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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 13 (2022) - Issue 8, August

Review Articles

 
Title
Views
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1.

MEDICINAL EFFECTS OF NIGELLA SATIVA IN GYNECOLOGICAL DISORDERS: A SYSTEMATIC REVIEW

Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and “Gynecology”. In the first stage, the total articles obtained from searching the above databases using the above keywords were p...

S. H. K. Deepthika, K. P. K. R. Karunagoda and P. K. Perera *

Institute of Indigenous Medicine, University of Colombo, Colombo, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.13(8).2977-87

2977-2987

315

242

2.

CARDIAC REMODELING: A HARMFUL OR PROTECTIVE MECHANISM OF MYOCARDIUM

Cardiac remodeling is a progressive morphological change of the myocardium in response to various pathophysiological overloads. Cardiac remodeling occurs due to various mechanisms associated with GPCR and growth receptors. Fundamentally cardiac remodeling is an adaptive mechanism of the myocardium against various overloads. However, depending upon the frequency, strength, and type of overload, the...

Sunny Dhiman *, Inder Kumar, Priyankul Palia and Pankaj Kumar

School of Pharmacy Abhilashi University Mandi, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).2988-99

2988-2999

158

101

3.

EFFECTIVENESS OF GUANFACINE IN SMOKING CESSATION – A SYSTEMATIC REVIEW

Background: Guanfacine is a drug used to treat ADHD (attention deficit hyperactivity disorder) and treatment for hypertension from 1986, approved by the FDA. Recently it had been deduced that Guanfacine could also be employed in smoking cessation as a pharmaceutical aid. This could be attributed to the physiological effect that the drug has on the human body, such as decreased heart rate and blood...

V. Aravinth, I. Nanda Balan, Lubna Fathima *, K. Sunder Kote, Bhavana Jawahar and R. Elakya

Department of Public Health Dentistry, Madha Dental College and Hospital, Kundrathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3000-06

3000-3006

174

70

4.

EFFECTS OF AYURVEDIC THERAPY FOR THE MANAGEMENT OF AUTISM IN CHILDREN: A REVIEW

Introduction: Autism is a group of psycho-neuro-developmental diseases in which children fail to acquire social interaction and other regular motor and verbal milestones, and some developmental issues are suspected. According to recent reports, prevalence rates have risen drastically from 4-6/10,000 in the early 1960s to 40-60/10,000 now. According to Ayurvedic literature, Unmada is a term for psy...

Nitu Sinha * and Nisha Kumari Ojha,

Department of Kaumarbhritya, National Institute of Ayurveda, Deemed To Be University (De Novo), Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3007-17

3007-3017

120

82

5.

AN OVERVIEW ON HUMAN ETHER-A-GO-GO-RELATED GENE ASSAY

hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved in ventricular repolarization at the end of a cardiac action potential. Mutations in hERG channel result in torsade’s de pointes. The cardiotoxicity is mainly due to the prolongation of the QT interval caused by the blockage of hERG. Indeed, many therapeutic drugs are withdrawn from the market as well as drug...

Arulkumar Vishali * and Muthuswamy Umamaheswari

Department of Pharmacology, Sri Ramakrishna Institute of Paramedical Sciences Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3018-27

3018-3027

138

57

6.

REVIEW ON ROLE OF NUTRACEUTICALS IN STRESS MANAGEMENT

Stress is a complicated process that affects everyone differently. When the body is exposed to stressors, it initiates a series of coordinated responses called "stress responses," which include behavioral changes, immunological regulation, hormone release, and various physiological changes. Stress is the physiological response to risk or pressure, and it displays physically as fatigue or energy lo...

Ashwini Asalak, Shilpa Raut, Mayur Bidkar, Prajakta Shingote and Anjali Bedse *

Department of Pharmaceutics, K. K. Wagh College of Pharmacy, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3028-35

3028-3035

64

38

7.

