Volume 9 (2018) - Issue 10, October
The aim of this review article is to reflect the current availed study on green synthesis of silver nanoparticle and its future prospects to treat chronic diseases. The development of eco-friendly and reliable techniques for synthesis of silver nanoparticles is a vital step in the area of nanotechnology. The researchers have shown more interest and attention on this because of its unique propertie...
A REVIEW OF CLASSICAL, PROPRIETARY AND PATENTED AYURVED PRODUCTS AND THEIR INGREDIENTS IN LIVER / SPLEEN DISEASES
Liver disease is the tenth most common cause of death in India as per the World Health Organization and may affect every one in Five Indians. In spite of consistent human effort and drug discovery, modern drug has very little to offer. Nonetheless, Ayurved classical proprietary and patented formulations have shown promising results. The present study provides a general review of the Ayurved produc...
A REVIEW ON PHARMACOGNOSY, PHYTOCHEMISTRY AND PHARMACOLOGICAL ACTIVITY OF CARICA PAPAYA (LINN.) LEAF
Papaya (Carica papaya Linn.) is well known for its nutritional as well as medicinal value since long time. The medicinal properties of fruit and other parts of papaya are well known in the different system of traditional medicine including Ayurveda. Its various parts has been reported for various disease conditions viz. fever, swellings, jaundice, gonorrhea, bilious fever, itches, eczema, and rheu...
Traditional medicines, derived from medicinal plants, are used by about 60% of the world's population. Plants of the genus Terminalia which consist of about 200-250 species are widely used as traditional medicine. The aim of this study was that review morphologic and toxonomic characteristics, pharmacological effects, traditional usage and products that derived of Terminalia in reports that publis...
Black pepper, the ‘King of spices’ (Piper nigrum L.), is a widely used spice, known for its pungent odour. From time immemorial, plant sources were used in traditional systems of medicine and day-to-day common use, such as in meal preparation and cosmetic purposes. This is due to their vast pharmacological potential with minimum side effects. Among the various species of the Piperaceae family,...
The efficiency of drug discovery and designing process can be increased by effective strategies given by computational methods. Drug designing is an intense, time consuming and an interdisciplinary venture. Traditionally, drugs were discovered by synthesizing compounds in a long-drawn-out and multi-step process. Recent studies have shown an increase in day by day demand of novel and more efficient...
Tuberculosis (TB) is one of the second most deadly infectious disease which causes for morbidity as well as mortality. This communicable infectious disease is caused by Mycobacterium tuberculosis. It can produce silent, latent infection as well as progressive, active disease. Globally, 2 billion people are infected and roughly 2 million people die from tuberculosis each year. Despite for all the m...
The aim of the study is to investigate the capacity of pyrimidine derivatives like the active ingredient of Xymedon (I) and its derivative, salt-like conjugate with L-ascorbic acid (II) to stimulate liver recovery when damaged by toxic hepatitis. The study was done on out breed white rats. The liver damage was induced by carbon tetrachloride (injected 50% oil solution subcutaneously, once per day,...
DEVELOPMENT OF MESOPOROUS SILICA NANOPARTICLES OF RITONAVIR WITH ENHANCED BIOAVAILABILITY POTENTIAL: FORMULATION OPTIMIZATION, IN-VITRO AND IN-VIVO EVALUATION
The objective of the study was to develop mesoporous silica nanoparticles for the poorly water soluble drug ritonavir (RTV) for enhancement of in-vitro dissolution and corresponding in-vivo bioavailability. A comparative assessment between 2D-hexagonal silica nano-structured MCM -41NPs and 3D cubic pore system MCM -48NPs on drug release rate was also investigated. RTV (BCS class II drug), was load...
