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ANTIMICROBIAL ACTIVITY OF PSIDIUM GUAJAVA AND MANILKARA ZAPOTA AGAINST HUMAN PATHOGENIC BACTERIA
Natural drugs are boom to mankind. They have few side effects as compared to allopathic medicines. Psidium guajava, is an important food crop and medicinal plant in tropical and subtropical countries is widely used like food and in folk medicine around of the world. Psidium guajava linked with the antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic,...
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FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM COMPRESSION COATED TABLETS BY OKRA GUM AS A BINDER
The purpose of the present study was to formulate Losartan potassium compression-coated tablets using okra gum as a binder along with synthetic hydrophilic polymers like various grades of Hydroxypropyl methylcellulose (HPMC) and compare the different parameters. The effect of different concentration of okra is to be used in the formulations with varying concentration of the polymers, elucidating t...
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1790
EVALUATION OF ANTICONVULSANT ACTIVITY OF THE LEAVES ETHANOLIC AND AQUEOUS EXTRACTS OF NYCTANTHES ARBORTRISTIS LINN. AGAINST SEIZURES INDUCED BY PENTYLENETETRAZOLE AND ELECTROCONVULSIVE SHOCK IN MICE
Nyctanthes arbortristis Linn. (Oleaceae) which has been used as an antiepileptic remedy in tribal people of India (Orissa and Bihar) along with its use in Ayurveda, Sidha and Unani systems of medicine was evaluated for anticonvulsant activity against experimental seizures. The leaves ethanolic and aqueous extracts of N. arbortristis protected mice against tonic convulsions induced by maximal elect...
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HOMOLOGY MODELLING, SECONDARY STRUCTURE PREDICTION AND PHYLOGENETIC COMPARATIVE ANALYSIS OF PHOSPHOLIPASE A2FROM DIFFERENT ORGANISMS
Phospholipase A2 is the enzyme that catalyzes the hydrolysis of the sn-2 fatty acyl bond of phospholipids, liberating free fatty acids and lysophospholipids. These enzymes are found in mammalian tissues, insects, reptiles, urochordates, invertebrates and echinoderms. Some of the PLA2 are toxic in nature. Venom from snakes and insects is largely composed of melittin, which is a stimulant of PLA2...
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DISINTEGRANT EFFECT OF FINGER MILLET (ELEUSINE COROCANA) STARCH ON DISSOLUTION PROFILE AND DISINTEGRATION TIME IN HIGH DOSE TABLETS
Starch was extracted from the grains of finger millet (Eleusine corocana), by steeping in water for 24 hours. The extracted starch was used as a disintegrant, at the concentrations of 2.5-12.5%w/w to compressed paracetamol tablet in comparism with maize starch BP. Results show that, there is no significant difference in the disintegration time or dissolution rate of tablets containing the two star...
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1744
POTENTIAL HERBS AGAINST DIABETES MELLITUS – AN UPDATE
Diabetes or Madhumeha as per Ayurveda is a disease in which there is improper functioning of insulin and as a result, the sugar level in the blood increases. Diabetes may cause heart problem, kidney failure, blurred vision if not treated timely with proper medication. Medicinal plants have been used since ancient times for the treatment and management of diabetic mellitus (DM) in traditional medi...
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DNA BINDING AND NUCLEASE ACTIVITY OF STRUCTURALLY CHARACTERIZED COPPER(II) COMPLEX
A mononuclear copper(II) complex [Cu(bpy)2(NO3)] NO3 H2O (bpy = 2,2’-bipyridine) has been synthesized and characterized based on physico-chemical spectral data. The complex is characterized based on electronic, IR and ESR spectroscopies. The structure of the complex is determined by single crystal X-Ray crystallography. The complex crystallizes in monoclinic space group P-1. Structural analy...
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EVALUATING ADJUNCTIVE ROLE OF PPI AS ANTI INFLAMMATORY AGENT IN KNEE OSTEOARTHARITIS: A PROSPECTIVE STUDY IN TERTIARY CARE HOSPITAL
Osteoarthritis (OA) is one of the main causes of disability worldwide. Patients are mostly treated with NSAIDS with PPI and H2 blockers, analgesics, opoids etc in everyday practice. In addition to anti-secretory effects, PPIs have anti-oxidant and anti-inflammatory actions in vitro. But the role of PPIs as anti-inflammatory agents remains to be explored. Aim: Present study was aimed to compare eff...
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1928
PREVALENCE AND CORRELATION OF VIRAL INFECTION (HEPATITIS B OR/AND HEPATITIS C) AMONG HYPERTENSIVE AND DIABETIC PATIENTS IN MALAYSIA AND INDONESIA WHO UNDERWENT HEMODIALYSIS
Background: Increase prevalence of viral infection such as hepatitis B or/and hepatitis C are followed by high incidence of mortality among hemodialysis patients. Objective: To determine prevalence and correlation of viral infection (Hepatitis B or/and Hepatitis C) among Hemodialysis Patients that died for the last five years in Indonesia and Malaysia in relation to gender, age, causes, and countr...
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VIRTUAL SCREENING OF SAPONIN DERIVATIVES TARGETING ENZYMES ENDOTHELIAL NITRIC OXIDE SYNTHASE AND CYTOCHROME P450 2E1
Saponin derivatives from Vietnamese ginseng are proven for their efficacies in modulating oxidative stress, but there had been no reports about the interaction between them and two enzymes, endothelial nitric oxide synthase (eNOS) and cytochrome P450 2E1 (CYP2E1). eNOS and CYP2E1 are proposed to be attractive targets for the development of inhibitors against oxidative stress, a contributing factor...
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