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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 9 (2018) - Issue 9, September

Review Articles

 
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1.

CEREBRAL PALSY: GENERAL MOTOR DISABILITY IN CHILDHOOD

Cerebral palsy is main general motor disability in the infancy and 2 to 2.5 per 1000 live births affected by the cerebral palsy. The movement restrictions in the cerebral palsy are credited to non-progressive interruption that occurs in developing brain of the infants. It is characterized by means of spasticity, weakness of muscle, primitive reflexes loss, interfering of growth of normal motor con...

A. Arya * and A. Punia

Department of Pharmaceutical Education and Research, BPS Women University, South Campus, Bhainswal Kalan, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3579-88

3579-3588

2045

955

2.

EFFECTIVE MEDICINAL PLANTS IN TREATING HEPATITIS B

Medicinal plants and natural products have many applications in the treatment of viral diseases, due to much lower side effects. Different types of hepatitis, especially hepatitis B, are of the viral diseases whose treatment using herbal medicines is currently of great interest due to the limited availability of effective chemical drugs and having numerous side effects. Due to the attention paid t...

Z. N. Samani and M. R. Kopaei *

Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(9).3589-96

3589-3596

16707

1498

3.

DRIED MATRIX SPOTING – AN INNOVATIVE SAMPLE PREPARATION TOOL IN BIOANALYSIS

Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of xenobiotics (drugs and their metabolites and biological molecules in unnatural locations or concentration) and biotics (macromolecules, proteins, DNA, large molecule drugs, metabolites) in biological system. The focus of bioanalysis in the pharmaceutical industry is to provide as quantitative measure o...

A. P. Ayre *, P. S. Chaudhari, J. Shaikh, S. Jagdale and O. Agrawal

Department of Quality Assurance, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Thane, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3597-07

3597-3607

1733

563

4.

SYZYGIUM CUMINI (LINN.) – AN OVERVIEW ON MORPHOLOGY, CULTIVATION, TRADITIONAL USES AND PHARMACOLOGY

Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like anti- diabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotectiv...

R. K. Bijauliya *, S. Alok, M. Sabharwal and D. K. Chanchal

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3608-20

3608-3620

2047

640

Research Articles

 
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5.

FORMULATION AND EVALUATION OF LIPOSOMES OF FENOFIBRATE PREPARED BY THIN FILM HYDRATION TECHNIQUE

The objectives of the present study were to use design of experiments (DOE) for formulation and optimization liposomal formulations and study the impact of process variables on quality attributes of the complex liposomal formulation system. Several factors may have contributed to the slow pace of commercialization of liposome drug products during the last decade: 1) the difficulties associated wit...

S. G. Amin, D. A. Shah and R. H. Dave *

Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York, USA.

DOI: 10.13040/IJPSR.0975-8232.9(9).3621-37

3621-3637

2663

641

6.

IN-VIVO PRELIMINARY EXAMINATION OF MORINGA OLEIFERA LEAVES EXTRACT AS ANTIAGING CANDIDATE IN SWISS WEBSTER MALE MICE (MUS MUSCULUS)

Free radicals are molecules with an unpaired electron that very unstable and react quickly with other compound to gain stability. Once the process is started, it can be a cascade reaction resulting disruption of a living cell. The free radicals formed in our body are combated by antioxidants then interact with free radicals and terminate the chain reaction before vital molecules are damaged. Morin...

M. Imamsari, M. Pertiwi-Koentjoro, A. P. Nurhayati, Isdiantoni and E. N. Prasetyo *

Microbiology and Biotechnology Laboratory, Biology Department, Faculty of Natural Science - Institut Teknologi Sepuluh Nopember (ITS), Gedung H Kampus ITS Keputih Sukolilo, Surabaya, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(9).3638-46

3638-3646

1233

561

7.

DYSLIPIDEMIC AND PROTECTIVE EFFECTS OF ASPIRIN AND CLOPIDOGREL IN OBESE RATS

Introduction: Antiplatelets play a crucial role in improving many metabolic disorders and complications, including dyslipidemia, atherosclerosis, diabetes mellitus and cardiovascular diseases. The most common and effective antiplatelets used widely are aspirin and clopidogrel. The aim of this study is to evaluate the dyslipidemic and protective effects of aspirin and clopidogrel in obese rats. Mat...

Doa’a Anwar Ibrahim

Department of Pharmacology Unit, Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, University of Science and Technology, Sana’a, Yemen.

DOI: 10.13040/IJPSR.0975-8232.9(9).3647-55

3647-3655

926

465

8.

MALDI-TOF MS BIOTYPER AND POLYMERASE CHAIN REACTION FOR RAPID IDENTIFICATION OF STAPHYLOCOCCUS AUREUS AND PSEUDOMONAS AERUGINOSA IN NON-STERILE PHARMACEUTICAL PREPARATIONS

Absence of pathogenic bacteria is a must for passing the microbiological quality control inspection of non-sterile pharmaceutical products. The identification of microbial contaminants by conventional methods is time-consuming and labor-intensive. The overall aim of the study was to test non-conventional methods as polymerase chain reaction (PCR) and Matrix Assisted Laser Desorption Ionization Tim...