ASSESSMENT OF FREE RADICAL SCAVENGING ACTIVITY AND ANTIOXIDANT MEDIATED HEPATOPROTECTIVE EFFECTS OF MALLOTUS ROXBURGHIANUS MUELL. IN DOXORUBICIN INDUCED OXIDATIVE STRESS IN SWISS ALBINO MICE
The aim of this study was to investigate the phytochemical constituents and therapeutic potential of various solvent extracts of Mallotus roxburghianus both in-vitro and in-vivo. Free radicals scavenging activities of various extracts were determined in a cell free system and the hepatoprotective effects was investigated in doxorubicin induced oxidative stress in Swiss Albino mice by estimating va...
EXPLORING IN-VIVO AND IN-VITRO OXALIS CORNICULATA L. FOR PHYTOCHEMICALS USING NON-TARGETED LC-MS APPROACH AND ITS ANTIOXIDANT CAPACITY
Oxalis corniculata Linn. (Oxalidaceae) is the nutraceutical important medicinal plant containing essential nutrients like sodium, potassium, calcium, nitrogen and magnesium and also gives health protection due to the presence of secondary metabolites of therapeutic importance. Present study highlights the phytochemical constituents present in the methanolic extract of in-vivo and in-vitro O. corni...
EFFECT OF POLYMER IN RELEASE PROFILE OF EXTENDED RELEASE MATRIX TABLET OF ANTI-HYPERTENSIVE DRUG & TO STUDY IMPACT OF AGGLOMERATIVE PHASE OF COMMINUTION (APOC) METHOD ON DRUG RELEASE
The objective of this study is to develop extended release matrix tablet of antihypertensive drug benidipine hydrochloride (BH) and to study its drug release pattern. BH has mean elimination half-life is ~3 h and requires dosing every 4 - 5 h in order to maintain optimal relief and is used orally in the management of hypertension and angina pectoris, but this frequent administration produces side ...
SYNTHESIS AND ANTI-MYCOBACTERIAL ACTIVITY OF SOME NOVEL ANACARDIC ACID DERIVATIVES FROM CASHEW NUT SHELL LIQUID
Synthesis and anti-mycobacterial activity of some novel derivatives of anacardic acid viz., 2-Ethoxy-6-pentadecyl benzamide (APHK-1), 1-(2-methoxy-6-pentadecylbenzyl)-4-hydroxy ethylpiperazine (APHK-2), 1- (2-hydroxy-6-pentadecyl)- N- (hydroxyl ethylaminoethyl) benzamide (APHK-3) and compounds 20-34 from saturated anacardic acid which was obtained from natural product cashew nut shell liquid (CNSL...
L-asparaginase has been accepted clinically as an anti-tumour agent for the effective treatment of acute lymphoblastic leukaemia and lymphosarcoma. This enzyme also possesses L-glutaminase activity and causes immunological problems. Hence, efforts have been made to develop mutants with lower or no glutaminase activity. In the present study, a homology model of L-asparaginase obtained from Pectobac...
A NEW STEBILITY INDICATING RP-HPLC-PDA METHOD FOR SIMULTANEOUS ESTIMATION OF NEOMYCIN AND FLUOCINOLONE IN PHARMACEUTICAL TABLET DOSAGE FORM
A simple, selective, ingenuous, reasonable, speedy, Reverse Phase High Performance Liquid Chromatography (RP-HPLC) was developed for simultaneous estimation of neomycin and fluocinolone in its tablet dosage form. The separation was eluted using a mobile phase of buffer and methanol in the proportion of 50:50 a pumped at a flow rate of 1 ml/min besides 250 nm as a UV detection wavelength. The stati...
Naturally occurring non-starch polysaccharides are known for their therapeutic value. This paper describes isolation, characterization and evaluation of glucose lowering potential of one such plant polysaccharide isolated from the leaves of the plant Vitex negundo. It was isolated and characterized using various analytical techniques and biochemical tests which confirmed the presence of carbohydra...
ASSESSING THE GENOTOXIC AND CYTOTOXIC RESPONSES OF THE H-29 CANCER CELL LINES ON THE ETHANOLIC EXTRACTS OF THE OYSTER MUSHROOM, PLEUROTUS OSTREATUS VAR. FLORIDA
Globally, colorectal cancer is the third most common known today. Lack of cheap, rapid, safe and reliable cancer treatments resulted to the continued pursuit to find natural sources of bioactive compounds that can be cytotoxic or damaging to the DNA of cancer cells. One of the potential resource is the edible oyster mushroom (Pleurotus ostreatus var Florida) reported to have medicinal properties. ...
