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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 4 (2013) - Issue 1, January

Review Articles

 
Title
Views
PDF
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1.

PROTEINS AND PEPTIDES AS TARGETING CARRIERS IN ANTICANCER DRUG DELIVERY: A REVIEW

The treatment of cancer is limited by a number of factors including the low therapeutic index of most chemotherapeutic agents, the emergence of drug- and radiation-resistant tumor cells, tumor heterogeneity and the presence of metastatic disease. One of the means to improve the therapeutic index of drugs is by selective or ‘targeted’ delivery to tumor sites. Tumor-directed therapy has the pote...

Alemu Tekewe*, Murad Saleh and Meron Kassaye

Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).1-18

01-18

2464

702

2.

ANIMAL MODELS OF CANCER: A REVIEW

Cancer is the second leading cause of death worldwide. In USA three persons out of five will develop some type of cancer. Beyond these statistics of mortality, the morbidity due to cancer presents a real scary picture. Last 50 years of research has rendered some types of cancer curable, but still the major fear factor associated with this disease is unchanged. Animal models are classified accordin...

Archana M. Navale

Department of Pharmacology, Parul Institute of Pharmacy, Limda, Waghodia, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).19-28

19-28

2997

736

3.

MICRO-TAG: A NOVEL TECHNIQUE OF SECURITY IN PHARMACEUTICALS

According to FDA estimates about 10% of all drugs sold worldwide are counterfeit. Annual global trade in counterfeit goods is estimated to be $600 billion and growing. Counterfeit goods and drugs leads real threat to consumer safety as well as loss of companies brand value and profits. Till date, dosage authentication required forensic analysis in a laboratory which is a slow process involving app...

Jayprakash S. Nogaja

SVERI’s College of Pharmacy, Pandharpur, Dist- Solapur, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).29-33

29-33

3755

864

4.

CONFORMATIONAL ANALYSIS: A REVIEW

Conformational analysis is an important step in molecular modeling as it is necessary to reduce time spent in screening of compounds for activity. Most drugs are flexible molecules with the ability to adopt different conformations by means of rotation about single bonds. Conformations play an important role in prediction of not just physico-chemical properties but also the biological activity of t...

Jasmine Uthuppan* and Kriti Soni

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi-110062, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).34-41

34-41

5929

1640

5.

COLON TARGETED DRUG DELIVERY SYSTEM: A REVIEW

Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive ...

R.B. Desi Reddy, K. Malleswari*, G. Prasad and G. Pavani

Department of Pharmaceutics, Nalanda institute of Pharmaceutical sciences, Kantepudi, Guntur, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).42-54

42-54

3455

1137

6.

A TECHNICAL NOTE ON GRANULATION TECHNOLOGY: A WAY TO OPTIMISE GRANULES

To provide an updated technical note on granulation technology (GT), mostly on novel GT, that will help researcher working/engaged in designing an efficient GT for getting granules with desired features. Granules were most widely used in the production of pharmaceutical oral dosage forms. Advancement in GT had revolutionized the sphere and resulted in development of several processes. Each and eve...

Mahammed Athar A. Saikh

Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, SHIATS, Allahabad-221 007, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).55-67

55-67

4068

7248

7.

CYCLODEXTRIN INCLUSION COMPLEX TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS: A REVIEW

Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, melting, kneding, spray drying, freeze drying, co-evaporation has been reported to enhance the solubili...

V.B. Chaudhary * and J. K. Patel

Assistant Professor, Pharmaceutics department, Shri Sarvajanik Pharmacy College, Nr. Arvind baug, Mehsana, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).68-76

68-76

15476

1268

8.

NEED FOR NEW HYPOGLYCEMIC AGENTS: AN OVERVIEW

Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Insulin deficiency in turn leads to chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. It is the most common endocrine disorder and by the year 2010, it is estimated that more than 200 million people worldwide will have DM and 300 million will subs...

Muhammad Shoaib Akhtar , Nadeem Irshad*, Abdul Malik and Yousaf Kamal

Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).72-82

77-82

1700

817

9.

BUCCAL PATCHES: A REVIEW

Buccal route is an attractive route of administration for systemic drug delivery and it leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism provides high bioavailability. Buccalbioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditiona...

Pradeep Kumar Koyi* and Arshad Bashir Khan

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Sarjapura Main Road, Carmelaram post, Bangalore - 560035, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).83-89

83-89

6629

1222

10.

CHRONOTHERAPY: A REVIEW

Chronotherapy refers to the use of circadian, ultradian, infradian & seasonal or other rhythmic cycles in the application of therapy. There are number of conditions which show a circadian pattern and advantage could be taken by timing and adjusting the administration of drugs according to the circadian rhythm of the disease. Some of the conditions, which may be significantly benefited, are hyp...

Manpreet Kaur* and Rajni Bala

Chitkara College of Pharmacy, Chitkara University, Rajpura- 140 401, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).90-02

90-102

4211

734

11.

ETHNOPHARMACOLOGICAL PROPERTIES OF CURCUMA LONGA: A REVIEW

Curcuma longa(Turmeric) is a member of the ginger family (Zingiberaceae) and is thought to be indigenous to the Indian subcontinent. It is grown and harvested commercially in India, China, and many regions of tropical Southeast Asia. Turmeric is an approved food additive and is commercially available at low cost. Indigenous systems of medicine, including the Ayurvedic systems, have widely used tur...

Nitesh Kumar* and Sunil Kumar Sakhya

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and A. H., Rewa – 486 001 Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).03-12

103-112

3969

1262

12.

ANTIEMETICS: A REVIEW

The act of emesis is controlled by the vomiting centre in the medulla, which integrates afferent input from the vestibular system, the chemoreceptor trigger zone (CTZ), the cortex and the gut. Nausea and vomiting induced by several cancer chemotherapy agents is often the most distressing side effect of treatment. The mechanism of action of antiemetic is related to blockage of various type of recep...