DIFFERENT TYPES OF DIAGNOSTIC AND TREATMENT METHODS FOR ACUTE LYMPHOBLASTIC LEUKEMIA AND APPLICATIONS OF EXTRACELLULAR THERAPEUTIC ENZYME L-ASPARAGINASE

The extracellular L-Asparaginase is an amidase group enzyme. In recent years enzymes gained greater importance in clinical research. The enzyme's capability to convert L-Asparagine into Aspartic acid and ammonia is the motivation after its anti-cancer action. ALL is a type of hematologic cancer that mainly affects children at the age of 2 to 10 years. L-asparaginase is a basic constituent of ALL a...

Maram Bhargavi and Ravuri Jaya Madhuri *

Department of Applied Microbiology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3036-42

3036-3042

31

25

8.

HYPERTROPHIC CARDIOMYOPATHY

Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle with preserved or increased ejection fraction. It is commonly asymmetrical, with the most severe hypertrophy involving the basal interventricular septum. The histological features of HCM include myocyte hypertrophy and disarra...

P. Soni Dixitha *, M. Vijaya Bhargavi and M. Sumakanth

Department of Pharmaceutical Chemistry, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3043-55

3043-3055

52

23

9.

ETHICAL LANDSCAPE OF HERBAL MEDICINES

Remarkable numbers of people have a false belief in naturally obtained herbal medicines as they are safe to use, omitting the fact that herbal medicines have pharmacological action like allopathic medicines. Many plants are poisonous and there is less safety data available for herbal medicines. Adverse drug reactions associated with herbal medicines are overdose and toxicity, herb interactions and...

M. S. Umashankar *, A. Rakesh Rosario, S. Pavithra and S. Lavanya

Department of Pharmacy, SRM College of Pharmacy, Faculty of Medical and Health Science, SRM Institute of Science and Technology, S. R. M. Nagar, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3056-61

3056-3061

70

32

10.

A REVIEW ON THE CURRENT STATUS OF MULTI-DRUG RESISTANT STAPHYLOCOCCUS AUREUS AND ITS FUTURE PROSPECTS

Infectious diseases are the most significant cause of fatalities worldwide. Staphylococcus aureus could be a common human infective microorganism that will trigger various infectious diseases, like soft tissue and skin infections, osteomyelitis, bacteremia, endocarditis, and fatal respiratory illnesses. In recent decades, because of the evolution of microorganisms and the abuse of antibiotics, the...

Sanchita Choubey

Department of Microbiology, Dr. D.Y. Patil Arts, Commerce and Science College, Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3062-68

3062-3068

56

34

11.

BIOTECHNOLOGICAL APPLICATION OF PECTINASE

Pectinase is a collection of enzymes that degrade pectin into simpler compounds known as galacturonic acids. Microbes and plants largely produce pectinase, and it has a wide range of biotechnological applications in food, agriculture, industry, the environment and medicine. Fruit juices, coffee, cocoa, tea, jams and jellies are all made with pectinase in the food industry. Furthermore, pectinase, ...

Kelemu Mulluye * and Yimeslal Atnafu

Department of Biotechnology (ULMD) Haramaya University, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.13(8).3069-77

3069-3077

57

21

12.

PHYTOACTIVE AS CHELATORS OF IRON WITH THE POTENTIAL TO MITIGATE ITS SIDE EFFECTS AND ENHANCE IRON ABSORPTION

Iron deficiency anaemia afflicts a large proportion of the human population, compromising productivity and quality of life. Iron supplements are widely prescribed for treating anaemia.  However, poor compliance due to side effects, particularly gastrointestinal side effects, remain a hurdle in alleviating the problem, leading to unabated high prevalence. Thus, a fresh look at novel approaches to ...

Shobha A. Udipi *, Jayashree Joshi, Gurmeet Singh, Sujata Sawarkar, Aashish Phadke, Arati Prabhu, Neerja Rastogi and Ashok B. Vaidya

Hon Director Integrative Nutrition and Ayurceuticals, Kasturba Health Society-Medical Research Centre, Vile Parle(W), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3078-02

3078-3102

37

23

13.

MARSDENIA TENACISSMA: A REVIEW ON ITS TAXONOMY & ITS MEDICINAL APPLICATION

Marsdenia tenacissima (MT), a traditional herbal medicine (Family Asclepiadaceae), during the past several years, there has been increasing interest in the uses of various medicinal plants from the traditional system of medicine for the treatment of different ailments. The present review highlights the pharmacognosy, phytochemistry, and pharmacological study of Marsdenia tenacissima. In this, phar...

