Volume 1 (2010) - Issue 10, October
Holistic living is an art of living in harmony with nature and deals with a concern for the whole universe. The term holistic medicine is derived from the term “Holism” which means that a living being is not to be viewed as a composite of different organs but as an integrated entity viewed as a whole. The holistic concept takes into account individual’s physical, spiritual, nutritional and e...
Eye is most unique organ of the body. Various drug delivery systems are used to deliver drug into eyes are used but there are various limitations of conventional systems so researchers are finding new ways by which contact time, bioavailability and residence time can be enhanced as well as patient discomfort and frequency of dose can be reduced. The conventional dosage forms are account for 90% of...
Over the past two decades, intranasal drug delivery has shown tremendous promise for systemic delivery of therapeutic agents, although the potential of the nose as a route of administration has been known since ancient time. Psychotropic and hallucinogenic agents have been used as snuff in many parts of the world for hundreds of years. Because of rich vasculature and highly permeable structure, na...
Aseptic processing is a widely used technology in the field of pharmaceutical, biotech, and medical device industries for the preparation of sterile materials. The term aseptic processing as it is applied in the pharmaceutical industry refers to the assembly of sterilized components and product in a specialized clean environment. Aseptic processes are some of the most difficult processes to conduc...
The objective of the project is to develop a comprehensive database of Nuclear Receptor (NR) Superfamily-Ligand. Nuclear Receptor Superfamily represents one of the most important families of drug targets in pharmaceutical development. Nuclear Receptor) Superfamily-Ligand is a novel public NR-related chemical genomic database that is primarily focused on the correlation of information between NRs a...
DASAPUSHPAM: THE TRADITIONAL USES AND THE THERAPEUTIC POTENTIAL OF TEN SACRED PLANTS OF KERALA STATE IN INDIA
The Western Ghats of Kerala is famous for its medicinal plant wealth and the tradition of indigenous system of therapy, specifically the Ayurveda. Dasapushpam constitute a group of ten potential herbs which are culturally and medicinally significant to the people of Kerala in India. They are a group of ten herbs with which the ladies decorate their hairs and dance the Thiruvathira Kali on the day ...
Rhein and several analogues thereof, are particularly important from commercial point of view and are known for their use in the treatment of degenerative diseases of the joints, for example osteoarthritis, osteoporosis and rheumatoid arthritis. Rhein occurs in nature in plant families such as Cassia, Rheum and Rhamnus, but in a very less concentration. Aloin, a natural substance isolated from var...
A RAPID AND SENSITIVE METHOD FOR THE QUANTITATION OF MONTELUKAST IN HUMAN PLASMA USING LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY
A simple, precise and reproducible liquid chromatography–tandem mass spectrometry method has been developed and validated according to the United States - Food and Drug Administration (US-FDA) guidelines for the quantitation of Montelukat in human plasma using Neverapine as an internal standard. Montelukast is a fast acting and potent cysteinyl leukotriene receptor antagonist which is being used...
The present paper deals with the microbial studies of the complex Co(II) & Cu(II) with antibiotic drug Tetracycline, a formula Co (C22 H24 N2 O8) MoO4 4H2O and Cu (C22 H24 N2 O8) MoO4 3H2O has been suggested on the basis of elemental analysis and molar conductance for the newly synthesized complex. The microbial studies of synthesized complex were studied on pathogenic bacteria using gram ...
PEROXYNITRITE SCAVENGING AND TOXICITY POTENTIAL OF DIFFERENT FRACTIONS OF THE AERIAL PARTS OF BACOPA MONNIERA LINN.
Bacopa monniera is locally referred as Brahmi Shak, has been reputed to use in the Ayurvedic system of medicine for centuries. In our ongoing study to identify the scavenger of ONOO- from natural sources, the aerial parts of Bacopa monniera Linn. was evaluated to scavenge authentic peroxynitrites (ONOO-) and to inhibit total reactive oxygen species (ROS) generation, in kidney homogenates using 2',...
Modern medicines are gaining less attention due to their limited availability and affordability in human intestinal helminthesis. Thus, most of the world’s population depends to a greater extent on traditional medical remedies. Carissa spinarum, Linn. (Apocynaceae) is a small spinous, evergreen shrub growing throughout India in dry regions. Further, C. spinarum roots are traditionally used for t...
PREVENTIVE EFFECT OF DIOSMIN, A BIOFLAVONOID, ON GLYCOPROTEIN CHANGES IN STREPTOZOTOCIN-NICOTINAMIDE-INDUCED TYPE 2 DIABETIC RATS
The present study was designed to investigate the effect of diosmin on the levels of glycoprotein components in plasma and tissues of streptozotocin (STZ)-nicotinamide (NA) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (45 mg/kg b. w). Diosmin (DS) (100 mg/kg b. w) was administered orally for 45days. The effects of diosmin on plasma gl...
