CHEMICAL PROFILING, ADME PREDICTION OF BOERHAVIA DIFFUSA LINN. AND CRATEVA NURVALA BUCH. HAM IN THE MANAGEMENT OF UROLITHIASIS
Background: This study was carried out to investigate qualitative and quantitative phytochemical analysis and free radical scavenging activity of Boerhavia diffusa (root) and Crateva nurvala (bark) along with certain computational ADME (Absorption, Distribution, Metabolism, Excretion) parameters of compounds analyzed from Boerhavia diffusa (root) and Crateva nurvala (bark). Methods: The dried powd...
HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF Cr6+ (nM) IN GELATIN CAPSULE USING AgF/Ag2WO4 NANOCOMPOSITE
The present work deals with a novel synthesis of AgF/Ag2WO4 nanocomposite by co-precipitation method. The morphology and size of the synthesized AgF/Ag2WO4 nanocomposite were confirmed by Ultraviolet-Visible (UV-Vis) spectroscopy, Fourier Transform-Infrared (FT-IR) spectroscopy, Transition Electron Microscopy (TEM) and X-Ray Diffraction (XRD) analyses. The performance of the nanocomposite was succ...
The extensive study on O - methylated flavonoids reveals that substitution with methyl group enhances the radical scavenging behavior in certain compounds. Due to potential applications of C-glycosides in metabolic engineering, methylation in these flavonoids needs to be analyzed in both theoretical and experimental levels for their radical scavenging behavior. In this work naturally occurring C- ...
IN VITRO ANTI-INFLAMMATORY ACTIVITY OF VARIOUS EXTRACTS OF LEAF AND BARK OF HOLOPTELIA INTEGRIFOLIA PLANCH
The different extracts of leaf and bark of the plant Holoptelia integrifolia were investigated for in-vitro anti-inflammatory activity by human red blood cell membrane stabilization (HRBC) method. The HRBC membrane stabilization activity of the petroleum ether extract of leaf at the concentration of 200 mg/ml showed 68.12+/-1.05 % and petroleum ether extract of bark at the concentration of...
A STUDY OF POSSIBLE PROTECTION BY NEFIRACETAM ON ESLICARBAZEPINE INDUCED MEMORY IMPAIRMENT IN TEMPORAL LOBE EPILEPSY
Memory impairment (MI) is commonly seen in epilepsy and is at times aggravated by antiepileptic therapy. Recent studies reported that co-administration of nootropic agent with an antiepileptic drug (AED) might decrease the MI. This study was designed to evaluate MI activity of Eslicarbazepine (ESL) in temporal lobe epilepsy (TLE) and to assess the protective effect of Nefiracetam (NEF) which is a ...
A new, precise, rapid, accurate RP-HPLC method was developed for the estimation of Decitabinein pharmaceutical dosage form. After optimization the good chromatographic separation was achieved by Isocratic mode with a mixture of Ammonium Acetate buffer of pH 4.5: Acetonitrile (985:15) v/v as the mobile phase withDevelosil Rp Aqueous-AR-5 (150 x 4.6 mm, 5 µm), column as stationary phase at flow rat...
An unusual type of the long-lasting pyelonephritis demonstrating a long-lasting granulomatous disease resulting in a non-functional kidney in the patient is generally linked with xanthogranulomatous pyelonephritis. The name itself suggests this involves a granulomatous progression that is chronic, due to a chronic or sub-acute infection in the patient inciting a chronic but incomplete immune react...
The aim of the present study was to investigate antioxidant activity, total polyphenols and total flavonoids contents of extracts from two Moroccan Teucrium species (Teucrium polium and Teucrium aurum). The Antioxidant activity was evaluated in-vitro by three assays namely, free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP) and t...
RISK OF DEVELOPING DEPRESSION AND ITS IMPACT ON QUALITY OF LIFE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME – A SOUTH INDIAN SCENARIO
Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disorders, affecting the patient’s psychological functioning and satisfaction with life. Settings and Design: Tertiary care hospital based case-control study was conducted. Material and Methods: the study was effectuated in 372 patients in total, including an equal number of cases and controls.PHQ-9 was used to det...
The liquisolid technique is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dried powder by simple physical blending with selected carrier and coating material. The in vitro dissolution property of poorly water soluble Nifedipine was improved by exploring the potential of liquisolid technique. Different liquisolid tablets were prepared by...