IN-VITRO EVALUATION OF THE ANTIOXIDANT POTENTIAL, TOTAL PHENOLIC AND FLAVONOID CONTENTS AND ANTIBACTERIAL ACTIVITY OF LAMIUM ALBUM EXTRACTS
Lamium album is used as a blood purifier, in the treatment of the respiratory tract diseases, diarrhea and bleeding. In this study antioxidants and anti-bacterial activities of its aerial parts and roots were investigated. Extracts were prepared by Soxhlet apparatus. Methanol used as extracting solvent. Phenol and flavonoids contents and antioxidant properties were evaluated by different methods. ...
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF METFORMIN HYDROCHLORIDE USING AGAR AS NATURAL SUPER DISINTEGRANT
The objective of the present work is to develop orodispersible tablets of Metformin hydrochloride using agar as natural super disintegrant to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Fast dissolving drug delivery system has numerous advantages over conventional dosage form like tablet, capsule, syrups etc. Formulation of nine batches out of which b...
The Bacillus subtilis is anaerobic gram-positive, dominant and non-pathogenic bacterial workhorses in industrial fermentations. In present work, B. subtilis LC4 cultured on a number of combinations of TY-medium with peels and peeled-off rotten potatoes to investigate its growth and level of secondary metabolites production including acetic acid. Cell culture was harvested after 42 and 62 h and max...
Cyamopsis tetragonoloba is widely used by people and is found to have multiple medicinal utilities. Four (chloroform, ethyl acetate, methanolic and aqueous) extracts of Cyamopsis tetragonoloba fruit were therefore, analysed by Gas Liquid Chromatography and Mass Spectrometry analysis to assess their phytochemical constituents. The chloroform extract of Cyamopsis tetragonoloba fruits showed the pres...
Objective: Guggulu is one of the important dravya (drug) used in Ayurvedic formulations since ancient time which means “Protection against diseases”. Ashuddha guggulu has physical and chemical impurities which need to be eliminated before using in formulation by shodhana. The present study was conducted to evaluate and compare the effect of different shodhana processes i.e. Samanya shodhana an...
A STUDY ON THE IN-VITRO ANTIFUNGAL, LARVICIDAL AND ANTIOXIDANT ACTIVITIES OF ROOT AND SHOOT OF BIOPHYTUM SENSITIVUM (LINN.) DC.
The present study assayed the antifungal, larvicidal and antioxidant properties of the aqueous and acetone extracts of root and shoot of Biophytum sensitivum (Linn.) DC. The aqueous extracts of both root and shoot had little activity against the three test fungi such as A. niger, A. flavus and Penicillium. The acetone shoot extract was also ineffective against these fungi. However, the acetone roo...
Oxidative stress is involved in the pathogenesis of various degenerative diseases like cancer, inflammation etc. Thus, the study of antioxidant activity of natural molecules has remained a fertile ground for the researchers. In continuation of that effort, the present study was designed to evaluate the antioxidant, cytotoxic, antibacterial and anti-inflammatory potential of chloroform extract of S...
FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN SENILITY INDUCED STERILITY OF MALE WISTAR RATS – A HISTOMORPHOMETRIC STUDY
Ageing is associated with the diminished function of various tissues in the body. The gonadal function declines with age. In male, there is progressive atrophy of the sperm producing elements of the testes, resulting in diminished spermatogenesis. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium ...
RENAL FUNCTION OUTCOMES IN PATIENTS RECEIVING TDF – CONTAINING ANTIRETROVIRAL THERAPY: A RETROSPECTIVE PILOT STUDY IN NAMIBIA
Introduction and Aims: Combination antiretroviral therapy (cART) has improved morbidity and mortality in patients with HIV across countries including countries in sub-Sahara Africa. However, cART is associated with renal impairment. The lack of pre-cART data in a recently published study limited the discussion on renal-based treatment outcomes with cART, which could have important clinical implica...