Amit Kumar* and Anoop Kumar

Jaipur College of Pharmacy, affiliated to Rajasthan University of Health Sciences, Jaipur, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).13-23

113-123

4680

1171

13.

IMMEDIATE RELEASE DRUG DELIVERY SYSTEM (TABLETS)

Tablet is the most popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. There are novel types of dosage forms that act very quickly after administration. The basic approach used in development tablets is the use of superdisintegrants...

Rishikesh*, Mohiuddin Ahmed Bhuyian, Irin Dewan, Drishti Rani Ghosh & Md. Asraful Islam

Department of Pharmacy, University of Asia Pacific, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).124-31

124-131

3011

2905

14.

NEEDLE FREE INJECTION SYSTEMS

Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free technology offers the very obvious benefit of reducing patient concern about the use of needle. Needle free injection gives very effective injections for a wide range of drugs and bioequivalent to syringe and needle,   results in less pain, a...

Rapolu Bharath Kumar and Zuheb Ur Rahman

Department of Pharmaceutics, CMR College of Pharmacy, Kandlakoya (V), Medical, Hyderabad- 501401, A.P, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).132-47

132-147

5584

1125

15.

A COMPREHENSIVE REVIEW OF PLANTS USED AS CONTRACEPTIVES

Evaluation of herbs for anti-fertility effects has been in progress worldwide for several decades to identify effective and safe substances for control of population explosion. This population explosion will have negative impact on our economic policies and would simultaneously misbalance our socio-economic infrastructure. Family planning has been promoted through several methods of contraception,...

Dusmanta Kumar Pradhan*, Manas Ranjan Mishra , Ashutosh Mishra , Ashok Kumar Panda , Rajani Kanta Behera, Shivesh Jha and Sanjaya Choudhury

Associate Professor, Gayatri College of Pharmacy, Jamadarpali, Sambalpur-768200, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).148-55

148-155

8077

1685

16.

PHARMACOLOGICAL IMPORTANCE OF CITRUS FRUITS

This paper reviews the pharmacological importance of citrus fruits. Citrus fruits are used for various pharmacological importance. According to literature the citrus fruit possess anti-cancer, antimicrobial, antioxidant, antiulcer, anti-inflammatory, and hypolipidemic and hepatoprotective properties....

Amita Tomar*, Mridula Mall and Pragya Rai

Assistant Professor, Pharmacy College Itaura Chandeshwar, Azamgarh- 276128, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).156-60

156-160

4602

1880

17.

SOLID LIPID NANOPARTICLES: AN ADVANCED DRUG DELIVERY SYSTEM

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticle (SLN) dispersions have been proposed as a new type of colloidal drug carrier system suitable for intravenous administration. Solid lipid nanoparticles (SLN...

Raghu Nandan Reddy* and Arshia Shariff

Department of pharmaceutics, Krupanidhi College of pharmacy, Sarjapura main road, Carmelaram post, Bangalore-560035, Karnataka, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).161-71

161-171

3295

674

18.

SOFT MALLEABLE VESICLES TAILORED FOR ENHANCED DELIVERY OF ACTIVE AGENTS THROUGH THE SKIN: AN UPDATE

Ethosomes  are  noninvasive  delivery  carriers  that  enable drugs  to  reach  the  deep  skin  layers  and/or  the  systemic circulation. These are soft, malleable vesicles tailored for enhanced delivery of active agents.  They are composed mainly of phospholipids, high concentration of ethanol and water. The high concentration of  ethanol makes  the  ethosomes  unique,  as ...

Sandeep Kumar Parihar*, Mithun Bhowmick, Rajeev Kumar and Balkrishna Dubey

Department of Pharmaceutics, TIT-College of Pharmacy, Anand Nagar, Bhopal, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).172-80

172-180

1665

676

19.

DRUG REGULATORY STATUS ASSIGNMENT CRITERIA: A CONTRAST AMONG 2 COUNTRIES

After a laborious and extravagant procedure the drug finally enters the market for use. But who determines the new drug status as a prescription only or an OTC? There is a clear cut contrast between the US and India with respect to their assignment guidelines and the future prospect of a new drug. In the US the regulatory status of the approved drug is determined as per the FDA guidelines (FDCA of...

Anoop Paruchuri*, Vini Pavithran , M. Pavani , S. Selvamuthukumaran and G. P. Mohanta

Department of Pharmacy Practice, Annamalai University, Annamalai Nagar-608002, Tamil Nadu, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).181-83

181-183

1906

886

20.

ATYPICAL ANTIPSYCHOTICS FROM SCRATCH TO THE PRESENT

Mental illness constitutes the second-largest disease burden in the United States. Psychosis is one of the most common and severe mental illnesses. It is an extremely devastating condition characterised by delusions, hallucinations, distortion of thoughts and deteriorating social functioning experiences. Psychosis in all human societies has approximately same incidence of occurrence as in accordan...

Ashish Chauhan*, Amit Mittal, Pradeep Kumar Arora

Department of Pharmaceutical Sciences, Lovely School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-144402, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).184-04

184-204

2428

919

Research Articles

 
Title
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21.

SONOPHORESIS EFFECT ON THE PERMEATION OF METRONIDAZOLE USING 3D SKIN EQUIVALENT

Transdermal drug delivery is highly advantageous method for drug administration, yet the compact structure of stratum corneum is an effective barrier which limited the use of this route to very few drug molecules. Ultrasound enhances the permeation through the skin by altering this barrier function in a phenomenon named sonophoresis. This study aimed to evaluate the effect of variable ultrasonic c...

Mai Aldwaikat*, Mohammed Alarjah , Jacki Willis , Timothy Mason

Sonochemistry Applied Research Centre, Coventry University, Coventry, CV1 5FB, England

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).205-14

205-214

1944

545

22.