Puja R. Basule *, Juhi U. Bandre, Uplabdhi Kohre, Atul T. Hemke and Milind J. Umekar

Department of Pharmaceutical Chemistry, Smt. Kishoritai Bhoyar College of Pharmacy Kamptee, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3103-11

3103-3111

53

27

14.

A BRIEF REVIEW ON HIBISCUS SABDARIFFA LINN WITH THEIR MEDICINAL USES AND PHARMACOLOGICAL ACTIVITY

Hibiscus sabdariffa Linn is a medicinal plant commonly known as Rosella, Sorrel, Jamaica, red-Ambadi, Queensland jelly plant etc. belonging to the family Malvaceae. Since ancient times, it has played an important role in treating various diseases. It enlarges great importance for its therapeutic potential. It is native to India, tropical Africa, and many countries like Brazil, Australia, Hawaii, F...

Himanshu C. Chaudhari * and Ghanshyam M. Chavan

PSGVP Mandal’s College of Pharmacy, Shahada, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3112-27

3112-3127

57

25

15.

EXPLORATION OF INDIAN SARSAPARILLA HEMIDESMUS INDICUS (L.)

From the primordial times' plants are standard as a chief resource for mankind. In the traditional system of medicine, Indian sarsaparilla Hemidesmus indicus (Family Asclepiadaceae) is a commonly well-known medicinal plant. This plant contains various phytoconstituents belonging to flavonoids, tannins, glycoside, sterols, and volatile oil. In the traditional system, the plant Hemidesmus indicus is...

Reema Dash *, Raghunandan Hota, Smrutiranjan Dash, Ashutosh Meher and Chandan Das

The Pharmaceutical College, Samaleswari Vihar, Tingipali, Barpali, Bargarh, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3128-36

3128-3136

37

20

16.

INVESTIGATIONAL TREATMENT OF COVID-19

The novel coronavirus disorder 2019 (COVID-19) outbreak commenced in early December 2019 in the capital metropolis of Wuhan, Hubei province, People’s Republic of China and precipitated a world pandemic on march 11, 2020. Though some the international locations have succeeded in slowing down the price of the unfold of this pandemic, most the international locations throughout the globe are nevert...

Snehal Anil Satpute

Pratibhatai Pawar College of Pharmacy, Shrirampur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3137-45

3137-3145

65

20

17.

TINOSPORA CORDIFOLIA – FROM A HUMBLE PLANT TO THE MOST BASIC INGREDIENT FOR FOOD – AN OVERVIEW

Natural products with medicinal value are becoming increasingly important in food preservation. Tinospora cordifolia, a plant commonly known as Guduchi, is highly beneficial in the medicinal field and has been used for centuries to treat various diseases. Due to the discovery of active components in Tinospora species and their potential for disease control, this plant has gained interest across th...

R. Anusha and Jyoti Prabha Bishnoi *

Amity Institute of Biotechnology, Amity University Rajasthan, Industrial Area, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3146-53

3146-3153

37

18

18.

COMPREHENSIVE STUDY OF ACACIA LEUCOPHLOEA (ROXB.): TRADITIONAL USES, PHYTOCHEMISTRY AND PHARMACOLOGICAL SIGNIFICANCE

Herbal remedies have been utilized in medical practice for thousands of years and are recognized notably as a significant and widely available resource for health treatment. Traditional botanicals and herbal supplements have been deemed to be mild, non-toxic and even safe due to their natural nature. Acacia leucophloea (Roxb.) Willd. belongs to the family Mimosaceae, recognized as a diverse reso...

Aseem Setia, Mrinal Sharma, Sanjay Nagdev *, Shashi Alok, Gaurav Mude, Megha Verma, Sudarshan Behere, Pradeep Golani and Devendra Singh Lodhi

Department of Pharmacy, Gyan Ganga Institute of Technology and Sciences, Jabalpur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3154-62

3154-3162

45

29

Research Articles

 
Title
Views
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Cited
19.

