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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 4 (2013) - Issue 10, October

Review Articles

 
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1.

THE DIELS-ALDER-REACTION WITH INVERSE-ELECTRON-DEMAND – A REVIEW OF AN EFFICIENT & ATTRACTIVE CLICK-REACTION CONCEPT

Here, we review the development of prospective image processing systems in molecular diagnostics and of pharmacologically active ingredients for patient-specific therapeutic approaches. These projects require not only high demands on quality, safety, and specificity but also, rapid, efficient and irreversible ligation routes during the synthesis of future pharmaceuticals. The Diels-Alder ligation ...

Manfred Wiessler , Waldemar Waldeck , Ruediger Pipkorn , Peter Lorenz , Jürgen Debus , Hans-Hermann Schrenk , and Klaus Braun*

Department of Imaging and Radio-oncology, German Cancer Research Center, INF 280, D-69120 Heidelberg, Germany

DOI:

3678-3698

2582

667

2.

CHEMISTRY OF HYALURONIC ACID AND ITS SIGNIFICANCE IN DRUG DELIVERY STRATEGIES: A REVIEW

Hyaluronic acid is an important naturally occurring polysaccharide present in extracellular matrices. The network-forming, viscoelastic and the charge characteristics of hyaluronic acid are important to many biochemical functions of living tissues. Its involvement in many diseases such as cancer, arthritis and osteoporosis, and the fact that it has specific protein receptors present on the cell su...

R. Khan*, B. Mahendhiran and V. Aroulmoji

Scientific Research Consultant, Rumsey, Old Bath Road, Sonning, Berkshire, RG4 6TA, England, UK

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3699-10

3699-3710

3731

452

3.

ARE THE MELATONIN SUPPLEMENTS POTENTIAL TREATMENT OPTIONS? A SYSTEMATIC REVIEW

Introduction: Melatonin is a neuro-hormone secreted from the pineal gland and involved in various regulatory activities in body. Ever-increasing use of melatonin supplements and enlarging research evidences make the authors undertook the review to arrive at a qualitative conclusion whether melatonin supplements can act as potential treatment options or not. Methodology: A comprehensive search w...

Subhranil Saha*, Munmun Koley and Sandip Patra

Senior Research Fellow, Clinical Research Unit (Homoeopathy), Gokhel Road, Arabindopally, Siliguri 734006, West Bengal, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3711-30

3711-3730

2107

548

4.

A REVIEW ON ANIMAL MODELS OF DEPRESSION

As described by the world health organization (WHO), depression is the most common and serious disorder leading to suicide. Numbers of synthetic drugs are available for the treatment of this fatal disease, but are associated with serious complications. A wide diversity of animal models has been used to examine antidepressant activity. These range from relatively simple models sensitive to acute tr...

Madhu Devi* and Ramica Sharma

Rayat Institute of Pharmacy, Railmajra (SBS Nagar), Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3731-36

3731-3737

2667

683

5.

SOURCE, PRODUCTION AND BIOLOGICAL ACTIVITIES OF PICEATANNOL: A REVIEW

Phenolic compounds are group of molecules which contain different families of secondary metabolites. Phenolic compounds, secondary metabolites, are abundantly found in plants and are mostly categorized into two major groups: non-soluble compounds and soluble compounds. Stilbenes which come under the category of soluble compounds of phenolics are small molecules, ranges in their weight from ~200 to...

A. Kukreja*, A. Mishra and A. Tiwari

School of Biotechnology, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Airport Bypass Road, Bhopal-462033, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3738-45

3738-3745

1676

696

6.

BENEFITS OF HERBAL EXTRACTS IN COSMETICS: A REVIEW

Herbal extracts are primarily added to the cosmetic formulations due to several associated properties such as antioxidant, anti inflammatory, antiseptic and antimicrobial properties. Even today, people in rural and urban areas depend upon herbs for traditional cosmetics. Information on the herbal cosmetics was collected via electronic search (using pub med, scifinder, Google Scholar and web of sci...