S. E. Qadee, O. Helmy *, T. Almorsy and M. Ramadan

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.9(9).3656-63

3656-3663

1320

449

9.

FORMULATION, CHARACTERIZATION AND IN-VIVO APPLICATION OF ORAL INSULIN NANOTECHNOLOGY USING DIFFERENT BIODEGRADABLE POLYMERS: ADVANCED DRUG DELIVERY SYSTEM

The overall objective of this research is to improve the oral bioavailability of insulin through encapsulation in nanoparticles formulated by "ionotropic pre-gelation followed by polyelectrolyte complexation technique". The preparation variables such as initial drug concentration, polymer: polymer ratios, crosslinker concentration, stirring speed, stirring time, pH of drug / polymer mixture were i...

M. Kassem, A. Ali and A. El-badrawy *

Military Medical Academy, Cairo, Egypt.

DOI: 10.13040/IJPSR.0975-8232.9(9).3664-77

3664-3677

1333

583

10.

QUANTIFICATION OF VITAMIN B – 12 CONTENT IN MULTIVITAMINS AND ELEMENTS IN MINERAL SUPPLEMENTS IN CHILE, BY TOTAL REFLECTION X-RAY FLUORESCENCE

This manuscript presents the application of a detailed set of analytical technologies to the content of assorted micronutrient supplement and mineral supplement products on the market in the city of Concepcion, Chile. We applied TXRF as a screening technique for the evaluation of 1) The vitamin B-12 content in multivitamins and 2) the elemental composition (P, K, Ca, Mn, Cr, Fe, Cu and Zn) in mine...

G. Riffo, C. Ramírez-Lama, L. Agüero and L. Bennun *

Applied Physics Laboratory, Physics and Mathematics Faculty, Concepcion University, Chile.

DOI: 10.13040/IJPSR.0975-8232.9(9).3678-88

3678-3688

893

316

11.

EFFECT OF METHANOL EXTRACT OF ANARCARDIUM OCCIDENTALE (CASHEW) STEM BARK ON SOME BIOCHEMICAL PARAMETERS OF CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY IN RATS

Purpose: Anacardium occidentale (Cashew) has been used by Folk medicines as a remedy for many diseases. In this study, we investigated the ameliorative activity of methanolic stem bark extract of Anacardium occidentale. Methods: Blood samples of the rats from each group were collected by tail bleeding for baseline biochemical test to know the state of the animals’ liver before the inducement of ...

J. Suurbaar *, A. M. Donkor, M. Donkor, M. Saeed, F. Alimatu-Sadia and D. F. Samuel

Department of Chemistry and Biochemistry, Faculty of Applied Sciences, University for Development Studies, Navrongo Campus, Ghana.

DOI: 10.13040/IJPSR.0975-8232.9(9).3689-95

3689-3695

797

386

12.

SYNTHESIS, ANTITUBERCULAR EVALUATION AND DOCKING STUDIES OF NOVEL BENZIMIDAZOLE ANALOGUES

A series of (Z)-3-((1H-benzo[d]imidazol-2-yl)methyl)-substituted thiazolidine-2,4-dione (9a-n) have been synthesized and evaluated for their mycobacterium inhibitory activity against Mycobacterium tuberculosis H37Rv strain. The structures of the newly synthesized compounds were characterized by FTIR and NMR spectral analysis. Most of the synthesized compounds showed moderate to good anti-tubercula...

D. M. L. Araujo, M. M. Maste *, S. Alegaon and A. Saxena

Department of Pharmaceutical Chemistry, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research, Belagavi - 590010, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3696-04

3696-3704

1004

337

13.

IN-SILICO DESIGN, SYNTHESIS AND IN-VITRO ANTI-TUBERCULAR AND ANTI-MICROBIAL SCREENING OF NOVEL BENZIMIDAZOLE DERIVATIVES

The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares  such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligan...

P. T. Manju *, A. A. Smith and V. Padmaja

College of Pharmaceutical Sciences, Government Medical College, Trivandrum - 695011, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3705-11

3705-3711

785

295

14.

ANTI-EDEMATOUS AND ANTIHYPERALGESIC ACTIVITIES OF ROSUVASTATIN IN INFLAMMATORY PAIN MODEL IN RATS

Statins exhibit their pharmalogical effects by competitive inhibition trough binding with active sites of enzymes. Rosuvastatin, of all statines, has the most binding interactions with the enzyme, and being the most potent statin, it is presumed that the strength of enzyme binding directly influences its potency. Reduction of derivatives of mevalonic acids results with decreased risk of cardiovasc...

L. Alagić- Džambić *, F. Bečić, E. Bečić, M. Pašić- Kulenović, S. Muratović and T. Bego

Development and Registration Department, Bosnalijek, Jukićeva, Sarajevo, Bosnia and Herzegovina.

DOI: 10.13040/IJPSR.0975-8232.9(9).3712-17

3712-3717

762

367

15.

