, belonging to the Acanthaceae family and commonly referred to as vasa or vasaka, is a prominent herbal remedy within Ayurvedic, Unani, and Homeopathic medicine systems. Vasaka is widely distributed across India and tropical regions in Southeastern Asia. This plant is recognized for its rich reservoir of phytoconstituents, notably vitamin C and various alkaloids. Alkaloids such...
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A DISCUSSION ABOUT INSULIN PLANT
"Costus igneus," popularly known as the "insulin plant," is a herb that has been used for medicinal purposes in Southeast Asia since ancient times. It is just recently that the plant was imported to India, and in the southern region of the country, it is being grown as an appealing plant. In addition to other phytochemicals, the insulin plant contains elements such as steroids, alkaloids, flavonoi...
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Research Articles
THE CONCENTRATION/RESPONSE FUNCTION BEHAVIORSOF NONCALORIC AND CALORIC SWEETENERS
Sweeteners are generally described in terms of their sweetness potencies relative to sucrose references. And, while caloric sweeteners have been found to have potencies invariant with sucrose reference concentration, noncaloric sweeteners decrease in potency as sucrose reference concentration increases. In this study, we develop methodology to determine the Concentration/Response functions for 9 (...
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EX-VIVO STUDIES OF THE EFFECT OF WHEATGRASS ON GLUCOSE RELEASE AND GLUCONEOGENESIS USING CORTISOL-INDUCED HEPATOCYTES
Cortisol is one of the vital glucocorticoids secreted by the adrenal glands and is also referred to as the “stress hormone” as the synthesis and release of cortisol by the adrenal glands is directly proportional to the stress levels in an individual. It is a catabolic hormone that stimulates gluconeogenesis and has an indirect role in liver and muscle glycogenolysis. It facilitates lipid, prot...
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EFFECT OF ALOE VERA JUICE ON TOTAL BLOOD COUNT AGAINST TOXICITY INDUCED BY ETHIONAMIDE AND PARA AMINO SALICYLIC ACID IN SPRAGUE-DAWLEY RATS
Fresh Aloe vera plant leaves were brought from botanical garden and sample was identified and brought to the laboratory in the Department of Zoology, Patkar-Varde College, Goregaon (W), Mumbai. 50 grams of leaves were then grounded with 50ml of distilled water in sterilized pestle and mortar. The yield will be calculated based on weight of the extract compared to the weight of the pulp of the leav...
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HYPOGLYCEMIC AND HEPATOPROTECTIVE EFFECT OF MERREMIA VITIFOLIA IN MICE
Traditionally, Merremia vitifolia meets multipurpose medicinal uses in tribal areas. Therefore, the study worked on hypoglycemic and hepatoprotective effects on animal models to meet the research gap on this plant. Methanolic stem extract at 200 mg/kg and 400mg/kg were administrated orally to determine the effects on blood glucose and hepatic enzymes. The highest dose showed a significant (p < ...
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EVALUATION OF PHYTOCHEMICAL PROPERTIES AND ANTIOXIDANT ACTIVITIES OF DIFFERENT SOLVENT EXTRACTS OF PASPALUM CONJUGATUM LEAVES GROWING IN BANGLADESH
Secondary metabolites found in various plants play an important role in curing various diseases and are used as important raw materials for the production of traditional and modern medicine. One of these plants, Paspalum conjugatum, a member of the Poaceae family, has been used for different purposes since prehistoric times. In this research work, we extracted the powdered leaves of P. conjugatum...
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CLINICAL SPECTRUM AND ECHO-CARDIOGRAPHIC FEATURES IN VHD PATIENTS OF TERTIARY CARE HOSPITAL IN TAMIL NADU
Objectives: Valvular Heart Disease (VHD) is an important cause of cardiovascular morbidity and mortality worldwide. The aim of this study was to establish the frequency of VHD on the basis of echocardiographic parameters, assess etiological factors, quantify the clinical spectrum and evaluate the medical management of VHD. Methods: This observational cross-sectional study was conducted for a perio...