Amreen Fatima*, Shashi Alok , Parul Agarwal, Prem Prakash Singh and Amita Verma

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3746-60

3746-3760

11541

3630

7.

HERBAL PHYTOCONSTITUENTS OVERVIEW: A NEW THERAPEUTIC APPROACH IN MANAGEMENT OF CARDIAC DISORDERS

Worldwide, cardiac disorders constitute a leading cause of morbidity and mortality. Cardiac disorders include high blood pressure, atherosclerosis, arrhythmia, congestive heart failure, stroke etc. Increase in incidence of cardiac disorders is a manifestation of lifestyle changes. Although modern drugs are effective in preventing the cardiac disorders, their use is often limited because of their s...

Pankaj Bhatt

Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar- 140 111, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3761-69

3761-3769

2076

609

8.

HERB-DRUG INTERACTION: AN OVERVIEW

Plants have always provided an important source of medicines. They may be used by natives in folk medicine and later adopted by conventional western medicine as their efficacy was confirmed. Any pharmacological modification caused by herbal substances to another prescription medication (diagnostic, therapeutic or other action of a drug) in or on the body. An herb might increases or decreases the e...

Anil Kumar Pasi

College of Pharmacy, IPS Academy; Rajendranagar, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3770-74

3770-3774

1948

523

9.

INDIGOFERA ASPALATHOIDES VAHL EX. DC. (SIVANAR VEMBU): A PHYTO PHARMACOLOGICAL REVIEW

Since ancient times, herbal drugs are used in traditional system of medicine such as Siddha, Ayurvedaand Unani. The allopathic system of medicine adopted many medicinal plants to derive newer molecules for challenging diseases. The plant Indigofera aspalathoides which is well known as ‘Sivanar vembu’ is widely used for skin diseases. Phytochemical and Pharmacological researchers have screened ...

K.K. Omprakash*, G. Subash Chandran and V. Velpandian

Department of Pothu Maruthuvam, Sivaraj Siddha Medical College, Salem-636 307, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3775-81

3775-3781

6828

1216

10.

CURRENT STRATEGIES IN HERBAL DRUG DELIVERY FOR ARTHRITIS: AN OVERVIEW

Arthritis is still a challenge for medical research. Pharmaceutical research has resulted in several new approaches for treatment/management of arthritis including drugs like the biologic disease modifying anti-rheumatic drugs (DMARDs). Several disadvantages like serious side effects, high costs and requirement of parenteral administration still invite more research in this area to provide a conve...

Sunita Y. Ranade* and Ram S. Gaud

Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle (West), Mumbai – 400 056, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3782-94

3782-3794

2814

3209

11.

ANTIOXIDANT AND ANTICANCER THERAPEUTIC POTENTIALITY OF MUSHROOMS: A REVIEW

Cancer is a substantial world health threat, & a largest cause of death in peoples of various age groups and economic backgrounds. This dramatic increase in the global burden of cancer has spurred research and many pharmacological studies as an attempt to limit the progression of this disease. Painful, expensive chemotherapy by dietary supplements have come forth as a novel significant approac...

Arvind K. Sharma , Madhu Gupta , Archana Shrivastav and A.M. Jana*

155/B Sharda Vihar, City Center, New high court road, Gwalior, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3795-02

3795-3802

2710

696

12.

RECENT NOVEL ADVANDCEMENTS IN PELLET FORMULATION: A REVIEW

Pelletization can be defined as an agglomeration process that converts fine powders or particles of a bulk drug and excipients into small, free-flowing, more or less spherical units, called pellets. The size of the pellets is 0.5-2mm. Pellets have the free flowing capacity and have low porosity about 10%. Preparation methods include direct pelletizing,powder layering,Suspension or Solution layerin...