LIPOSOMAL GEL AS OCULAR DELIVERY SYSTEM FOR DICLOFENAC SODIUM: IN- VITRO AND IN-VIVO STUDIES

The aim of this work is to formulate topically effective controlled release ophthalmic liposomal gel for targeting diclofenac sodium to the eye in an attempt to heal the inflamed tissue of ocular ulcerative area.  Large unilamellar vesicles (LUVs) and multilamellar vesicles (MLVs) gel formulations composing of phosphatidylcholine (PC) and cholesterol (CH) in the molar ratios of (7:2; 7:4 and 7:7)...

Omaima A. Sammour , Mahmoud A. Mahdy , Hanan M. Elnahas* and Ayman A. Mowafy

Pharmaceutics and Pharmaceutical Industry Department, Faculty of Pharmacy, Zagazig University2, Zagazig, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).215-24

215-224

1902

603

23.

DRUG USE EVALUATION OF SHENMAI INJECTION IN THE FIRST AFFILIATED HOSPITAL OF BENGBU MEDICAL COLLEGE: A PROSPECTIVE ANALYSIS

Introduction: To investigate the evaluation pattern of Traditional Chinese medicine injection, establish the drug use evaluation(DUE) standards of shenmai injection, and implement of DUE programs of shenmai injection in the First Affiliated Hospital of Bengbu Medical College. Methods: Three hundred and thirty four patients were included in this retrospective analysis. The study duration was divide...

Qingping Shi*, Feng Ding , Ran Sang , Yan Liu and Haoyu Yuan

Department of Pharmacy, the first Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).225-30

225-230

1792

538

24.

ANALYSIS OF THE CHANGES IN PRICING REGULATION ON LEADING ANALGESICS MEDICINES PRICES AND UTILIZATION IN BULGARIA

In 2004, the new pricing regulation was enforced in Bulgaria. It liberates the OTC medicines pricing procedure from reference pricing to registration according to marketing authorization holder proposal. The goal is to analyse the changes in the pricing regulations concerning OTC and its impact on prices and utilization of analgesic medicines. Two main hypotheses are tested in the study. H1: The ...

N.D. Mateev, M.M. Manova* and G. I. Petrova

Faculty of Pharmacy, Departement of Social Pharmacy, Medical University Sofia, 2 Dunav Str., Sofia 1000, Bulgaria

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).231-36

231-236

1718

487

25.

EFFECT OF CHRONIC ALCOHOLIZATION BY KOUTOUKOU ON THE WEIGHT AND ORGANS (LIVER, HEART AND KIDNEY) OF TREATED RATS (RATTUS NORVEGICUS)

Purpose: We evaluate the chronic consumption of koutoukou (KTK) on the weight and organs (liver, heart and kidney) of treated rats. Methods: This study was focused on animals divided into four (4) and by sex. One of the groups being used as control receives distilled water as drinking water; the three other groups receive KTK in their drinking water at a rate of 5 %, 10 % and 12 % for 90 days. ...

L. Tehoua , B.A. Konan*, M.K.G. Bouafou and J.Y. Datté

Laboratory of Nutrition and Pharmacology, UFR-Biosciences, Félix Houphouët Boigny University, 22 BP 582 Abidjan 22, Côte d’Ivoire

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).237-42

237-242

2008

858

26.

ANTIMICROBIAL ACTIVITY OF CLEMATIS BRACHIATA THUNB LEAF EXTRACTS

The antimicrobial activity as well as phytochemical screening of the hexane, acetone, methanol and water extracts of Clematis brachiata Thunb (Ranunculaceae) leaves was investigated. The agar dilution assay method was used for the evaluation of the antimicrobial activity of extracts against 10 bacteria and four fungal species. The phytochemical screenings were performed by using the standard proce...

M. Mostafa* and A.J. Afolayan

Principal Scientific Officer, Analytical Research Division, BCSIR Laboratories, Dhaka, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).243-47

243-247

1679

576

27.

IN VITRO AND IN VIVO EVALUATION OF DICLOFENAC POTASSIUM LYOPHILIZED ORALLY DISINTEGRATING TABLETS

Diclofenac Potassium, a sparingly soluble non-steroidal anti-inflammatory drug, was taken as candidate for decreasing the onset of action time and increasing its bioavailability by overcoming its first pass metabolism. Diclofenac Potassium orally disintegrating tablet (ODT) formulations were developed using lyophilization technique. The freeze dried tablet formulations were prepared by freeze-dryi...

Mohamed Aly Abd El Aziz Aly El Degwy*, Saadia Tayel , Mohamed A. El-Nabarawi and Randa Tag A. El Rehem

Formulation Section Head, Mepaco Pharmaceutical Company 1, El Sharkia, Egypt

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).248-59

248-259

2325

937

28.

IN VITRO EVALUATION OF ANTIBACTERIAL AND ANTIFUNGAL PROPERTIRS OF TERMINALIA BELERICA

The research work was conducted with the fruits of Terminalia belerica (Fam: Combretaceae) to investigate antibacterial & antifungal activities. The fruits of the plant were successively extracted by cold extraction process by using two solvents namely ethanol and acetone. Antimicrobial activities of the extracts of both solvents were investigated by a simple agar diffusion method using ten pa...

Mir Monir Hossain*, S. M. Moazzem Hossen, Md. Shahidul Islam, Tasmuna Tamrin Tanmy, Abonti Barua and Jahidul Alam

Department of Pharmacy, University of Science & Technology Chittagong (USTC), Foy’s Lake, Chittagong-4202, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).260-64

260-264

1521

722

29.

ASSESSMENT OF DRUG USE PRACTICES AND COMPLETENESS OF PRESCRIPTIONS IN GONDAR UNIVERSITY TEACHING REFERRAL HOSPITAL

Background: Rational drug use is a tool through which safe, effective and economic medication is provided. Rational prescribing ensures adherence to treatment and protects drug consumers from unnecessary adverse drug reactions. Rational dispensing on the other hand, promotes the safe, effective and economic use of drugs. Objectives: The aim of this study was to assess drug use practices and com...