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PHARMACOGNOSTIC, PHYTOCHEMICAL AND PHYSICO-CHEMICAL EVALUATION OF LEAVES OF TRAGIA INVOLUCRATA LINN.,
Background: Tragia involucrata Linn., leaves are traditionally used for the treatment of liver disorders, eczema, viral infections, headache, respiratory infections, etc. There is lack of documentation of safety data and non-availability of quality control standards for the ayurvedic traditional medicines. Aim & Objective: The aim of the study was designed to determine the pharmacognostic, phy...
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IN-VIVO ANTI-ARTHRITIC EFFECT OF COMPARATIVE STUDY OF POLYHERBAL FORMULATIONS (MUNIPAYN, RUMALAYA FORTE) IN FCA INDUCED ARTHRITIC RATS
Rheumatoid arthritis (RA) is one of the most prevalent chronic inflammatory joint diseases which affect approximately 1% adult population in the worldwide. Polyherbal ayurvedic formulations (Munipayn and Rumalaya forte) reported to be effective as anti-inflammatory and anti arthritic activity. In-vitro anti-inflammatory of individual formulations (Munipayn and Rumalaya forte) were evaluated by alb...
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NOVEL SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF ACECLOFENAC AND CURCUMIN IN DEVELOPED DOSAGE FORM
Introduction: Aceclofenac (ACE) and Curcumin (CUR) are anti-inflammatory drugs utilized for osteoarthritis and rheumatoid arthritis. ACE, As NSAID inhibits prostaglandins, while CUR, a natural polyphenol, exhibits antioxidant and anticancer properties. Combining them may offer synergistic benefits for inflammatory diseases. Objective: To develop a UV spectrophotometric method for simultaneous dete...
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PHARMACOGNOSTIC EVALUATION OF SETARIA ITALICA L. CARYOPSIS – A NUTRITIONAL AND THERAPEUTIC MILLET IN AYURVEDA
Setaria italica L. is one of the world’s oldest crops, which has been cultivated and domesticated about 8000 years ago. It is known for its ecological, nutritional and medicinal properties. In Ayurveda, it is called kangu/priyangu and is believed to nourish the body tissues and absorb excessive fluids besides, widely used in the treatment of various disorders. Since, no reports are available on ...
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ANTI-INFLAMMATORY STUDIES OF TERMINALIA CATAPA USING IN-VITRO METHODS AND MOLECULAR DOCKING AGAINST CYCLOOXYGENASE-II ENZYME
In the present investigation, sequentially extracted plant samples from T. catappa in water, methanol, ethanol and hexane were evaluated for COX-2 inhibitory activity. The in-vitro anti-inflammatory activity of selected samples showing promising COX-2 inhibition assessed using thermally induced protein denaturation assay. A total of nineteen compounds belonging to various phytochemical class...
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A CROSS-SECTIONAL ANALYSIS OF HEALTH-RELATED MISLEADING ADVERTISEMENTS REPORTED BY SIDDHA REGIONAL RESEARCH INSTITUTE, PUDUCHERRY
Background: Misleading advertisements in the healthcare sector, particularly concerning Ayurveda, Siddha, Unani, and Homeopathy (ASU & H) products, pose significant risks to public health. Despite existing regulations, the prevalence of such advertisements remains a concern, necessitating comprehensive strategies for mitigation. Methods: This cross-sectional analysis examines misleading advert...
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EXEMPLIFYING THE ANTIDYSLIPIDAEMIC POTENCY OF PTEROCARPUS MARSUPIUM EXTRACT IN MITIGATING HIGH-FAT DIET-INDUCED DYSLIPIDAEMIA IN RODENT MODEL
We evaluated the antidyslipidemic activity of extract of Pterocarpus marsupium (PM: Vijayasar) in adult Charles Foster rats of both sexes and compared this activity with that that of Atorvastatin (Atorva). 4 groups were made [Gp 1- Control group (no drug), only high fat diet (HFD); Gp 2- HFD +PM (to evaluate the role of PM in the prevention of dyslipidemia); Gps 3 & 4- only HFD]. This was the ...