M. Harisha Kumari*, K. Samatha, Anna Balaji and M.S. Uma Shankar

Department of Pharmaceutics, Trinity College of Pharmaceutical Sciences, Peddapally, Karimnagar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3803-22

3803-3822

5678

1751

13.

IMPORTANCE OF EMBELIA RIBES: AN UPDATE

Embelia ribes Burm F.  is large scandent shrub, disturbed throughout India and belongs to the family Myrsinacae. It is commonly known as false black pepper or Vidanga. E. ribes grows in semi-evergreen and deciduous forests at an altitude of 1,500m found in central and lower Himalayas, Arunachal Pradesh, Assam, Bengal,   Orissa, Andhra Pradesh and Madhya Pradesh throughout India. Embelia ribes h...

Bharat Lal and Neeraj Mishra*

Department of Pharmaceutics, ISF College of Pharmacy, Ferozepur Road, Ghal Kalan, Moga, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3823-38

3823-3838

7784

1792

Research Articles

 
Title
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Cited
14.

HPLC-UV METHOD DEVELOPMENT FOR ATORVASTATIN CALCIUM MICRO-EMULSION DETERMINATION IN RAT PLASMA AND ITS APPLICATION TO ELUCIDATE PHARMACOKINETIC BEHAVIOR AFTER ORAL ADMINISTRATION TO RATS

A simple, rapid and validated high performance liquid chromatography (HPLC) method with UV detection for the quantification of atorvastatin Calcium microemulsions (ATC-MEs) in rat plasma was developed. The assay procedure involved chromatographic separation using a C-18 chromatographic column (250 mm × 4.6 mm, i.d., 5 μm) and a mobile phase of methanol/water (containing 0.05 % glacial acetic aci...

Liandong Hu*, Weihua Song , Hailei Zhang, Deliang Gu

College of Pharmaceutical Sciences , Hebei University, Baoding, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3839-44

3839-3844

1746

423

15.

SPECTROFLUORIMETRIC DETERMINATION OF TOLTERODINE TARTARATE IN PURE FORM AND PHARMACEUTICAL PREPARATION

A Simple, rapid, sensitive, accurate and precise spectrofluorimetric method was developed for the determination of tolterodine tartrate (TOL) in bulk powder and in pharmaceutical preparation. This method is based on measuring the native fluorescence of TOL in methanol at 313 nm after excitation at 285 nm using 1 ml of phosphate buffer pH 6. All variables that affect fluorescence intensity such as ...

Mohammed W. Nassar, Khalid A. Attia, Hamed M. Abou-Seada and Ahmed El-Olemy Allam*

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3845-49

3845-3849

1401

360

16.

CHITOSAN-BASED INTRATUMORAL INJECTABLE NANOPARTICLES FOR GENE DELIVERY TO PANCREATIC CANCER CELLS

One of the obstacles to effective intratumoral gene delivery lies in low transfection efficiency of non-viral vectors. Thus, in this study we evaluate the application of Diethyl methyl chitosan (DEMC) in intratumoral gene delivery of pancreatic cancer. DEMC/ pEGFP nanoparticles are prepared by polyelectrolyte complexation. After nanoparticle characterization via atomic force microscopy (AFM), in i...

S. Safari , H. Akbari , M. Soleimani , M.H. Zarrintan , F.A. Dorkoosh , B. Larijani , M.A. Oghabian and M. Rafiee Tehrani*

Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3850-56

3850-3856

1316

371

17.

INDIAN NATURAL ZEOLITE CATALYZED SYNTHESIS OF β-AMINOHETERONAPTHOL AND THEIR POTENT ANTIMICROBIAL EFFICACY

A highly resourceful, elegant, simple and green technique with exceptionally facile reaction conditions of one pot three component reaction was applied to synthesized series of novel mannich base having an array of biologically and pharmaceutically active novel heterocycles. The present protocol offered a valuable alternative to known methods and will find applications in the field of green synthe...

