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DRUG UTILISATION EVALUATION OF CORTICOSTEROIDS IN TERTIARY CARE TEACHING HOSPITAL
Objective: Steroids are widely prescribed and used by practitioners due to powerful anti-inflammatory and immunosuppressive actions. So, care should be exercised in the rational selection of steroids. The main aim of our study is to assess prescribing patterns, demographic and clinical variables such as drug interactions associated with corticosteroid administration and steroidal use in a tertiary...
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LINEAR RESPONSE APPROXIMATION (LRA) APPROACHES FOR CALCULATING BINDING AFFINITIES OF QUINAZOLINE ANALOGUES AS ALK5 INHIBITORS
Quinazoline and its analogues have important therapeutic value in the treatment of cancer to induce apoptosis in cancer cells in a proliferation-independent manner. The binding free energies of quinazoline based inhibitors of kinase were computed using linear interaction energy method with a surface generalized Born (SGB) continuum solvation model in the human ALK5 kinase domain. A training set of...
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EX-VIVO PENETRATION OF NANOMETRIC ZnO and TiO2 ACROSS ACTINICALLY DAMAGED PORCINE SKIN: DEVELOPMENT OF AN ALBINISTIC SKIN PROTECTION TREATMENT
The skin penetration and safety of nanometric zinc oxide and titanium dioxide incorporated in a cosmeceutical cream, specifically designed to retard skin actinic damage in tropical Oculocutaneous albinism was investigated ex-vivo through simulated actinically damaged porcine skin. Franz diffusion cells were used in an experiment modeled in line with related work done by Diembeck et al (1999); the ...
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PRELIMINARY ANTIMICROBIAL ACTIVITY AND CYTOTOXICITY OF PLANT EXTRACTS (ROOTS) OF COCCINIA GRANDIS (FAMILY: CUCURBITACEAE) h
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing...
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CAUSE OF ANTIRETROVIRAL DRUG CHANGES AMONG PATIENTS ON ANTIRETROVIRAL THERAPY AT THE ART CENTER IN DESSEI REGIONAL REFERRAL HOSPITAL, ETHIOPIA
Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the futur...
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ANTIDIABETIC EFFECT OF ETHANOLIC SEED EXTRACT OF DECALEPIS HAMILTONII WIGHT AND ARN ON OXIDATIVE STRESS AND ENZYMIC ACTIVITIES IN ALLOXAN INDUCED DIABETIC RATS
Decalepis hamiltonii Wight and Arn. is an indigenous medicinal plant, which has a folk reputation in Western and southern India as hypoglycemic agent. The present investigation was carried out to evaluate the antidiabetic effect of ethanolic seed extract of Decalepis hamiltonii in alloxan induced diabetic Albino rats. Blood glucose levels and body weights of control and diabetic rats were monitore...
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SYNTHESIS AND CHARACTERISATION OF CHALCONE BASED COPOLYESTERS AND THEIR ANTICANCER ACTIVITY
Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyest...
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ANTIOXIDANT CHANGES IN WISTAR ALBINO RATS AFTER ACUTE HEAT STRESS
Introduction: Global warming is one of the major issues in the current scenario. Heat stress is known to affect both physical and mental task. Imbalance in the maintenance of temperature leads to oxidative stress and damage to the body systems. Several studies have been documented on various stressors and its impact on antioxidant status. Aim: The present study was done to evaluate the antioxidant...
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ANTIOXIDANT POTENTIAL OF TRAGIA INVOLUCRATA LINN ON STREPTOZOTOCIN INDUCED OXIDATIVE STRESS IN RATS
In Traditional Ayurvedic system of treatment Tragia involucrata Linn. is intended to use for diabetic patients has been screened for antioxidant activity. For antioxidant studies, aqueous ethanolic extract of Tragia involucrata (AEETI) was administered orally for 28 days at a dose of 250 and 500 mg/kg body weight to Streptozotocin- Nicotinamide induced Wistar rats. All the animals were sacrificed ...
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FLAXSEED OIL AMELIORATES METHOTREXATE-INDUCED OXIDATIVE STRESS AND HEPTO-RENAL TOXICITY IN MALE RATS
This study aimed to investigate the protective effect of flaxseed oil against hepato-renal toxicity induced by methotrexate. Rats treated with methotrexate exhibited elevations in the levels of AST, ALT, ALP, γGT, LDH, urea, creatinine, uric acid, and bilirubin. Furthermore, the levels of MDA, NO and the relative ratio of the gene expression of COX-2 and iNOS were significantly increased, accompa...
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