Volume 16 (2025) - Issue 4, April
Review Articles
A NOVEL APPROACHAND ADVANCEMENT IN RESPIRATORY DRUG DELIVERY SYSTEM
The respiratory drug delivery system (RDDS), which delivers drugs straight to the lungs for quicker effect and better bioavailability, is essential for treating respiratory disorders. It works particularly well for treating lung infections, COPD, and asthma. Metered-dose inhalers (MDIs), dry powder inhalers (DPIs), nebulizers, and sophisticated aerosol formulations are examples of technology that ...
352
414
A COMPREHENSIVE GUIDE TO THE PATHOPHYSIOLOGY OF DIABETES MELLITUS & INNOVATIONS IN THE TREATMENT
Diabetes mellitus is a chronic metabolic disorder characterized by high levels of glucose in blood due to non-secretion of insulin or insulin insensitivity. Diabetes mellitus can cause many complications, acute complications include non ketotic hyperosmolar coma and diabetic ketoacidosis. Different types of diabetes mellitus are available – Type 1 diabetes mellitus (hormone dependent diabetes) a...
324
192
IMPACT OF PHARMACEUTICAL POLLUTION ON NATURE AND ITS MANAGEMENT: A GLOBAL ALERT
Drugs taken by humans and animals find their way into rivers, lakes, and even drinking water and can have devastating effects on the environment. This review summarizes the research regarding pharmaceutical industry emissions and the health risks of pharmaceutical wastewater exposure.The present review is prepared by the extensive literature survey using different search engines like google.com, P...
349
193
A REVIEW ON DEVELOPMENT OF ANTIMICROBIAL AND LIQUID/BLOOD REPELLENT SURGICAL GOWN FOR HOSPITAL USAGE
Recently care regarding functional finishing of medical apparels such as liquid/blood repellent and antimicrobial has increased due to the risk of harmful microbes generation on these fabrics while coming in contact with fluids such as blood, sebum etc. Of the various medical textiles, surgical apparels are important textile products as they protect health care workers from microbial contamination...
267
137
HERBAL INTERVENTIONS FOR DERMATOLOGICAL DISORDERS
Herbal medicines have gained recognition for their potential in treating various skin disorders, driven by both traditional practices and modern scientific research. The efficacy of these natural remedies can be attributed to their diverse chemical compositions, which often include bioactive compounds with antimicrobial, anti-inflammatory, and antioxidant properties. The skin is the body's largest...
311
140
MANAGEMENT OF CARDIOVASCULAR DISEASE
Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity globally, with 17.9 million deaths in 2019. In India, the CVD epidemic is characterized by rapid accumulation, early age of disease onset, and high case fatality rates. India experienced a 59% increase in premature mortality from 23.02 million in 1990 to 37. Million in 2010. Despite improvements in diagnosis and treatme...
147
54
NANOCRYSTALS FOR IMPROVED DRUG DELIVERY: A REVIEW
Nanocrystals are crystalline particles having particle size range of 100 to 1000 nm. However, these nano-sized systems are thermodynamically unstable, stabilizers are required to incorporate them. The poorly soluble drugs lead to problems like poor absorption and therapeutic failure. One such method to overcome these solubility problems is the development of nanocrystals. These systems reduce part...
185
60
NASYA IN AYURVEDA: AN IN-DEPTH ANALYSIS OF ITS MECHANISMS
Nasya, one of the core detoxification therapies in Ayurveda, involves the administration of medicinal substances through the nasal passage. It is particularly effective for disorders affecting the head and neck region (above the clavicle), but it also influences the nervous and endocrine systems systemically. In Ayurveda, the nasal cavity (Nasa) is seen as a direct pathway to the brain (Shiras), a...
173
57
AI-DRIVEN INNOVATIONS IN PHARMACOVIGILANCE: TRANSFORMING DRUG SAFETY SURVEILLANCE FOR THE FUTURE
The practice of Pharmacovigilance focuses on identifying, evaluating and preventing drug-related adverse events, also referred to as ADRs, which ensure the safety of pharmaceuticals. Regarding these changes in healthcare systems, it is becoming very important to implement new technologies, such as artificial intelligence, in pharmacovigilance operations that promise to enhance drug safety monitori...
