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BIOAVALIBILITY ENHANCEMENT OF RESVERATROL USING SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM DEVELOPED APPLYING CENTRAL COMPOSITE DESIGN
The objective of current study was to develop self-nanoemulsifying drug delivery systems using long-chain triglycerides of resveratrol to enhance its bioavailability. Solubility studies performed in different lipids, surfactants and cosurfactants. Phase diagrams constructed to select areas of nanoemulsion. SNEDDS formulation optimized using 33 central composite design (CCD) considering lipid (X1),...
4004
1910
HEPATOPROTECTIVE POTENTIAL OF YOUNG LEAVES OF TRITICUM AESTIVUM LINN. AGAINST CCl4 INDUCED HEPATOTOXICITY
The plant selected for the activity is obtained from the ninth day young leaves of Triticum aestivum Linn. belonging to the family Poaceae. The plant is commonly known as Wheatgrass which is used for various medicinal and health benefits for many years. It is considered as a cleansing and purifying agent from ancient times and yet can be used for its healing properties because of its nutritional v...
4003
1654
EFFECT OF CURCUMIN ON CHEMICALLY INDUCED OSTEOARTHRITIS
Osteoarthritis is characterized by degeneration of cartilage and its underlying bone within a joint as well as bony overgrowth. The main causes of Osteoarthritis are abnormality in limb, in development of joint, hereditary factors, history of joint injury, stress etc. Conventionally analgesics are used to reduce the pain, inflammation, joint swelling and stiffness. But these drugs have many side e...
4003
1441
IN- SILICO ANALYSIS OF MOST SUITABLE DRUG FOR PATHOGENIC BACTERIA CAUSING PERIODONTITIS
The human oral cavity is a complex biological system in which members of a microbial community interact with themselves as well as with different host structures and components Neisseria sp., Haemophilus influenzae and Campylobacter jejuni cause periodontitis . The pathogenesis of this dental infection is a multi factorial process that results in a serious degenerative disease of the periodontiu...
4002
1550
STANDARDIZATION OF SIDDHA POLYHERBAL FORMULATION PANCHABAKIYA CHOORANAM THROUGH ICPOES AND FTIR TECHNIQUES
Siddha system of medicine is a traditional medicinal system being followed mainly in South India. It is better known as one among the AYUSH medicinal system. The present study aims to standardize the Siddha poly-herbal formulation Panchabakiya chooranam (PBC), which is mentioned in the Siddha classical text Anuboga vaidya Brahma ragasyam indicated for stomach burn, burning sensation in anus and di...
4002
1513
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF SCHIFF’s BASE MUTUAL PRODRUGS OF NAPROXEN
Background: A Schiff base, a pharmacologically privileged scaffold and a nitrogen analog of an aldehyde or ketone in which the C=O group is replaced by C=N-R group. Mutual prodrug is a Carrier linked prodrug consist of two pharmacologically active substances together in a single moiety. Objective: The goal of the study is to synthesize combined form of the various Schiff’s bases with Naproxen fo...
4002
1516
EVALUATION OF IMPACT OF MEDICATION RECONCILIATION IN STROKE PATIENTS IN A TERTIARY CARE HOSPITAL
Stroke is a medical condition in which poor blood flow to the brain results in cell death and is the second most common cause of death after coronary artery disease. Stroke patients with added co-morbidities on an average are prescribed with 6-10 medications which increase the potential for Drug-Related Problems (DRPs) including inappropriate dose or indication for medication and Adverse Drug Even...
4001
1714
PRECLINICAL EFFICACY AND SAFETY OF HERBAL FORMULATION FOR MANAGEMENT OF WOUNDS
Background: Medicinal plants in Tripathi hills and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products developed by local herbalist and sold to the public are not standardized and lack efficacy and safety data to support use. Objective: to evaluate the medicinal plants...
4000
1535
ROLE OF THE INCRETINS IN HYPOGLYCEMIC EFFECT OF PHLOGACANTHUS THYRSIFLORUS NEES IN CHEMICALLY INDUCED DIABETIC MICE
Objective: This study was aimed to evaluate the role of GLP-1, GIP in the hypoglycemic activity of Phlogacanthus thyrsiflorus Nees. Materials and Methods: We have evaluated the influence of Phlogacanthus thyrsiflorus Nees, a traditionally used antidiabetic medicinal plant on some metabolic parameters, glucose homeostasis, insulin production, glucagon like peptide 1 (GLP1) and gastric Inhibitory Po...
4000
1983
ANTIOXIDANT POTENTIAL OF PHLOROGLUCINOL; AN IN-VITRO APPROACH
Phloroglucinol is a polyphenol and a component of phlorotannins belonging to the Laminariaceae family. Phloroglucinol has many positive effects on health. The present study was aimed to evaluate the antioxidant potential of phloroglucinol by comparing it with Standard antioxidant viz, ascorbic acid. The antioxidant potential of phloroglucinol was estimated using free radicals such as 1, 1-diphenyl...
4000
1985