Endalkachew Admassie*, Birhan Begashaw and Wubshet Hailu

Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).265-75

265-275

2284

1205

30.

BIOEQUIVALENCE STUDY OF TWO BRANDS OF PHENYTOIN SODIUM 100MG FORMULATIONS IN HEALTHY ADULT MALE RABBITS

The objective of the study was to compare the bioavailability of a single oral 100 mg dose of two brands of phenytoin sodium formulations available in the Nepalese market. Formulation B was taken as test drug and compared with the innovator brand which was taken as reference standard. A randomized, two-way crossover study was done in six healthy adult male rabbits. All six rabbits received a singl...

Saroj Nepal , Suhrid Banskota , Nirmal Marasini, Biki Gupta , Shyam Prasad Lohani , Shova Basnet and Bal Mukunda Regmi*

Institute of Medicine, Tribhuvan University, Kathmandu, Nepal

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).276-81

276-281

3893

605

31.

DEVELOPMENT AND VALIDATION OF A NEW HPLC METHOD FOR THE ESTIMATION OF AZITHROMYCIN IN BULK AND TABLET DOSAGE FORM

A simple, reproducible and efficient reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for quantitative determination of azithromycin in drug substance. The separations were carried out on a Xterra C18 column (150 ×4.6 mm; 5µ) with UV detection at 215 nm. The mobile phase consisting of acetonitrile and phosphate buffer (pH adjusted to 7.5) in a ratio of 5...

Irin Dewan*, Tasnuva Amin , Md. Faisal Hossain , Moynul Hasan , Sayeeda Fahmee Chowdhury , Mahjabeen Gazi and S.M. Ashraful Islam

Assistant Professor, Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).282-86

282-286

2646

818

32.

FORMULATION DEVELOPMENT AND IN VITRO – IN VIVO CHARACTERIZATION OF ORAL FAST DISINTEGRATING FILMS OF A DRUG MEANT FOR CHRONIC DISEASE

The objective of the work was to design oral FDFs of a drug meant for management of chronic disease like type-2 diabetes mellitus which affects mostly elderly population.  Glimepiride was the drug of choice because of its low dose. Since in vitro dissolution rate is the rate limiting step in drug absorption for class II drugs, in the present work,it was also proposed to make a complex of the drug...

P. Vijayalakshmi*, E. Surender , B. Pragna , Md. Zia Askary , Lohidasu Borubhadra , A.J. Balamurugan and Hemant Joshi

Department of Pharmaceutics, Vijaya College of Pharmacy, Hyderabad, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).287-95

287-295

1708

1085

33.

ANTIMICROBIAL ACTIVITY OF CRUDE EXTRACT OF CITRUS HYSTRIX AND CITRUS MAXIMA

Since plants are used as therapeutic agents, the present study was conducted to evaluate the antibacterial activities of methonolic extracts of different components of Citrus hystrix and Citrus maxima (Red and White) fruit. Studies on the antibacterial activity of methanolic extracts of leaf, peel, and pulp of Citrus hystrix and Citrus maxima (Red and White) fruitwas conducted using agar disc diff...

Arumugam Abirami, Gunasekaran Nagarani and Perumal Siddhuraju*

Bioresource Technology Lab, Department of Environmental Sciences, Bharathiar University, Coimbatore – 641 046, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).296-00

296-300

5456

1385

34.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR NITAZOXANIDE IN POWDER FOR SUSPENSION DOSAGE FORM

A simple, precise, accurate, rapid and reproducible RP-HPLC method has been developed for the determination of Nitazoxanide in powder for suspension dosage form. Chromatography was carried out on an ODS C18 column (250 x 4.6 mm x 5 µm length), using a mixture of acetonitrile and 0.005 mol L-1 tetra n- butyl ammonium hydrogen sulphate (54:46 v/v) as the mobile phase at a flow rate of 1 mL/min and ...

Sharifa Sultana*, Tanbir Ahammad , Md. Ashraful Islam and A.S.S. Rouf

Lecturer, Department of Pharmacy, Daffodil International University, 102 Shukrabad, Mirpur Road, Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).301-05

301-305

2030

592

35.

ANALYSIS OF BIOACTIVE COMPOUNDS AND ANTIMICROBIAL ACTIVITY OF MARINE ALGAE KAPPAPHYCUS ALVAREZII USING THREE SOLVENT EXTRACTS

The seaweeds are economically valuable resources, used as food, fodder, fertilizer and medicine and thus useful to mankind in many ways. In the present study, Kappaphycus alvarezii, a marine alga, has been analysed for the presence of bioactive products using three solvent extracts. Antimicrobial activity was also done using the same extracts of seaweed. The results revealed that the selected seaw...

V. Prabha*, D.J. Prakash and P.N. Sudha

Head & Assistant Professor, Department of Biochemistry, D.K.M College for Women, Vellore-632 001, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).306-10

306-310

2805

784

36.

ISOLATION AND CHARACTERISATION OF A NEW ALLELOCHEMICAL FROM PARTHENIUM HYSTEROPHORUS L.

Parthenium hysterophorus L.  is commonly known as “Gajar ghas" in Hindi and belongs to family Composite. It is an annual herb erect up to 1.5 m in hight. Its stems is branched and covered with trichomes. Its leaves are pale green, branched and covered with soft fine hairs. In Homoeopathy system, allergies caused by Parthenium can be treated by a drug prepared from Parthenium. Root decoction ...

R. N. Yadava* and Shirin Khan

Natural Products Laboratory, Department of Chemistry, Dr. H. S. Gour Central University, Sagar, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).311-15

311-315

1528

943

37.

IN-VIVO ANTI-INFLAMMATORY EFFECT OF AQUEOUS AND ETHANOLIC EXTRACT OF SIDA RHOMBIFOLIA L. ROOT

Inflammation plays an imperative role in pathophysiology of various diseases. Sida rhombifolia L. (Malvaceae), commonly known as Atibala is traditionally used for numerous medicinal purposes in India. The present study was carried out to demonstrate the in vivo anti-inflammatory effect of aqueous and ethanolic extract of Sida rhombifolia L. root using Wistar rats by carrageenan induced acute infla...