COMPARATIVE STUDY OF PHARMACOGNOSTIC PARAMETERS, ANTIOXIDANT AND ANTICHOLINESTERASE POTENTIAL OF BRASSICA NAPUS AND BRASSICA OLERACEA VAR. ACEPHALA

Introduction: Green leafy vegetables are known for their anti-alzheimer potential. There are many leafy vegetables, however, that have not been examined scientifically for this activity. The present study was designed to evaluate antioxidant and antiacetylcholinesterase activities of two Brassica species namely B. napus and B. oleracea var. acephala, along with the comparison of their pharmacognos...

S. Kaur * and R. Shri

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3718-24

3718-3724

736

356

16.

FORMULATION, CHARACTERIZATION AND IN VITRO / EX VIVO EVALUATION OF TROLAMINE SALICYLATE – LOADED TRANSFERSOMES AS TRANSDERMAL DRUG DELIVERY CARRIERS

The percutaneous delivery of salicylates to muscle and joints via the application of trolamine salicylate including transfersomes is the goal of this study and is beneficial for the treatment of inflammatory muscle, tendon and joint diseases. In this study, Trolamine salicylate permeability parameters through rat skin were evaluated with different trasfersome formulations in comparison with contro...

B. S. Makhmalzadeh, A. Salimi *, A. Nazarian and G. Esfahani

Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(9).3725-31

3725-3731

1013

349

17.

A MATHEMATICAL APPROACH OF EXPLORATION TOWARDS EXTREME RISK FACTOR IN CANCER OF OPTIMAL CONDITION

The aim of this present investigation is to identify the most important risk factor for cancer by means of a mathematical model. The study begins with considering some types of cancer viz. breast, colorectum as well as lung and bronchus cancer as most of the cancer patients suffer from these types of cancers. Teaching-Learning-Based Optimization technique is applied to sorting out the most lethal ...

P. Majumder *, A. K. Saha and M. Majumder

Department of Mathematics, National Institute of Technology, Agartala, Barjala, Jirania, Tripura, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3732-42

3732-3742

635

338

18.

DESIGN AND FORMULATING GLICLAZIDE SOLID DISPERSION IMMEDIATE RELEASE LAYER AND METFORMIN SUSTAINED RELEASE LAYER IN BILAYER TABLET FOR THE EFFECTIVE POSTPRANDIAL MANAGEMENT OF DIABETES MELLITUS

In order to effectively manage the diabetic mellitus type-II hyperglycemic surge, bilayered tablets comprising of gliclazide in immediate release layer (IRL) and metformin in sustained release layer (SRL) have been designed and fabricated for years. Gliclazide suffers from reduced aqueous solubility of 0.19 mg/mL which remained a crucial problem for the biological effect as a result of reduced dis...

P. S. Gangane *, M. M. Kadam, D. K. Mahapatra, N. M. Mahajan and U. N. Mahajan

Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3743-56

3743-3756

1050

398

19.

STUDIES ON THE EFFECT OF CORE AND SURFACE CROSS-LINKING AGENTS IN PECTIN BEADS ON THE ENTRAPMENT OF INSULIN

Ionotropic gelation, a characteristic property, has become one of the easy, simple and mild ways of encapsulating variety of drugs, enzymes and proteins, prepared by various polysaccharides. The externally cross linked beads with calcium chloride and zinc chloride were suitable for water soluble and low molecular weight drugs. Insulin, encapsulated in a calcium pectinate gel beads by dispersing th...

V. Prabakaran * and N. V. S. Madhav

Directorate of Research and Development, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3757-63

3757-3763

767

304

20.

ANTIDIABETIC AND ANTI-INFLAMMATORY EFFECT OF PROBIOTIC LACTOBACILLUS PARACASEI MCC3195 IN HIGH FRUCTOSE FED TYPE 2 DIABETIC RATS

The aim of this study was to investigate the antidiabetic and anti-inflammatory effects of probiotic Lactobacillus paracasei MCC3195 in high fructose fed type 2 diabetic rats. High fructose diet was used to induce type 2 diabetes in male albino wistar rats. L. paracasei MCC3195 was administered to rats at a single dose of 2x108 cfu/ml per rat for 8 week. The body weight, fasting blood glucose, ora...

B. Mahajan *, S. K. Snehi and V. Singh

Department of Microbiology, Barkatullah University, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3764-73

3764-3773

1280

397

21.

IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF POLYALTHIA LONGIFOLIA (SONN.) THWAITE SEEDS

The present study is designed to evaluate the in vitro antioxidant and in-vivo anti-inflammatory activities of Polyalthia longifolia (Sonn.) Thwaite seeds. Initially, the extracts (Nonpolar to polar) were screened for in-vitro antioxidant activity by DPPH, nitric oxide radical, hydroxyl radical, and superoxide radical considering ascorbic acid as standard. Among the extracts the ethyl acetate and ...

C. V. Thonangi * and A. Akula

Pharmacology Division, A.U. College of pharmaceutical Sciences, Andhra University Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3774-80

3774-3780

978

343

22.

