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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 1 (2010) - Issue 10, October

Review Articles

 
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1.

HOLISTIC MEDICINE: STEPPING STONES OF NEW LIFE IN MODERN MEDICINE

Holistic living is an art of living in harmony with nature and deals with a concern for the whole universe. The term holistic medicine is derived from the term “Holism” which means that a living being is not to be viewed as a composite of different organs but as an integrated entity viewed as a whole. The holistic concept takes into account individual’s physical, spiritual, nutritional and e...

K. Jiny Varghese*, M. Elezabeth Koshy, A. Soumya Mary, K. S. Silvipriya and S. Resmi

Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, AIMS Healthcare Campus, AIMS Ponekkara P. O., Kochi, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).1-10

1-10

1841

528

2.

AN OVERVIEW AND ADVANCEMENT IN OCULAR DRUG DELIVERY SYSTEMS

Eye is most unique organ of the body. Various drug delivery systems are used to deliver drug into eyes are used but there are various limitations of conventional systems so researchers are finding new ways by which contact time, bioavailability and residence time can be enhanced as well as patient discomfort and frequency of dose can be reduced. The conventional dosage forms are account for 90% of...

K. S. Rathore*, R. K. Nema and S. S. Sisodia

B N Girls College of Pharmacy, Udaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).11-23

11-23

2083

824

3.

NEWER ADVANCEMENT IN NASAL DRUG DELIVERY SYSTEM

Over the past two decades, intranasal drug delivery has shown tremendous promise for systemic delivery of therapeutic agents, although the potential of the nose as a route of administration has been known since ancient time. Psychotropic and hallucinogenic agents have been used as snuff in many parts of the world for hundreds of years. Because of rich vasculature and highly permeable structure, na...

Addisu Yenet, Nisha M. Joseph*, S .Palani, Zelalem Ayenew, Musie Ghezu and Anish Zacharia

School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).24-29

24-29

2034

1156

4.

ASEPTIC PROCESSING RISK MANAGEMENT: A REVIEW

Aseptic processing is a widely used technology in the field of pharmaceutical, biotech, and medical device industries for the preparation of sterile materials. The term aseptic processing as it is applied in the pharmaceutical industry refers to the assembly of sterilized components and product in a specialized clean environment. Aseptic processes are some of the most difficult processes to conduc...

E. Gopinath*, Raghvendra S. Bhadauria, Amit Mishra, Vinod Kumar Soan and D. P. Gupta

Shrinathji Institute of Pharmacy, upali oden Nathdwara, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).30-40

30-40

4341

1642

5.

NOVEL NUCLEAR RECEPTOR SUPER FAMILY DATABASE

The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs a...

Akshay A. Bhat, Vinay Sridhar, Hemanth Kumar K., Abhilash M.*

UST Global, Technopark, Trivandrum, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).41-49

41-49

1508

469

6.

DASAPUSHPAM: THE TRADITIONAL USES AND THE THERAPEUTIC POTENTIAL OF TEN SACRED PLANTS OF KERALA STATE IN INDIA

The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day ...

K. Jiny Varghese*, J. Anila, R. Nagalekshmi, S. Resiya and J. Sonu

Department of Pharmacognosy & Phytochemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, AIMS Healthcare Campus, AIMS Ponekkara P. O., Kochi, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).50-59

50-59

12696

3491

Research Articles

 
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7.

SYNTHESIS OF 4, 5-DIHYDROXY-9, 10-DIOXOANTHRACENE-2-BENZYL CARBOXYLATE ESTER FROM RHEIN

Rhein and several analogues thereof, are particularly important from commercial point of view and are known for their use in the treatment of degenerative diseases of the joints, for example osteoarthritis, osteoporosis and rheumatoid arthritis. Rhein occurs in nature in plant families such as Cassia, Rheum and Rhamnus, but in a very less concentration. Aloin, a natural substance isolated from var...

Rajesh S. Gavit* and K. S. Laddha

Medicinal Natural Products Research Laboratory (MNPRL), Institute of Chemical Technology (ICT), Nathalal Parikh Marg, Matunga, Mumbai (MH), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).60-64

60-64

1919

748

8.

A RAPID AND SENSITIVE METHOD FOR THE QUANTITATION OF MONTELUKAST IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY

A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States - Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used...

S. Gunasakaran *, Nageshwara Rao, S. Arunkumar and A. Olaganathan

Azidus Laboratories Limited, Chennai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).65-72

65-72

1665

640

9.

TETRACYCLINE COORDINATION COMPOUND AS ANTIMICROBIAL AGENT

The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8)   MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram ...

