Volume 16 (2025) - Issue 9, September
Review Articles
CANCER CHEMOTHERAPY-INDUCED CACHEXIA: THE ORPHAN DISEASE
Cancer remains a major cause of mortality worldwide, with chemotherapy serving as a cornerstone of cancer treatment. While effective in targeting malignant cells, chemotherapy is associated with debilitating side effects, including cachexia a complex, multifactorial syndrome characterized by unintentional weight loss, muscle wasting, fatigue, and reduced physical function. This condition arises fr...
1119
5072
A NOVEL ANTIOXIDANT-DAPAGLIFLOZIN COMBINATION: COMBATING DIABETIC KIDNEY DISEASE AT THE CELLULAR LEVEL
At present, the significant cause of chronic kidney disease (CKD) is said to be Diabetic Kidney Disease (DKD). This condition considerably impacts cost of healthcare, mortality and morbidity worldwide. Current treatment options for DKD basically focusses on Blood Pressure (BP) regulation, glycemic control along with suppression of Renin-Angiotensin-Aldosterone System (RAAS). The advancing nature o...
1099
5008
RECENT ADVANCEMENT IN THE DEVELOPMENT OF THERAPEUTIC PEPTIDES
Peptides are naturally occurring biologics, which provide essential functions as hormones, growth factors, biological messengers, anti-infective, neurotransmitters, and antimicrobials. Peptide hormones such as insulin, vasopressin, oxytocin, and gonadotropin-releasing hormone have significantly accelerated advances in modern drug development fields, including biology, chemistry, pharmacology, and ...
1129
4998
ANUPDATED CLINICAL REVIEW OF ABNORMAL VAGINAL DISCHARGE AND REPRODUCTIVE TRACT INFECTION
Vaginal discharge is the commonest symptom reported in reproductive tract infection the recognition and diagnosis of the correct cause of abnormal vaginal discharge (AVD) can be challenging due to the wide spectrum of infectious agents. Reproductive tracts infections (RTIs) can cause serious physical and psychological harm, and this harm is not limited only to the women themselves, but also a seri...
1136
4968
ASSOCIATION OF ALCOHOL USE DISORDERS (AUD) AND PSYCHIATRIC MORBIDITIES AND THEIR TREATMENT MODALITIES
The prevalence of psychiatric disorders in AUD, the association between the severity of AUD and psychiatric disease, the influence of treatment of AUD on relief of psychiatric symptoms and vice-versa has been studied in various parts of the world. In India, the influence of various socio-economic factors and the lifestyle of the individuals is different to other parts of the world. There is paucit...
186
4925
ADJUNCTIVE EFFECT OF LOCALLY DELIVERED MINOCYCLINE MICROSPHERES IN CHRONIC PERIODONTITIS: A SYSTEMATIC REVIEW
Objective: Chronic periodontitis, an inflammatory disease of the supporting tissues of teeth, is usually treated non-surgically by scaling and root planing. Minocycline is used as a local drug delivery and can be used as an adjunctive agent. The study aims to determine the efficacy of minocycline microspheres as a local drug delivery agent in treating chronic periodontitis. Methods: Randomized con...
1064
4941
A COMPREHENSIVE REVIEW ON BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR PHARMACEUTICALS
Bioanalysis is most widely used for drug discovery and development. Bioanalytical methods have been working for the quantitative estimation of drugs, or its metabolites and biomarkers in its biological samples. The steps involved in bioanalysis comprise of many steps that are from sample collection to sample analysis and then data reporting. The first step involves sample collection from clinical ...
1038
4888
IMPACT OF OCT-1 GENETIC VARIATION ON METFORMIN RESPONSE AND ITS GASTROINTESTINAL SIDE EFFECTS
Metformin used successfully by clinicians over the decades as a first-line treatment for hyperglycemia also it was a popular treatment for type-2 diabetes in those who are overweight, when diabetes is not controlled by a healthy diet and lifestyle changes. Genetic factors place an important role in modulating metformin efficacy and toxicity in which OCT- 1 was a major transporter of metformin so g...
993
4898
INVASOMES IN COSMETICS: ENHANCING SKIN PENETRATION AND ACTIVE INGREDIENT DELIVERY
Invasomes, within the scope of transdermal medication delivery and cosmetic formulations, nowadays have emerged as impressive technology and are described in comprehensive detail in this review paper. Essentially, invasomes are built from a unique substance, techniques, and processes that can enable active compounds to penetrate easier into the skin than standard liposomes, with the help of phosph...
1013
4900
COMPREHENSIVE REVIEW ON THERAPEUTIC APPLICATIONS OF AI IN LEUKAEMIA: A MULTI-OMICS APPROACH
It is leukaemia, where immature white blood cells keep growing at a very fast pace and disrupt normal blood production. While there are many advances in treatment, genetics diversity, drug resistant and technological limits remain. Likewise, such AI combined with multi dimension approaches (genetics, transcriptomics, proteomics, metabolism, and epigenetics) has altered leukaemia research. Divining...
