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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 14 (2023) - Issue 11, November

Review Articles

 
Title
Views
PDF
Cited
1.

A CRITICAL REVIEW ON THE EFFECT AND TOXICITY OF CADMIUM MEDIATED STRESS IN PLANTS

Cadmium (Cd) is one of the non-essential and highly toxic environmental pollutants. It causes serious environmental and agricultural problems. It ranks seventh on the list of the twenty most toxic metals. Dietary cadmium intake is much higher than the upper limit reported by FAO/WHO. Sources of environmental Cd contamination, soil factors affecting Cd uptake, Cd dynamics in the soil rhizosphere, u...

Prity Basak and Bhaskar Choudhury *

Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5087-97

5087-5097

787

553

2.

REVIEW ON THE IMPACT OF DIABETES ON KIDNEY DISEASE

Diabetic kidney disease (DKD) is the main reason for end-stage renal disease on a global scale. About 40% of developing diabetic kidney disease, which is the most common cause of chronic kidney diseases worldwide. Although ESRD may be the most complication of diabetics, as a result of their physical health and any co-morbidities they may have, such as obesity, hypertension, dyslipidemia, intrarena...

Yasir Ansari *, Akhilesh Patel, Kulbhushan Haldeniya, Rajesh Sharma, Mohd Haneef, Sourabh Kosey and Ramesh Kumar

Department of Pharmacy Practice, NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5098-09

5098-5109

720

431

3.

STEM CELL – A HOPE FOR FUTURE HEALTHCARE SECTOR

Stem cell-based therapeutics have considerable potential to treat a variety of illnesses that are now incurable. Because of recent scientific advancements, the area of applied medical research has taken a positive turn, and stem cell-based techniques have moved considerably closer to clinical applications. Since their discovery, stem cells have revolutionized medical research and dramatically alte...

Gaurav D. Patel, Snehalata Pradhan, Tapan Kumar Behera, Deepak Kumar Pattnaik, Sameer Ranjan Sahoo and Arun Kumar Pradhan *

Centre for Biotechnology, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5110-23

5110-5123

624

314

4.

CURRENT LAWS GOVERNING COMPARATIVE STUDIES AND CLINICAL TRIALS IN INDIA, THE UNITED STATES, EUROPE, AND SINGAPORE

Clinical trials (CTs) are carried out to investigate novel, patient-acceptable, and more effective interventional procedures. Specific regulatory criteria for conducting CTs are recommended by the country's drug regulatory authority, and these guidelines are followed when conducting CTs. The USFDA oversees regulating CTs in the USA in accordance with the Federal Food, Drug, and Cosmetic Act's 21 C...

P. Kala Sree, S. Princely Ebenezer Gnanakani *, K. P. S. Praneetha and G. Sumalatha

Department of Pharmaceutical Biotechnology, Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5124-40

5124-5140

672

517

5.

A REVIEW ON NIOSOMAL SUSPENSION CONTAINING CEFPODOXIME PROXETIL

Cefpodoxime proxetil is an oral antibiotic belonging to 3rd generation Cephalosporin category. It has shown its antibiotic activity against both Gram positive and Gram-negative bacteria and has high stability in the presence of β-lactamase except Enterococci species. The drug has found its effectiveness in pediatric patients in treating respiratory tract infections. At the present time the most f...

M. Sharma * and K. Bains

Himalayan Institute of Pharmacy, Kala-Amb, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5141-49

5141-5149

647

318

6.

THE ORPHAN DRUG ACT: INCENTIVES, CHALLENGES, AND MARKET TRENDS

Orphan drugs are used to treat rare diseases that affect fewer than 200,000 people in the United States. Development and approval of orphan drugs are challenging due to the limited patient population and substantial development costs; the U.S. Food and Drug Administration (FDA) has established several programs, such as the Orphan Drug Designation program and Orphan Product Grants program to encour...

Maleeha Masood, Trapti Saxena * and Maariyah Tahseen,

Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5150-55

5150-5155

341

138

7.

THERAPEUTIC POTENTIAL OF MEDICINAL PLANTS IN TREATMENT OF ANXIETY IN CONTEXT TO NEUROTRANSMITTER: AN OVERVIEW

Anxiety is a negative emotional state marked by tension, unease, and emotions of concern and fear. Across the globe, women are more likely than males to suffer from anxiety disorders. Insomnia, cold or sweaty hands and/or feet, shortness of breath, an inability to be steady and calm, dry mouth, numbness or tingling in the hands or feet, nausea, abdominal discomfort, dizziness, pins and needles, fe...

Dhara Parekh *, Vipul Gajera and Tanvi Desai

Department of Pharmacology, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5156-68

5156-5168

262

146

8.

