Volume 13 (2022) - Issue 10, October
Cancer is the world's second-largest cause of death. Although substantial progress has been made in treating and controlling cancer progression, there are still significant flaws and space for improvement. During chemotherapy, several unfavourable side effects might arise. Natural-derived substances are attracting scientific and academic attention since they are thought to have fewer hazardous sid...
A SYSTEMATIC REVIEW OF AN INVASIVE PLANT SPECIES: VERBESINA ENCELIOIDES (CAV.) BENTH. & HOOK. F. EX A. GRAY
An introduced, non-native, exotic, or alien species are those that grow in areas outside of their natural habitats. They get introduced deliberately or accidentally into new areas by anthropogenic activities or naturally through water, wind, etc. In non-native areas, these species invade rapidly due to the non-availability of natural enemies (prey) in a new habitat. Therefore, these fast-spreading...
Quorum sensing is a peculiar mechanism of microbial communication through the induction of various signalling autoinducer molecules having several gene expression regulatory activities of different virulence factors that control microbial. This enables a systematic path of inhibiting microbial growth and its infection production efficacy by indirectly regulating the Quorum sensing activity of the ...
Periodontitis is a multifactorial disease. It has several associations with hormonal fluctuations; the body undergoes several physiological hormonal mechanisms. In several physiological conditions, hormonal fluctuations have been observed. One such condition is pregnancy. Several hormones are at play during pregnancy; one such hormone is PTH. Parathyroid hormone is essential to increase the matern...
Curcumin is a highly potent, nontoxic, bioactive agent found in turmeric and has been known for centuries as a household remedy to many ailments. The main active ingredient of turmeric is curcumin, a polyphenol that helps prevent and control neurological, respiratory, cardiovascular, metabolic, inflammatory and autoimmune diseases and some cancers. The major drawbacks of curcumin are low absorptio...
The reason for this assessment became the blessing of the use of nanoparticles in lung disease. Nanotechnology has a critical characteristic in inhalation. The dosage shape of pulmonary drug shipping reaches to without delay into a scientific cycle to obtain the impact of the drug. The nanoparticles have a nanosize that achieves the preferred healthy without inflicting infection as compared to sta...
The scope for patients suffering from Autism Spectrum Disorder today is far brighter than what it was a century ago. A few of these individuals, after great efforts, can read, write and communicate reasonably well while living in their homes rather than support institutions. Nevertheless, a large segment of adults suffering from Autism cannot work full-time to earn their livelihood. To add to the ...
FUNDAMENTAL PRINCIPLE AND APPLICATIONS OF IONTOPHORESIS IN CONTEMPORARY ADVANCEMENT OF DRUG DELIVERY SYSTEM: A CRITICAL APPRAISAL
The skin is the human body's biggest organ, with a surface region of around 2 m2. Generally, the skin was seen as an impermeable boundary. Yet, as of late, it has been progressively perceived that unblemished skin can be utilized as a port for the topical or ceaseless foundational organization of medications. For drugs that have short half-lives, a transdermal course gives a consistent method of o...
Wattakaka volubilis (L. f) Stapf, belonging to the family of Asclepiadaceae, has a history of use in traditional medicine in numerous countries. Traditionally the plant has been used for the treatment of diabetes, eye infections, snake bites, boils, skin problems, jaundice etc. A tribal community called Kurinjan has been using this plant to reduce blood glucose level. This plant is a tall woody cl...
Introduction: Long life, good health, and healthy development are all dependent on proper nutrition. Well-fed children do better in school, develop into healthy adults, and offer their children a better start in life. Undernutrition, on the other hand, remains a major issue, particularly among children who are deprived of adequate food in developing countries. Childhood undernutrition is an underl...
MICROWAVE-ASSISTED SYNTHESIS AND IN-SILICO SCREENING OF NOVEL SUBSTITUTED 1, 3, 4-THIADIAZOLE DERIVATIVES FOR TREATING ANTIVIRAL AGENTS
Background: Cancer is one of the deadly diseases, accounting for nearly 10 million deaths every year. Cancer is one of the leading dreadful conditions which most people. Cancer is may due to genetic change, which interferes with normal growth mechanisms. A mutant cell divides and produces abnormal masses. Cancer cells can break away from the mass (or tumour) and travel via the bloodstream or lymph...
