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A STUDY TO EVALUATE THE EFFECT OF RESTRAINT STRESS ON ANTIOXIDANTS STATUS IN RATS
ABSTRACT: Stress exerts detrimental effects on several cellular functions through impairment of antioxidant defences, leading to oxidative damage and onset of many cardiovascular and neurological diseases. The restraint stress or immobilization stress is widely accepted model to induce emotional stress and the deleterious effect of restraint stress on the biological system is well documented. The ...
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FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF DOXAZOSIN MESYLATE
The objective of the present investigation was to develop a sustained release (SR) tablets of Doxazosin Mesylate by wet granulation technique using a combination of synthetic polymers (Eudragit RS-100 and Eudragit RL-100). Different batches of Doxazosin Mesylate sustained release tablets were prepared by using microcrystalline cellulose as diluents by wet granulation technique. The compatibility o...
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A COMPREHENSIVE REVIEW ON THE USEFULNESS OF TELEHEALTH INTERVENTION FOR CHILDREN WITH DISABILITY WITH SPECIAL REFERENCE TO SAUDI ARABIA
Background: Healthcare requirements have changed gradually from the primitive ages to this modern era. Information and communication technology has opened innovative techniques like home healthcare for patients through telehealth use. Aims: 1. To find out the usefulness and effectiveness of telehealth intervention on the daily living activities amongst children with disability in Saudi Arabia. 2. ...
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SUBSTANTIATION OF THE PRESERVATIVE IN THE COMPOSITION OF THE IMMUNOBIOLOGICAL DRUG “CANDIDOCYDE”
Over the last decade the incidence of candidiasis has dramatically increased. To fight candidal infections vaccines with immune modulating properties have been actively investigating in recent years. In our previous studies it was found that the immunobiological drug under the conditional name “Candidocyde” based on the antigens of C. albicans and C. tropicalis fungi possessed the protective a...
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A STUDY COMPARING RESCUE MEDICATIONS: ARFORMOTEROL AND SALBUTAMOL NEBULIZATION IN EXACERBATION OF NON-SEVERE ASTHMA AT A TERTIARY CARE CENTER, NOT NEEDING HOSPITALIZATION
Objectives: Arformoterol is the (R, R) - enantiomer of formoterol, a short and long acting β-2 agonist bronchodilator and is distinguishable from the racemic (R, R/S,S) - diasteriomer of formoterol, which is most commonly used. Some in vitro data show significant bronchodilatation, inhibition of inflammation and marked baseline airway reversibility with arformoterol. Yet, there is a dearth of stu...
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DIFFERENCE BETWEEN NATIVE AND MUTANT RHIZOBIUM ON GROWTH OF VIGNA MUNGO L.
The present study, carry out the use of plant growth promoting rhizobacteria, were used to improve the yield in crop. The Rhizobium strains isolated from legumes plant Mimosa pudica L and this strain was mutated by using UV radiation. The plant growth hormones were detected by native as well as mutant Rhizobium strains by paper chromatography techniques. The same strains use in conducted to green ...
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DEVELOPMENT AND VALIDATION OF FTIR SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF TELMISARTAN AND HYDROCHLOROTHIAZIDE IN PURE AND PHARMACEUTICAL DOSAGE FORMS
A new analytical method has been developed for the simultaneous estimation of Telmisartan and Hydrochlorothiazide in their pure and pharmaceutical dosage forms by using Fourier Transform Infrared (FTIR) Spectroscopy. This method involves the extraction of Telmisartan and Hydrochlorothiazide from tablets using chloroform and direct measurement in liquid phase mode using reduced path length cell. Th...
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SYNTHESIS OF SOME 2, 3-DIARYL-6-ISOXAZYL-QUINOLINE-4-CARBOXYLIC ACID DERIVETIVES
A series of some new substituted quinolines were synthesized by Doebner reaction, a three component coupling of various aromatic amines with two aldehydes and phenyl pyruvic acid, the intermediate 2, 3-diary-6-acetyl-quinoline-4-carboxylic acids were reacted with various aromatic aldehydes in the presence of basic medium using Claisen-Schmidt condensation in order to afford the corresponding chalc...
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SCREENING OF AN INDIGENOUS MEDICINAL PLANT – MADHUCA LONGIFOLIA FOR ITS ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES
Madhucalongifolia is an economically important medicinal tree growing throughout the subtropical region. This research article deals with the antioxidant and antimicrobial properties of M. longifolia. The antioxidant properties of the seed were determined by hydrogen peroxide scavenging activity and reducing power assay. The methanol extract exhibited more antioxidant activity than water extract...
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NEW SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TOLTERODINE IN BULK AND PHARMACEUTICAL FORMULATION
Simple, fast and economic spectrophotometric methods were developed for determination of Tolterodine in bulk and pharmaceutical dosage forms using water as the solvent. The quantitative determination of the drug was carried out using the zero order derivative measured at 281.5 nm, first order derivative measured at 274 nm and area under curve was measured in wavelength range of 276-286 nm. Calibra...
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