Kiran Khandarkar, Manoj Shanti , Mudrika Ahmed , Jyotsna Meshram

Lecturer, G. H. Raisoni Academy of Engineering & Technology, Shraddha Park, Nagpur-440016, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3857-70

3857-3870

2391

476

18.

CHARACTERISATION OF FLAVONOID GLYCOSIDES IN PHARMACOPOEIAL PREPARATION OF CISSUS VERTICILLATA (L) NICOLSON & C. E. JARVIS) USING HPLC-DAD AND HPLC-MS

According to Brazilian regulation, the registration of phytomedicines must inform the characterisation of, at least, one of their constituent. In order to contribute to this goal, a tincture of Cissus verticillata (L.) Nicolson & C.E. Jarvis prepared with ethanol 96oGL was investigated. This plant species is widely used due its hypoglycaemic properties, to control diabetes, and empirically to ...

W. L. R. Barbosa*, F. F. Vincieri , S. Gallori, L. N. Pinto , A. S. B. Silva and J. N. Anunciacao

LaCrEM, Faculty of Pharmacy, Federal University of Pará, Rua Augusto Corrêa, nº 01, CEP 66075-110, Guamá, Belém, Pará, Brazil

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3871-76

3871-3876

1465

566

19.

FORMULATION AND IN VIVO EVALUATION OF VETERINARY CHLORPROMAZINE SOLUTIONS FOR INTRAMUSCULAR INJECTION

The purpose of the study was to present the know-how of preparing intramuscular injection forms of chlorpromazine HCl  (CPZ) solutions for use in veterinary medicine. Aqueous solutions of CPZ were prepared aseptically at concentrations of 10 or 25 mg/ml. The CPZ formulations were intended for veterinary use only. The concentrations of CPZ in the solutions were 1 or 2.5% which were formulated main...

Nabaa K.A. Al-Hayani and Fouad K. Mohammad*

Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3877-83

3877-3883

1520

351

20.

DEVELOPMENT AND VALIDATION OF SECOND ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF ATENOLOL AND NIFEDIPINE IN COMBINED DOSAGE FORM

A simple, precise, accurate and reproducible spectrophotometric method has been developed for Simultaneous estimation of Atenolol and Nifedipine by employing second order UV derivative Spectrophotometric method in Water: ACN (60:40). The Second order derivative absorption at 245.63 nm (zero cross point of Nifedipine) was used for quantification of Atenolol and 218.7 nm (zero cross point of Atenolo...

Hiral B. Patel*, Bhavna A. Patel and Shraddha J. Parmar

P.G. Department of Pharmaceutical Sciences, Sardar Patel University, Vallabh Vidyanagar- 388 120, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3884-88

3884-3888

1329

331

21.

PREPARATION AND EVALUATION OF ANTIFUNGAL PROPERTY OF A POLYHERBAL FORMULATION CONTAINING ACHYRANTHES ASPERA AND PLECTRANTHUS AMBOENICUS

Research in complementary therapies and alternative medicines is increasing and formulating therapeutic medicines based on these findings has become the need of the hour. The present research aims to formulate and evaluate a polyherbal gel containing Achyranthes aspera and Plectranthus amboenicusextract. The formulation was designed by using alcoholic as well as aqueous extract of Achyranthes aspe...

Varun S. Mali* and Raju R, Wadekar

Department of Pharmacognosy, STES Sinhgad Institute of Pharmaceutical Sciences, Kusgaon Bk., Lonavla, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3889-93

3889-3893

1215

613

22.

FOSTERED ANTIARTHRITIC UPSHOT OF MORINGA OLEIFERA LAM. STEM BARK EXTRACT IN DIVERSELY INDUCED ARTHRITIS IN WISTAR RATS WITH PLAUSIBLE MECHANISM

The present research exertion was undertaken to evaluate the antiarthritic effect of methanolic extract of Moringa oleifera Lam stem bark. The extract was subjected to preliminary phytochemical investigation and antiarthritic activity was evaluated with turpentine oil, formaldehyde and CFA induced arthritis. Other parameter like body weight and hematological estimation were carried out.The result ...