IN-SILICO DESIGN AND DOCKING STUDY OF SOME 4-(10-ACETYL-10H-PHENO-THIAZINES-3-YL)-1-PHENYLAZETIDIN-2-ONE DERIVATIVES

Background: The current study used computational approaches to investigate the molecular, physicochemical and drug-like properties of some 4-(10-acetyl-10H-phenothiazines-3-yl)-1-phenylazetidin-2-one derivatives. Methods: The structures of the compounds were drawn using Chemdraw ultra12 and smiles were generated using ACD chem sketch software. The physicochemical and molecular properties were calc...

Sandip Sen *, Bairam Ravindar, Sirikonda Jala and Laxmi Dharabonia

Department of Pharmaceutical Chemistry, School of Pharmacy, Gurunanak Institute Technical Campus, Ibrahimpattnam, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3163-73

3163-3173

130

67

20.

NOVEL FORMULATION AND ANALYTICAL EVALUATION OF BI-LAYERED TABLETS OF ENALAPRIL MALEATE, HYDROCHLOROTHIAZIDE AND NIFEDIPINE

The present research is intended for the formulation development, optimization, and in-vitro evaluation of bi-layer tablets containing Enalapril maleate, hydrochlorothiazide in the immediate release layer and Nifedipine in the sustained release layer based on GEMINEX technology. The impact of formulation variables such as combination of polymers and coating solution on the drug release was evaluat...

Srinivasarao Jagarlamudi * and Gopinath Chakka

Department of Pharmaceutical Science, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3174-86

3174-3186

110

61

21.

GREEN SYNTHESIS OF SILVER NANOPARTICLES (AGNPS) USING MANILKARA ZAPOTA FRUIT EXTRACT: POTENTIAL ROLE IN CATALYTIC DEGRADATION OF METHYLENE BLUE DYE

Present study reported a simple, rapid, eco-friendly and economical method for efficient production of AgNPs utilizing Manilkara zapota (M. zapota) extract. UV-Vis spectroscopic analysis was employedto ascertain the formation and stability of the synthesized AgNPs. The AgNPs were further characterized using TEM (Transmission Electron Microscopy), DLS, FT-IR, and XRD. The AgNPs exhibited a clear SP...

Sonia Parashar and Munish Garg *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3187-93

3187-3193

110

50

22.

ANALGESIC ACTIVITY OF ETHANOLIC, HEXANE AND CHLOROFORM EXTRACTS OF SESAME SEED BY THERMAL HEAT METHOD IN ALBINO MICE

Background: Pain is a common symptom having huge public health importance. Conventional analgesics relieve pain effectively but cause various unwanted side effects. Hence the search for a novel analgesic with favourable risk-benefit profile is essential. Objectives: The current study was undertaken to investigate the analgesic activity of the ethanolic, hexane and chloroform extracts of sesame see...

K. Dayana and M. R. Manasa *

Department of Pharmacology, Karwar Institute of Medical Sciences, Karwar, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3194-98

3194-3198

105

59

23.

EXPLORING THE DIVERSITY OF ENTEROPATHOGENS IN NEONATES

Diarrhea alters the movement of ions and water that follows an osmotic gradient and leads to Loose, watery stools, abdominal cramps, abdominal pain, fever, bloating, blood, and mucus in the stool. Numerous critical cases have been observed in both infants and adults. The main objective of this study is based on an exploration of risk factors of diarrheal infection caused in neonates by entering pa...

S. Pal, K. K. Mishra, D. C. Sharma and D. K. Sharma *

Department of Microbiology, Mewar University, Mewar, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3199-07

3199-3207

108

53

24.

USING AN IMMUNOINFORMATIC APPROACH, IDENTIFICATION OF B-CELL ENVELOPE PROTEOME FOR MULTIPATHOGENIC DENGUE AND ZIKA VIRUSES

Mosquitoes are carriers of the DENV and ZIKV diseases. DENV and ZIKV are epitopes. The current performance and technique of some of the most frequently used B-cell epitope predictors used for DV and ZV proteomes are reviewed in this paper. Our specific prediction methods, ABC pred, BC pred, and AAP Methods, as well as FBC pred, were utilized to predict 1529 B cell epitopes. For the B cell epitops,...

Neeraj Kumar Dixit

Department of Biotechnology, Saroj Institute of Technology & Management, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3208-23

3208-3223

34

18

25.