Background: Triphala is exclusively used in more than 200 drug formulations in Indian system of Medicine. The formulation process of polyherbal drugs changes the physiochemical properties of the whole drug which need to be studied and understood. Objective: The present work aims to perform the organoleptic features (color, odor, taste), and physicochemical parameters such as pH, loss on drying, as...
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tw...
STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SITAGLIPTIN PHOSPHATE AND METFORMIN HCl IN TABLETS BY HPLC
An accurate, simple, new, precise, rugged and stability indicating method was developed for simultaneous estimation of sitagliptin and metformin HCl in tablets. The developed method was rapid and economic. The Chromatographic separation was achieved isocratically on a C-18 column by using ammonium acetate buffer (adjusted to pH 5.0 with glacial acetic acid): MeOH (60:40 v/v). Octane -1-sulfonic ac...
The work was under taken as an attempt to prepare quick release films of ebastine with the purpose of developing a dosage form for very quickly on set of action, which will be beneficial in managing severe condition of allergies, aiding in enhancement of bioavailability. It is necessary to prepare ebastine as fast dissolving oral films to bypass the first pass metabolism. Ebastine was prepared as ...
Jackfruit peel is one among the under-utilized waste materials. In the present study, cellulose was extracted from de-pectinated peel. The peel was treated with alkali followed by a chemical process treatment. The yield of jackfruit cellulose was 27g / 100g of dry matter. Water and oil holding capability was a good retention value and higher hydration capacities of cellulose. The bulk, true densit...
EFFECT OF ALOE VERA EXTRACT AND ISONIAZID – RIFAMPICIN DRUG ON LIVER HISTOLOGICAL STUDIES OF MALE WISTAR RATS
The study carried out to find the effect of Aloe vera extract on the toxicity induced by INH - RIF in male Wistar albino rats. We have perform the experiments on rats for 30 days and found the effect on histological alternations of liver by two different method. Firstly, by Compound microscopy and the same tissues were further process through SEM microscopy. We have found the effect of Aloe vera e...
A topological index is a numeric quantity from the structural graph of a molecule. It has become a very useful tool in the prediction of pharmacological, toxicological and physico - chemical properties of a compound. In this paper, we have computed some topological indices of triangular silicate TsL (n) and triangular oxide TOL (n) networks....
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF NOVEL 2-ARYL BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTIFUNGAL AGENTS
In the present study a series of novel 2-aryl substituted benzothiazoles were synthesized. The synthesized benzothiazole (BTA) derivatives were characterized physicochemically, by elemental analysis and spectral (IR and 1H-NMR) analysis. The synthesized compounds were screened for their in-vitro antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans by cup plat...
STANDARDIZATION OF SALAVANA UPANAHA CHURNA: A HERBAL COMPOUND DRUG USED FOR UPANAHA IN SPASTIC CEREBRAL PALSY
Background: Salavana upanaha churna is a herbal compound drug consisting of Godhuma churna (Triticum aestivum L.), Rasna churna (Pluchea lanceolata (DC.) Oliv. & Hiern), Devadaru churna (Cedrus deodara (Roxb.) G.Don), Erandamoola churna (Ricinus communis L.), Vidanga churna (Embelia ribes Burm.f.), Vacha churna (Acorus calamus L.) and Saindhava lavana (rock salt) as main ingredients. Salavana ...
SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF SUBSTITUTED-2, 3-DIMETHYL-N-(3-(4-PHENYL PIPERAZIN-1-YL) PROPYL)-6, 7-DIHYDRO-5H-BENZO  ANNULENE-8-CARBOXYLIC ACIDS
Benzosuberones and phenylpiperazinyl moieties are important heterocyclic compounds which constitute many biological activities which include anti bacterial, anti fungal, anti inflammatory, antioxidant, antitubercular and anti cancer activities. A novel series of 2,3-dimethyl-N-(3-(4-phenyl piperazin-1-yl)propyl)-6,7-dihydro-5H-benzo annulene-8-carboxylic acids (5a-e) have been synthesized in go...