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COMPARISON OF IMPROVEMENT IN HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH VERNAL KERATOCONJUNCTIVITIS TREATED WITH BEPOTASTINE BESILATE (1.5%) AND OLOPATADINE HYDROCHLORIDE (0.1%) TOPICAL SOLUTIONS
Vernal keratoconjunctivitis (VKC) is a chronic inflammatory condition affecting the cornea and conjunctiva of young children. Health-related quality of life (HRQoL) is impaired in children with VKC. Mast cell stabilizers are often offered as the first-line therapy for VKC. In this study, the effects of two types of mast stabilizers on HRQoL were compared.This was a prospective, open-label, randomi...
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FORMULATION AND EVALUATION OF PERIODONTAL FILMS CONTAINING LEAF EXTRACT OF PSIDIUM GUAJAVA FOR TREATING PERIODONTITIS
The aim of this study was to investigate the antibacterial activity of Psidium guajava leaf extract in periodontal film for inserting in periodontal pockets. The study was performed by formulating bioerodible periodontal film containing Psidium guajava leaf extract by simple solvent casting method using two different polymers namely natural chitosan and semi synthetic HPMC. The formulated periodon...
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DEVELOPMENT AND EVALUATION OF MOUTH DISSOLVING TABLETS OF OMEPRAZOLE FOR ENHANCED BIOAVAILABILITY
The purpose of this research was to examine the development of a mouth-dissolving tablet formulation of omeprazole to enhance its rapid absorption through the buccal mucosa, which would facilitate the onset of therapeutic effects more quickly. Formulation was difficult for omeprazole because of its low solubility and permeability, which places it in the IV class of drugs according to the Biopharma...
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METHOD DEVELOPMENT, VALIDATION, AND STABILITY INDICATING STUDIES OF HYDROCHLOROTHIAZIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY UV-SPECTROSCOPY
Development of UV spectrophotometric method for the estimation of Hydrochlorothiazide was done by Q-Absorbance ratio method and area under curve method and stability indicating studies using methanol as solvent. In the present research, we have made an attempt to develop a simple, specific, accurate, precise and reproducible method for the estimation of hydrochlorothiazide by UV spectrophotometric...
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EFFECT OF TRIDAX PROCUMBENS LEAF EXTRACT INCORPORATED PVA FILM ON POSTHARVEST QUALITY OF VITIS VINIFERA
Vitis vinifera (Grape) encounters several difficulties during their shelf life, including weight loss, browning and softening. Packaging is one of the effective solutions to preserve fruits from postharvest loss. Tridax procumbens (T. procumbens) leaves are rich in bioactive compounds and possess good antioxidant and antimicrobial activity. This study evaluates the efficiency of T. procumbens leaf...
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RAPID ESTIMATION OF ESCITALOPRAM IMPURITIES IN MULTIPLE BRANDS USING COMPREHENSIVE STABILITY INDICATING RP-HPLC METHOD
This study aimed regarding application of comprehensive stability-indicating analytical method for estimation of Escitalopram impurities in multiple brands of pharmaceutical dosage forms using reverse phase high-performance liquid chromatography. The comprehensive stability-indicating analytical method applied utilized an isocratic mode with a C18 column. The mobile phase comprised a phosphate buf...
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NOVEL PARAMETERS TO DEFINE BIO-EFFICACY OF SHILAJIT RESIN AND ITS VALIDATION
Shilajit, a herbo-mineral blackish brown resin, extracted from humic rocks, is attributed to several therapeutic claims in Ayurveda like antiaging, health-promoter, immune- booster, urogenital problems and bio-enhancer. The lack of strong parameters for its quality control and standardization; and the knowledge gap to explain its mechanism of action are the important factors behind its restricted ...