Pranay Guru

Department of Engineering Chemistry, People’s College of Research & Technology, Bhopal (M P), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).73-77

73-77

1441

507

10.

PEROXYNITRITE SCAVENGING AND TOXICITY POTENTIAL OF DIFFERENT FRACTIONS OF THE AERIAL PARTS OF BACOPA MONNIERA LINN.

Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO- from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO-) and to inhibit total reactive oxygen species (ROS) generation, in kidney homogenates using 2',...

M. B. Alam, M. S. Hossain, M. Asadujjaman, M. M. Islam, M. E. H. Mazumder and M. E. Haque*

Department of Pharmacy, Atish Dipankar University of Science & Technology, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).78-83

78-83

1464

504

11.

IN VITRO ANTHELMINTIC ACTIVITY OF DIFFERENT EXTRACTS OF ROOT OF CARISSA SPINARUM

Modern medicines are gaining less attention due to their limited availability and affordability in human intestinal helminthesis. Thus, most of the world’s population depends to a greater extent on traditional medical remedies. Carissa spinarum, Linn. (Apocynaceae) is a small spinous, evergreen shrub growing throughout India in dry regions. Further, C. spinarum roots are traditionally used for t...

Ranjit Kumar Harwansh*, Debapriya Garabadu, Md. Akhlaquer Rahman, Priyanka S. Garabadu

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Central University , Bilaspur (CG), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).84-88

84-88

1496

509

12.

PREVENTIVE EFFECT OF DIOSMIN, A BIOFLAVONOID, ON GLYCOPROTEIN CHANGES IN STREPTOZOTOCIN-NICOTINAMIDE-INDUCED TYPE 2 DIABETIC RATS

The present study was designed to investigate the effect of diosmin on the levels of glycoprotein components in plasma and tissues of streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (45 mg/kg b. w). Diosmin (DS) (100 mg/kg b. w) was administered orally for 45days. The effects of diosmin on plasma gl...

Leelavinothan Pari*, Subramani Srinivasan and Mohammed Saddiq

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar, Tamilnadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).89-95

89-95

1690

747

13.

DEVELOPMENT AND IN VITRO EVALUATION OF MICRONIZED SUSTAINED RELEASE MATRIX TABLET OF CARVEDILOL

Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dis...

B. Chatterjee and T. K. Pal*

Bioequivalence study centre, Department of pharmaceutical technology, Jadavpur University, Kolkata (WB), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).96-02

96-102

1479

555

14.

DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS

Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardan...

J. Ayyappan*, P. Umapathi and Darlin Quine

Department of Research and Development, Micro Labs Ltd, 67/68-A, Third Phase, Peenya Industrial Area, Bangalore, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).103-13

103-113

1274

534

15.

EVALUATION OF ANTIOXIDANT AND HYPOLIPIDEMIC ACTIVITY OF VEDIC GUARD, A POLYHERBAL FORMULATION

The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxi...

K. N. Bharathi * and D. E. Shankar

Department of Pharmacology, Visveswarapura Institute of Pharmaceutical Sciences, 22nd Main, 24th Cross, B. S. K II stage, Bangalore, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).114-27

114-127

1530

694

16.

STUDY OF PHYTO CHEMICAL, ANALGESIC AND ANTI ULCER ACTIVITY OF EXTRACTS OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM LINN.

The dried aerial parts of Cardiospermum halicacabum Linn were subjected to extraction using the solvents (petroleum ether, chloroform, Ethyl acetate and ethanol) in increasing order of polarity. The prepared extracts were then subjected to preliminary phytochemical analysis. It was found plant possesses carbohydrates, alkaloids, sterols, flavanoids and saponins. All extracts were selected for furt...

P. Muthumani*, R. Meera, S. Venkatraman, Sundara Ganapathy and P. Devi

Department of Pharmaceutical Chemistry, K M College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).128-37

128-137

1574

611

17.

IN VITRO ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF COSTUS SPECIOSUS (KOEN.) SMITH RHIZOME

This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the rhizome of Costus speciosus (Zingiberaceae). The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, total phenolic content and flavonoid content were studied. Costus speciosus exhibited potent total antioxidant activity which was expressed as an eq...

M. K. Jha, M. B. Alam, M. S. Hossain and A. Islam*

Department of Pharmacy, Bangladesh University, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).138-44

138-144

2294

989

18.

THE PREVALENCE OF FUNGI ON THE POST HARVESTED GUAVA (PSIDIUM GUAJAVA L.) IN AKSUM

Guava is one of the most liked fruit items in Ethiopia and has its own economical importance. In concern with that a project experiment cum survey was carried out on the prevalence of post-harvest diseases of guava was conducted in Aksum in the months of January and March, 2009. During the experiment, 80 samples of diseased guava fruits were collected from different sites of Aksum, Ethiopia. The i...