A COMPREHENSIVE REVIEW ON EMERGENCE, TRANSMISSION, DIAGNOSIS AND TREATMENT OF NIPAH VIRUS

Currently, COVID-19 pandemic is a major zoonotic disease that has killed millions of people all over the world. Similarly, Nipah virus (NiV), causes severe acute respiratory syndrome (SARS) along with febrile encephalitis. NiV belongs to the class of paramyxovirus of the genus Henipavirus is a deadly virus that has caused several outbreaks in recent years. Despite the fact that NiV causes a small ...

Diptee Gupta *, Sudhir Kumar and Anchal Srivastava

Krishna Institute of Pharmacy & Sciences, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5169-80

5169-5180

321

161

9.

A COMPREHENSIVE REVIEW ON REGULATORY REQUIREMENTS OF PHARMA-CEUTICAL DRUG PRODUCTS IN CIS AND GCC COUNTRIES

India may have a potential in the Commonwealth of Independent States (CIS) region. Pharmaceuticals are difficult to register with the CIS region's regulating organisation because of the turmoil among these countries. The CIS includes Russia, Ukraine, Kyrgyzstan, Uzbekistan, Tajikistan, Kazakhstan, Turkmenistan, Azerbaijan, Armenia, Belarus, Moldova, and Georgia. These call for various regulatory s...

S. Princely Ebenezer Gnanakani *, P. Kala Sree and K. P. S. Praneetha

Department of Pharmaceutical Biotechnology, Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5181-96

5181-5196

828

412

10.

HYPHENATION OF RAMAN SPECTROSCOPY WITH MASS SPECTROSCOPY: A REVIEW

A spectroscopic method called Raman spectroscopy is frequently employed to discover the vibrational modes of molecules. Raman spectroscopy is frequently used in chemistry to give compounds a unique structural fingerprint. Using mass spectroscopy, one or more molecules present in a sample can have their mass to charge ratio (m/z) measured. It is frequently possible to estimate the precise molecular...

K. Bhavya Sri *, B. Hema and Mogili Sumakanth

Department of Pharmaceutical Analysis, RBVRR Women’s College of Pharmacy, Barkatpura, Hyderabad, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5197-05

5197-5205

296

170

11.

A CRITICAL APPRAISAL ON MEDICINAL COROLLARY OF MOORINGA OLEIFERA IN MIDDLE OF VARIED AILMENT

Diabetes is currently not well managed in the allopathic medical system. The dysfunction and damage to several organs, including as the blood vessels, heart, nerve fibres eyes, kidneys, and, neurons are chronic repercussions of long-term blood glucose elevations. There are many different therapy options available, but they frequently have negative side effects and cannot provide complete relief. T...

Shital Nehere * and Kiran Bhise

Allana College of Pharmacy, K. B. Hidayatullah Road, Azam Campus, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5206-11

5206-5211

259

162

12.

A REVIEW OF DIFFERENT DISSOLUTION METHODS

Dissolution is an authorized test used by Pharmacopoeias for assessing drug arrival of solid and semisolid measurement structures. The primary utilization of dissolution testing incorporates the biopharmaceutical portrayal of medication items as a device to guarantee reliable item quality and to predict in-vivo drug bioavailability. Dissolution testing was initially grown for solid orals; later on...

R. Thirumalaikumaran *, G. Lithikkaa and K. A. Kailash

Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences (DU), Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5212-21

5212-5221

407

236

13.

A BRIEF STATEMENT: DEVELOPMENTS IN NANOCARRIER DELIVERY SYSTEMS USING GRAPHENE

One of the most important difficulties in contemporary medical biology is the creation of a cutting-edge, effective drug delivery system with a considerable improvement in its efficacy and increased therapeutic value. The advancement and development of innovative drug-delivery nanocarrier systems with accuracy and reduced side effects have been made possible by merging nanomaterial science with mo...

Saddam *, Suman and Shashi Alok

Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5222-30

5222-5230

260

153

14.

EXCISIONAL NEW ATTACHMENT PROCEDURE

Periodontitis is a complex infectious disease of supporting structures of teeth caused by specific microorganisms or groups of microorganisms. Formation of a new connective tissue attachment and bone deposition are the main goals of periodontal therapy. The excisional new attachment procedure (ENAP) is especially sub-gingival curettage performed with a knife performed by internal bevel incision pe...

M. Kalaiyazhagi, S. Sangeetha *, N. K. Savithri, N. Gautham Kumar, N. Gowri Shankar and R. Nivetha

Department of Periodontology, Madha Dental College and Hospital, Kundrathur, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5231-35

5231-5235

921

502

15.

PHYTOTHERAPY IN FUNCTIONAL HEPATIC INJURY

Since ancient times, natural products, especially plants have been utilized to treat variety of disorders, and an astounding number of contemporary medications have been created from them. All across the world, liver problems are prevalent. These conditions are only mildly handled traditionally; however, allopathic treatment always makes the situation worse when used to address more severe conditi...