Studies to exploit wild mushrooms as a source of biologically active compounds are gaining importance in the recent years. In that view, the present study was carried out to evaluate the bioactives of wild edible macrofungi, Lentinus squarrosulus Mont. The specimen was subjected to various biochemical tests with the view to establish standards for their identity and chemical composition. To identi...
PHARMACOGNOSTICAL AND PHYSICO-CHEMICAL EVALUATION OF AN INDO-SRI LANKAN ETHNOMEDICINAL PLANT SPECIES POLYALTHIA KORINTI (DUNAL) BENTH. & HOOK. F.
Polyalthia korinti (Dunal) Benth. & Hook. F. is a rare Indo - Sri Lankan species of Annonaceae family and are traditionally used by tribal people of Ghats region, India for treating several ailments. The number of mature plants and the area of its distribution are too low and this species is placed under the vulnerable critically endangered category. The present study deals with the pharmacogn...
SYNTHESIS AND CHARACTERIZATION OF PVA BASED POLY (ACRYLIC ACID – CO – ACRYLAMIDE) SUPER POROUS HYDROGELS COMPOSITES
The aspiration of the coeval cramming is connate with the entirety of second generation Super Porous Hydrogel Composites (SPHCs) with polyvinyl alcohol as a melded material. Conglomerates were unified by proving gas fanning approach. For coalescence, 50% Acrylamide solution (AM) and 50% Acrylic Acid solution (AA) were used as a monomer, 2.5% N, N’-methylene bisacrylamide (BIS) as a cross linker,...
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ORAL DECOCTION OF PTEROCARPUS SANTALINUS BARK WOOD POWDER IN ACUTE INFLAMMATION MODEL
Background: Raktachandan / Pterocarpus santalinus is mentioned to have edema reducing property in Ayurvedic literature. Studies have been performed using its methanolic extract for anti-inflammatory, analgesic and antioxidant activities. Since, Ayurveda advises to use it as a decoction, we planned to study the acute anti-inflammatory activity of decoction prepared from Pterocarpus santalinus bark-...
Antibiotic resistance continues to pose a significant problem in the management of bacterial infections despite advances in antimicrobial chemotherapy and supportive care. Therefore, it is necessary to search the other alternatives that can be effective in the treatment of these infections. The present work was aimed to evaluate the antibacterial and antibiotic-potentiation activities of lemon aga...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF AMIKACIN IN PURE AND MARKETED FORMULATION USING HPLC
The aim of the study was to develop an easy, sensible and rapid method for the estimation of amikacin in both pure and marketed formulation by pre derivatisation technique using reverse phase C18 column in HPLC. In this RP-HPLC method Shimadzu LC 20 AD of PDA detector was used with LC solutions software. In this method gradient elution with a mobile phase of acetonitrile and acetate buffer in the ...
EVALUATION OF ANTIMICROBIAL TREATMENT PRACTICES FOR URINARY TRACT INFECTIONS IN PREGNANT WOMEN IN TERTIARY CARE CLINICAL SETTINGS OF PAKISTAN
Urinary tract infections (UTIs) are the most common infections of pregnancy and pose great therapeutic challenges. The objective of the present study was to evaluate and compare the antimicrobial treatment practices for UTIs during pregnancy in comparison with the standard treatment guidelines. A prospective cross sectional study was conducted on 782 pregnant female patients suffering from UTIs in...
SYNTHESIS OF SILVER NANOPARTICLES USING SWERTIPUNICOSIDE AND ITS ACTIVITY ON HUMAN BREAST CANCER CELL LINE (MCF-7)
In the current study, synthesis of silver nanoparticles (AgNPs) using swertipunicoside was tested against human breast cancer cell line (MCF-7). The swertipunicoside was tested against the normal cell line such as vero cells to find out the toxicity of the compound. The synthesized AgNPs were characterized using UV-visible spectroscopy, x - ray powder diffraction (XRD), fourier-transform infrared ...