Shiju Mathew

Department of Natural Sciences, Aksum University, Aksum, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).145-49

145-149

1669

655

19.

PHYTOCHEMICAL SCREENING AND IN VITRO ANTIMICROBIAL ACTIVITY OF BUTEA MONOSPERMA (L) BARK ETHANOLIC AND AQUEOUS EXTRACT

Infectious diseases are the second leading cause of death worldwide. Treatment of infections continues to be problematic in modern time because of the severe side effects of some drugs and the growing resistance to antimicrobial agents. Butea monosperma (L) bark ethanolic and aqueous extract has shown good efficacy against Bacillus cereus. Pseudomonas aerugenosa and Escherichia Coli in concentrati...

Pattari Lohitha*, V. Ravi Kiran, K. R. Mohan Babu, K. Nataraj, P. Alankritha Rani, N. Madhavi, M. Chaitanya and N. Divya

Vishnu Institute of Pharmaceutical Education and Research (VIPER) - Vishnupur, Narsapur, Medak Dist., Hyderabad (AP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).150-55

150-155

1676

615

20.

FORMULATION OF RANITIDINE HYDROCHLORIDE GASTRO RETENTIVE FLOATING TABLET BY USING DIFFERENT RATIO OF POLYMERS

The aim of the present investigation was to develop a novel gastro retentive dosage form of Ranitidine hydrochloride (RHCl) to achieve prolong gastric retention, increase drug bioavailability and to modulate the release of RHCl in the stomach, by using various ratios of HPMC E-15, a low-density grade polymer and it was cheaper and easily available along with Carbopol 934, as gel former. Sodium bic...

A. K. Dave, V. Saklle, Sachin Jain*, Ankit Jain, and A. Pawar

College of Pharmacy, I P S Academy, Indore (MP), India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).156-59

156-159

1683

773

21.

PHARMACOGNOSTICAL INVESTIGATIONS ON ACACIA LEUCOPHLOEA STEM BARK

The plant Acacia leucophloea Roxb is reported to have great medicinal value in Indian medicine. The present study deals with the pharmacognostical investigation on stem bark of Acacia leucophloea. Pharmacognostical evaluation such as macroscopical and microscopical characters, ash value, moisture content and extractive values were carried out.    ...

Arun Kumar Gupta, Rajesh Gupta* and G. Aiswarya

Sri Sai College of Pharmacy, Dalhousie road, Badhani, Pathankot, Punjab,India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).160-63

160-163

1647

692

22.

EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERS

The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physi...

Pragati Shakya*, N. V. Satheesh Madhav and Ashok K. Shakya

Faculty of Pharmacy, Integral University, Kursi Road, Lucknow, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).164-68

164-168

1307

634

23.

PHYTOCHEMICAL AND PHARMACOLOGICAL SCREENING OF SPHAERANTHUS INDICUS LINN. FOR ANTIMICROBIAL ACTIVITY

Sphaeranthus indicus Linn (Asteraceae) is a common annual spreading herb found in rice field throughout India. Six crude extracts were prepared from the whole plant Sphaeranthus indicus using different solvents by cold maceration process. The extracts were subjected to screening to detect potential antimicrobial activity against S. aureus, B. substillus, P. Gentamycin and Nystatin as standard by c...

Subin Mary Zachariah*, Leena K. Pappachen, T. P. Aneesh, Lincy Alex, G. Sumith, MABLE Sheeba John, M. C. Praseetha and R. Nagalekshmi

Amrita School of Pharmacy, Amrita Viswavidyapeetham University, AIMS Health Science Campus, Ponekkara P. O., Kochi, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).169-73

169-173

1872

1121

24.

HEMINTHOLYTIC POTENTIAL OF CYMBOPOGON CITRATUS LEAVES EXTRACT AND ITS FORMULATION AS AN EMULSION

The present communication deals with the laboratory studies carried out to determine the antihelmintic activity of Cymbopogon citratus leaves extracts against Pheritima posthuma. Methanolic and aqueous extracts were used as test solutions. Piperazine citrate was used as standard drug and normal saline as a control. Study involved the determination of time of paralysis as well as time of death of w...

M. S. Gore *, H. L. Tare, S. R. Deore, J. S. Bidkar and G. Y. Dama

SGMSPM’s Sharadchandra Pawar College of Pharmacy, Otur (Dumbarwadi), Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.1(10).174-77

174-177

1468

709