ANTIAPOPTOTIC MECHANISM FOR THE IMPLEMENTATION OF THE HEPATOPROTECTIVE EFFECT OF PYRIMIDINE DERIVATIVES
The present study aimed to study the effect of the drug Xymedon and its conjugate with L-ascorbic acid exhibiting hepatoprotective activity on the apoptosis of rat liver cells against the background of the influence of hepatotoxic agent tetrachloromethane. Though the general effects of Xymedon and its conjugates with various biogenic acids have been studied, the molecular markers affected by the c...
EFFECT OF AQUEOUS EXTRACT OF CRYPTOLEPIS SANGUINOLENTA ADMINISTRATION ON THE METABOLISM OF CHLOROQUINE VIA CYTOCHROME P450 ISOZYMES
Concurrent administration of herbal medicines and conventional drugs is a common practice globally, especially as the patronage of medicinal plants increases across the world. This study aimed to determine the effect of Cryptolepis sanguinolenta administration on the metabolism of chloroquine by evaluating specific Cytochrome P450 isozymes. Reconstituted freeze dried Cryptolepis sanguinolenta was ...
INVESTIGATING AND SEQUENCING OF THIOL-SPECIFIC ANTIOXIDANT GENE IN A SYRIAN STRAIN OF LEISHMANIA TROPICA
Cutaneous leishmania is a common medical problem in Syria, which has become yet more widespread in most of the Syrian governorates after the current war. An effective vaccine is needed to prevent a large scale spread of leishmaniasis in the country. In this regard, protein vaccination has shown promising prospects of creating this much-needed vaccine. Thiol Specific Antioxident (TSA) plays a funda...
NEUROTHERAPEUTIC EFFECT OF BERGENIN ON CUPRIZONE-INDUCED DEMYELINATION BY REGULATING NEUROLOGICAL FUNCTIONS ASSOCIATED WITH MOTOR ACTIVITY, OXIDATIVE STRESS, AND HISTOLOGICAL ALTERATIONS IN THE CORPUS CALLOSUM OF C57BL/6 MICE
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system characterized by Neuroinflammation, oligodendrocyte loss, and axonal pathology. Bergenin, a chief phytochemical constituent of Bergenia species, has been shown to exert anti-inflammatory and antioxidant effects. The cuprizone (CPZ) model is an established mouse model of MS and causes demyelination and induces ...
A TRAILBLAZING ENDEAVOUR TO EXPLORE THE ROLE OF TULASI PUSHPA AS SANDHANA DRAVYA (FERMENTING AGENT) IN SANDHANA KALPANA
Sandhāna kalpanā (Fermentation process) is a unique procedure implemented in Ayurveda for the preparation of fermented alcoholic and acidic medicinal formulations. Sandhāna dravyās (fermenting agents) act as fermentation initiators in them. The commonly used Sandhāna dravyās are Dhātakipuṣpā (flowers of Woodfordia fruticosa), madhūkapuṣpā (flowers of Madhuka indica) and yeast. Almost...
EVALUATION OF THE NEUROPROTECTIVE ACTIVITY AND COGNITIVE ABILITY OF AEGLE MARMELOS ETHANOLIC LEAVES EXTRACT AND ESTROGEN IN ESTROGEN COMPROMISED FEMALE RATS USING SCOPOLAMINE-INDUCED ALZHEIMER’S MODEL
Alzheimer’s disease, the most common form of dementia, is higher in elderly women than men. Escape latency time of Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) is less than group 2 (Scopolamine and letrozole). As shown by the results, the decrease in AChE level in Group 3 (Donepezil) and Group 6 (AMEE and Estradiol) indicates restoration of Ach level in the brain. Increased GSH level was...
A smile is a basic and universal facial expression and is an interaction between the teeth, the lip, and the gingival outlines. The smile plays a significant role in the communication and appearance of an individual. As the esthetic demand increases, obtaining a “perfect smile” has become a major goal for many people of this generation. One of the most important features of dental and facial a...