Srikar Barik *, P. K. Panda and Diptimayee Jena

Department of Pharmacology, UDPS, Utkal University, Vanivihar, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5236-46

5236-5246

286

168

Research Articles

 
Title
Views
PDF
Cited
16.

OPTIMISATION AND EVALUATION OF CAFFEINE ORALLY DISSOLVING FILMS

Caffeine anhydrous is used as a stimulant to improve individual alertness and mental focus due to its ability of inhibiting the function of phosphodiesterase enzyme in the cells. Recent studies also discovered where caffeine reduced the risk of Parkinson’s disease by its inhibitory action on adenosine receptor. With the aim of masking the bitter taste of caffeine, increasing the compliance and c...

S. X. Chong * and S. M. Loong

Faculty of Pharmacy, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, 47810 Petaling Jaya, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.14(11).5247-52

5247-5252

617

345

17.

DESIGN, DEVELOPMENT AND FORMULATION OF ECONAZOLE NITRATE CO-CRYSTAL LOADED GEL TO CURE TOPICAL ANTIFUNGAL DISEASE

In the past years many drug discoveries were investigated to be poorly soluble in aqueous medium. These poorly aqueous soluble drugs include Econazole Nitrate (ECZN) having high permeability. ECZN is an effective, potent anti-fungal drug used to cure large range of fungus. Oral administration of ECZN causes gastrointestinal irritation. To overcome or avoid the “first pass metabolism” and to op...

Mohammad Wais, Priyanka S. Gala * and Anagha Raut

Department of Pharmaceutics, H. K. College of Pharmacy, Oshiwara, Jogeshwari [W], Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5253-68

5253-5268

637

507

18.

MOLECULAR DESIGN AND ANTI-BREAST CANCER ACTIVITY OF TUPICHINOL E IN HER2+ BREAST CANCER AND EGFR SENSITIZED TO OSMERTINIB THERAPY

The epidermal growth factor receptor is a tyrosine kinase receptor and its overexpression triggers cancers. EGFR inhibition is one of the most unique and popular technique for cancer treatment. There are various approved EGFR inhibitors like osmertinib, lapatinib, afatinib, etc. Huge natural products are discovered every year and Rhamnocitrin derivative Tupichinol E obtained from the Northern Sikk...

Adyasa Samantaray, Debasish Pradhan *, Lalatendu Mohanty and Nalini Ranjan Nayak

University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5267-73

5267-5273

695

346

19.

DESIGN AND STATISTICAL OPTIMIZATION OF METFORMIN HYDROCHLORIDE LOADED FLOATING MICROSPHERES: INFLUENCE OF NATURAL POLYMERS

Floating microspheres have been showing high potential for gastro retention and provide an efficient means of enhancing bioavailability and controlling the release of drugs. Metformin hydrochloride is an effective antidiabetic that required controlled release due to its Short half-life of about 4.5-7 hours and bioavailability 50-60 %. The present research works aim is to develop, evaluate and stat...

V. K. Asna Khalid * and M. Krishna Pillai

Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5274-80

5274-5280

578

317

20.

TO EVALUATE RHEOLOGICAL SYNERGISM BY COMBINING HYDROPHILIC POLYMERS AND OPTIMIZATION BY SIMPLEX MIXTURE DESIGN

It appears that you have conducted a study on the preparation of Glipizide sustained-release tablets using different HPMC (hydroxypropyl methylcellulose) polymers of varying viscosity grades, specifically HPMCK 4M and HPMC K 15M, in different proportions. The concentration of the polymers was optimized using a simplex mixture design, with HPMC K4M, HPMC K15M and lactose as the components of the mi...

Ashwini R. Madgulkar, Mangesh R. Bhalekar and Yash Abhay Saoji *

Department of Pharmaceutics, AISSMS College of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5281-89

5281-5289

494

285

21.

FORMULATION AND EVALUATION OF CARBAMAZEPINE BILAYER TABLET FOR BIMODAL RELEASE

Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine used for the treatment of acute manic and mixed episodes associated with bipolar I disorder.  In the present study bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one la...

M. Shankrayya *, Sagar T. Kulakarni, D. M. Vinayaka, Sathwik, A. K. Sourav, Sabreen Taj and R. P. Kishor Rahul

Department of Pharmaceutics, S. C. S. College of Pharmacy, Harapanahalli, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5290-97

5290-5297

266

154

22.