The objective of the present study is to develop a pharmaceutically stable sustained release matrix tablets of Baclofen and perform the pre-compression, post compression and in-vitro evaluation studies of developed formulation. In this study sustained release matrix tablets of Baclofen were prepared by wet granulation method using mannitol, HPMC K4M, sodium alginate, HPMC K15 in various concentrat...
DEVELOPMENT AND VALIDATIONOF OF STABILITY INDICATING HPLC METHOD FOR DETERMINATION OF ACOTIAMIDE HYROCHLORIDE
A simple and rapid stability indicating HPLC method for acotiamide hydrochloride was developed and validated. The stationary phase used was thermo gold cyno (250 × 4.6 mm) 5 μ with a mobile phase consisting of mixture of acetonitrile and 10 mM KH2PO4 in water in the ratio of 80:20 v/v at a flow rate of 0.8ml/min. Detection was carried at 284 nm. The retention time observed was 8.1 ± 0.2 min. Th...
Background: Cervical cancer is the second most common cancer in women worldwide, with over 90% of cases the occurring in developing countries. India attributes to about 15% of the cancer deaths in the world mostly in rural areas. This dangerous disease can be effectively prevented by creating awareness programs and the possibility of effective management with early screening. Methodology: A prospe...
EFFECT OF ASPARAGUS CURILLUS ON LEVELS OF MATRIX METALLO PROTEINASES IN GCF AND SALIVA OF PERIODONTAL PATIENTS
This study was planned to evaluate the anti-inflammatory effect of roots of Asparagus curillus in periodontal inflammation via assessing gingival crevicular fluid (GCF) and salivary inflammatory markers namely MMP-8, -9, 13, TIMP-1 and IL-6. Samples of GCF and saliva were obtained from patients with chronic periodontitis (n = 98) and healthy controls (n = 27). Study population (n = 98) was divided...
Terminalia catappa Linn. belongs to the family Combretraceae found in tropical regions of Asia, Africa and Australia, which is commonly called as Indian almond, sea-almond, tropical almond, wild badam. The fruit is useful in bronchitis and bowels. Juice of leaves is used in the preparation of the ointment for scabies, leprosy, cutaneous diseases and also as analgesic. The root bark is used in dyse...
EFFECT OF VITAMIN B12 SUPPLEMENT ON SERUM LEVELS OF VITAMIN B12 AND MEMORIZING ABILITY ON PRESCHOOL CHILDREN
This research aimed to analyze the effect of vitamin B12 supplementation on vitamin B12 serum level and memorizing ability of preschool children. A community - randomized controlled trial of 29 preschool children (4-6 year) was conducted for six months. Subjects were divided into two groups, treatment group (received 10 mcg of vitamin B12 daily syrup) and control group (placebo). Serum vitamin B12...
IN-VITRO HYPOGLYCEMIC EFFECT OF FOENICULUM VULGARE MILL. SEEDS ON THE CARBOHYDRATE HYDROLYZING ENZYMES, α-AMYLASE AND α-GLUCOSIDASE
Diabetes is a metabolic disorder characterized by absolute or relative deficiency of insulin. Today, globally many therapeutic approaches are being innovated to decrease the postprandial glucose levels and adsorption through the inhibition of enzymes, α- amylase and α- glucosidase. Presently, these two enzymes offer for the maintenance of glucose levels in diabetic patients by hydrolyzing the ca...
Nowadays, the organic way of farming gains much more important and the people believe that the production of plants with organic farming has more nutrients and a lot of health benefits. In this, the green leafy vegetables occupy an important place among the food crops as they provide an adequate number of vitamins and minerals for humans. Solanum nigrum L. and Trigonella foenum-graecum L. are comm...
A new drug delivery system for H2 receptor antagonist ranitidine hydrochloride was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of time. Floating mucoadhesive tablets of ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ran...