ANTIDIABETIC POTENTIAL OF HYDROALCOHOLIC EXTRACT OF LEAVES OF NYCTANTHES ARBORTRISTIS IN ADRENALINE AND ALLOXAN-INDUCED DIABETIC RATS
Diabetes mellitus, a metabolic disorder, is a serious universal health problem. The incidence of the disease is increasing in the world in all ethnic groups. Various medicinal plants are conventionally used in the treatment or management of the disease. In this investigation, an attempt was taken to evaluate the antidiabetic property of hydroalcoholic extract of leaves of Nyctanthes arbortristis i...
FORMULATION, OPTIMIZATION AND EVALUATION OF GLIMEPIRIDE TRANSFERO-SOMAL GEL FOR ANTIDIABETIC ACTIVITY IN RATS
Transferosomes are a special liposome type consisting of phosphatidylcholine and an edge activator. Glimepiride is a second-generation sulphonylurea exerting its effects in patients with type II Diabetes. Glimepiride is hydrophobic in nature possess less solubility and permeability. The study aims to formulate, optimize and evaluate Glimepiride Transferosomal gel for antidiabetic activity in Rats....
EVALUATION OF THE ANTIHYPERTENSIVE ACTIVITY OF R-(+)-PULEGONE IN L-NAME INDUCED HYPERTENSIVE WISTAR RATS
Objectives: The present study was aimed to assess the anti-hypertensive effect of PLG in L-NAME-induced hypertensive rats. Methods: Wistar rats of 200-240g were given L-NAME (40 mg/kg body weight/day/p.o.) in drinking water daily for 4 weeks to induce hypertension. Rats were randomly divided into six groups: control, L-NAME control, Verapamil (20 mg/kg, p.o.), and PLG (5, 10, and 20 mg/kg, p.o.)...
EFFICACY OF IVERMECTIN AND DOXYCYCLINE AS AN ADJUNCT TO REMDESIVIR IN SEVERE COVID-19 CASES – A RETROSPECTIVE ANALYSIS
Introduction: Covid-19 pandemic has posed new challenges to humanity. The definitive cure is yet to be found, while drug repurposing holds the key so far. Remdesivir had been used for the treatment of novel corona-virus. Ivermectin and Doxycycline have also been recommended for treating Covid-19, but their efficacy has not been studied extensively. Methods: We conducted a retrospective study durin...
Background: Diabetes mellitus is one of the most common metabolic disturbances associated with carbohydrates, lipids, proteins, and relative or absolute insulin depletion. Various long-term complications of diabetes develop due to chronic hyperglycemia and insulin resistance. Chronic kidney disease (CKD) and diabetes mellitus (DM) are major public health problems worldwide. Turmeric is one of the ...
PREPARATION AND CHARACTERISATION OF LORNOXICAM LOADED TRANS-FEROSOME: A NOVEL CARRIER FOR ENHANCED TRANSDERMAL DELIVERY
To study and investigate transfersomes as a transdermal delivery system for the poorly soluble drug, Lornoxicam-loaded transfersomes were prepared with non-ionic surfactants like span 80 and tween 80 by the rotary evaporation-sonication method. Drug & polymer was dissolved in an organic solvent mixture of chloroform and ethanol (1:1, v/v). The outcome of the work is that prepared formulations ...
PHYTOCHEMICAL AND PHARMACOGNOSTICAL SCREENING OF JASMINUM MULTIFLORUM (BURM. F.) AND JASMINUM MESNYI (HANCE) STEMS
Jasminum multiflorum and Jasminum mesnyi, the ornamental shrubs belonging to family Oleaceae are widely distributed throughout India. Despite their use in the essence industry for making perfumes, oils, and creams, these species are also used in the healing wounds and ulcers, constipation, flatulence, skin diseases, rheumatism, stomatitis, diabetes, stress, antiseptic, diuretics, and gastric distu...