P. Logeswari*, V. Dineshkumar , S.M. Prathap Kumar and P.T.A. Usha

Research Scholar, Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur-680651, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).316-21

316-321

1989

952

38.

SIMULTANEOUS ESTIMATION OF DICLOFENAC SODIUM AND TOLPERISONE HYDROCHLORIDE IN COMBINED PHARMACEUTICAL FORMULATION

Three simple, rapid, precise and accurate spectrophotometric methods have been developed for simultaneous analysis of Tolperisone Hydrochloride (TOL) and Diclofenac Sodium (DIC) in their combined dosage form. Method A, Simultaneous equation method (Vierodt’s method) applies measurement of absorptivities at two wavelengths, 261.00 nm (λmax of Tolperisone Hydrochloride) and 279.00 nm, (λmax of D...

Bhavesh Gevriya* and R.C. Mashru

Quality Assurance Laboratory, Centre of Relevance and Excellence in Novel Drug Delivery System, Pharmacy Department, G. H. Patel Building, Donor’s Plaza, The Maharaja Sayajirao University of Baroda, Fatehgunj, Vadodara – 390 002, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).322-27

322-327

1835

765

39.

ETHNOMEDICINAL PLANTS USED IN THE TRADITIONAL PHYTOTHERAPY OF CHEST DISEASES BY THE GUJJAR-BAKERWAL TRIBE OF DISTRICT RAJOURI OF JAMMU & KASHMIR STATE

Ethnobotanical study was conducted in district Rajouri, Jammu And Kashmir State aiming at identifying plants used to treat chest diseases mainly related to respiratory system. A semi-structured questionnaire was used to interview members of the tribal population including traditional healers, herb sellers, and other villagers. The plant parts used as well as the modes of preparation and administra...

Abdul Rashid

Earth Foundation International (EFI), Flat No. 110, Poonch House, Talab Tillo, Jammu- 180002, Jammu Kashmir, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).328-33

328-333

2360

921

40.

ANTIOXIDANT ACTIVITY OF ISOLATED FLAVONOIDS FROM THE LEAVES OF CORCHORUS AESTUANS LINN.

Preliminary phytochemical investigation of various extracts of leaves of Corchorus aestuans Linn showed the presence of flavonoids, carbohydrates, saponins, phytosterols, phenolic compounds, triterpenoids, cardiac glycosides and tannins. An attempt has been made to isolate flavonoids and perform antioxidant potential of the same. The antioxidant activity was performed by two in-vitro testing metho...

Rashmika Patel * and Manish Patel

Assistant Professor, Department of Pharmacognosy, B. Pharmacy College, Rampura-Kakanpura, Ta. Godhra, Dist. Panchmahal, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).334-40

334-340

1509

628

41.

FORMULATION AND EVALUATION OF PROBIOTIC TABLETS CONTAINING ANTI-INFLAMMATORY DRUG

The aim of present study was to formulate and evaluate probiotic tablets containing anti-inflammatory drug Mesalazine. Matrix tablets were prepared using Sodium alginate and Hydroxypropylmethylcellulose acetate succinate (HPMCAS) as matrix forming components, with three different combinations by wet granulation method. The granules were evaluated for angle of repose, bulk density, tapped density, ...

K. D. Lone* and J. A. Dhole

Assistant Professor in Pharmaceutics, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune-411033, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).341-46

341-346

2295

1245

42.

ANTIOXIDANT PROPERTIES OF POLYGALA CHINENSIS L. WHOLE PLANT ON ALLOXAN INDUCED DIABETIC RATS

Administration of ethanol extract of Polygala chinensis whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The treatment also resulted in significant increase in reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) in serum, liver and kidney. The res...

K. Rajalakshmi and V.R. Mohan*

Ethnopharmacology Unit, Research Department of Botany, V. O. Chidambaram College, Tuticorin, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).347-51

347-351

1805

567

43.

ANTIHYPERGLYCEMIC EFFECT OF CHITOSAN OF PODOPHTHALMUS VIGIL IN STREPTOZOTOCIN INDUCED DIABETIC RATS

The present study was designed to investigate the antihyperglycemic activity of chitosan of Podophthalmus vigil on normal and streptozotocin (STZ) diabetic rats. Diabetes was induced into male albino wistar rats by intraperitonial administration of STZ. Chitosan was administered orally at three different doses to normal and STZ-diabetic rats for 30 days. The diabetic rats showed an increase in lev...

K. Prabu* and E. Natarajan

Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai-608 502, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).352-59

352-359

2000

578

44.

CONCEPTS OF ANTI-HIV THERAPY & ITS APPLICATIONS IN RESOURCE POOR SETTINGS

HIV since its invention has become global burden. In last two decades of the HIV prevalence many anti-retroviral drugs have been developed. Poor countries like India have started central government funded programmes to tackle the menace of the HIV. These programmes have been started because many people cannot afford costly ART drugs. In this review article, we have discussed current ART regimens a...

P.D. Shankpal, J.H. Hotwani, K.A. Chitnis and A.S. Limaye*

Department of Pharmacology, Topiwala National Medical College & B Y L Nair Ch. Hospital, Mumbai- 400 008, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).360-70

360-370

1455

533

45.

HEPATOPROTECTIVE ACTIVITY OF LAGENARIA SICERARIA (MOLINA) STANDLEY FRUITS AGAINST PARACETAMOL INDUCED HAPATOTOXICITY IN MICE

Aim and Objectives: Fruit juice of Lagenaria siceraria (LS) belonging to Cucurbitaceae family, has been used traditionally to treat jaundice and to cure certain liver disorders. Antioxidants are well known for their hepatoprotective effect and in curing liver disorders. In this study, hepatoprotective and antioxidant effects of fruits were investigated. Materials and Methods: The coarsely powde...

