A collective assessment of all the morphometric measurements like size, weight, color and shape of the parathyroid gland is important in the determination of its normalcy. After that the histological examination for stromal and intracellular fatty content helps to determine the normalcy of the gland. There have been several studies on morphology of human parathyroid gland, but the grand total of c...
Guillain-Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system. Association of TLR2 and IL-8 polymorphism with higher expression level has already been studied in many inflammatory and autoimmune diseases. However, the possible role of TLR2 and IL-8 polymorphism in GBS remains unknown. Therefore, the current study investigated the TLR-2 (Arg677Trp & A...
SPECTROPHOTOMETRIC DETERMINATION OF ETHAMBUTOL IN PURE AND PHARMACEUTICAL FORMS USING TRIPHENYL METHANE DYES
Simple and sensitive extractive spectrophotometric methods for the determination of Ethambutol in pure form and in pharmaceutical formulations using triphenyl methane dyes have been developed. The developed methods involve formation of coloured chloroform extractable ion-pair complexes of the drug with triphenyl methane dyes viz., bromocresol green (BCG), bromocresol purple (BCP) and bromophenol b...
Stress is part and parcel of our life and stress management is gaining importance day by day. Traditional mantras are reported to be very effective for and safe methods. Hence the traditional knowledge of mantras should be practiced, preserved and propagated. Om Namah Shivaya is a most potent and popular mantra, which is at the heart of the Vedas and Tantra. The present study was aimed to observe ...
STUDY OF ANALGESIC-NALBUPHINE AS A COMPONENT OF BALANCED ANAESTHESIA IN OTOLARYNGORHINOLOGICAL SURGERY
Back ground: Use of proper analgesics as adjuvant to balanced anaesthesia can calm the patient, reduce stress and decrease the need of higher doses of inhalation agents. Some examples of analgesics are opioids, NSAIDS, NDMA receptor antagonists (ketamine). Nalbuphine is a synthetic opioid agonist-antagonist analgesic of the phenantherene series. We conducted this study with the aim to observe the ...
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING SPECTRO-PHOTOMETRIC METHOD FOR THE ESTIMATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage ...
EVALUATION OF ANTIDIABETIC POTENTIAL OF WITHANIA SOMNIFERA BY GLUCOSE UPTAKE ASSAY ON 3T3 F442A FIBROBLAST (ADIPOCYTE) CELLS
Antidiabetic potential of leaf and root extracts of Withania somnifera from Nimuch, Lucknow, Mumbai and Karnataka regions of India were evaluated against 3T3F442A fibroblast (3T3 adipocyte) cell line using glucose uptake assay. Leaf extracts from all the four regions were active on the cell line tested. Samples from Mumbai region found to be more active when compared with other regions. Root extra...
A liquid chromatographic method has been developed and validated for the determination of the clinical trial combination of Solifenacin succinate and Tamsulosin hydrochloride. Effective chromatographic separation was achieved on an eclipse XDB-C18 (4.6 mm X 150 mm, 5µm) column using isocratic reverse phase technique. The mobile phase employed was ACN: 20Mm sodium phosphate buffer (0.2% Triethylam...
The main purpose of this study was to evaluate hydrogel matrix systems of hydroxypropylmethylcellulose (HPMC) for oral release of poorly water-soluble drugs, by using triamcinolone (TR) as drug model. The influence of HPMC ratio (%) and compaction force (Kgf) on system performance were studied. Thus, several batches of tablets containing 10 mg of TR were prepared using distinct proportions of HPMC...
PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were ran...