SCREENING STUDY OF THREE MEDICINAL PLANTS FOR THEIR ANTIOXIDANT AND CYTOTOXIC ACTIVITY

Plants have been used in traditional medicine for several thousand years since which may have been described to have curative value. Terminalia chebula (TC), Terminalia arjuna (TA) and Holarrhena antidysenterica (HA) are very important medicinal plants in the traditional Indian systems of Ayurveda and Siddha. In this work, fruit of Terminalia chebula, bark of Terminalia arjuna and Holarrhena antid...

K. Soumya, J. Jesna and S. Sudheesh *

School of Chemical Sciences, Kannur University, Payyanur Campus, Kannur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3781-87

3781-3787

789

297

23.

ANTIHYPERGLYCEMIC AND ANTIOXIDATIVE EFFECT OF HYDRO-METHANOLIC EXTRACT OF LEAF OF ABROMA AUGUSTA IN STREPTOZOTOCIN INDUCED DIABETIC MALE ALBINO RAT

The present study was conducted to investigate protective effect of hydro-methanolic (2:3) extract of leaf of Abroma augusta in streptozotocin induced diabetic male albino rat. For this purpose animals were divided into three treatment groups (n = 6): control group, STZ induced diabetic group (STZ 4 mg / 0.1 ml citrate buffer/ 100 g body weight), hydro-methanolic extract of leaf of Abroma augusta ...

U. Saha, C. Ghosh and Chhanda Mallick *

Clinical Nutrition and Dietetics, Department of Biomedical Laboratory Science and Management, (UGC Innovative Funded Department), Vidya -sagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3788-94

3788-3794

896

322

24.

FORMULATION AND EVALUATION OF STOMACH – SPECIFIC NOVEL GASTRO-RETENTIVE FORMULATIONS OF 5-FLUOROURACIL FOR TARGETING GASTRIC CANCER

Intravenous administration of 5-Fluorouracil (5FU) produces severe systemic, dose-related side effects due to its cytotoxic nature, additionally, 5FU is rapidly absorbed from the stomach after oral administration. Therefore a combined floating-bioadhesive tablet (FBT) of 5FU has been developed in order to reduce the dose and associated side effects in other sites of the body. The tablets were prep...

R. N. Panigrahy *, S. K. Panda and P. R. Veerareddy

Department of Pharmaceutical Sciences, Biju Patnaik University of Technology, Rourkela, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3795-03

3795-3803

961

327

25.

STUDY OF THE ANTI-TUMOR ACTIVITY OF SYNTHETIC PYRIDO [2,3-d]PYRIMIDINES, PYRIMIDINES AND CORRESPONDING CHALCONE DERIVATIVES

Chalcones (3a-m) was prepared by condensing 4-aminoacetophenone (1) with various aromatic aldehydes (2a-m) according to Claisen-Schmidt condensation. These 4-aminochalcones on cyclization with guanidine hydrochloride under basic alcoholic conditions gave 2,4,6-trisubstituted pyrimidines 4a-m with quantitative yields. Novel 4-amino-5,7-disubstituted pyrido[2,3-d]pyrimidines 6a-g were synthesized vi...

S. R. Atla *, R. Sistla and R. P. Yejella

Department of Pharmaceutical Analysis and QA, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3804-14

3804-3814

833

328

26.

DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR ACECLOFENAC

Self-microemulsifying drug delivery system (SMEDDS) of Aceclofenac (ACE) was aimed at overcoming the problems of poor solubility. ACE is practically insoluble in water as a result it shows erratic oral absorption and affects the bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of ...

M. P. Ratnaparkhi * and P. D. Chaudhari

Department of Pharmaceutics, Marathwada Mitra Mandals College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3815-26

3815-3826

1030

354

27.

FORMULATION DEVELOPMENT AND EVALUATION OF CANDESARTAN BUCCAL TABLETS

Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal ta...

B. Padmaja *, S. R. Satla and R Raparla

Department of Pharmaceutics, Vaageswari Institute of Pharmaceutical Sciences, Karimnagar, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3827-32

3827-3832

905

345

28.

DRUG UTILIZATION PATTERN IN CARDIOLOGY INTENSIVE CARE UNIT IN A TERTIARY HEALTH CARE INSTITUTION

Aims and Objectives: To evaluate the current prescription pattern of drug utilization in patients admitted in cardiology intensive care unit (ICU) and to find out drug use indicators. Methods: It was a retrospective, observational hospital based study which was done for 6 months after obtaining permission from the institutional human ethics committee. The prescriptions of both genders and of any a...

K. Adhikari * and S. Phukan

Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3833-38

3833-3838

757

283

29.

IN-SILICO MOLECULAR DOCKING STUDIES ON THE PHYTOCONSTITUENTS OF CORCHORUS TRILOCULARIS (LINN.) FOR ITS ANTIATHEROSCLEROTIC ACTIVITY AND ADMET PREDICTION

Atherosclerosis is a condition where the arteries become narrowed and hardened due to an excessive build up of plaque around the artery wall. The disease disrupts the flow of blood around the body, posing serious cardiovascular complications. Liver X alpha receptor (LXRα) is highly expressed in liver, function as cholesterol sensors with important roles in regulating cholesterol homeostasis. The ...