Extrapyramidal symptoms (EPS) are the most common adverse effect of antipsychotic drugs. Haloperidol is atypical antipsychotic agents which has high potency, effectively used against delusion, hallucinations and have increased propensity to cause drug induced EPS. The adverse effects of haloperidol include muscle stiffness, parkinsonism, uncontrolled or slowed movements of any part of the body. He...
ANALYSIS OF CRYSTAL STRUCTURES OF DIPEPTIDYL PEPTIDASE 4 (DPP 4) CO-CRYSTALLIZED WITH DIVERSE INHIBITORS
Crystal structures of target are an indispensible tool in modern methods of rational drug design and discovery. Hence, judicious selection of crystal structures for virtual screening and ligand docking is essential. In recent times, a number of new chemical entities (NCEs) have been introduced into the drug discovery pipeline with these methods in treatment of type 2 diabetes. Dipeptidyl peptidase...
CHARACTERIZATION OF VERAPAMIL HYDROCHLORIDE ENTRAPPED IN POLY (LACTIDE-CO-GLYCOLIDE) (PLGA) PARTICLES
The optimized microparticles of Verapamil hydrochloride entrapped in Poly(lactide-co-glycolide) (Verapamil HCl-PLGA) was prepared through solvent displacement method and lyophilization. The optimization parameters for the formulation include particle size, polydispersity index, zeta potential, and entrapment efficiency. The final product was further characterized based on percent particle recovery...
GASTROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF TRICHOSANTHES DIOICA FRUIT ON EXPERIMENTAL GASTRIC ULCER IN RATS
Peptic ulcer is a condition associated with a number of factors involving excessive acid secretion in the stomach. This condition is difficult to control with single drug therapy and complete cure cannot be achieved. Even after discontinuation of the drug the relapse rate is high, and the long-term use of synthetic drugs produces adverse effects on the human body. The present study is expected to ...
EVALUATION OF NUTRITIONAL AND PHYSICO-CHEMICAL CHARACTERISTICS OF DIETARY FIBRE ENRICHED WITH CARROT POMACE PASTA
ABSTRACT: Fibre rich pasta were prepared by substituting refined wheat flour with carrot pomace powder (CPP) at 5%, 15%, and 25% and evaluated for its physical properties, chemical composition, textural properties and sensory characteristics. The fat content of the pasta showed no pronounced variation. The hardness of the pasta increased with increase in the level of incorporation of CPP in the fl...
EFFECT OF PHARMACEUTICAL CARE TRAINING ON KNOWLEDGE ATTITUDE AND PRACTICES OF PHARMACISTS IN MAHARASHTRA
The objective of the study was to assess the effect of Pharmaceutical care training on Knowledge, Attitude and Practices of Pharmacists from various settings. In this prospective interventional study, a validated Knowledge, Attitude and Practice questionnaire was administered, before and after an educational training to the pharmacists belonging to hospital, community and corporate settings of Pun...
EFFECT OF PUTRANJIVA ROXBURGHII WALL. ON PHAGOCYTOSIS AND CHEMOTAXIS BY POLYMORPHONUCLEAR LEUKOCYTE CELLS (IN-VITRO STUDY)
Polymorphonuclear leukocytes or neutrophils are important components of host defense machinery. They are the first line of defense against invading microorganisms. In the present research work, ability of human neutrophils to phagocytose was studied in-vitro by exposing the polymorphonuclear leukocytes to Candida albicans and the phagocytic capacity was evaluated using aqueous extract of leaves po...
ATTITUDE PERCEPTION AND RECOMMENDATIONS BY ”Pharm. D” STUDENTS UNDER-GOING THEIR COURSEWORK IN A GOVERNMENT UNIVERSITY – A MAILED QUESTIONNAIRE SURVEY
Background: The quality of education offered by Pharmacy institutions in the country varies widely. There are only a few institutions which maintain internationally recognized standard. Aim: To assess the pharmacy student’s (Pharm. D) perception today, their course, curriculum, and facilities provided. Methods: A postal survey was conducted on the Pharm. D students in Tamil Nadu, India, affiliat...