Vikas Kumar*, Amita Verma , Danish Ahmed, Nikhil Kumar Sachan , Firoz Anwar and Mohd. Mujeeb*

Department of Phytochemisty & Pharmacognosy, Faculty of Pharmacy, Jamia Hamdard , New Delhi- 110 062, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3894-01

3894-3901

1533

535

23.

THE REAL-WORLD STUDY OF SHENMAI INJECTION AND ITS ADVERSE REACTIONS ASSOCIATED TO PATIENTS IN CHINESE HOSPITALS: A PROSPECTIVE RESEARCH

Shenmai injection (SMI) is the Traditional Chinese Medicine Injection (TCMI) prepared by Red Ginseng and Radix Ophiopogonis extract. The aim of this study is to reveal the real-word of SMI, to evaluate its use and its adverse reactions associated to patients.A prospective, observational combined nested case-control clinical research carried out in two tertiary care teaching hospitals and two secon...

Qing-ping Shi, Xiao-dong Jiang*, Jinxiu Zhu, Yan Liu , Rang Sang , Feng Ding , Mu-hua Wang , Dao-hua Guo, Pei-lan Shi , Mei-ling Yu , Shengtong Wei , Zhiming Xin , Ru Song , Shu-qiang Zhang

Department of Pharmacy, the first Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, 233004, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3902-09

3902-3909

1441

427

24.

PHARMACOGENOMIC STUDIES OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENOTYPES IN SUSPECTED CAD PATIENTS

Recent studies have attempted to identify specific genes that contribute to cardiovascular health and disease. Response to various drugs like statins differs from individual to individual, due to polymorphic variations in drug metabolizing genes related to pharmacogenomics of the diseases. The aim of this study was to find out the association of Cholesteryl ester transfer protein (CETP) gene polym...

Javeed Ahmad Tantray , Y. Shiva Kumar and Kaiser Jamil*

Genetics Department, Bhagwan Mahavir Medical Research Centre, 10-1-1, Mahavir Marg, AC guards, Hyderabad- 500 004, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3910-16

3910-3916

1263

461

25.

ANTIOXIDANT ACTIVITY OF PLANTS AT CHINNATIRUPATHI, SALEM, TAMIL NADU, INDIA

This study was carried out during March - April 2013. The fresh leaves collected were extracted with water and used for antioxidant assay. Nitric oxide scavenging activity, Reducing power assay, Metal chelating activity, Phosphomolybdenum activity was assayed and also secondary metabolites such as phenol, flavonoid was estimated. These metabolites play a major role in antioxidant activity.  Here,...

M. Krishnaveni*, P. Madhaiyan, S. Durairaj, L. Amsavalli and R. Chandrasekar

Department of Biochemistry, Periyar University, Salem- 636 011, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3917-19

3917-3919

1217

403

26.

A VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF ANAGRELIDE IN CAPSULE DOSAGE FORMS

An accurate and precise high performance liquid chromatographic method was developed for quantitative estimation of anagrelide in capsule dosage forms. Chromatographic separation of the drug was achieved on a Kromosil C18 column (150 x 4.6 mm; 5µ) by isocratic elution using a mobile phase consisting of phosphate buffer (pH 2.5) and acetonitrile (75:25 v/v) at a flow rate of 1.2 mL/min. The drug i...

K. Sujatha*, C. Palavan , J.V.L.N. Seshagiri Rao

Senior Lecturer, Department of Pharmacy, Government Polytechnic, Visakhapatnam – 530 007, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3920-24

3920-3924

1458

454

27.

PRELIMINARY PHYTOCHEMICAL ANALYSIS & ANTIBACTERIAL ACTIVITY AGAINST CLINICAL PATHOGENS OF MEDICINALLY IMPORTANT ORCHID CYMBIDIUM ALOIFOLIUM (L.) SW.