R. Dhanalakshmi *, P. Manimekalai and R. Manavalan

Department of Pharmacology, Edayathangudy. G. S. Pillay College of Pharmacy, Nagapattinam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3839-44

3839-3844

1573

333

30.

QUALITATIVE AND QUANTITATIVE ASSESSMENT OF BIOACTIVE PHYTOCHEMICALS IN GOBINDOBHOG AND BLACK RICE, CULTIVATED IN WEST BENGAL, INDIA

Phytochemicals are bioactive compounds produced by plant through primary and secondary metabolism. Phytochemicals are found to be more effective than conventional synthetic chemicals. Rice is considered as the staple food for most of the people residing in this part of world, i.e., the eastern part of India. There are many varieties of rice cultivated in West Bengal, India and among which Gobindob...

S. Bhattacharyya and S. Roy *

Department of Zoology, University of Gour Banga, Malda, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3845-51

3845-3851

900

387

31.

DEVELOPMENT AND VALIDATION OF UV VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ACECLOFENAC AND TRAMADOL IN BULK AND DOSAGE FORM

Objective: Simple, rapid, sensitive, precise and reproducible specific UV spectrophotometric method for the determination of Aceclofenac (ACE) and Tramadol (TRM) in bulk drug and pharmaceutical dosage form were developed and validated. Methods: A simple double beam UV spectrophotometric method has been developed and validated with different parameters such as linearity, precision, repeatability, l...

S. Mali *, S. Ahmad and V. M. Shastry

Department of Quality Assurance, Gangamai College of Pharmacy, Nagaon, Dhule, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3852-57

3852-3857

1135

324

32.

IN-SILICO SCREENING OF FLAVONOLS AGAINST BRUGIA MALAYI ASPARAGINYL tRNA SYNTHETASE

Lymphatic Filariasis is one of the most abandoned tropical diseases caused by the parasite, Brugia malayi. The existing conventional drugs act generally on the larval stages of the parasite. The enzyme asparaginyl tRNA synthetase is an excellent molecular target as it plays a crucial role in protein synthesis. Evidences based on the literature presented clues to discover the flavonoids as potentia...

P. A. Kamble * and S. J. Wadher

School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3858-62

3858-3862

637

255

33.

DEVELOPMENT AND VALIDATION OF A LIQUID CHROMATOGRAPHY-ELECTRO-SPRAY IONIZATION-MASS SPECTROMETRY METHOD FOR THE QUANTITATION OF ERGOCALCIFEROL IN HUMAN PLASMA

A LC-MS method was developed and validated for determination of ergocalciferol in human plasma. n-hexane was used as extraction solvent while kinetex C18 50*2.1 mm, 1.7µm was used as analytical column for chromatographic separation. Mobile phase was acetonitrile: 0.1% formic acid in methanol (90:10). Turbo ion spray with positive polarity was used as an interface with API QTRAP 5500 LC/MS/MS syst...

A. Tiwari *, B. Dawkhar, M. Bagul and S. Goswami

Department of Doctoral Studies, R. K. University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3863-69

3863-3869

821

323

34.

FORMULATION AND PHYSICOCHEMICAL EVALUATION OF MEDLAR (MESPILUS GERMANICA L.) AND OAK (QUERCUS CASTANEIFOLIA C. A. MEY.) EFFERVESCENT TABLETS

Effervescent tablet is a convenient oral dosage form, which has special ingredients. This potency of effervescent tablet helps to delivered drugs, effectively. Medicinal plants have a wide range of usage in the world. Mespilus germanica (Rosaceae) and Quercus castaneifolia (Fagaceae) are important medicinal plants used in several diseases such as diarrhea. Medlar and oak, the fruits of M. germanic...

A. Davoodi, H. B. Jouybari, H. Fathi and P. Ebrahimnejad *

Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, 17th Kilometer of Sea Street, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(9).3870-75

3870-3875

791

291

35.

COMPARATIVE STUDY ON FILTER EFFICIENCY OF DIFFERENT BRANDS OF CIGARETTES BY MICROSCOPIC AND SPECTROSCOPIC TECHNIQUES

Internationally there has been research on large scale for determination of efficiency of cigarette filters but in India it still remains a topic of discussion. Being the second largest consumers of tobacco and tobacco products and one of the largest and fastest growing consumers of cigarettes, such studies need to be undertaken at a greater level to assess the risk and hazards of cigarette smokin...

J. K. Suthar and A. Pandey *

Institute of Forensic Science, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3876-82

3876-3882

851

277

36.

DETERMINATION OF PALBOCICLIB IN HUMAN PLASMA USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY – ULTRAVIOLET DETECTION

A simple, sensitive, and high-performance liquid chromatography ultraviolet detection (HPLC-UV) method was developed and validated for the quantification of palbociclib in human plasma. Plasma samples were processed by solid phase extraction using an Oasis hydrophilic-lipophilic balance extraction cartridge (1 mL, 30 mg). Commercial imatinib was used as an internal standard. Palbociclib and imatin...

R. B. Nalanda, A. S. Rao * and D. Gowri Sankar

Department of Pharmaceutical Analysis and Quality Assurance, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3883-88

3883-3888

1344

378

37.