COMPARISON AND EVALUATION OF DISPENSING ERRORS FROM 2017 TO 2018 AT KING ABDULAZIZ MEDICAL CITY (KAMC) AND KING ABDULLAH SPECIALIZED CHILDREN’S HOSPITAL (KASCH), RIYADH, THROUGH THE SAFETY REPORTING SYSTEM (SRS)

Any errors in medical dispensing may threaten the patient's life. Hence, this research aimed to compare and evaluate the dispensing errors and to identify its prevalence and severity through the safety reporting system (SRS) and providing feedback at “King Abdulaziz Medical City, Central Region (KAMC-CR)” and “King Abdullah Specialized Children’s Hospital (KASCH)”.The KAMC-SRS was used t...

Saleh Al-Anazi *, Saad Al-Obaidy, Haya Al-Mufirj, Abdullah Alroumi, Thamer Al-Otaibi, Amerah Al-Saleh, Fawziah Almutairi, Huda Al-Enazi and Tahani Al-Sufian

King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, College of Pharmacy, Riyadh, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.13(8).3224-29

3224-3229

30

24

26.

CONTROLLED DELIVERY OF METFORMIN: FORMULATION DEVELOPMENT AND IN-VITRO CHARACTERIZATION OF MATRIX TABLETS USING NATURAL AND SYNTHETIC POLYMERS

Diabetes Mellitus is a chronic metabolic disorder that has become increasingly evident, necessitating more stable and continuous therapeutic monitoring. Metformin Hydrochloride, being the primary treatment choice in type II Diabetes, presents certain limitations like improper GI absorption and the need for multiple dosing. Controlled drug delivery proves to be a better option in such conditions to...

Shilpa Lakinapally * and Ramakrishna Raparla

Centre of Pharmaceutical Sciences, IST, JNTUH, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3230-41

3230-3241

29

25

27.

EVALUATION OF RATIONAL DRUG USE AND EFFICACY OF VARIOUS COMBINATIONS OF ANTIHYPERTENSIVE DRUGS COMMONLY PRESCRIBED FOR THE MANAGEMENT OF HYPERTENSION IN CKD PATIENTS AT TERTIARY CARE HOSPITAL

To evaluate the rational drug use and efficacy evaluation of various combinations of Antihypertensive drugs commonly prescribed for the management of hypertension in CKD patients at tertiary care hospitals. This is an observational and comparative study. A randomized trial was carried out in 300 patients after obtaining the consent for 1 year in a tertiary care hospital in Mahabubnagar. The data c...

Sana Butool *, Faheemuddin and Musarrath Mubeen

Department of Pharmacology, Smt. Sarojini Ramulamma College of Pharmacy, Mahabubnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3242-48

3242-3248

38

19

28.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NEWER COUMARIN DERIVATIVES AS ANTIMICROBIAL AGENTS

For the synthesis of a series of novel Coumarin derivatives, an efficient and easy approach has been designed. 1H-NMR and Fourier Transformed Infrared (FTIR) characterize the structures of freshly synthesized compounds, which are then evaluated for antibacterial activity in vitro by calculating the zone of inhibition and minimum inhibitory concentration. The antibacterial and antifungal activity o...

Jayshree Kokat * and Bharat Jadhav

Department of Pharmaceutical Chemistry, Abasaheb Kakade College of B. Pharmacy, Bodhegaon, Ahmednagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3249-53

3249-3253

33

26

29.

VITAMIN C, THIAMINE AND HYDROCORTISONE IN SEPTIC SHOCK: A RETROSPECTIVE ANALYSIS

Background: Sepsis leads to approximately 11 million deaths annually. Objectives: We studied the effectiveness of using a combination of intravenous hydrocortisone (50mg QID), Ascorbic Acid (1.5g QID), and Thiamine (200mg BD) (HAT) to reduce mortality among septic patients compared to a historical control group. Materials and Methods: This retrospective, observational study was conducted between J...

Mariam Varsha Joseph, Zubair Umer Mohamed *, Dipu Sathyapalan, Merlin Moni, Sabarish Balachandran, Greeshma C. Ravindran, Fabia Edathadathil, Arya S. Kumar and Georgy Paniker

Department of Anaesthesiology and Critical Care, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3254-60

3254-3260

30

13

30.