C.V. Panchal*, Jyotiram A. Sawale , B. N. Poul and K.R. Khandelwal

Assistant Professor, Maharashtra College of Pharmacy, Nilanga, Dist. Latur- 413 521, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).371-77

371-377

1799

648

46.

COMPARATIVE IN-VITRO QUALITY EVALUATION OF ERYTHROMYCIN STEARATE TABLETS MARKETED IN ADDIS ABABA, ETHIOPIA

In this study, an attempt was made to assess the physicochemical equivalence of four brands of Erythromycin stearate tablets marketed in Addis Ababa. Identity, weight uniformity, disintegration, dissolution and assay for the content of active ingredients were evaluated using the methods described in the British Pharmacopoeia 2007. All the samples passed the identity, disintegration, and dissolutio...

Gebremariam Birhanu, Frehiwot Kassa, Ariaya Hymete and Ayenew Ashenef*

Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).378-85

378-385

2620

698

47.

PROSPECTIVE OBSERVATIONAL, NON-RANDOMIZED, PARALLEL SEQUENCE STUDY FOR ASSESSMENT OF ADVERSE DRUG REACTIONS DUE TO CHEMOTHERAPEUTIC TREATMENT IN DIFFERENT TYPES OF CANCER PATIENTSABSTRACT

Objective: To assess incidence, causality, severity, predictability and preventability of adverse drug reactions (ADRs) in hospitalised oncology patients. Materials and Methods: A prospective observational, non-randomized, parallel sequence study was conducted at Dr B. Borooah Cancer Institute (BBCI) after getting an approval from human ethical committee. Patients hospitalised at BBCI from Aug ...

Mrugank B.P. *and Hareesha R.P.

Clinical Research Scientist, Division of Research and Development, Alembic Pharmaceuticals Limited, Vadodara, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).386-91

386-391

1630

540

48.

SYNTHESIS, CHARACTERIZATION AND COMPARATIVE STUDY OF CERTAIN METAL-1, 3-DIKETONATES

A substantial interest in rational design of novel transition metal complexes which bind and cleaves duplex DNA has been a motivation of the present investigation. This DNA adhesion of metal complex which targets bacterial DNA and cleaves it thereby results in an effective antibacterial agent. In the present work two series of metal diketonates were prepared by using diketones like acetyl acetone ...

K.L. Krishnakumar* and R. Manju

Department of Chemistry, Nehru College of Pharmacy, Pampady-680597, Kerala, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).392-95

392-395

1515

599

49.

FORMULATION AND EVALUATION OF CONTROLLED RELEASE FLOATING TABLETS OF LAMIVUDINE EMPLOYING HPMC K4M AND SODIUM ALGINATE

Lamivudine, a BCS Class I synthetic nucleoside analogue, has a  a  short  biological  half-life  of  5–7  and is mainly absorbed in the upper gastrointestinal  tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as m...

M. Srinivasa Rao*, K.S.N. Madhuri, G. Vijaya Kumar

Department of Pharmaceutics, A.K.R.G. College of Pharmacy, Nallajerla – 534112, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).396-00

396-400

2779

953

50.

DEVELOPMENT AND VALIDATION OF A STABILITY INDICATING ASSAY METHOD OF MESALAMINE BY USING DIFFERENT STRESS DEGRADATION CONDITIONS

A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of mesalamine in bulk and tablet dosage form. Solution of mesalamine in distilled water shows maximum absorbance at 330 nm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml with the slope, intercept, correlation coefficient, detection and quantitation limits were also calcula...

S. H. Gatkal*, P. R. Mhatre, V. V. Chopade and P. D. Chaudhari

Department Of Quality Assurance Techniques, Modern College of Pharmacy Nigdi, Pune-411044 Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).401-06

401-406

2458

1571

51.

FORMULATION AND IN-VITRO EVALUATION OF ACECLOFENAC ORODISPERSIBLE TABLETS

The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and c...

S. Dharani*, K. Ramesh kumar, k. Elango, S. Hemalatha, P. Stephen and I. Nishanth

Department of Pharmaceutics, College of Pharmacy, Madras Medical College, Chennai-600003, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).407-10

407-410

1663

555

52.

GASTROPROTECTIVE EFFECTS OF FRUITS OF TRIBULUS TERRESTRIS L. IN PYLORUS-LIGATED WISTAR RAT MODEL

Tribulus terrestris L. (TT; Zygophyllaceae) is employed in the folk medicine against sexual impotence, oedemas, abdominal distention and cardiovascular diseases. Gastroprotective (i.e. antiulcer and anti-secretory) potential of methanolic extract of TT fruits was evaluated in pylorus-ligated rat model of Wistar rat. The methanolic extract of TT was tested orally at the doses of 150, 300 & 600 ...

Javed Akhtar Ansari*, Md Faruque Ahmad and Fakhruddin Ali Ahmad

Assistant Professor, Department of Pharmacology, MESCO College of Pharmacy, 13-5-741, MEC, Mustaeedpura, Karwan Road, Hyderabad-500 006, India.

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).411-14

411-414

1693

965

53.

EVALUATION OF ANTI- TUSSIVE ACTIVITY OF LEAVES OF CAESALPINIA BONDUCELLA F. IN EXPERIMENTALLY INDUCED COUGH IN MICE

Cough is a natural reflex expulsive defense mechanism of the body, for clearing excess secretions, mucous, inhaled irritants, toxins or foreign substance in the respiratory tract.It is the most common symptom of respiratory disease. When cough becomes serious, opioids are effective, but they have side effects like sedation, constipation, some addiction liability and also compromise the respiratory...

Sanjay Jain*, Rakesh Barik, Nidhi Yadav and Shivpal Singh

Department of Pharmacognosy, Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).415-18

415-418

1729

588

54.

