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A STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ANALYSIS OF VILDAGLIPTIN AS BULK DRUG AND FROM ITS PHARMACEUTICAL DOSAGE FORM
Vildagliptin chemically (S)-1-[N-(3-hydroxy-1- adamantyl) glycyl] pyrrolidine-2-carbonitrile, is a potent dipeptidyl peptidase IV (dip-IV) inhibitor, a drug for the treatment of diabetes. DPP-IV inhibitors represent a new class of oral antihyperglycemic agents to treat patients with type 2 diabetes. The Present work describes the development and validation of a new simple, accurate, precise and st...
4237
1957
NOCTURNAL ENURESIS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF PANDANUS ODORATISSIMUS L. PEDUNCLE
Nocturnal Enuresis treatment activity in rabbits by measuring the changes in urine volume and concentrations of electrolytes as well as bladder capacities. In addition, antioxidant activity was measured using free radical scavenging (DPPH method) and antimicrobial activity against human bacterial pathogens using agar diffusion technique. Pandanus Odoratissimus L. peduncle showed no toxic effect wi...
4236
2039
ANTIDIABETIC ACTIVITY OF BERBERIS ASIATICA (D.C.) ROOTS
Barberries are a large group of evergreen shrubs, found in Lalitpur, Allahabad, Bhopal and Haldwani etc. It is an evergreen shrub. Commonly, its fruits are called as berries. This plant is generally use in case of diabetes and mouth ulcer, as a traditional use. Type 2 diabetes mellitus (formerly called NIDDM, type II or adult-onset) is characterized by insulin resistance in peripheral tissue and a...
4236
1474
MICROBIAL CONCRETE: THE PIONEERING WORK ON REPAIRING CONCRETE
The global demand of concrete is increasing every year and generally is considered as most consumed material on earth. But concrete is vulnerable to deterioration, corrosion, and cracks, and the consequent damage and loss of strength requires immensely expensive remediation and repair. One such mechanism that receives increasing attention in recent years is the ability for self-repair. So a nove...
4236
1567
COMBINATION THERAPY AND ITS IMPLICATION ON CLINICAL EFFICACY OF ARTEMISININS- REVIEW
Artemisinin and its derivatives have successfully been used in treatment of falciparum malaria infections in various parts of the world. More importantly, they have proved effective against strains resistant to conventional antimalarials such as chloroquine and mefloquine in those parts of the world where malaria is endemic. Only one clinically relevant artemisinin-resistant human malaria has been...
4235
1454
SYNTHESIS, CHARACTERIZATION OF SOME 2-AZETIDINONE DERIVATIVES FROM 4- NITRO ETHYL BENZOATE BY MICROWAVE METHOD AND EVALUATION OF THEIR ANTIMICROBIAL ACTIVITY
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, series of five novel azetidinones are synthesi...
4234
4522
DESIGN AND EVALUATION OF BILAYERED MUCOADHESIVE FILM OF CEFPODOXIME PROXETIL
The objective of the present work was to formulate and evaluate a sustained release gastroretentive dosage form. A mucoadhesive bilayered film was prepared consisting of an Immediate Release (IR) and a Controlled Release (CR) layer. The film is folded into a Hard Gelatin Capsule which after administration into GIT unfolds and adheres to the GI mucosa. Cefpodoxime Proxetil is an antibiotic of BCS C...
4233
1803
PHARMACOLOGICAL AND PHYTOCHEMICAL EVALUATION OF ANTI-ULCEROGENIC POTENTIAL OF SOLANUM NIGRUM
Anti-ulcer activity of the Solanum nigrum L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorde...
4233
1595
IMPROVED EFFICIENCY AND REDUCED COSTS DURING INFUSION THERAPY WITH PREMIXED PREPARATIONS COMPARED TO FREEZE-DRYING POWDER
Background: An excessive medical expenditure is becoming a main barrier to good health for several people in China. Hence, there is a need to control this rising medical cost to reduce the financial burden placed on family and society in general. Objective: Our aim was to understand the expenses incurred during the use of two forms of infusion therapy- the premixed preparations and the freeze-d...
4233
1602
EFFICACY OF SODIUM HYPOCHLORITE IN CONTROLLING BACTERIAL INFECTIONS IN FIFTH INSTAR LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)
Bacterial diseases are highly virulent and cause significant crop loss in Anthereae mylittadrury (Daba TV).Therefore an attempt has been made to evaluate the efficient concentration of sodium hypochlorite in controlling bacterial infection through studies on mortality, Total haemocytes, Protein carbonyl content, Alanine transaminase, Aspartate transaminase in the fifth in star larvae. Results reve...
4233
1885