QUALITY BY DESIGN (QBD) APPROACH TO DEVELOP STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT FOR BILASTINE AND MONTELUKAST
Background and Objectives: As per requisition of current regulatory requirements, the simple, rapid and sensitive method by 33 factorial QbD approach was established and validated for Bilastine (BST) and Montelukast (MNT) by RP-HPLC. Method: A simple RP-HPLC method has been developed and validated with different parameters such as linearity, precision, repeatability, LOD, LOQ, accuracy as per Inte...
IN-VITRO AND IN-VIVO NEUTRALIZING POTENTIAL OF RAUVOLFIA SERPENTINA ROOT EXTRACT AGAINST BUNGARUS CAERULEUS VENOM
Snakebite is an international health hazard that needs attention in terms of effective management and better treatment to recover the health of the affected individuals and society. Tribal populations and folk therapists across the world have been using innumerable plants to treat snakebite difficulties. In the present study, the efficacy of aqueous extracts of Rauvolfia serpentina root for neutra...
COMBATING THE EMERGING DRUG-RESISTANT PSEUDOMONAS AERUGINOSA BY AN ANTIBIOTIC PURIFIED FROM THE NOVEL STREPTOMYCES VIOLASCENS STRAIN VS
Aim: The emergence of drug-resistant pathogens enforces the isolation of potent and novel antibiotic-producing Streptomyces sp., from the undisclosed ecological niches. Methodology: Unique Streptomyces violascens strain VS isolated by serial dilution agar plate method and strain confirmed by 16S rDNA sequencing. Antibacterial assay against multidrug resistant Pseudomonas aeruginosa isolated from b...
ULTRA DILUTED ARSENIC-INDUCED ALTERED CYTOKINE GENE EXPRESSIONS IN EMBRYONATED EGGS CHALLENGED WITH SARS-COV-2 SPIKE PROTEIN RBD ANTIGEN
Introduction / Objective: In this study, we aimed to elucidate the action of ultra-diluted (potency 6CH as per homeopathic pharmacopeia) ethanolic extract of Arsenicum album (Arsenic 6CH) on cytokine gene expression changes along with alteration of hepatic histology in Gallus gallus embryo (embryonated egg) challenged with the spike protein (S protein RBD of Delta SARS-CoV-2). Methods: Allantoic f...
EFFECT OF GERMINATION ON POLYPHENOL CONTENTS AND ANTIOXIDANT ACTIVITY IN MUSTARD SEEDS (BRASSICA NIGRA) GROWN IN ETHIOPIA
Mustard seeds, in some countries, are used as a traditional medicine for the treatment of snakebite, toothache, and epilepsy, as well as to treat skin diseases because of their high sulphur content. The aim of this study was to investigate the effect of three germination periods on the polyphenol contents and antioxidant activity of mustard seeds. Phenolic compounds were determined by the Folin-Ci...
INDIGENOUS AND UNDER-UTILISED OIL SEEDS OF BOTSWANA: PROXIMATE COMPOSITION, PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY
Proximate composition, qualitative screening for phytochemicals (terpenoids, steroids, tannins, oxalates, coumarins, phenols, saponins, and flavonoids) and antioxidant properties in four selected indigenous oilseeds: morama (Tylosema esculentum), mongongo (Schinziophyton rautenenii), mogose (Bauhinia petersiana) and kgengwe (Citrulus lanatus (Thunb.) Mansf.) from Botswana was examined. A significa...
FREE RADICAL SCAVENGING POWER POTENTIATES ANALGESIC, ANTI-INFLAMMATORY AND CNS DEPRESSANT ACTIVITY OF ALANGIUM SALVIIFOLIUM WANG
Alangium salviifolium wang. Family Alangiaceae used as a traditional medicinal plant. The objective of this study was to evaluate the comparative phytochemical and in-vitro antioxidant activity along with analgesic, anti-inflammatory, and central nervous system (CNS) depressant activities of peel and seed extract of Alangium salviifolium fruit. Quantitative phytochemical analysis for total phenoli...