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EFFICACY OF A 12-MONTH VERY LOW-CALORIE KETOGENIC DIET (VLCKD) IN GLYCEMIA COMPARED WITH PARAMETERS BEFORE STARTING THE REGIME IN PATIENTS WITH OBESITY AND TYPE 2 DIABETES. A CLINICAL STUDY
In obese patients with noninsulin-dependent diabetes mellitus (NIDDM), reducing calorie intake improves glycemic control. The present study tested the theory that controlling calorie intake has an important role in long term, independent of weight loss in metabolic regulation of NIDDM patients. 23 women included in this study were selected, Antidiabetic therapy (except metformin) was discontinued ...
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PATIENT TREATMENT SATISFACTION AND MEDICATION ADHERENCE IN HYPERTENSIVE PATIENTS VISITING A TERTIARY CARE HOSPITAL IN INDIA: A CROSS SECTIONAL STUDY
Objectives: This observational cross-sectional study is aimed to assess the medication adherence and treatment satisfaction in hypertensive patients. This study was conducted at a public tertiary care hospital. Methods: Hypertensive patients of both the sex groups aged >60 years visiting outpatient department were enrolled. The Morisky Medication Adherence Scale and the Medication Interview Sat...
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GREEN SYNTHESIS OF SILVER NANOPARTICLES USING PLUMBAGO ZEYLANICA LEAF EXTRACT AND THEIR ANTIBACTERIAL, ANTIFUNGALAND LARVICIDAL ACTIVITIES
The metal nanoparticles have attention among researchers who wish to use them for development of new generation antimicrobial compounds. Silver nanoparticles are one of the widely used nanoparticles due to their antimicrobial properties. The present work deals with the Eco-friendly green synthesis of silver nanoparticles using leaf extract of Plumbago zeylanica, Characterization and their biologic...
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DISCOVERY OF INTERLEUKIN-6 INHIBITORY PROPERTIES OF THE COMPOUNDS DETECTED FROM METHANOLIC LEAF EXTRACTS OF PLECTRANTHUS AMBOINICUS (LOUR) SPRENG. THROUGH MOLECULAR DOCKING
Plectranthus amboinicus, locally called Karpooravalli in Tamil Nadu, India, is known for its various traditional therapeutic properties. Rheumatoid arthritis is a chronic autoimmune disease where uncontrolled inflammatory markers are released to induce bone damage and pain. In this study, the methanolic extract of P. amboinicus was characterized phytochemically and subjected to in-silico analysis ...
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ANTI-PSORIATIC ACTIVITY AND HPTLC FINGERPRINTING OF PREPARED POLY-HERBAL CREAM
The current investigation's goal is to prepare polyherbal cream by using plant extracts of Terminalia chebula, Sapindus trifoliatus, Psoralea corylifolia and carry out high-performance thin layer chromatography fingerprinting to confirm that the corresponding extracts utilized as standards contain the active ingredients. Cream of plant extract prepared by using fusion method and the prepared cream...
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ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITY OF GREWIA HIRSUTA VAHL. LEAVES
Objectives: Grewia hirsuta Vahl. is a shrub explored for medicinal applications. It has anti ageing, boosting immunity, prevents loss and grey hair etc. Ethnopharmacological data suggests that the plant is extensively used as a nerve tonic and to enhance the cognitive properties. The basis of these medicinal uses seems to be antioxidant and anti cholinesterase activity. In order to establish the s...
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STUDY ON PRESCRIPTION PATTERN OF ANTI-DIABETIC MEDICATION AMONG TYPE 2 DIABETES MELLITUS PATIENTS
Background: Diabetes mellitus (T2DM) is a disorder in which the amount of sugar in the blood is elevated. Doctors often use the full name that is Diabetes Mellitus rather than Diabetes alone to differentiate from Diabetes Insipidus. Diabetes Insipidus is a relatively rare disorder that does not affect the blood glucose levels but just like Diabetes Mellitus, causing increased urination. Method: A ...