153
58
REVOLUTIONIZING DRUG DEVELOPMENT: THE SYNERGY OF AI AND BIOINFORMATICS IN SHAPING FUTURE THERAPEUTICS- A REVIEW
The combination of bioinformatics and AI improves the precision and productivity of medication development. Artificial intelligence (AI)-powered tools such as AlphaFold and Atomwise speed up the discovery process, and natural language processing (NLP) helps with literature mining and medication repurposing. Advanced approaches such as automated drug testing and quantum computing are also being stu...
334
61
Research Articles
FORMULATION AND EVALUATION OF CURCUMINOIDS- CAPSAICINOIDS-EUDRAGIT® EPO TRANSDERMAL FILM FOR ANTI-INFLAMMATORY ACTIVITY IN WISTAR RATS
Background: This study presents the extraction, fractionation, formulation, and evaluation of transdermal polyherbal films containing Curcumin and Capsaicin for potential anti-inflammatory use. Capsicum annuum extract underwent ethanol-based extraction and fractionation, isolating alkaloids for further study. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, polyphen...
214
130
COMPUTATIONAL INSIGHTS INTO THE BINDING EFFICIENCY OF PHYTOCOMPOUNDS IN ERANDADI KWATHAM: A MOLECULAR DOCKING APPROACH
Rheumatoid arthritis (RA) is a chronic inflammation disorder that primarily affects the joints and leads to the progressive destruction of joints, synovial hyperplasia bone, and cartilage degeneration. Globally 1% of the world population was affected by rheumatoid arthritis. The present study focused to identify the bioactive phytocompounds of polyherbal formulation- Erandadi Kwatham and to determ...
218
110
FORMULATION AND EVALUATION OF MUCOADHESIVE GEL FOR ORAL CANDIDIASIS
Oral candidiasis (OC) is a common fungal infection characterized by white patches on the oral mucosa, often triggered by factors like immunosuppression and medication use. It can affect anyone, regardless of age or background. The formulation of mucoadhesive gels for the treatment of oral candidiasis is a promising area of research. The gel enhances the residence time of the drug at the site of in...
297
141
MICROSPONGE BASED CANDESARTAN CILEXETIL LOADED PULSINCAP FOR ACHIEVING CHRONOMODULATED DRUG DELIVERY
Candesartan Cilexetil (CC) traditional dosage form has poor bioavailability and quick first pass metabolism, which leads to rapid elimination of the drug from the system and reduced plasma drug concentration during early morning heart attack incidence. The primary purpose of the Candesartan Cilexetil chronotherapeutic formulation is to optimally release the medicine in greater amounts in the early...
179
109
FORMULATION AND CHARACTERIZATION OF TOPICAL PROPRANOLOL HYDROCHLORIDE GEL FOR INFANTILE HAEMANGOMIA
Propranolol hydrochloride, a non-selective beta-blocker, has emerged as a first-line treatment for infantile hemangioma due to its vasoconstrictive, anti-antigenic, and pro-apoptotic effects on endothelial cells. This research focuses on the development of topical gel, for the localized treatment of infantile hemangioma, aiming to reduce systemic side effects while enhancing therapeutic efficacy. ...
199
115
A NEW RS HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF IMPURITIES IN LOSARTAN POTASSIUM IN PHARMACEUTICAL DOSAGE FORM
Losartan is used for hypertension, including in people with left ventricular hypertrophy (enlarged heart muscle), and kidney dysfunction among type II diabetics. It may also delay progression of diabetic nephropathy. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria (>30 mg/24 hours). A Rela...