FORMULATION AND EVALUATION OF FICUS BENGHALENSIS LOADED CANDY FOR TOOTHACHE

People utilise plants regularly all around the world for the treatment and prevention of a wide range of illnesses. One abundant plant found in India is the banyan tree, Ficus benghalensis Linn. Oral and dental hygiene is the primary factor of a human being to lead a healthy life. The aim of this study is to design Ficus benghalensis Linn. candy to improve patient oral health, toothache, and accep...

Harish Sharma, Pankaj Sharma *, Abhishek Parashar and Vinay Jain

Department of Pharmaceutics, Shri Ram College of Pharmacy, Morena, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5298-05

5298-5305

395

189

23.

A QUESTIONNAIRE STUDY ON KNOWLEDGE AND ATTITUDE TOWARDS EVIDENCE BASED MEDICINE AMONG INTERNS AND POSTGRADUATES IN A TERTIARY CARE TEACHING HOSPITAL

Background: Evidence based medicine (EBM) integrates the best available data from clinical research into clinical practice. Residents (PGs & CRRIs) are at the frontiers of healthcare who are still struggling to adapt the paradigm shift in the practice of medicine. This study aims to explore the knowledge and attitude of EBM among residents in a tertiary teaching hospital. Materials and Methods...

A. R. Razia *, R. V. Ramanarayan Reddy, G. Senthil, S. Vijayalakshmi, T. A. R. Raja, R. Sridevi, M. Krishnakishore

Department of Pharmacology, Melmaruvathur Adhiparasakthi Institute of Medical Sciences and Research, Melmaruvathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5306-10

5306-5310

411

156

24.

FABRICATION AND STATISTICAL OPTIMIZATION OF LIPID-BASED NANOPARTICLES FOR THE ENCAPSULATION OF DOLUTEGRAVIR SODIUM

Dolutegravir, an integrase strand transfer inhibitor (INSTI), is a BCS class II, poorly soluble antiretroviral medication that has been licenced by the FDA for the treatment of HIV infections. DTG has a number of drawbacks, including limited oral bioavailability (16%), hepatotoxicity, and instability in an acidic environment. Due to the medication's limited solubility, 84% of the dose is eliminate...

Sreethu K. Sreedharan and C. U. Amrutha *

Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5311-18

5311-5318

346

146

25.

STATISTICAL OPTIMIZATION OF TOPICAL CREAM CONTAINING VITAMIN D3 NANOPARTICLES FOR ANTI-AGING EFFECT: BOX-BEHNKEN DESIGN

Aging is defined as decreased maximal function and reserve capacity in all body, organs, resulting in an increased likelihood of disease and death. One of the reasons for Premature Aging is deficiency of Vitamin D3. The main aim of the research work is to develop and evaluate the Nanoparticle based Anti-aging cream of Vitamin D3 for Premature aging. Six formulations were prepared by Nano precipita...

S. Aiswarya * and K. Reshma Fathima

Department of Pharmaceutics, Grace College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5319-25

5319-5325

263

135

26.

LABRAFAC WL1349 AIDED LYOPHILIZE SOLID DISPERSION OF OLMESARTAN MEDOXOMIL

Water solubility is the rate limiting step in dissolution and bioavailability. Olmesartan medoxomil is BCS class-II drugs having low water solubility. Olmesartan medoxomil acts on cardiovascular system and used in the treatment of hypertension as antihypertensive agent. Olmesartan medoxomil have low water solubility and low bioavailability as 26%. In this research study we made Olmesartan medoxomi...

Rakesh Madhukar Bachhav, Avinash Balasaheb Gangurde, Rupesh Krishna Deore, Vinod A. Bairagi and Rahul Yuvraj Pagar *

Department of Pharmaceutics, K. B. H. S. S. Trust’s Institute of Pharmacy, Oppo. Jajuwadi Compound, Bhaygaon Raod, Malegaon, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5326-32

5326-5332

261

141

27.

IDENTIFICATION OF ABIOTIC STRESS-RESPONSIVE MIRNA TARGET NETWORK IN PHOENIX SP, A MANGROVE SPECIES

A very tiny non-coding RNA molecule with a length of 20 to 24 nucleotides, called microRNAs or miRNAs. They control gene expression by targeting mRNAs with sequence-specificity. Depending on the degree of complementarity with the target mRNA sequences, this might result in translational repression or mRNA destruction. They are very crucial for controlling growth and development in plants. Research...

Quazi Sayeed Ahmad, Sutripto Ghosh, Sharmistha Bhandari and Tamalika Chakraborty *

Department of Life Science, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5333-39

5333-5339

276

140

28.

ANTIMICROBIAL ACTIVITY IN METHANOLIC SEED EXTRACT OF ANNONA SQUAMOSA

Annona squamosa (sugar apple) is commonly cultivated in tropical South America occasionally in southern Florida as well as in Jamaica, Puerto Rico, Barbados, and dry regions of Australia. It was growing in Indonesia early in the 17th century and has been widely adopted in southern China, tropical Africa, Egypt, and the lowlands of Palestine. This plant is a small well-branched tree or shrub that b...

