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TOLERANCE STUDY OF “SPIRULINE PLUS” AND EVOLUTION OF BIOLOGICAL PARAMETERS IN PEOPLE LIVING WITH HIV-1 FOR TWELVE MONTHS
Spirulina is an algae used in our country for people living with HIV (PLHIV) and it is known especially for its therapeutic immunostimulatory effects. Spirulina capsules produced locally enriched in zinc and selenium called "spiruline plus" were formulated and given to PLHIV. The objectives of this randomized placebo controlled trial were to assess the tolerance by reporting side effects and t...
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APPLICATION OF STEM CELL THERAPEUTIC AGENTS TO CONTROL CRITICAL DISEASE
Stem cell research has been hailed for the potential to revolutionize the future of medicine with the ability to regenerate damaged and diseased organs. On the other hand, stem cell research has been highly controversial due to the ethical issues concerned with the culture and use of stem cells derived from human embryos. This article presents an overview of what stem cells are, what roles they pl...
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DOUBLE LIPOSOMES MEDIATED DUAL THERAPY OF AIDS RELATED OPPORTUNISTIC FUNGAL INFECTIONS AND AIDS
To deliver zidovudine (AZT) to asialoglycoprotein receptors, drug-containing galactosylated liposomes were prepared. Simultaneously, miconazole nitrate (MCZ) was entrapped in the outer liposomal bilayer of double liposomes for the treatment of opportunistic fungal infections. Galactosylated liposomes were entrapped in double liposomes. The galactose binding Ricinus communis lectin was used for the...
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DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA-1
Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impac...
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EFFECT OF CURCUMIN ON CHEMICALLY INDUCED OSTEOARTHRITIS
Osteoarthritis is characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The main causes of Osteoarthritis are abnormality in limb, in development of joint, hereditary factors, history of joint injury, stress etc. Conventionally analgesics are used to reduce the pain, inflammation, joint swelling and stiffness. But these drugs have many side e...
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SYNTHESIS AND SPECTRAL STUDIES OF Mn (II) COMPLEXES WITH 2-HEPTANONE SEMICARBAZONE AND THIOSEMICARBAZONE
Complexes of Manganese(II) of general composition Mn(L)2X2 have been synthesized with ligand 2-heptanone semicarbazone and 2-heptanone thiosemicarbazone (where L = 2-heptanone semicarbazone or 2-hepatanone thiosemicarbazone and X=Cl-, SO42-, CH3COO-, NCS-, ClO4-) The IR spectral data of ligands indicate the involvement of sulphur/oxygen and nitrogen in coordination to the central metal. The ...
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ROLE OF DEFERASIROX, AN ORAL IRON CHELATOR IN PREVENTION OF ISCHEMIC REPERFUSION MYOCARDIAL INJURY IN ALBINO RABBITS
An experimental study was carried out after getting approval from institustional animal ethical committee to study the role of oral iron chelator, deferasirox in prevention of myocardial ischemic reperfusion injury in albino rabbits. Albino Rabbits of either sex were divided into two groups control (n=5) and test group (n=5), receiving deferasirox. Experiments were done using isolated heart perf...
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HISTOPATHOLOGIC EFFECTS OF C. METULIFERUS E MEY (CUCURBITACEAE) FRUITS IN ALBINO RATS
The fruit extract of C. metuliferus was evaluated for its phytochemical and histopathologic properties. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, sterols, saponins and cardiac glycosides. The histopathological effects of C. metuliferus fruit extract on the liver, kidney, spleen and pancreas of male adult albinos rats were investigated after daily oral administr...
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EFFECTS OF JUSSIAEA REPENS L ON SPERM DNA INTEGRITY IN MALE ALBINO RATS
Fertility control is an issue of global challenge. Researchers are trying to develop male herbal contraceptives from natural sources. Jussiaea repens L (JR) is such an herb which is reported to have non toxic antigonadal activity in male rats. The present study has designed to evaluate whether crude queous extract of JR affects the DNA integrity of spermatozoa and also to study whether its actions...
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DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF EMPAGLIFLOZIN AND METFORMIN HYDRO-CHLORIDE IN COMBINED DOSAGE FORM
Two simple spectrophotometric methods have been developed for the simultaneous estimation of Empagliflozin and Metformin hydrochloride from the tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 224 nm (λmax of Empagliflozin) and 233nm (λmax of Metformin hydrochloride) using Methanol and Water as diluent. Method – II Absorption ...
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