Cymbidium aloifolium is a potent medicinal epiphytic orchid plant in the Indian systems of medicine. Traditionally this plant was used in the treatment of Anti-inflammatory, Paralysis, joining fractured bones, fever, weakness of eyes, chronic illness, burns, sores etc. In the present study three different solvent (Hexane, Chloroform, Methanol) extracts ofCymbidium aloifolium plant was studied for ...

B. Radhika*, J.V.V.S.N. Murthy and D. Nirmala Grace

Department of Biotechnology, Centre for Research, Dr. V.S. Krishna Government P.G. College, Visakhapatnam, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3925-31

3925-3931

2363

993

28.

DETERMINATION OF ANTI-TUBERCULAR ACTIVITY OF FOUR INDIAN MEDICINAL PLANTS AGAINST MYCOBACTERIUM TUBERCULOSIS BY BROTH MICRO DILUTION METHOD

Tuberculosis is one of the oldest killer diseases of mankind. It is an airborne communicable disease caused by transmission of aerosolized droplets of Mycobacterium tuberculosis. The increasing incidence of MDR- and XDR-TB worldwide highlighted the urgent need to search for newer anti-tuberculosis compounds/drugs.The World Health Organization (WHO) estimated that approximately 80% of world populat...

Soundhari Chidambaram* and Rajarajan Swaminathan

PG & Research Department of Microbiology & Biotechnology, Presidency College, Chennai -5, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3932-37

3932-3937

1667

774

29.

EVALUATION OF HAEMATINIC ACTIVITY OF POLYHERBAL FORMULATION IN HgCl2 INDUCED ANAEMIA IN LABORATORY ANIMALS

Anaemia constitutes serious health problem in many countries. It is widespread public health problem, and the fourth leading cause of hospital admissions and the second factor contributing to death. Anaemia is characterized by low count of haemoglobin. The empirical use of herbal preparations in the treatment of anaemia dates from ancient times. Despite the obvious effectiveness and efficacy of ir...

Pradnya N. Jagtap*, Vaishali R. Undale and A.V. Bhosale

PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Tal- Purandar, Dist- Pune, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3938-52

3938-3952

1779

474

30.

IN-VITRO ANTIOXIDANT ACTIVITY OF SOLANUM SISYMBRIFOLIUM AERIAL PARTS

Objective: Recently, natural plants have received much attention as sources of biological active substances including antioxidants. In the present study we investigated In-vitro antioxidant activity of hexane, ethyl acetate and ethanol extracts of Solanum sisymbrifolium aerial parts. Methods: In-vitro antioxidant activity was evaluated for extracts by using free radicals Superoxide (Riboflavin pho...

Ravi Kumar Jangiti, Ganga Rao Battu and Karuna Maheshwari Jakkamsetti*

A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3953-57

3953-3957

1291

411

31.

IN VITRO STUDIES OF AMLODIPINE BESYLATE TABLET AND COMPARISON WITH FOREIGN BRAND LEADER IN NEPAL

The aim of this study was to investigate the physicochemical properties of amlodipine besylate tablets. Tablets containing 5 mg of amlodipine besylate were prepared using Generally Regarded as Safe (GRAS) excipients. Preformulation studies were carried out using Fourier Transform Infrared (FTIR) spectroscopy and High Performance Liquid Chromatography (HPLC). Dissolution studies were performed to a...

Tekendra Pant*, Kanchan Mishra and Robhash Kusam Subedi

R & D Department, Deurali-Janta Pharmaceuticals Pvt. Ltd, Kathmandu- G.P.O Box: 4239, Nepal

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3958-64

3958-3964

2715

3237

32.