Carvedilol, a non selective β blocking drug under the biopharmaceutical classification system (BCS) class II, is widely used in the treatment of hypertension. Solubility of this drug is very low which affects in low dissolution rate and in turn affect the bioavailability of this drug following oral administration. The micronization of drug is one of the technological procedures to improve the dis...
DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS
Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardan...
The present study was undertaken to evaluate antioxidant and hypolipidemic activity of Vedic guard, a polyherbal formulation comprising of Terminalia arjuna, Withania sominefera, Bacopa monnierii, Tinosporia cardifolia, Commiphora mukul and many other plant extracts, all of which are classifieds in Ayurveda as Rasaayanas which are reported to promote antioxidant and hypolipidemic activity. Antioxi...
STUDY OF PHYTO CHEMICAL, ANALGESIC AND ANTI ULCER ACTIVITY OF EXTRACTS OF AERIAL PARTS OF CARDIOSPERMUM HALICACABUM LINN.
The dried aerial parts of Cardiospermum halicacabum Linn were subjected to extraction using the solvents (petroleum ether, chloroform, Ethyl acetate and ethanol) in increasing order of polarity. The prepared extracts were then subjected to preliminary phytochemical analysis. It was found plant possesses carbohydrates, alkaloids, sterols, flavanoids and saponins. All extracts were selected for furt...
This study evaluated the in vitro antioxidant and cytotoxic potential of methanolic extract of the rhizome of Costus speciosus (Zingiberaceae). The different antioxidants assays including total antioxidant activity, DPPH, nitric oxide (NO) scavenging, total phenolic content and flavonoid content were studied. Costus speciosus exhibited potent total antioxidant activity which was expressed as an eq...
Guava is one of the most liked fruit items in Ethiopia and has its own economical importance. In concern with that a project experiment cum survey was carried out on the prevalence of post-harvest diseases of guava was conducted in Aksum in the months of January and March, 2009. During the experiment, 80 samples of diseased guava fruits were collected from different sites of Aksum, Ethiopia. The i...
PHYTOCHEMICAL SCREENING AND IN VITRO ANTIMICROBIAL ACTIVITY OF BUTEA MONOSPERMA (L) BARK ETHANOLIC AND AQUEOUS EXTRACT
Infectious diseases are the second leading cause of death worldwide. Treatment of infections continues to be problematic in modern time because of the severe side effects of some drugs and the growing resistance to antimicrobial agents. Butea monosperma (L) bark ethanolic and aqueous extract has shown good efficacy against Bacillus cereus. Pseudomonas aerugenosa and Escherichia Coli in concentrati...
FORMULATION OF RANITIDINE HYDROCHLORIDE GASTRO RETENTIVE FLOATING TABLET BY USING DIFFERENT RATIO OF POLYMERS
The aim of the present investigation was to develop a novel gastro retentive dosage form of Ranitidine hydrochloride (RHCl) to achieve prolong gastric retention, increase drug bioavailability and to modulate the release of RHCl in the stomach, by using various ratios of HPMC E-15, a low-density grade polymer and it was cheaper and easily available along with Carbopol 934, as gel former. Sodium bic...
The plant Acacia leucophloea Roxb is reported to have great medicinal value in Indian medicine. The present study deals with the pharmacognostical investigation on stem bark of Acacia leucophloea. Pharmacognostical evaluation such as macroscopical and microscopical characters, ash value, moisture content and extractive values were carried out. ...
EVALUATION OF DATE PALM POLYSACCHARIDE (DPP) AS A BIOMUCOADHESENT AND ITS COMPARISON WITH VARIOUS MUCOADHESIVE POLYMERS
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physi...
PHYTOCHEMICAL AND PHARMACOLOGICAL SCREENING OF SPHAERANTHUS INDICUS LINN. FOR ANTIMICROBIAL ACTIVITY
Sphaeranthus indicus Linn (Asteraceae) is a common annual spreading herb found in rice field throughout India. Six crude extracts were prepared from the whole plant Sphaeranthus indicus using different solvents by cold maceration process. The extracts were subjected to screening to detect potential antimicrobial activity against S. aureus, B. substillus, P. Gentamycin and Nystatin as standard by c...
The present communication deals with the laboratory studies carried out to determine the antihelmintic activity of Cymbopogon citratus leaves extracts against Pheritima posthuma. Methanolic and aqueous extracts were used as test solutions. Piperazine citrate was used as standard drug and normal saline as a control. Study involved the determination of time of paralysis as well as time of death of w...