133
52
DESIGN AND BIOLOGICAL PROFILING OF A NOVEL (2,4-BIS(ARYLAMINO) THIAZOL-5-YL) (THIOPHEN-2-YL) METHANONE DERIVATIVE: IMPACT OF SUBSTITUENT VARIATIONS
A series of novel (2,4-bis(arylamino) thiazol-5-yl) (thiophen-2-yl) methanone derivatives were synthesized and analyzed using various analytical and spectral techniques, including elemental analysis, IR spectroscopy, ¹H NMR, ¹³C NMR, and mass spectrometry to ensure comprehensive structural validation and accurate determination of their chemical composition and framework. Structural optimization...
125
85
ISOLATION, IDENTIFICATION AND ANTIMICROBIAL ACTIVITY OF ENDOPHYTES FROM ERYNGIUM FOETIDUM LEAF ALONG WITH ITS PHYTOCHEMICAL SCREENING THROUGH STANDARD PROTOCOLS
Eryngium foetidum commonly known as cilantro or spiny coriander is a tropical perennial herb known for its distinctive aroma and medicinal properties. While it is mainly used as a culinary herb, it has long been valued in traditional medicine for a variety of health benefits. The present study was intended to analyse the phytochemicals present in the ethanolic extract of the leaf. Qualitative anal...
159
56
VULVOVAGINAL CANDIDIASIS AMONG FEMALES OF REPRODUCTIVE AGE AT A TERTIARY CARE CENTER, WESTERN UTTAR PRADESH
Background: Vulvovaginitis is an inflammation or infection of vulva and vagina. Candida is a commensal micro-organism which mainly colonizes the mucosal surfaces of human body such as gastrointestinal tract, respiratory tract and genitourinary tract. This study aimed to find prevalence of vulvovaginal candidiasis and determine antifungal susceptibility pattern of clinical Candida isolates among sa...
131
69
PHARMACOGNOSTICAL INVESTIGATION OF AERIAL PARTS OF THE POLYGONUM PLEBEIUM R. BR.
Background: Medicinal plants are gaining popularity due to their reputation for being safe and effectively addressing fundamental health care demands. Standardizing medicinal products is the most recommended option because herbal therapy is becoming more and more popular worldwide. Objective: The present study examines various pharmacognostic characteristics that ensure the safety, efficacy, and p...
132
59
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF LEVOCETIRIZINE DIHYDROCHLORIDE
Levocetirizine Dihydrochloride is an orally active, non-sedative antihistamine drug. To determine the assay content of Levocetirizine Dihydrochloride drug substance, a very simple, accurate, specific, and precise UV-Spectrophotometric method has been built up as well as evaluated. The suggested method comprises dissolving Levocetirizine Dihydrochloride in distilled water and subjecting the consequ...
130
59
FORMULATION AND EVALUATION OF TRAZODONE HCL LOADED THERMO-REVERSIBLE IN-SITU INTRANASAL GEL
This study aimed to design and evaluate a thermoreversible, mucoadhesive intranasal gel formulation of Trazodone HCl for enhanced drug delivery to the brain. Pre-formulation processes involved characterization of the drug using UV spectroscopy, FTIR, and DSC techniques to confirm drug purity and compatibility with excipients. The nasal gel was formulated using Poloxamer 407 (19%) and Carbopol 934P...
137
56
FORMULATION AND EVALUATION OF CLINDAMYCIN NANOSUSPENSION LOADED LYOPHILIZED POWDER FOR EFFICIENT TREATMENT OF AXILLARY OSMIDROSIS
The aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity...
133
53
DESIGN AND DEVELOPMENT OF APREMILAST MICROEMULSIONAS A POTENTIAL DOASGE FORM FOR THE EFFICIENT TREATMENT OF PSORIATIC NAIL DYSTROPHY THROUGH TRANSUNGUAL ROUTE
The aim of present study was to develop microemulsion formulation of apremilast for the topical treatment of nail psoriasis, a challenging condition due to the nail's dense structure limiting drug penetration. Apremilast, a PDE4 inhibitor, offers an effective systemic approach but faces bioavailability challenges and potential side effects when administered orally. To address these issues, apremil...
