Most Popular
PURIFICATION AND SEPERATION OF INDIVIDUAL CURCUMINOIDS FROM SPENT TURMERIC OLEORESIN, A BY- PRODUCT FROM CURCUMIN PRODUCTION INDUSTRY
Turmeric, curcuma longa L of Zingiberaceae family is a widely cultivated spice in India and other Asian countries. Turmeric is rich in curcuminoids, and recognized for their broad spectrum of biological activities, curcuminoids vary in chemical structures, physico-chemical characteristics as well as the functional properties. This study focused on separation of individual curcuminoids from spent t...
10487
3623
A STUDY ON DIHYDROFOLATE REDUCTASE AND ITS INHIBITORS: A REVIEW
Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as antibiotics. This study focuses on structure of Dihydrofolate, its interaction with specific amino acids, mechanism of DHFR catalysis. The reason of study was to focus on compounds which can...
10456
2085
NUTRITIONAL AND HEALTH IMPLICATIONS OF LEGUMES
Legumes are plants in the family Fabaceae characterized by seeds in pods that are often ediblethough sometimes poisonous. The nutrient content (protein, carbohydrate and micronutrients) of legumes contribute to address under-nutrition, especially protein-calorie malnutrition among children and nursing mothers in developing countries where supplementing cereal-based diets with legumes is suggested ...
10452
2991
OCULAR DRUG DELIVERY: A REVIEW
The route of choice for the treatment of ophthalmic diseases is by the topical route because of the blood ocular barrier. The most commonly utilized conventional preparations of ophthalmic dosage forms are the solutions, suspensions and ointments which are relatively inefficient as therapeutic systems. Following administration, a large proportion of the topically applied drug is immediately dilute...
10446
2696
HYDROTROPHY: NOVEL SOLUBILITY ENHANCEMENT TECHNIQUE: A REVIEW
Drug discovery and development plays a major role in the world and serves mankind. The major criteria to be considered and given importance in drug development is the solubility of a drug. Among all newly discovered chemical entities, about 40% of drugs fail to reach the market due to their poor aqueous solubility or lipophilicity. Poor solubility is not only a problem for formulation development ...
10443
2382
A REVIEW ON ANTI-VENOM ACTIVITY OF SOME MEDICINAL PLANTS
In almost every part of the world, where venomous snake occur, numerous plant species are used as folk medicine to treat snake bite. The mortality associated with snake bites is a serious public health problem as the estimated death incidence per year is about 1,25,000 globally. In India, about 35,000 to 50,000 people reportedly die of snake bite; although, unreported cases may be even more in rur...
10442
3460
SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM: A LIPID BASED DRUG DELIVERY SYSTEM
Administration of drug by oral route is the most effective and acceptable route as it has better therapeutic efficacy, low cost and good patient compliance. More than 40% of new drugs are poorly water soluble. These drugs present development challenges and also have poor bioavailability. Although many formulation approaches like solid dispersions, complexation, pH modification exist, novel lipid b...
10431
2459
A REVIEW ON THE ROLE OF PHARMACOGENOMICS IN DRUG DISCOVERY AND DEVELOPMENT
Pharmacogenomics (constitute both branch i.e pharmacology and genetic) is the study of the role of genetics in drug response. It deals with the effect of genetic variation on drug response in patient by correlating the gene expression with the pharmacokinetic parameter i.e absorption, distribution metabolism and excreation. The Pharmacogenomics is used in the research to increase the safety and ef...
10394
2344
WHAT SUITS BEST FOR ORGAN WEIGHT ANALYSIS: REVIEW OF RELATIONSHIP BETWEEN ORGAN WEIGHT AND BODY / BRAIN WEIGHT FOR RODENT TOXICITY STUDIES
Organ weight analysis is an important endpoint for identification of potentially harmful effects of test compounds in toxicology studies. Organ weight differences are often accompanied by differences in body weights between treatment groups which make the organ weight interpretation more difficult. We have evaluated the relationship between organ weight and body/brain weight based on statistical a...
10389
2119
VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW
Vinpocetine, a semisynthetic derivative alkaloid of Vincamine, an extract from the periwinkle (plant) Vinca minor is the first full-fledged nootropic (a supplement positively affecting the mind). Vinpocetine is safe and non-toxic with an amazing array of functional and structural benefits for improved health. Vinpocetine appears to improve a person's ability to acquire new memories and to restore ...
10356
2890