EVALUATION OF SEEDS OF AN INDIAN SACRED PLANT AEGLE MARMELOS, FOR THEIR ANTIOXIDANT AND CYTOTOXIC POTENTIAL

Introduction: The seeds of Aegle marmelos (bael) are less explored for their therapeutic activity; cytotoxic activity of bael seeds was yet to be studied. The present study aims at finding the cytotoxic activity of the successive extracts and the flavonoid fraction from the methanolic extract of the seeds. Methods: The extracts were prepared using solvents (petroleum ether, chloroform, ethyl aceta...

D. Parmar * and M. Apte

Department of Quality Assurance, Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3261-74

3261-3274

33

19

31.

ANTIBIOTICS SENSITIVITY PATTERN OF E. COLI SPECIES ISOLATED AT TERTIARY CARE HOSPITAL

Worldwide antimicrobial resistance is a serious problem and differs from region to region. This study has designed the determination of the incidence and sensitivity pattern of Escherichia coli (E. coli) and discusses the general issues related to antimicrobial resistance. Prospective study was carried out between JAN to April 2020. Samples of urine, blood, pus and miscellaneous (fluids, swabs and...

Vipin Kumar and Vipin Kumar Sharma

Gurukul Kangri University, Haridwar, Haridwar, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3275-79

3275-3279

34

16

32.

ROBUST SIMPLE ANALYTICAL TECHNIQUE FOR DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR ESTIMATION OF TENELIGLIPTIN IN PHARMACEUTICAL DOSAGE FORM

As per the ICH guidelines and regulatory authorities' worldwide, it has become mandatory to establish a stability-indicating assay method (SIAM) for the drug substance (DS) and drug product (DP) to generate the stability data. It was undertaken to develop a precise, accurate, reliable, rapid, simple and specific method for estimating Teneligliptin free of interference from its probable degradation...

Bhagyashri A. Borade *, Sachin J. Dighade and Suhas P. Padmane

Institute of Pharmacy & Research Badnera, Amarvati, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3280-87

3280-3287

22

15

33.

EVALUATION OF ANTI-ALZHEIMER ACTIVITY OF ETHANOLIC EXTRACT OF ORIGANUM VULGARE LEAVES IN WISTAR ALBINO RATS

Alzheimer's disease, the most frequent cause of dementia, is a major global health concern with enormous societal and individual ramifications. Some of the hallmarks linked with AD include a decrease in acetylcholine (ACh) levels in the synapse, the buildup of extracellular beta-amyloid plaques, and tau protein intraneuronal tangles. Low levels of ACh have been linked to memory and reasoning probl...

Shivam Varma and Imtiyaz Ansari *

Department of Pharmacology, Oriental College of Pharmacy, Sector 2, Behind Sanpada Railway Station, Sanpada West, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3288-97

3288-3297

36

24

34.

STUDY OF SPECIFICITY, SENSITIVITY, EFFICIENCY & CLINICAL CORRELATION BETWEEN TIMP-1 AND MIF PROTEIN AS BIOCHEMICAL MARKERS IN COLORECTAL CANCER PATIENTS

Background: Colorectal cancer is the fifth most common cancer and the leading cause of cancer-related deaths in India. The incidence, mortality, and prevalence rates are consistently higher. Precautionary measures in preventing colorectal cancer still remain a challenging issue. Aims and Objectives: This study was undertaken to correlate the specificity, sensitivity & efficiency of TIMP-1 and ...

Padmini Habbu *, N. Ananthi and Abdul Kayyum Shaikh

Department of Biochemistry, Saveetha Medical College and Hospital Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3298-03

3298-3303

32

25

35.

CARDIOPROTECTIVE EFFECT OF SANDAL WOOD (SANTALUM ALBUM LINN.): AN EXPERIMENTAL TRAIL

Background: In the Unani System of Medicine, Sandal safed (Sandalwood) is used in many cardiac problems as it possesses Mufarreh (exhilarant) and Muqawwi Qalb (cardiotonic) activities. The present study was designed to evaluate the cardioprotective effect of Sandal safed in Isoproterenol-induced Myocardial Infarction. Methods: Male Wistar rats, weighing 150-200gm, divided into five groups of ten i...