Anshuman Bhattacharya, Anindita Pal, Soumya Datta *, Souvik Biswas, Arijit Das, Pallakhyi Chanda, Dipan Roy, Sarbani Roy, Mrinmoy Nag, Souvik Chattopadhyay and Amartya Sen

Bharat Technology, Jadurberia, Uluberia, Howrah, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5340-48

5340-5348

462

182

29.

MICRONUCLEUS COUNT AND ITS PREDICTIVE VALUE IN CERVICAL PAP SMEARS AT A TERTIARY CARE CENTRE, TRICHY DISTRICT, TAMIL NADU

Objectives: Fragmented micronucleus is a good prognostic indicator for monitoring and detecting chromosomal / genetic damage in human population. The objective of this study was to count the cells with presence of micronucleus in cervical pap smears in women with reproductive age group and to detect its predictive value. To substantiate the importance of Micronucleus evaluation in routine Pap smea...

Jeevaraj Giridharan * and Ronald. J. Bosco

Srinivasan Medical College and Hospital, Samayapuram, Trichy, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5349-53

5349-5353

258

150

30.

IN-VITRO ANTIOXIDANT AND ANTI-INFLAMMATORY EVALUATION OF SUCCESSIVE EXTRACTS OF ZIZIPHUS NUMMULARIA

Ziziphus nummularia is commonly found plant in dry regions of South Asia such as India, Pakistan. Z. nummularia contains numerous phytochemicals such as flavonouds, alkaloids that are responsible for numerous biological activities. In current study, elaborative pharmacognostic studies on the leaves of Z. nummularia were done for standardization purposes for future studies. The study includes morph...

Hitesh Malhotra, Vandana Garg * and Govind Singh

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5354-66

5354-5366

308

152

31.

A STUDY ON THE ASSESSMENT OF PAIN AND SLEEP IN PATIENTS UNDERGOING HEMODIALYSIS AND PERITONEAL DIALYSIS

Background: Perception of pain and sleep disturbances are more prevalent in patients undergoing Dialysis. Assessing and determining the pain intensity and sleep disturbances help to establish the need for treatment, which is an important part of therapeutic intervention as they may affect the patient’s Quality of life (QOL). This study was aimed to assess pain intensity and sleep disturbances in...

M. Niranjan Babu, Jyothi Basini *, B. S. Chathurya, Dayana Buduru, Divya Lakavath and M. Durga Prasad

Department of Pharm. D, Seven Hills College of Pharmacy, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5367-72

5367-5372

307

142

32.

DEVELOPMENT AND VALIDATION OF NOVEL RP- HPLC METHOD FOR SIMULTANEOUS ANALYSIS OF PREGABALIN AND DULOXETINE IN SYNTHETIC MIXTURE

A sensitive, rapid, precise and accurate RP-HPLC method was developed for simultaneous estimation of Pregabalin and Duloxetine in synthetic mixture. To introduce a chromophoric group in Pregabalin structure, derivatization was carried out through benzoylation reaction. RP- HPLC method is carried out using Hypersil BDS column C18 (250 cm × 4.6 cm, 5 μm). Mobile phase used as combination of Methan...

Ojash Patel * and Mona Patel

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, SSSRGI, Mehsana, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5373-79

5373-5379

473

332

33.

TERATOGENIC EFFECT OF DRUGS AT DIFFERENT STAGES OF PREGNANCY

Objective: Teratogens play a crucial role in the 4-5% of infants who are born with physical or functional abnormalities in this world. Teratogens are recognized for their capacity to harm fetuses or neonates. Observations: Pregnancy-related exposure to certain substances may result in birth abnormalities or malformations of the fetus, such as behavioral or emotional problems, low IQ, physical defo...

Arup Pramanick, Indranil Roy, Aparna Datta *, Shailee Dewan and Vandana

Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata Group of Institutions, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5380-89

5380-5389

680

403

34.

EFFECT OF MUSIC THERAPY IN PATIENTS UNDERGOING CAESAREAN DELIVERY UNDER SPINAL ANAESTHESIA

Background: Increased anxiety in patients undergoing caesarean delivery has a negative impact on fetus and mother. Music therapy can have beneficial effects. The aim of our study was to determine the effects of preoperative and intraoperative music therapy on anxiety, pain, patient satisfaction and postoperative nausea and vomiting in patients undergoing caesarean delivery under spinal anaesthesia...

Vrinda Oza, Swati Kariya, Parthkumar D. Vadgama * and Vandana S. Parmar

P. D. U. Government Medical College, Hospital Chowk, Jamnagar Road, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5390-98

5390-5398

300

156

35.