DEVELOPMENT & EVALUATION OF SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF ATOVAQUONE IN PHARMACEUTICAL DOSAGE FORM

A very simple and selective U. V. Method was developed and validated for the estimation of Atovaquone in pure form and the nanosuspension. The adequate drug solubility and maximum assay sensitivity was found in 8.00 Ph IPA Phosphate Buffer in 40:60 ratios v/v. The absorbances were measured at the λmax. of 494 nm in the wavelength range of 200-800 nm. The linear calibration range was found to be 2...

Varsha H. Chungde*, Ajit A. Phalke, C. G. Kulkarni and K. B. Burade

Government College of Pharmacy Karad, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3965-70

3965-3970

1363

813

33.

IDENTIFICATION OF NEW HIV-1 PROTEASE INHIBITORS BY MULTIPLE LINEAR REGRESSION (MLR) AND PHYSICO-CHEMICAL DESCRIPTORS

In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some 5,6-dihydro-2-pyrones derivativesusing statistical work.Using only 4 topological and physico-chemical molecular descriptors, we have achieved 84.81% correct classification of the compounds with and without its activity.A heurisimatedtic algorithm selects the best multipl...

Kumar Nandan*, Md. Belal Ahmad , Kumar Ranjan and Baidyanath Sah

Research Scholar, Department of Chemistry, T.N.B. College, T.M. Bhagalpur University, Bhagalpur- 812 007, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3971-75

3971-3975

1085

371

34.

FORMULATION OF REGIOSELECTIVE FLOATING MATRIX TABLETS OF DEXTRO-METHORPHAN USING GAS FORMING TECHNIQUE AND EVALUATION

The present study deals with the formulation and evaluation of gastroretentive floating tablets of dextromethorphan. Dextromethorphan is a highly potent and commonly used antitussive agent. It has no narcotic, analgesic or addictive properties and its potency as an antitussive agent is almost equal to that of codeine. The purpose of this research is to increase the gastric residence time by prepar...

Sree Priya Artham*, Pradeep Reddy Thotamagari , Praveen kumar Manthena and Shrutika Chillal

Priyadarshini College of Pharmaceutical Sciences, Chwdaryguda, Ghatkesar, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3976-91

3976-3991

1350

1062

35.

IN-SILICO ANALYSIS AND HOMOLOGY MODELING OF ANTIOXIDANT PROTEINS OF ORYZA SATIVA SUBSP. JAPONICA (RICE)

Rice is much revered oriental food and the most important tropical cereal crop. It is the staple food of about half the human race and is often the main source of calories and the principal food of many millions of people. Health benefits of rice include providing fast and instant energy, stabilizing blood sugar levels and providing essential source of vitamin B1 to human body. In this study...

Chirag Prajapati* and Roma Patel

Department of Computer Science (Bioinformatics), Veer Narmad South Gujarat University, Surat, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).3992-00

3992-4000

1356

412

36.

IMPACT OF PEPTOSTREPTOCOCCUS ON TYPE 2 DIABETES MELLITUS RELATED SECONDARY ROOT CANAL INFECTIONS

Aim: The purpose of this study was to assess the impact of Peptostreptococcus on type 2 diabetes mellitus patients with secondary root canal infections by evaluating the prevalence of this bacterial species using culture and PCR technique and to correlate their association with specific endodontic signs and symptoms in Indian population. Materials and method: 88 subjects scheduled for root cana...

Moksha Nayak *, Subbannayya Kotigadde , Harish Shetty , R.V. Vineet and Beena Antony

Department of Conservative Dentistry & Endodontics, KVG Dental College and Hospital, Sullia- 574 239, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4001-09

4001-4009

1607

394

37.

STANDARDIZATION OF ‘BHUNIMBADI CHURNA’ – AN AYURVEDIC POLYHERBAL FORMULATION

Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The present work is an attempt to standardize ‘Bhunimbadi Churna’, an Ayurvedic polyherbal formulation, used in fever and diabetics etc. The various parameters performed included organoleptic characteristics, physico-chemical parameter, physical characteristics of Churna, prelimina...