Kamal Ahmed, Najeeb Jahan*, S. Heena Kausar and Shamim Irshad

Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3304-17

3304-3317

35

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36.

DESIGN AND MOLECULAR DOCKING STUDIES OF N1-CHLOROACETYL-7-SUBSTITUTED- 4-METHYL-1, 5-BENZODIAZEPINE-2-ONE DERIVATIVES

Molecular Docking is an effective and competent tool for in-silico screening. It is playing an important and ever-increasing role in rational drug design. The main application lies in this structure-based virtual screening is the identification of new active compounds towards a particular target protein. In present investigation, few N1-chloroacetyl-7-substituted- 4-methyl-1, 5-benzodiazepine-2-on...

Dinesh Rishipathak *, Dipak Patil and Manisha Raut

Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3318-23

3318-3323

31

22

37.

COMPARATIVE EVALUATION OF ANALGESIC ACTIVITY OF SSRI (FLUOXETINE) AND SNRI (DULOXETINE AND VENLAFAXINE) IN EXPERIMENTALLY INDUCED CHRONIC NEUROPATHIC PAIN MODEL

Objectives: To investigate and compare the analgesic effect of fluoxetine (FLU), duloxetine (DUL) and venlafaxine (VEN) in animal models of chronic pain. Methods: Chronic pain was induced in albino rats using spared nerve injury and vincristine. Rats were divided into Control group/ Normal Saline (NS5), DUL group, FLU group, and VEN group. In spared nerve injury, sural branch of sciatic nerve was ...

R. P. Patil, V. S. Deshmukh *, J. B. Jaju and G. R. Pawar

Department of Pharmacology, Vilasrao Deshmukh Government Medical College, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3324-32

3324-3332

50

102

38.

ANTI-DIABETIC ACTIVITY OF THE METHANOLIC EXTRACT OF SEEDS OF SYZYGIUM CUMINI IN STZ-INDUCED TYPE I DIABETES IN RATS

Background: Syzygium cumini (SC) usually acknowledged as Jamun. All components of the Jamun may keep used medicinally because of a wide range of diseases like cough, diabetes, dysentery and inflammation. Objectives: Present investigational on the anti-diabetic activity of the methanolic extract seeds of SC in STZ-induced Type I Diabetes in rats. Methods: Extracted SC was to be evaluated the toxici...

Yousef Ahmed Saleh Haimed *, Pankaj Kumar Sharma and Deepak Kumar Jha

Department of Pharmacy, Apex University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3333-42

3333-3342

27

33

39.

ASSESSING THE FLOATING DRUG DELIVERY SYSTEM USING THE MODEL ANTI-DIABETIC DRUG GLIMEPIRIDE

Floating drug delivery systems can increase the gastric retention time by manufacturing the systems with a density less than the gastric contents of the stomach. This causes the system to float over the gastric contents in the stomach without affecting the gastric emptying rate for a prolonged period. Glimepiride was selected as a model drug to increase oral bioavailability and efficacy. Hydroxyp...

Bhargab Jyoti Sahariah, Ibadahun Lyne Gatphoh, Apurba Talukdar, Manoj Kumar Deka, Ripunjoy Bordoloi and Chanam Melody Devi *

NETES Institute of Pharmaceutical Science, NEMCARE Group of Institutions, Mirza, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3343-49

3343-3349

39

18

40.

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF LEAF EXTRACTS OF BERBERIS ARISTATA AND ABIES WEBBIANA: THE ETHNOMEDICINAL PLANTS

This study was carried out to investigate the antibacterial and antifungal potentials of Abies webbiana and Berberis aristate Linn. The study aims to assess the antimicrobial activity and determine the zone of inhibition of extracts on some bacterial and fungal strains. The extracts determined the antimicrobial activity using the agar disc diffusion method. The antibacterial and antifungal activit...

Sucheta Gautam, Neetu Sachan, Avijit Mazumder, Rupa Mazumder and Dilipkumar Pal *

Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.13(8).3350-56

3350-3356

49

26