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A NEW ANTIOXIDANT ACTIVE COMPOUND FROM THE ENDOLICHENIC FUNGUS, PENICILLIUM CITRINUM INHABITING THE LICHEN, PARMOTREMA SP.
Context: Endolichenic fungi are the microorganisms living inside the thalli of the lichen and found to be a new source of bioactive secondary metabolites. This is an underutilized source of bioactive compounds and has not been studied extensively. Genus, Parmotrema is one of the foliose lichens with largely rounded lobes and occurs on rocks of rain forests, sub-montane and montane forests in Sri L...
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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF FAMOTIDINE WITH HYDROPHILIC POLYMERS BY SOLID DISPERSION TECHNIQUE
Objective: In the present study to enhance solubility and in vitro dissolution of poorly aqueous soluble drug Famotidine by preparing solid dispersions using the Kneading method. Methods: Solid dispersions of the drug were prepared by the kneading method using Kollidon and Povidone K30 (as a carrier). Eight different drugs: Carrier ratios were prepared by Factorial design taking three factors, i.e...
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IN-VITRO AND IN-VIVO EFFICACY OF ROOT EXTRACT OF LAWSONIA INERMIS AGAINST INFLAMMATORY PARADIGM
The study was carried out to evaluate anti-inflammatory activity of alcoholic extract of roots of Lawsonia Inermis (LILAC). In-vitro anti-inflammatory activity was evaluated by Cyclooxygenase inhibitory assay wherein the LIALC showed a dose-dependent inhibition of both the enzymes with IC50 values of 58.2 μg/ml for COX-1 and 7.38 μg/ml for COX-2. In RBC membrane stabilization activity, LILAC at ...
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MITOGENIC, ANTIOXIDATIVE AND ANTIMICROBIAL ACTIVITIES OF G-90 AND COELOMIC FLUID FROM EARTHWORM AS A THERAPEUTIC AGENT, A REVIEW
The mitogenic activity in earthworms should be accompanied by antioxidative and antimicrobial activities during the healing or regeneration of their amputated part. These activities are achieved by bioactive macromolecules in their tissue and coelomic fluid. The antioxidative activity applied to prevent the cellular function from oxidative damage and assist cell multiplication. The antimicrobial a...
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ASSESSMENT OF PYRAZINO-PYRIMIDINE COMPOUND AND SOME INFLAMMATORY BIOMARKERS IN PATIENTS WITH TYPE 2 DIABETES
Neopterin, pyrazino-pyrimidine compound, is a metabolite of guanosine triphosphate and is produced by the activated monocytes, macrophages and dendritic cells upon stimulation by interferon gamma produced by T-lymphocytes. Aim: This study purposed to analyze the serum level of neopterin and to evaluate its correlation with other markers of inflammation in patients with type 2 diabetes at various s...
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DESIGN, SYNTHESIS, DOCKING STUDY AND PHARMACOLOGICAL EVALUATION OF NOVEL -2- (5-(1H-INDOL-3-YL)- 1, 3, 4-THIADIAZOL -2 -YLIMINO) -5 -(SUBSTITUTED BENZYLIDENE) THIAZOLIDIN-4-ONE ANALOGUES
A series of novel analogues of 2-(5-(1H-indol-3-yl)-1, 3, 4-thiadiazol-2-ylimino)- 5- (substituted benzylidene)thiazolidine-4-one have been synthesized. The structures of newly synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and Mass spectroscopy. The synthesized compounds showed significant antibacterial activity against gram-positive bacteria: Staphylococcus aureus (MTCC 3160), Ba...
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DUAL ROLE OF ARJUNOLIC ACID AND B12 IN MITIGATING SODIUM ARSENITE INDUCED MALFUNCTION OF FEMALE REPRODUCTIVE ORGANS
The present study was proposed to delineate the curative role of arjunolic acid and vitamin B12 alone or in combination against arsenic induced oxidative stress and female reproductive dysfunction. The Wistar strain adult female rats were treated with sodium arsenite at the dose of 1.0 mg/100 gm body weight orally for first eight days. Next eight days rats were treated with arjunolic acid (1.0 mg/...
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DEVELOPMENT AND VALIDATION OF NOVEL UV SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF MEBENDAZOLE IN PHARMACEUTICAL FORMULATION
Mebendazole is a broad-spectrum anthelmintic drug that is widely used in the treatment of helminthic infections. A simple, accurate, and precise UV-visible spectrophotometric method has been developed and validated for the determination of Mebendazole in tablet formulation. The solvent used for the development of the proposed method was Phosphate buffer 6.8 at 278.6 nm. The Beers' law was obeyed i...
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MAPPING OF NATURAL KAPOSI SARCOMA INHIBITOR USING NETWORK BIOLOGY APPROACH
Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predi...
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BARRIERS IN UPTAKE OF SCREENING OF CERVICAL CANCER
Background: Cervical cancer is the second most common cancer in women worldwide, with over 90% of cases the occurring in developing countries. India attributes to about 15% of the cancer deaths in the world mostly in rural areas. This dangerous disease can be effectively prevented by creating awareness programs and the possibility of effective management with early screening. Methodology: A prospe...
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