SYNTHESIS OF SOME NOVEL OXADIAZOLE BASED CHALCONE DERIVATIVES AS ANTI-BACTERIAL AGENTS

A series of 1, 3, 4-oxadiazole derivatives were designed and out of which six compounds have been synthesized via four step synthetic scheme and evaluated for antibacterial activity using cup plate method. The compounds were previously characterized by IR, 1H-NMR spectral analysis. The compounds with hydroxyl and methoxy substituted phenyl rings showed higher activity than the chloro substituted d...

P.K. Arora*, A. Mittal, G. Kaur, and A. Chauhan

Department of pharmacy, Lovely Professional University, Jalandhar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).419-24

419-424

1493

477

55.

INFLUENCE OF ENVIRONMENTAL FACTORS ON THE GROWTH OF BUILDING DETERIORATING FUNGI: ASPERGILLUS FLAVUS AND PENICILLIUM CHRYSOGENUM

The performance of whole building depends on many factors: structure, coating, environment, climate, type of use, service etc. Fungi are essential for the survival of our global ecology but they may pose a significant threat to the health of occupants when they grow in our buildings. The most important factor that affect microbial growth on buildings materials are temperature, moisture and nutrien...

Padma Singh* and Mamta Chauhan

Department of Microbiology, Kanya Gurukul Campus, Gurukul Kangri How to cite this article: Singh P and Chauhan M: Influence of Environmental factors on the growth of building deteriorating fungi: Aspergillus flavus and Penicillium chrysogenum. Int J Pharm Sci Res. 2013; 4(1); 425-429. University, Haridwar-249407, Uttarakhand, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).425-29

425-429

5478

824

56.

AN ETHNOPHARMACOLOGICAL STUDY ON COMMONLY USED TRADITIONAL PLAN & HERBAL TREATMENT IN MALAYSIA FOR ORANG ASLI PEOPLE

A qualitative ethnopharmacological survey was carried out among a local Orang Asli tribe to gather information on the use of medicinal plants in the region of Kampung Buluh Nipis. After meeting and interviewing some informants we have gotten some few traditional plants and treatment used by Orang asli people in their daily life. After Study the results showed that majority of the Orang Asli, of Ka...

Arindam Das , B. K. Gupta , Bhole Nath , Mohd. Shahimi Mustapha

Faculty of Pharmacy, Lincoln University College , Mayang Plaza, No. 1, Block A, Jalan SS 26/2, Taman Mayang Jaya, 47301, Petaling Jaya, Selangor, Malaysia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).430-33

430-433

2993

897

57.

WHAT PATIENTS WANT TO KNOW ABOUT THEIR MEDICATION? : A SURVEY OF INPATIENTS AND OUTPATIENTS AT GONDAR UNIVERSITY HOSPITAL

Patients want and are seeking more information about drug and nondrug treatment options. While a great deal of patient information about medications, treatments, and diseases exists, much of it contains conflicting, inaccurate, poorly written, or non–evidence-based information. The objective of the study was thus, to assess what patients want to know about their medications at Gondar University ...

Alemayehu Berhane*, Abiey Getahun, Asfaw Azanaw and Sherefedin Hamza

School of Pharmacy, University of Gondar, Gondar, Ethiopia

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).434-39

434-439

2115

564

58.

POLYSACCHARIDES FROM ALOE LEAF MUCILAGE AS POTENTIAL IMMUNOLOGICAL-BASED ANTI-FERTILITY AGENTS

Mucilaginous exudates from Aloe leaf containing polysaccharides, of which the major proportion has been reported to be composed of acetylated mannose molecules such as Acemannan and other high molecular weight polysaccharides. These polysaccharides, have been reported to elevate the Granulocyte Macrophage Colony Stimulating Factor (GMCSF) ultimately leading to the infiltration of macrophages at re...

Shubhranshu Gupta*, Larissa Pereira, Rohit Dugar and Rajesh Patil

Sinhgad Institute of Pharmaceutical Sciences, Sinhgad Technical Education Society’s, Off Pune-Mumbai Expressway, Kusgaon (bk.), Lonavala, Pune-410401, Maharashtra, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).440-44

440-444

2184

1372

59.

ANTIBACTERIAL POTENTIAL, PHYTOCHEMICAL INVESTIGATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEIN OF DIFFERENT FRACTIONS OF ACALYPHA INDICA

Medicinal plants are extensively used to cure various infectious diseases in human. Our present study was undertaken to investigate antibacterial activity in leaf, stem and root extracts of Acalypha indica against the human pathogens such as Staphylococcus sp, E. coli, Salmonella sp, Klebsiella pneumonia and Pseudomonas. The shade dried leaves, stem and root powder was used to prepare extracts by ...

D. Kanchana Devi* and A. Vimal Raj

Department of Microbiology, Hindusthan College of Arts and Science, Coimbatore-28, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).445-52

445-452

1559

653

60.

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF 4-BENZYLIDENE- PYRAZOLIDINE-3, 5-DIONE DERIVATIVES

In the present research work, diethyl malonate and phenyl hydrazine were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro-butyl and 4-nitrooxy-butyl substitution at nitrogen atom. The synthesized products were characterized by...

Harish Kumar* and Sandeep Jain

Drug Design and Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar-125001, Haryana, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).453-57

453-457

2279

846

61.

HYPOGLYCEMIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF PEPEROMEA PELLUCIDA (L.) HBK (PIPERACEAE)

The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 t...

Hasib Sheikh*, Shotabdi Sikder , Sagar Kumar Paul , A.M. Rashedul Hasan , Md. Mofizur Rahaman and Sangita Paul Kundu

Lecturer, Department of Pharmacy, Bangladesh Institute of Medical Science (BIMS), N/23, Nurjahan Road, Mohammadpur Dhaka-1207, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).458-63

458-463

2837

2178

62.

EXPLORATION OF HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF SOLANUM NIGRUM – AN EXPERIMENTAL STUDY

Introduction: Solanum nigrum (S. nigrum) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of S. nigrum against experimentally induced hepatotoxicity in albino rats. Aim of the study: To explore the hepatoprotective activity of S. nigrum. Materials and M...