EVALUATION OF IN-VIVO ANTI-INFLAMMATORY ACTIVITY OF MONO HERBAL SIDDHA FORMULATION KANDUPARANGI CHOORANAM (PYGMAEOPREMNA HERBACEA – ROOT POWDER) IN CARRAGEENAN-INDUCED PAW EDEMA & PLEURISY IN WISTAR ALBINO RATS

Introduction: Monoherbal or polyherbal formulation, which is used in Siddha medication, have a wide variety of phytochemical substances as primary and secondary metabolites, which show many pharmacological activities, including the anti-inflammatory effect. Materials and Methods: The anti-inflammatory activity of Kanduparangi chooranam (KC) was evaluated by using carrageenan-induced paw edema and ...

C. B. S. Bharath Christian

Department of Maruthuvam, Santhigiri Siddha Medical College, Kerala University of Health Sciences, Pothencode, Thiruvananthapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5399-03

5399-5403

275

146

36.

COMPARISON OF BACTEC VERSUS CONVENTIONAL METHOD FOR CULTURE OF STERILE BODY FLUIDS IN A TERTIARY CARE HOSPITAL

Aim & Background: Body fluids are sent to clinical microbiology laboratory for culture to find the etiological agent causing the infection. This study was conducted to compare the culture results of sterile body fluids processed simultaneously by both conventional method and BACTEC blood culture system. Methods: Sterile body fluids except blood were included in the study. A total of 61 body fl...

Simranjit Kaur, Vishal Sharma * and Deepak Arora

Department of Microbiology, G. G. S. MCH, Faridkot, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5404-09

5404-5409

322

182

37.

DEVELOPMENT OF pH-INDEPENDENT MUCOADHESIVE PELLETS FOR EFFECTIVE TREATMENT OF VAGINAL CANDIDIASIS

Objective: The present investigation aims to develop pH-independent mucoadhesive pellets using the extrusion-spheronization procedure and the inter-polyelectrolyte complex (IPEC) of Chitosan-Carbopol 71G. Miconazole was used as a representative drug in this study. Materials and Method: It was found that the composition of the formulation impacts the extrusion of the prepared dough mass. The genera...

Bandaru Sravani, T. Reshma and Nawaz Mahammed *

Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K. R. Palli Cross, Anantapur, Chiyyedu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5410-21

5410-5421

250

135

38.

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF SELECTED CHENOPODIUM SPECIES

Chenopodium album, Chenopodium murale, and Chenopodium giganteum are annual herb. Almost 250 different species of Chenopodium can be found all over the world. They are grown for many purposes, including some for their green leafy vegetables and others for the grains they provide. The phytochemicals, proteins, carbohydrates, tannins, flavonoids, alkaloids, steroids, terpenoids, and saponins have at...

Hanuman Sahay Meena * and Rekha Vijayvergia

Department of Botany, University of Rajasthan, Jaipur, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5422-30

5422-5430

277

173

39.

EVALUATION OF ENDOCAN AND ENDOGLIN AS PREDICTIVE MARKERS OF ENDOTHELIAL DYSFUNCTION IN WISTAR ALBINO RATS TREATED WITH A SINGLE DOSE OF STZ AND HFD

A major susceptibility indicator for type 2 diabetes and cardiovascular diseases is obesity-related insulin resistance. Vascular endothelial cells strongly express the coreceptors for members of the transforming growth factor (TGF) superfamily, endocan and endoglin. Examining endocan and endoglin as potential indicators of cardiovascular complications in HFD rats with or without type 2 diabetes me...

Tarannum Perampalli *, Lavanya Prathap and G. Mydhili

Department of Biochemistry, Research Scholar, Saveetha University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5431-40

5431-5440

244

182

40.

FORMULATION AND EVALUATION OF BUTENAFINE HYDROCHLORIDE LOADED CUBOSOMAL GEL

The aim of this research was to develop and evaluate a cubosomal gel for the treatment of skin diseases such as athlete's foot (tineapedis), ringworm (tineacruris) and ringworm (tineacorporis). To increase the penetration of the drug and to provide longer duration of treatment this study was performed. Cubosomes are a novel nanoparticle system loaded with butenafine hydrochloride as an antifungal ...

Ritik Chauhan and Nirmala

School of Pharmaceutical Sciences, Rayat and Bahra University, V.P.O. Sahauran, Tehsil Kharar, Mohali, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5441-50

5441-5450

274

188

41.

EVALUATION OF ANTICANCER POTENTIAL OF METHANOLIC EXTRACT OF PETALS OF CHRYSANTHEMUM MORIFOLIUM AGAINST HUMAN LIVER CANCER CELL LINE (HEPG2)

Chrysanthemum morifolium is commonly known as chrysanthemum. It has been widely used in traditional medicine due to its various therapeutic effects. Past studies have shown that chrysanthemum extracts possess significant anticancer activity against breast, prostate, and colon cancer cells. The active compounds in chrysanthemum extracts such as flavonoids, sesquiterpenes, and triterpenoids have bee...