VALIDATING THE CONCEPT OF ISLAH-E-ADVIA BY PHYSICOCHEMICAL PARAMETERS WITH REFERENCE TO HALELA (TERMINALIA CHEBULA RETZ)
Background: Halela (Terminalia chebula Retz) is one of the constituents in the well-known Unani compound medicine Itriphal, which has been used for thousands of years to treat a variety of ailments. In order to improve the therapeutic activity of the drug, the present study adapted the process of Tadbeer / Mudabbar (rectification/purification) which is based on the concept of Islah-e-Advia. This p...
Background: The present study was carried to evaluate the phytochemical, antioxidant, and anti-diabetic potential of Abies pindrow leaf extracts. Methods: The extracted leaf samples of Abies pindrow in methanolic and hydroalcoholic solutions were evaluated for phytochemical and antioxidant activities. In-vitro antioxidant activity of both test samples was calculated by DPPH radical scavenging capa...
The use of natural compounds has become more preferable for reducing the severe complications of diabetes mellitus due to having a minimum cost and the least side effects. The recent study is aimed to diagnose in-vitro α-amylase inhibition activity and the molecular interactions of various phytocompounds like momordicoside A, momordicoside B, momordicoside C, momordicoside D, momor-dicoside E, ga...
COMPARATIVE ANALYSIS ON STRESS LEVEL AMONG THE MEDICAL AND ENGINEERING STUDENTS IN CHENNAI CITY, TAMILNADU-A CROSS-SECTIONAL STUDY
Background: Stress is an important factor determining the mental health of the individual. During this pandemic, a student's life has had a questionable influence in academics since an online platform was created to educate them. This study was done to assess the stress level among medical and engineering students. Materials and Methods: A cross-sectional study was conducted to assess the stress l...
In the present research work, measurement of viscometric parameters - Density, Molar Volume, Apparent Molar Volume, Viscosity, Specific Viscosity, and Fluidity of synthesized Vanadium (V) complex of commercial antihypertensive drug, Diltiazem has been reported in non-aqueous solvents of varying compositions. Composition of non-aqueous solvents selected for study is 20% and 40% methanol-water mixtu...
Cariogenic organisms are responsible for producing and developing tooth decay, which ends up in dental caries. It is commonly seen in both children and adults. The aim was to evaluate anticariogenic activity of Commiphora caudata leaf extract. Two different solvents such as acetone and 70% ethanol used against Lactobacillus casei and Streptococcus mutans. Agar well diffusion method and minimum inh...
KNOWLEDGE, ATTITUDE AND PRACTICE TOWARDS ANTIBIOTIC USE AND ANTIBIOTIC RESISTANCE AMONG MEDICAL STUDENTS: A CROSS-SECTIONAL STUDY
Background: Injudiciously use of antibiotics / antimicrobial agents poses a major public health threat worldwide. Medical students will be future prescriber of antimicrobial agents so they need to have a wide awareness of the use and resistance of antibiotics. Therefore, this study was planned to assess the Knowledge, Attitude and Practice (KAP) toward antibiotics usage and antibiotics resistance ...
EXPLORATION OF HAEMOLYTIC ACTIVITY AND ANTIBIOTIC SENSITIVITY OF BIOLUMINESCENT VIBRIO SPECIES FROM THOOTHUKUDI COAST
Bioluminescence, the phenomenon of light emission by living organisms, is widespread in the marine environment at all the trophic levels from bacteria to fish and is thought to play a crucial role in the general ecology of marine plants and animals. Bacterial bioluminescence is very sensitive to toxic materials and hence, several investigations have tested its application for determining the toxic...
LISINOPRIL PROTECTS THE LIVER AGAINST FUNCTIONAL DISORDERS AND HISTOLOGICAL DAMAGES INDUCED BY FERROUS SULFATE IN RATS
Iron overload has toxic effects on the body. Hepatotoxicity is a common finding in iron-overloaded patients, resulting from iron deposition in hepatocytes. Angiotensinɪɪ is involved in developing hepatic damage through its pro-oxidative properties. Therefore, the current study aimed to investigate the therapeutic effect of the ACE inhibitor, lisinopril, against ferrous sulfate-induced hepatic fu...