Vipin Kumar*, Sanjeev Sharma and Pankaj Kumar Modi

MD, Assistant Professor, Department of Pharmacology, Teerthanker Mahaveer Medical College, Moradabad, Uttar Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).464-70

464-470

1548

480

63.

ISOLATION OF EPICATECHIN FROM OXYSTELMA ESCULENTUM

Background: Oxystelma esculentum is used traditionally as diuretic, laxative, hepatoprotective and anti-ulcer. Objectives: The present work deals with the isolation and structure elucidation of Epicatechin from O. esculentum. Methods: Methanolic extract of the entire plant of O. esculentum was subjected to pilot TLC experiments and column chromatography. Results: This yielded a pure, whit...

D.J. Pandya* and I.S. Anand

Associate Professor, School of Pharmacy, RK Technical Campus, RK University, Rajkot, Gujarat, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).471-74

471-474

1765

630

64.

MOLECULAR DOCKING STUDIES OF PHYTOCHEMICAL COMPOUNDS WITH VIRAL PROTEASES

Viruses are the major pathogenic agents that can cause variety of diseases in humans, animals and plants. Several deadly diseases like Hepatitis A, Hepatitis C, encephalitis, meningitis, and influenza are caused by viruses. Due to the constant and rapid emergence of viral pathogens, current recommended commercial drugs for above diseases are becoming resistant. In this view in present study forty ...

Rajarajeshwari Ramaiah and P. Chitra Suresh

Department of Bioinformatics, Sri Ramakrishna College of Arts & Science for Women, Coimbatore, Tamil Nadu, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).475-82

475-482

2405

862

65.

STUDY OF STORAGE PERIODS OF CULTURE SUSPENSION OF STAPHYLOCOCCUS AUREUS

Staphylococcus aureus ATCC 6538 is an important strain of pharmaceutical and biotechnological industries. We studied the viability of culture suspension of Staphylococcus aureus strain ATCC 6538 at 2 to 8°C up to 360 days in 0.9% w/v NaCl. The culture suspension containing 10000 cfu/ml used in the study was stored at 2 to 8°C for 360 days in 0.9% w/v NaCl. Using 10 µl of above culture suspensio...

Kundan Kumar*, I.N. Mishra and Sandhya Jha

University Department of Bio-Technology, L.N. Mithila University, Darbhanga-846004, Bihar, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).483-85

483-485

1679

527

66.

FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING TABLET OF ENALAPRIL MALEATE

The present study was aimed at developing an oral floating system for Enalapril maleate with the objective to enhance the oral bioavailability of the drug. As it is a prodrug, oxidizing agent KMnO4 was used with distilled water and observed at 340 nm against a reagent blank, using PC Shimazdu UV Spectrophotometer. The obtained   standard graph of drug was a straight line with coefficient correla...

S.K. Dash*, A.S. Khan, R. Thakur, A. Padhan, D.K. Gupta and B.C. Behera

Department of Pharmaceutics, The Pharmaceutical College, Barpali, PO- Barpali, Dist- Bargarh-768028, Odisha, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).486-96

486-496

1956

1239

67.

FORMULATION AND EVALUATION OF PROGRAMMED RELEASE OCULAR INSERTS OF MIZOLASTINE

The main objective of this study was to prepare controlled release matrix type ocular inserts of mizolastine for the treatment of seasonal allergic conjunctivitis.The films were prepared by solvent casting technique using Eudragit RL100 and RS100 in different ratios with dibutylphthalate as the plasticizer. The films were evaluated for the physicochemical parameters. In-vitro studies were carried ...

Hema Bansal, Sadhna Khatry* and Sandeep Arora

Chitkara College of Pharmacy, Chitkara University, Rajpura-140401, Punjab, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).497-01

497-501

1578

581

68.

GREENING OF MANAGEMENT: SOCIAL RESPONSIBILITY OF INDIAN PHARMACEUTICAL INDUSTRY

The present time is an era of revolution as rapid changes and developments have been noticed in almost all spheres around the globe. In most of the countries the private sector has played a pioneer role to introduce several changes. The pharmaceutical industry through research and development has brought out a variety of products. There is much of experimentation, researches and trials. The improv...

Alok Kumar Mathur* and Aditi Vyas

Institute of Health Management Research, 1, Prabhu Dayal Marg, Near Sanganer Airport, Jaipur-302011, Rajasthan, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).502-05

502-505

1745

656

69.

CONTROLLED RELEASE FORMULATION DEVELOPMENT AND EVALUATION OF FELODIPINE MATRIX TABLETS BY USING HYDROPHOBIC POLYMERS

Felodipine is a long-acting 1, 4-dihydropyridine calcium channel blocker, used to control hypertension by selective action on peripheral resistance. The conventional felodipine tablet gives a rather high peak and comparatively low trough levels, due to rapid absorption and distribution. More sustained plasma concentrations might thus produce a more even effect on blood pressure.  The main aim of ...

S. Kiran Kumar*, T. Ramarao , D.B.R.N. Bikshapathi and K.N. Jayaveera

Department of Pharmaceutics, Vijaya college of Pharmacy, Hayathnagar, R.R. District, Andhra Pradesh, India

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).506-11

506-511

2227

837

70.

ANTIBACTERIAL AND CYTOTOXIC POTENTIAL OF DALBERGIA SPINOSA ROXB. LEAVES

Dalbergia spinosa Roxb. (Leguminosae) is a mangrove plant native to Asia and enjoys number of traditional uses. This paper describes the investigation of antibacterial and cytotoxic activity of the ethanol extract of D. spinosa leaves. Antibacterial activity of the ethanol extract of D. spinosa leaves was tested by disc diffusion assay and broth macrodilution assay. The extract was also tested for...

Sanjib Saha*, Md. Anisuzzman, Md. Khirul Islam, Himangsu Mondal and Chinmoy Talukder

Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh

DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).512-15

512-515

1669

533