FOLATE ANCHORED CONJUGATES OF POLY (AMIDOAMINE) (PAMAM) DENDRIMER FOR CONTROLLED SITE SPECIFIC DELIVERY OF PIROXICAM IN ARTHRITIC RATS

The purpose of the present study was to synthesize and evaluate the potential of folate-G.4.0-PAMAM dendrimer conjugates as acceptable vehicle for site specific delivery of piroxicam (PXM) to inflammatory regions and to determine its targeting efficiency in carreganan induced arthritic rats. PXM was selected as a model acidic anti inflammatory drug.  Folic acid was linked to the surface amino gro...

R. N. Prajapati *, S. K. Prajapati, S. Alok and R. Gupta

Institute of Pharmacy, Shri Venkateshwara University, Gajraula, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3889-96

3889-3896

786

290

38.

GREEN SYNTHESIS OF SILVER NANOPARTICLES USING LEAF EXTRACT OF AYAPANA TRIPLINERVIS AND ITS ANTIBACTERIAL ACTIVITY

Green synthesis of nanoparticle using plant extracts is an efficient alternative for the conventional process of preparation of nanoparticles by chemical and physical methods which leads to non-eco-friendly by-products.The main aim of the project was to produce silver nanoparticles (AgNPs) using leaf extracts of Ayapana triplinervis (Eupatorium triplinerve) a medicinally important herb and to asce...

S. S. Dev *, K. U. Vineetha and S. Francis

Department of Biotechnology, St. Peter’s College, Kolenchery, Kochi, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3897-02

3897-3902

1350

433

39.

HIGH – PERFORMANCE LIQUID CHROMATOGRAPHY METHOD VALIDATION AND DEVELOPMENT STRATEGY FOR RIFABUTIN

A simple, economical, accurate and precise high performance liquid chromatographic method was developed and validated for the determination of rifabutin. A Shimadzu LC-2010C HT version 3.01 system using a C-18 column with dimensions of 250 × 4.6 mm and silica particle size of 5 μm. Isocratic elution was employed with methanol, acetonitrile and water (75:25 v/v) were used. The flow rate was 1 ml/...

G. Singh * and A. K. Srivastava

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, (Banaras Hindu University) Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3903-07

3903-3907

972

356

40.

EVALUATION OF ANXIOLYTIC ACTIVITY OF HOMEOPATHIC REMEDY ARGENTUM NITRICUM OF 30 C POTENCY AFTER CHRONIC ADMINISTRATION IN RODENTS

Anxiety affects a large number of  the population that creates an economic burden. Various traditional medicines like barbiturates, benzodiazepines and SSRI’s are used as anxiolytics but due to their potential to produce adverse effect on cognition limits their chronic use. Several homeopathic remedies are used for treating anxiety. For the first time this study was designed to determine anxiol...

H. Anser *, R. Najam, H. Khatoon and S. S. Khan

Department of Pharmacology, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(9).3908-13

3908-3913

1555

295

41.

ANTIBACTERIAL ACTIVITY OF RUBIA TINCTORUM LINN. ROOT EXTRACTS

This research aimed to determine the antibacterial activity of methanolic, aqueous, chloroformic and petroleum ether extracts of Rubia tinctorum roots against two gram positive and two gram negative bacteria using agar well-diffusion method. The minimum inhibitory concentration (MIC) was determined using microdilution method. Extracts were dissolved in DMSO to obtain a concentration of 10% (w/v), ...

R. Ghafari *, N. Mouslemanie and R. Nayal

Department of Botany, Faculty of Science, University of Aleppo, Syria.

DOI: 10.13040/IJPSR.0975-8232.9(9).3914-18

3914-3918

798

297

42.

A STUDY ON CLINICAL PROFILE OF METABOLIC SYNDROME AND ITS IMPACT ON MYOCARDIAL INFARCTION AT A TERTIARY CARE HOSPITAL IN KERALA

Background: Metabolic syndrome has a significant impact on the severity and prognosis of various risk factors that may contribute to cardiovascular events. We examined the clinical profile and prevalence of MetS among MI patients along with the estimation of associated risk factors and determined the components of the MetS which conferred the paramount cardiovascular risk. Methods: A prospective o...

A. Pradeep * and L. Thomas

Department of Pharmacy Practice, Al Shifa College of Pharmacy, Poonthavanam, Kizhattur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3919-25

3919-3925

768

279

43.

ESTIMATION OF MACRO AND MICRO NUTRIENTS CONTENT IN THE LEAVES OF MURRAYA KOENIGII (L.) SPRENGE

The macro and micro nutrients content estimation was carried out for leaves of indigenous medicinal plant Murraya koenigii (L.) Sprenge collected from different places of North Karnataka region viz. Bidar, Kalaburagi, Shahapur, Sandur and Kappathgudda. About few kg of leaves of Murraya koenigii (L.) Sprenge plant material was collected and then they were washed in deionized water to eliminate cont...

M. Pattar, S. S. Teerthe and B. R. Kerur *

Department of Physics, Gulbarga University, Kalaburagi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3926-32

3926-3932

707

250

44.