Tadipatri Farmaan, P. A. Anirudh, M. Arun Kumar Naik, Juturu Lakshmi Prasanna Kumar, Albraa Hussien Ali and M. Vijaya Jyothi *

Department of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, K. R. Palli Cross, Chiyyedu Post, Anantapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5451-58

5451-5458

273

138

42.

GENOTOXICITY EVALUATION OF POLYPHENOLIC BIOINSECTICIDE FROM STREBLUS ASPER (PBSA) USING MOUSE BONE MARROW MICRONUCLEUS ASSAY

Isolation of plant-based pesticides gaining recent interest due to the clastogenic implications of synthetic insecticides. The polyphenolic-rich fraction from the stem bark of Streblus asper was proven as an insecticide against Dysdercus cingulatus. This study aims to evaluate the genotoxicity of polyphenolic bioinsecticide from Streblus asper (PBSA)  using the mouse bone marrow micronucleus assa...

L. Anila * and M. S. Hashim

Department of Biochemistry, NSS College, Nilamel, Kollam, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5459-64

5459-5464

294

142

43.

SYNTHESIS AND CHARACTERIZATION OF MUTUAL PRODRUGS OF MEFENAMIC ACID WITH OTHER NSAIDS

Inflammation and pain have all been successfully treated using nonsteroidal anti-inflammatory drugs. Today's nonsteroidal anti-inflammatory drugs (NSAIDs) are typically taken with restriction due to the gastric intolerance they create. The prodrug approach is quite effective in reducing the side effects caused by NSAIDs. Many nonsteroidal anti-inflammatory drug molecules have been modified in seve...

Simran, Arshi Hussain and Neelam Vashist *

Department of Chemistry, Gurugram University, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5465-71

5465-5471

500

171

44.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF THREE COMBINATION DRUGS REMOGLIFLOZIN ETABONATE, METFORMINE AND VILDAGLIPTIN BY RP-HPLC TECHNIQUE

Remogliflozin Etabonate, Metformin, Vildagliptin are anti-diabetic drugs. It inhibits the sodium-glucose transport proteins (SGLT), which are responsible - for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Several attempts were made on simultaneous analysis of Metformin with either Vildagliptin or Remogliflozin but no work we...

Tabassum Bano *, Madhuri Channawar and A. V. Chandewar

P. Wadhwani College of Pharmacy, Dhamangaon Road Yavatmal, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5472-83

5472-5483

400

215

45.

QUANTIFICATION OF VARIED MIRNAS IN EARLY AND LATE-ONSET PREECLAMPSIA COMPLICATING PREGNANCIES IN SOUTH INDIAN WOMEN- A COHORT STUDY

Introduction: Preeclampsia (PE) is a common pregnancy-related hypertensive disorder that may result from abnormal placental development and is a major threat to the mother’s and foetus’s life. Methods: Placental miRNAs (miRNAs) profile was investigated using next-generation sequencing for the identification of potential biomarkers playing a role in aberrant placental development and to underst...

Vinaya Vijayan *, R. Kannan, Y. Subhashini, S. Tarakeswari, B. Ram Reddy, Ramesh Bangaraiahgari, Rajesh Bangaraiahgari, Aparajita D’souza, Aruna Yerra, K. Divya, N. Udaya Kumar and Banala Rajkiran Reddy

Department of Physiology, Apollo Institute of Medical Sciences and Research, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5484-92

5484-5492

269

147

46.

ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF AZADIRACHTA INDICA SILVER NANOPARTICLES AGAINST ENTERIC PATHOGENS ISOLATED FROM EFFLUENT SAMPLES

The aim of this study was to evaluate the antimicrobial and antibiofilm activity of silver nanoparticles of Azadirachta indica (AISNPs) against the pathogens isolated from effluent. Green synthesis approach was opted for the synthesis of the synthesis of AISNPs by using the ethanolic extract of Azadirachta indica which was added to 1mM solution of AgNO3. These synthesized nanoparticles were molecu...

Kunal Madhav, Nitika Anand and Archana Pandita *

Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5493-03

5493-5503

258

135

47.

EVALUATION OF PHYTOCHEMICAL, ANTIMICROBIAL, IN-VITRO ANTIOXIDANT & ANTI-INFLAMMATORY STUDY OF METHANOLIC EXTRACT OF RAPHANUS SATIVUS FRUIT

Raphanus sativus L, belongs to the family Brassicaceae. Phytochemical analysis of its methanolic root extract revealed the presence of alkaloids, flavonoids, glycosides, tannin, phenolic compounds, triterpenoids and steroids. The antimicrobial activities and in-vitro Pharmacological activities like Antioxidant Activity and Anti-inflammatory activity of the root extract was assessed. Production of ...

