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GREEN APPROACH ON ACHIEVING ZINC OXIDE NANOPARTICLES AND ITS POTENTIAL BACTERICIDAL AS WELL AS ANTIOXIDANT ACTIVITY
Biosynthesis of nanoparticles by biological means especially plant extract plays a major role in the field of nanotechnology. In the present study, the aqueous extract of lemon peel (Citrus limon) was used for the green synthesis of ZnO nanoparticles using 0.1 M Zn(NO3)2 as a precursor in alkaline condition using NaOH with vigorous stirring for 3 h. ZnO NPs obtained were characterized by UV-vis sp...
3349
1689
A NOVEL METHOD FOR ESTIMATION OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY VISIBLE SPECTROPHOTOMETRY
A new, simple and low cost spectrophotometric method for the determination of teneligliptin, a new DPP IV inhibitor drug in bulk and pharmaceutical dosage form using sodium nitroprusside was developed. The absorbance maximum (λmax) of the resulted colored product was at 445 nm. As different solvents were tried methanol was found to be the most suitable solvent. The Beer’s law has been obeyed i...
3347
2004
EXPLORATION OF AMORPHOPHALLUS PAEONIIFOLIUS STARCH AS NATURAL BINDER
The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% ...
3347
1987
THERAPEUTIC POTENTIAL OF CUCURBITS AGAINST RADIATION INDUCED INFLAMMATION AND DAMAGE IN MICE GUT
Whole body or local irradiation to gut is known to induce significant damage to gut epithelium and crypt stem cells. A large population of microbes in the gut remains unaffected. We hypothesize that the modifications in diet and enteric microbial population may provide a non-toxic mechanism to counter radiation induced health deficit, especially in the gut and therefore investigated the effect of ...
3346
1563
A NEW ANTIOXIDANT ACTIVE COMPOUND FROM THE ENDOLICHENIC FUNGUS, PENICILLIUM CITRINUM INHABITING THE LICHEN, PARMOTREMA SP.
Context: Endolichenic fungi are the microorganisms living inside the thalli of the lichen and found to be a new source of bioactive secondary metabolites. This is an underutilized source of bioactive compounds and has not been studied extensively. Genus, Parmotrema is one of the foliose lichens with largely rounded lobes and occurs on rocks of rain forests, sub-montane and montane forests in Sri L...
3346
1475
EVALUATION OF ANTIPEROXIDATIVE POTENTIAL OF ASCORBIC ACID ON BUSULFAN-INDUCED LIPID PEROXIDATION USING 4-HYDROXY-2-NONENAL AND NITRIC OXIDE AS MODEL MARKERS
The study was designed with an aim to evaluate the antiperoxidative potential of ascorbic acid on busulfan-induced lipid peroxidation. The study was performed in vitro using goat liver as lipid source. This evaluation was done by measuring the 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of liver tissue homogenates as markers of lipid peroxidation. The study reveals the lipid peroxida...
3345
1426
DEVELOPMENT OF MEDICAL SAFETY DATA REPORTING PROGRAMS AND HEALTH EDUCATION CENTERS
The reporting of medical safety data (especially medical data related to drug effectiveness and patient safety) and the supplying of the health education and general medical culture are very important issues in any society. And as we all live in one world, so, we should deal with these issues as international issues not only as local issues, and there are reasons and problems make that only a few ...
3345
1364
STATUS OF GLUCOSE-6- PHOSPHATE DEHYDROGENASE – A RISK FACTOR FOR PREECLAMPSIA
Background and Objectives: Glucose 6-Phosphate Dehydrogenase (G-6PD) is a ubiquitous enzyme playing a key role in the metabolism of glucose. Reduced activity of G-6PD is one of the most prevalent and genetically determined hereditary defects of the human being. Recently, it has been suggested that reduced G–6PD activity in pre-eclampsia may act as a contributory factor for the development of thi...
3343
1594
DESIGN DEVELOPMENT AND EVALUATION OF GASTRO RETENTIVE FLOATING MICROSPHERES OF ATAZANAVIR SULFATE
The purpose of present study was to formulate the gastro-retentive floating microspheres of atazanavir sulfate to be retentive in the stomach for prolonged period of time. The gastro-retentive floating microspheres were prepared by double emulsion w1/o/w2 solvent evaporation technique and characterization for particle size, SEM, floating time, FTIR, DSC, and entrapment efficiency. The in-vitro dru...
3342
1623
SYNTHESIS OF SOME NEW 2-(N-SUBSTITUTED)- 3H- PHTHALAZIN- 1, 4- DIONE DERIVATIVES FOR THEIR ANTIHYPERTENSIVE ACTIVITY
Present study is reporting the result of the synthesis and evaluation of antihypertensive activity for N-substituted pthalazine 1,4-dione derivatives. N-substituted pthalazine 1,4-dione derivatives were synthesized by taking the Heterocyclic system, ethylglycinate, hydrazine hydrate and pthalic anhydride and were subjected to preliminary screening for antihypertensive activity in albino rats. The ...
3341
1915