136
55
FORMULATION, CHARACTERIZATION AND OPTIMIZATION OF TOPICAL HERBAL HYDROGEL CONTAINING ALOE VERA, TURMERIC AND MARIGOLD
The investigation of herbal components in topical formulations is a response to the growing desire for natural and effective remedies. The development, modification, and characterization of a topical herbal hydrogel intended for use in dermatological applications are the main objectives of this work. During the formulation procedure, plant extracts of Turmeric, Aloe vera and Marigold were chosen f...
167
64
LRTI-SYSTEMATIC APPROACHES TO DIAGNOSIS AND EFFECTIVE THERAPEUTIC MANAGEMENT
Introduction: Lower Respiratory Tract pulls in air from the upper respiratory tract, absorbs oxygen and release carbon dioxide in exchange, infection to this is known as LRTI. It includes Bronchitis, Bronchiolitis, Influenza, Pneumonia, COPD and Asthma. Patients were treated with many medications like Bronchodilators, antibiotics and antivirals. Objectives: To evaluate treatment assessment of resp...
138
54
PSYCHOGENIC NON-EPILEPTIC SEIZURE WITH DEPRESSION- A CASE STUDY
Psychogenic non-epileptic seizures (PNES), which intently look like epileptic seizures (ES), are regularly set off by mental trouble and address the most pervasive type of change issue experienced in clinical practice. Different states of being can both encourage and support PNES episodes. PNES episodes. Epilepsy, a common neurological disorder, imposes significant emotional and physical burdens, ...
218
62
DEVELOPMENT AND EVALUATION OF TEA TREE OIL INFUSED ANTIFUNGAL NAIL LACQUER: A PROMISING ALTERNATIVE FOR TREATING ONYCHOMYCOSIS
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on ...
152
57
THE EFFECTIVENESS OF BALLOON TAMPONADE IN THE PREVENTION AND TREATMENT OF POSTPARTUM HEMORRHAGE
Postpartum hemorrhage (PPH) is one of the leading causes of maternal morbidity and mortality, ranking third after throm-boembolism and hypertensive disorders. The primary goal of this study was to determine the effectiveness of balloon tamponade in the prevention and treatment of postpartum hemorrhage. The principle of balloon tamponade is to apply direct pressure to the bleeding vessels of the pl...
129
41
ASSESSMENT OF TOXICITY AND ANTIPROLIFERATIVE ACTIVITY OF PUTRANJIVA ROXBURGHII WALL.: A POTENTIAL THERAPEUTIC AGENT FOR THE TREATMENT OF ENDOMETRIOSIS
The utility of herbal medicines incresed for curative purposes in the past few years. They serve as a curative alternative for a significant section of the worldwide community. Nonetheless, assessing the reliability of such facilities continues to be challenging in guaranteeing their safe use. Acute and subacute toxicity studies were conducted in a rat model. The cytotoxicity assay and AO/PI stain...
111
56
KNOWLEDGE, ATTITUDE AND PRACTICE OF VACCINE VIGILANCE AMONG HEALTHCARE PROFESSIONALS IN A TERTIARY CARE TEACHING HOSPITAL
Introduction: Adverse events following immunisation (AEFI) are frequently underreported in India for numerous reasons, ultimately impacting the country's immunisation program. The current study evaluates the knowledge, attitudes, and reporting practices (KAP) on vaccine vigilance among physicians in our hospital. Objectives: To find out various causes of Under-reporting of adverse events subsequen...
125
50
QUANTITATIVE ANALYSIS OF CAFFEINE, EPHEDRINE, AND YOHIMBINE IN STIMULANT-BASED FAT BURNER SUPPLEMENTS
Introduction: The use of supplements in the fitness industry has experienced a notable surge due to the growing awareness of their potential health benefits. Fat burners, a popular type of supplement, are commonly employed to assist in weight loss. However, it is important to acknowledge that fat burners can have adverse effects on the body. Common side effects include increased heart rate, elevat...
249
81