IN-VITRO EVALUATION OF THE ANTIBACTERIAL POTENTIAL OF POLYHERBAL HAND WASH FORMULATION AGAINST SOME SKIN PATHOGENS
The aim of the present research work was the in-vitro evaluation of the antibacterial potential of polyherbal hand wash formulation against some skin pathogens. Herbal remedies are widely used in healthcare around the World. Herbal medicines have been widely used as effective preventative and treatment options for various ailments. There are a variety of hand washes available in the market many of...
FORMULATION AND EVALUATION OF ANTIBACTERIAL GEL CONTAINING ETHANOL EXTRACT OF THORNS OF BOMBAX CEIBA
Purpose: Formulation and evaluation of the herbal gel preparation from the thorn’s extract of Bombax ceiba to check its antibacterial activity against the bacteria Staphylococcus aureus and Propionibacterium acnes Methods: Agar well diffusion method was employed for this purpose. Results: Gel formulation of different concentrations of extract were formulated that is 2%, 4%, 6%, and 8%, respectiv...
NOVEL LIQUID CHROMATOGRAPHY / TANDEM MASS SPECTROMETRY METHOD OF WARFARIN IN BUFFERED RAT PLASMA AND ANALYSIS PLASMA PROTEIN BINDING ASSAY SAMPLES AS ITS APPLICATION
Sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for warfarin (WAR) in buffered SD (Sprague Dawley) rat plasma (PBS and Plasma: 50:50, v/v) using propranolol (PRP) as internal standards (IS) with the Plasma protein binding (PPB) assay samples to a determination of free and total warfarin. Plasma protein precipitation extraction ...
STUDIES ON THE PRELIMINARY PHYTOCHEMICAL SCREENING, IN-VITRO ANTIOXIDANT AND IN-VIVO TOXICITY OF BANANA INFLORESCENCE
The current study aimed at investigating the phyto-chemical constituents, in-vitro antioxidant activity and in-vivo acute oral toxicity of Banana inflorescence (blossom) of Musa acuminate. All the experiments were conducted using standard procedures. The results of the phytochemical screening revealed the presence of different types of secondary metabolites like alkaloids, phenols, saponins, flavo...
ASSESSMENT OF ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF SECONDARY METABOLITES FROM LEAVES AND FRUIT EXTRACT OF GYMNOSPORIA MONTANA
Objectives: Gymnosporia montana (family Celeastraceae), important shrub which is widely reported in Gujrat, India. In this study, our major objective is to screen secondary metabolites of methanolic leaves and fruit extract and determining its antioxidant and anti-inflammatory potential of this shrub. Materials and Methods: Leaves and fruit extract were subjected to methanol followed by phytochemi...
The present work deals with the formulation of containing aqueous extract of Tectona grandis (Teak) Leaves and prepared formulation against some Gram-positive and Gram-negative bacteria. The antibacterial activity of various T. grandis leaves extracts was measured by determining minimum inhibitory concentration (MIC) by cube dilution method and zone of inhibition by disc diffusion method agains...
Anorexia nervosa (AN) is a life-threatening condition with the highest mortality rate of all psychiatric disorders. The core physiological features of ANare the extreme overvaluation of shape and weight. Severe AN causes cardiovascular complications and majorly refeeding syndrome. The prominent features of refeeding syndrome include severe hypo-phosphatemia, hypokalemia and hypomagnesia, and other...
The aim of the present In-silico studies is to find out the potential protein target and find out the 3D structure of crustin antimicrobial protein in Portunus trituberculatus. Crustin are small cationic proteins assumed to be antimicrobial effectors against mainly Gram-positive bacteria. The swimming crab Portunus trituber-culatus is a commercially important crab species in East Asia countries...
SYNTHESIS, CHEMICAL CHARACTERIZATION AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF SOME NOVEL QUINOXALINES
Substituted quinoxaline has received considerable attention during the last few years as they are endowed with various biological activities and have a wide range of therapeutic properties. Piperazine has proven its worth in numerous clinically active drugs broader areas of therapeutic index. Hence, biologically important quinoxaline derivatives containing a piperazine moiety and Schiff base scaff...