B.C. Patel* and N.M. Patel

Research Scholar (Reg No- 1540), Hemchandracharya North Gujarat University, Patan, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4010-15

4010-4015

1840

859

38.

ADHATODA VASICA: EFFECT OF ADMINISTERING ETHANOLIC EXTRACT OF ADHATODA VASICA ON BLOOD COUNT AND SOD ENZYME ACTIVITY AGAINST EXPOSURE TO γ – RADIATIONS

In the present studies, antibacterial studies and medicinal effects of the ethanolic extract of Adhatoda vasica on the physiological variations including blood countvariations w.r.t. RBC, WBC, Hb and enzyme SOD activity of the subjects under study, Swiss Albino mice, on exposure to gamma radiations, have been evaluated.  Phyto-chemical analysis of A. vasica showed the presence of alkaloids, sapon...

Inderjeet Kaur*, Atul Kumar and Sushma Sharma

Department of Chemistry, Himachal Pradesh University Summer Hill Shimla- 171 005, Himachal Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4016-26

4016-4026

3243

653

39.

ANTIDIABETIC ACTIVITY OF HYDROETHANOLIC LEAF EXTRACT OF GYMNEMA HIRSUTUM WIGHT & ARN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

The present study has investigated the hypoglycaemic effect of oral administration of 50% ethanolic leaf extract of G. hirsutum Wight & Arn in normal and Streptozotocin–induced diabetic rats.  Albino Wistar rats (190 to 220 gm) were induced  diabetic condition by administration of Streptozotocin (STZ) (55 mg/kg bw) intraperitoneally.  50% ethanolic extract of G. hirsutum Wight & Arn l...

K. Thangavel* and V.A. Doss

Department of Biochemistry, PSG College of Arts & Science, Coimbatore-641014, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4027-31

4027-4031

1266

286

40.

EFFECT OF XYLIA DOLABRIFORMIS LEAVES EXTRACT ON HIGH FRUCTOSE DIET INDUCED C57BL/6J OB/OB DIABETIC MICE

The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, H...

Amaranth V. Banagar , B. Shivakumar*and K.N. Jayaveera

Head of the Department, Department of Pharmacology, SVERI’s College of Pharmacy, Solapur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4032-45

4032-4045

1514

387

41.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM

A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...

Uttam Prasad Panigrahy* and M. Divya Swetha

Department of Pharmaceutical Analysis and Quality Assurance, Malla Reddy College of Pharmacy, Secunderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4046-50

4046-4050

1186

410

42.

SYNTHESIS OF 2, 4, 5- TRIPHENYL IMIDAZOLE DERIVATIVES AND BIOLOGICAL EVALUATION FOR THEIR ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITY

On the basis of various literature survey, imidazole derivatives show various activity such as antimicrobial, anti-inflammatory, analgesic, antitubercular, anticancer etc. The possible improvements in the activity can be further achieved by slight modifications in the substituents on the basic imidazole nucleus. Having structural similarity with histidine imidazole compound can bind with protein m...

Swati D. Burungale* and M. J. Bhitre

C. U. Shah College Of Pharmacy, S. N. D. T. Women’s University, Juhu, Santacruz (W), Mumbai- 400049, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4051-57

4051-4057

4700

865

43.

PHARMACOGNOSTICAL, PHYSICOCHEMICAL AND ELEMENTAL INVESTIGATION OF AN AYURVEDIC POWDERED FORMULATION: SHATAVARYADI CHURNA

Most of the traditional systems of medicines are effective but the need is just to validate them to assess the quality, quantity and purity of the drugs. To support the same a polyherbal Ayurvedic powdered formulation Shatavaryadi churna used as immunomodulator, galactagogue, aphrodisiac and rejuvenator was taken for pharmacognostical, physicochemical and elemental investigation. Shatavaryadi chur...

Puspendra Kumar*, Shivesh Jha and Tanveer Naved

Address: Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(10).4058-66

4058-4066

1507

731