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TO EVALUATE THE HEPATOPROTECTIVE ACTIVITY OF DAUCUS CAROTA L AND CAMELLIA SINENSIS EXTRACT IN COMBINATION AGAINST AZATHIOPRINE-INDUCED LIVER INJURY IN RATS
Background: Daucus carota L contains a variety of carotenoids and well known for their antioxidant properties, in particular β-carotene. The antioxidant capability of polyphenols present in Camellia sinensis has been reported to be both chemo-protective and healing. The present work is about to evaluate the Hepatoprotective activity of Daucus carota L and Camellia sinensis extract combination aga...
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VALIDATION AND FORCED DEGRADATION BY RP-HPLC OF SELEXIPAG DRUG IN BULK AND DOSAGE FORM
A new simple, specific, accurate and stability-indicating reversed phase `high performance liquid chromatographic (HPLC) method was developed for the determination of Selexipag using a Grace C18 (250mm x 4.6ID, Particle size: 5 micron) a mobile phase consisting of Buffer (pH-7.4): Methanol 60:40, at a flow rate of 1.0 mL/min and ultraviolet detection at 294 nm. The retention times of Selexipag was...
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NOVAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF THREE POTENTIAL GENOTOXIC IMPURITIES IN DARUNAVIR PROPYLENE GLYCOLATE DRUG SUBSTANCE BY LC-MS/MS TECHNIQUE
A Liquid Chromatography-Mass Spectrometry (LC-MS/MS) method was used for quantification of potential genotoxic impurities (PGI) in the Darunavir propylene glycolate drug substance (API). Chromatographic separation was achieved using a column UPLC BEH C18, 1.7 μm (100×2.1mm), with a Mobile-phase-A was ammonium bi carbonate and Mobile-phase-B was acetonitrile in gradient elution mode at a flow rat...
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COMPARATIVE ANALYSIS OF BIOACTIVE COMPOUND EXTRACTION FROM BEET GREENS: A STUDY ON THE INFLUENCE OF SOLVENTS USED IN ULTRASONIC ASSISTED EXTRACTION
This study investigates the extraction of bioactive compounds from Beet vulgaris L. greens, a member of the Chenopodiaceae family known for its high antioxidant capacity. Despite being a horticultural product with substantial underused biomass, beet greens are traditionally discarded as waste, representing a lost opportunity for valuable bioactive components. This research focuses on the extractio...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF CHLORTHALIDONE AND AMLODIPINE IN PHARMACEUTICAL DOSAGE FORM
Background: To reduce the run and retention times of amlodipine and chlorthalidone in pharmaceutical dosage forms, a simple, affordable, time-efficient, stability-indicating, and accurate reverse-phase liquid chromatographic technique was developed. Successful chromatographic separation was achieved using Inertsil ODS-3V (250 x 4.6 mm, 5 μm particle size). A gradient consisting of water (pH 3 adj...
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KNOWLEDGE, ATTITUDE AND PRACTICE OF SELF-MEDICATION AMONG THE SECOND YEAR MBBS STUDENTS IN A TERTIARY CARE HOSPITAL: A QUESTIONNAIRE BASED STUDY
Introduction: Self-medication is becoming more and more common in our daily lives but it's an unhealthy and risky habit. It assumes that second year MBBS students holds special significance as they start to deepen their knowledge about diseases and medications, which forms a critical foundation for their medical education and future practice. This is the only study conducted in the northeastern re...
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GLUCOREGULATORY EFFECT OF METHANOLIC EXTRACT OF PICRALIMA NITIDA SEEDS IN RATS MADE DIABETIC BY ALLOXANE
Diabetes is a chronic disease characterized by fasting blood glucose levels above 1.26 g/L. The aim of the present study was to evaluate the effect of the methanolic extract of Picralima nitida seeds on insulin and blood glucose levels in diabetic rats. Diabetes was induced in normoglycemic rats by injection of 1 mL alloxane at a dose of 125 mg/kg bw for three consecutive days. Blood samples were ...
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