A STUDY ON THE ANTIMICROBIAL EFFECTS OF CRUDE PRINCIPLES EXTRACTED FROM PIPER BETLE LINN. LEAF STALKS AND OCIMUM SANCTUM LINN. LEAVES

The nature harbours a huge source of active principles possessing antimicrobial property. This phenomenon provokes microbiologists, ethnopharmacologist and natural product chemists to perform extensive research on phytoprinciples. The extensive use of these principles in phytotherapy is becoming an excellent alternative strategy against the occurrence of microbial resistance due to some convention...

P. G. Bhattacharya *, A. N. Chowdhury and P. Sutradhar

Department of Microbiology, Institute of Genetic Engineering, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3933-37

3933-3937

777

283

45.

PHARMACOGNOSTIC STUDIES ON LEAVES AND STEMS OF IPOMOEA SEPIARIA ROXB.

Ipomoea sepiaria Roxb., also known as Purple heart glory is a slender vine belonging to family Convolvulaceae. It is one among the ten sacred plants known collectively as “Dasapushpam” in Kerala. These plants are used for rejuvenating the body in the form of ‘karkidakakanji’ in the monsoon season in Kerala. Juice of the plant is used as deobstruent, diuretic, hypotensive, uterine tonic and...

B. Prasanth *, N. A. Aleykutty and J. Harindran

Department of Pharmacognosy, Nirmala College of Pharmacy, Muvattupuzha, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3938-43

3938-3943

796

283

46.

ANTIMICROBIAL ACTIVITY OF PSIDIUM GUAJAVA AND MANILKARA ZAPOTA AGAINST HUMAN PATHOGENIC BACTERIA

Natural drugs are boom to mankind. They have few side effects as compared to allopathic medicines. Psidium guajava, is an important food crop and medicinal plant in tropical and subtropical countries is widely used like food and in folk medicine around of the world. Psidium guajava linked with the antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic,...

A. Salunkhe *, S. Ghumre, S. Shirke, S. Nikam and V. Kadam

Bharati Vidyapeeth’s College of Pharmacy, C.B.D Belapur, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3944-48

3944-3948

955

312

47.

SCREENING THE EFFECT OF VASICINE IN MULTIPLE SCLEROSIS USING HUMAN TISSUE CHIP MODEL

From time immemorial pharmacologists and researchers have always been in search for novel drug screening methods. One such unique technique that is gripping the world by its leash is “human tissue chip technology”. This study explores the creation of Multiple Sclerosis (MS) using human tissue chip and assessing the ability of Vasicine a quinazoline alkaloid derived from Adhatoda Justiciae plan...

A. Balsundaram * and D. Chellathai

Department of Pharmacology, Sri Ramachandra Medical College and Research Institute, Porur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3949-54

3949-3954

731

262

48.

PHYSICO-CHEMICAL EVALUATION OF WHOLE PLANT OF COCCULUS PENDULUS (J.R. & G. FORST.) DIELS

The whole plant of Cocculus pendulus (J.R. & G. Forst.) Diels is reported to have quality medicinal values in traditional system of medicines. The various physico-chemical parameters included determination of extractive value, loss on drying, ash values, fluorescence analysis, HPTLC analysis and preliminary phytochemical analysis were performed. The preliminary identification of Cocculus pendu...

S. K. Ramala * and G. Alagumanivasagam

Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3955-59

3955-3959

768

272

49.

A STUDY OF ANTIMICROBIAL PRESCRIPTION PATTERN IN THE EAR, NOSE AND THROAT INFECTIONS AT A TERTIARY CARE TEACHING HOSPITAL, RAJKOT

Introduction: The ear, nose and throat (ENT) infections can be caused by a variety of microorganisms such as bacteria, fungi and viruses. Their treatment involves the use of appropriate antimicrobial agents and inappropriate use is closely linked to antibiotic resistance. Hence, present study was planned to evaluate the prescribing pattern of antimicrobials in the ENT outpatient department of a te...

D. A. Patel *, A. Pillai and U. M. Gohil

Department of Pharmacology, P. D. U. Government Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3960-63

3960-3963

766

298

50.

PRESCRIPTION PATTERN AND USE OF ANTIBIOTICS AMONG PEDIATRIC OUT PATIENTS IN RAJSHAHI CITY OF BANGLADESH

Excessive antimicrobial use leads to adverse drug effects, thus increased healthcare costs and promoting the emergence of antimicrobial resistance worldwide. The aim of the study was to evaluate the prescription pattern of antibiotics in pediatric outpatients at private hospitals in Rajshahi city of Bangladesh. WHO / INRUD prescribing indicators were used for the analysis of prescription pattern. ...

T. R. Paul, M. R. Hamid, M. S. Alam, N. L. Nishuty, M. M. Hossain, T. Sarker, Z. Hosan and M. I. I. Wahed *

Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.9(9).3964-70

3964-3970

1100

473

52.

DELAYED POST-OPERATIVE SURGICAL SITE INFECTION: SOURCE AND INVESTIGATION OF CAUSATIVE AGENT

About 70 middle aged (20 - 45 years) patients, including 40 males and 30 females, operated at Base Military Hospital, Meerut Cantonment Board, Meerut (India) developed typical symptoms of pus formation at surgical sites and opening of sutures after 30 - 45 days. To investigate the causative pathogen and source of infection, various samples were collected from wounds and various sites of Operation ...