S. Saha *, A. S. Afroz, A. Dey and S. Paul

Department of Pharmaceutical Technology, JIS University, Agarpara, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5504-10

5504-5510

251

159

48.

NUTRACEUTICAL AND ANTIOXIDANT ACTIVITY OF CLITORIA TERNATEA EXTRACTS

Clitoria ternatea was selected because it possesses various medicinal compounds of great significance based on its usage as an ayurvedic drug to cure various diseases. This study helps to understand the significance of plant sources that possess pharmacological activities and is good for health on regular consumption. A comparative study was thus conducted to analyze the potential antioxidant acti...

Kavitha G. Singh *, Shruti Biswas and G. Sneha

Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5511-16

5511-5516

288

201

49.

BENEFITS OF BALANCE TRAINING TO MAINTAIN EQUILIBRIUM AMONG OLD AGE PEOPLE

Introduction: Balance is an integral component of daily (functional) activities. It is very sensitive, complex and multifactorial. It is the ability to maintain the projection of the body’s centre of mass within manageable limits of the base of support, as in the standing or sitting or in transit to a new base of support, as in walking pattern (1). In old age ability to maintain balance is low a...

Rajan Balakrishnan *, Vanitha Krishna Subbaiah, Annie Thomas and B. Arun

MAHSA University, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.14(11).5517-21

5517-5521

277

148

50.

CASE REPORT ON GUILLAIN BARRE SYNDROME – ACUTE MOTOR AXONAL NEUROPATHY (AMAN)

Guillain-Barre syndrome occurs when the body's immune system targets a portion of the peripheral nervous system. In addition to the nerves that convey pain, temperature, and touch sensations, the condition can also impair the nerves that regulate muscular movement. This may lead to muscular weakness and/or loss of feeling in the arms and/or legs. A 12-year-old boy was taken to the hospital with ch...

A. Abishek, A. Priya and K. Arun Chander Yadav

Department of Clinical Pharmacology, Apollo Children’s Hospital, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5522-25

5522-5525

408

162

51.

CERVICAL POLYP TREATED WITH INDIVIDUALIZED HOMOEOPATHIC MEDICINE – CASE REPORT

A known case of a cervical polyp of a 26-year-old woman presented in the Outdoor-patient Department of Dr. D. Y. Patil Homoeopathic Medical College and Research Centre with complaints of abnormal bleeding in between periods, pain after coition, and profuse white discharge. USG reports confirmed the diagnosis of the cervical polyp. After a detailed history taking of the patient and considering a co...

S. Kadam *, P. Lamba, D. B. Sharma, P. A. Chaphekar and P. Aphale

Department of Homoeopathic Materia Medica , Dr. D. Y. Patil Homoeopathic Medical College & Research Centre, Pimpri, Pune, Maharashtra, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5526-31

5526-5531

927

251

52.

EVALUATION OF THE ROLE OF ZINC AS ADD-ON THERAPY ON GLYCAEMIC CONTROL AND SYMPTOMS AND SIGNS OF NEUROPATHY IN THE PATIENTS WITH DIABETES MELLITUS

Introduction: Diabetic neuropathy occurs in about half of the individuals with long-standing diabetes manifested as polyneuropathy, mononeuropathy and autonomic neuropathy. There is evidence indicating the involvement of zinc in diabetes. Aim: To evaluate the effect of Zinc as add-on therapy in Diabetic Neuropathy on the basis of clinical signs and symptoms and glycaemic control. Materials and Met...

Seemant Saurabh, Ravi Kant Tiwari *, Nilima Kumari and Anupam Sharma

Department of Pharmacology, United Institute of Medical Sciences, Rawatpur, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5532-40

5532-5540

726

168

53.

LACOSAMIDE AS AN ADD-ON THERAPY FOR DRUG-RESISTANT EPILEPSY: A PROSPECTIVE OBSERVATIONAL STUDY AT A TERTIARY CARE HOSPITAL IN SOUTH INDIA

Background: Epilepsy is a common and chronic neurological disorder. The prevalence of drug-resistant epilepsy (DRE) is reported as 25-30% among epileptic patients. So, there is a need of drugs for resistant epilepsy. Objective: To assess the effectiveness and tolerability of Lacosamide (LCM) as an add-on therapy in patients with Drug-Resistant Epilepsy in our patient population. Methods and Materi...

V. Prakash, G. Balaji and T. Siyamala Devi *

Department of Pharmacology, Chengalpattu Medical College, Chengalpattu, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(11).5541-54

5541-5554

263

162