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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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62.

PHYTOCHEMICAL AND TOXICOLOGICAL INVESTIGATION ON AQUEOUS EXTRACT OF POLYHERBAL PREPARATION

Polyherbal preparations (PHP) are   known to express high effectiveness in a vast number of diseases. In view of this, present investigation was carried out to identify phytochemical constituents of PHP, prepared from the aqueous extract of test plant powders of Mimusops elengi Linn., Strobilanthes barbatus Nees, Indigofera zollingeriana Miquel and Dillenia indica Linn. Phytochemical screening o...

R. Pasupula * and R. R. Pragada

Department of Pharmacology, St. Anns College of Pharmacy, Prtakasam, Vizianagaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(7).3083-93

3083-3093

3295

1476

9.

DUAL ROLE OF ARJUNOLIC ACID AND B12 IN MITIGATING SODIUM ARSENITE INDUCED MALFUNCTION OF FEMALE REPRODUCTIVE ORGANS

The present study was proposed to delineate the curative role of arjunolic acid and vitamin B12 alone or in combination against arsenic induced oxidative stress and female reproductive dysfunction. The Wistar strain adult female rats were treated with sodium arsenite at the dose of 1.0 mg/100 gm body weight orally for first eight days. Next eight days rats were treated with arjunolic acid (1.0 mg/...

M. Maity, H. Perveen and S. Chattopadhyay *

Department of Biomedical Laboratory Science and Management, and Clinical Nutrition and Dietetics division (UGC Innovative Department), Vidyasagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(7).3219-27

3219-3227

3294

1747

3.

MITOGENIC, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITIES OF G-90 AND COELOMIC FLUID FROM EARTHWORM AS A THERAPEUTIC AGENT, A REVIEW

The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial a...

K. Gudeta *, S. Kumari, A. Bhagat, J. M. Julka and R. Goyal

Faculty of Biological and Environmental Sciences, Shoolini University Biotechnology and Management Sciences, Solan, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.11(11).5298-07

5298-5307

3294

1824

56.

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF FAMOTIDINE WITH HYDROPHILIC POLYMERS BY SOLID DISPERSION TECHNIQUE

Objective: In the present study to enhance solubility and in vitro dissolution of poorly aqueous soluble drug Famotidine by preparing solid dispersions using the Kneading method. Methods: Solid dispersions of the drug were prepared by the kneading method using Kollidon and Povidone K30 (as a carrier). Eight different drugs: Carrier ratios were prepared by Factorial design taking three factors, i.e...

V. T. Wagh *, R. M. Gilhotra and R. D. Wagh

Department of Internal Medicine, College of Medicine, University of Hail, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.11(6).2996-02

2996-3002

3294

1649

50.

DEVELOPMENT AND VALIDATION OF NOVEL UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MEBENDAZOLE IN PHARMACEUTICAL FORMULATION

Mebendazole is a broad-spectrum anthelmintic drug that is widely used in the treatment of helminthic infections. A simple, accurate, and precise UV-visible spectrophotometric method has been developed and validated for the determination of Mebendazole in tablet formulation. The solvent used for the development of the proposed method was Phosphate buffer 6.8 at 278.6 nm. The Beers' law was obeyed i...

S. Shrivastava * and C. D. Kaur

Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.12(4).2317-22

2317-2322

3294

2493

16.

EXPLORATION OF AMORPHOPHALLUS PAEONIIFOLIUS STARCH AS NATURAL BINDER

The aim of the present work was to characterize the starchy components of Amorphophallus paeoniifolius tuber and evaluate its potential as a binder. The tuber starch was extracted and characterized in terms of Phyto-chemical and physicochemical properties. Cyproheptadine was selected as model drug, and drug excipient compatibility studies were carried. Granules containing 5%, 7.5%, 10%, and 12.5% ...

U. Y. Kandekar * and T. R. Abhang

JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathwade, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.11(12).6097-04

6097-6104

3293

1964

29.

DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL -2- (5-(1H-INDOL-3-YL)- 1, 3, 4-THIADIAZOL -2 -YLIMINO) -5 -(SUBSTITUTED BENZYLIDENE) THIAZOLIDIN-4-ONE ANALOGUES

A series of novel analogues of 2-(5-(1H-indol-3-yl)-1, 3, 4-thiadiazol-2-ylimino)- 5- (substituted benzylidene)thiazolidine-4-one have been synthesized. The structures of newly synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and Mass spectroscopy. The synthesized compounds showed significant antibacterial activity against gram-positive bacteria: Staphylococcus aureus (MTCC 3160), Ba...

P. Taya, D. K. Mehta * and R. Das

Department of Pharmaceutical Chemistry, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).701-11

701-711

3292

1495

47.

BARRIERS IN UPTAKE OF SCREENING OF CERVICAL CANCER

Background: Cervical cancer is the second most common cancer in women worldwide, with over 90% of cases the occurring in developing countries. India attributes to about 15% of the cancer deaths in the world mostly in rural areas. This dangerous disease can be effectively prevented by creating awareness programs and the possibility of effective management with early screening. Methodology: A prospe...

B. D. Jyothi

Clinical Pharmacist in Manipal Hospitals, Tadepalli, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(10).4416-21

4416-4421

3292

1301

30.

MAPPING OF NATURAL KAPOSI SARCOMA INHIBITOR USING NETWORK BIOLOGY APPROACH

Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predi...

Sadegh Saremy and Jayadeepa R. M.*

Institute of Computational Biology, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.3(3).853-57

853-857

3291

1512

17.

IN-VITRO AND IN-VIVO EFFICACY OF ROOT EXTRACT OF LAWSONIA INERMIS AGAINST INFLAMMATORY PARADIGM

The study was carried out to evaluate anti-inflammatory activity of alcoholic extract of roots of Lawsonia Inermis (LILAC). In-vitro anti-inflammatory activity was evaluated by Cyclooxygenase inhibitory assay wherein the LIALC showed a dose-dependent inhibition of both the enzymes with IC50 values of 58.2 μg/ml for COX-1 and 7.38 μg/ml for COX-2. In RBC membrane stabilization activity, LILAC at ...

E. N. Bharath, S. N. Manjula *, G. Bhavimani and K. Mruthunjaya

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(2).619-24

619-624

3290

1426