D. C. Sharma *, S. Singh, R. Sharma, C. Sharma, R. Singh and P. K. Srivastava

Department of Microbiology, Dr. Shakuntala Misra National Rehabilitation University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3976-79

3976-3979

685

266

53.

ANTICANCER DRUG INDUCED INFUSION REACTIONS: A SINGLE INSTITUTE EXPERIENCE

Objective: To know the occurrence, onset and severity of infusion reactions associated with anticancer drug in an oncology hospital. Methods: For the patients who developed infusion reactions, causative drug, cycle of therapy, onset and duration of reaction, associated symptoms were recorded. The adverse drug reaction reporting form (yellow form) was used to report the infusion reaction. On the ba...

P. Kunwor *, C. B. Avinash, M. S. Vishveshwara, Y. S. Madhavi and M. Vijayakumar

Department of Clinical Pharmacy, Nepal Cancer Hospital and Research Center, Harisidhhi, Lalitpur, Nepal.

DOI: 10.13040/IJPSR.0975-8232.9(9).3980-84

3980-3984

1066

293

54.

FORMULATION AND IN-VITRO EVALUATION OF DRY EMULSION OF MEFENAMIC ACID IN HARD VEGETARIAN CAPSULES

The dry emulsion formulation aims to improve the solubility and dissolution of mefenamic acid. Dry emulsions are attractive because they are physically and micro biologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions can be prepared by spray drying, lyophilisation and rotary evaporation. Dry emulsion prep...

M. S. Reddy * and S. Tanmayee

Centre for Pharmaceutical Sciences, IST, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3985-92

3985-3992

1035

376

55.

AN INVESTIGATION FOR PRESCRIPTION DRUGS IN AN ARENA OF VIRAL DISEASES

WHO’s global health expenditure data base explores internationally comparable data on health spending in all WHO Member States. The report incorporates data analytics for various diseases, health expenditure and death toll etc., globally. Viral diseases have always been a burning issue for morbidity and mortality, worldwide. Viral diseases such as Chickenpox, Malaria, Cholera, Bronchitis, Tuberc...

N. Singh * and G. Singh

Department of Chemistry, Lovely Professional University, Phagwara, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3993-98

3993-3998

777

273

56.

SYNTHESIS OF SOME NEW 2-(N-SUBSTITUTED)- 3H- PHTHALAZIN- 1, 4- DIONE DERIVATIVES FOR THEIR ANTIHYPERTENSIVE ACTIVITY

Present study is reporting the result of the synthesis and evaluation of antihypertensive activity for N-substituted pthalazine 1,4-dione derivatives. N-substituted pthalazine 1,4-dione derivatives were synthesized by taking the Heterocyclic system, ethylglycinate, hydrazine hydrate and pthalic anhydride and were subjected to preliminary screening for antihypertensive activity in albino rats. The ...

K. P. Namdeo * and S. Jaiswal

SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).3999-07

3999-4007

755

273

57.

MICROBIOLOGICAL STUDY OF INDIAN PANEER – A CASE STUDY OF DELHI CITY

Paneer has great value in diet because it is a rich source of high quality proteins, fat, and minerals. Paneer has a short life span of 2-3 days of refrigeration storage, but freshness of the product is lost after one day. So, the present study was carried out to know the quality of different brands of paneer sold in Delhi City. A total of 80 packets of eight different brands were analyzed for the...

N. Girdharwal

Department of MBA, KIET Group of Institutions, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).4008-14

4008-4014

2224

493

58.

ACUTE DERMAL TOXICITY AND IRRITABILITY STUDIES OF Ag2Ga NANONEEDLE MEDIATED SILVER FORMULATION AS PER OECD 402 AND 404 PROTOCOLS

We have developed Ag2Ga nanoneedles and achieved individual nanoneedles with diameter ranging from 200 to 250 nm with sharp tip and micro scale length required for a drug carrier to deliver drugs to site of application. Nanoneedles are designed to be inserted in human tissue and therefore they have to be compatible with the local environment of both in terms of toxicity and intended function. The ...

B. S. Wakure * and N. M. Bhatia

Bharati Vidyapeeth, College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(9).4015-20

4015-4020

854

293

59.

DETECTION OF B. ABORTUS S19 ON UTERINE RAT (RATTUS NORVEGICUS) WITH IMMUNOHISTOCHEMICAL METHOD

Objective: Brucellosis in humans is the most common zoonotic infection in the world. Brucellosis can be prevented by vaccination but no effective vaccines are known for prevention of human brucellosis and minimal impact of animal brucellosis. Outer membrane proteins (OMPs) of Brucella sp. have been the focus of vaccine development and the diagnosis of brucellosis. Methods: The pathogenesis study o...

F. Purnamawati *, S. Santoso and Aulanni’am

Biomedical Science Master Program, Medical Faculty, Universitas of Brawijaya Malang, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(9).4021-28

4021-4028

637

335