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Research Articles
EXPLORING THE ANTIOXIDANT POTENTIAL OF FLAVANONES IN STROBILANTHES HAMILTONIANA (STEUD.) BOSSER & HEINE: A COMBINED QUANTUM MECHANICAL, MOLECULAR DOCKING, AND BIOCHEMICAL ASSAY APPROACH
Strobilanthes hamiltoniana (Paalkurinji), a perennial herb of the Acanthaceae family, has traditional use in treating ulcers, diabetes, arthritis, and wounds. S. hamiltoniana leaves were extracted using ethanol, chloroform, and water, and screened for phytochemicals using standard protocols. LC-MS analysis was used to identify flavonoids. Antioxidant activity was evaluated via DPPH, HRS, and FRA...
1105
4970
DNA SEQUENCING, MUTATIONAL ANALYSIS OF NOVEL COMT GENE VARIANTS AND ITS PATHOGENICITY IN SCHIZOPHRENIA PATIENTS: ACROSS-SECTIONAL STUDY FROM TUMKUR DISTRICT OF SOUTH KARNATAKA
Introduction: Schizophrenia is a multi-factorial neuropsychiatric disorder, influenced by environmental and genetic factors. The catechol-O-methyltransferase (COMT) gene is a crucial for the metabolism of dopamine. It has been thoroughly investigated for its potential role in SCZ. At the same time; several variants in the COMT gene have been reported in diverse populations in South Karnataka but r...
1078
4954
DEVELOPMENT, OPTIMIZATION AND EVALUATION OF GASTRORETENTIVE TABLETS CONTAINING LOSARTAN POTASSIUM BY USING 32 FULL FACTORIAL DESIGN
Background: The present investigation was aimed at developing, optimize and evaluate gastroretentive floating tablets containing Losartan potassium to retain in the stomach for prolong and predictable period of time for hypertensive patients. In the present study, the effect of HPMC K15M showed prolong release of drug in gastric pH environment. Results: These formulations were evaluated for the pa...
1159
4955
A RANDOMIZED, OPEN LABEL, PROSPECTIVE STUDY TO COMPARE EFFICACY AND SAFETY OF LOSARTAN WITH AMLODIPINE VERSUS LOSARTAN WITH HYDRO-CHLOROTHIAZIDE IN THE TREATMENT OF NEWLY DIAGNOSED PATIENTS OF ESSENTIAL HYPERTENSION IN A RURAL TERTIARY HEALTH CARE CENTRE
Introduction: Hypertension is a leading global health concern, contributing significantly to cardiovascular morbidity and mortality. Despite the availability of various antihypertensive therapies, the optimal treatment regimen, particularly in diverse populations, remains a subject of ongoing research. This study aims to compare the efficacy, safety, and patient satisfaction of two commonly prescr...
1147
4958
FORMULATION DEVELOPMENT OF AMOXICILLIN MICROSPHERE USING NOVEL NATURAL POLYMER
Amoxicillin is an antibiotic beneficial for the treatment of some bacterial infections. When orally administered it is slowly and scarcely absorbed from the gastrointestinal tract. The objective of the present work was to formulate and evaluate microspheres of Amoxicillin and produce sustained drug delivery. Microspheres can be manufactured from various natural and synthetic materials. In these 14...
1128
4991
DRUG UTILIZATION STUDY IN INDOOR ADULT POST-OPERATIVE PATIENTS OF GENERAL SURGERY UNIT OF A TERTIARY CARE TEACHING HOSPITAL OF CENTRAL INDIA – A PROSPECTIVE OBSERVATIONAL STUDY
Background: Drug Utilization Study offers useful methods for teaching and training in drug therapy. In our setting, there is no such study that describes the use of drugs post-operatively. As a result, this study was conducted to investigate the post-operative drug utilization pattern in indoor post-operative patients. Aim: To study the prescribing trends of drugs used in indoor adult post operati...
1015
4908
TO CORRELATE LEVELS OF TNF-α, INSULIN, INSULIN RESISTANCE, ANTIOXIDANT ENZYMES AND LIPOPROTEIN PROFILE IN OBESE WITH TYPE 2 DM SUBJECTS
Obesity has become a matter of quality to health care administrators. The busy lifestyle of people made them prefer fast food instead of taking healthy food. But the people are not aware that fast food habits convert to diseases like obesity, type 2 diabetes mellitus (T2DM), dyslipoproteinemia etc. This case-control study was carried out in the Department of Biochemistry in collaboration with the ...
140
4900
EVALUATION OF HAIR GROWTH PROMOTING ACTIVITY OF ACALYPHA INDICA ETHANOLIC EXTRACT WHOLE PLANT
Traditionally, alopecia, a major illness throughout the world, has been treated with medicinal plants and their oils. Hair treatments, including those that stimulate hair growth, cost about $10 billion a year. A big worry is hair loss, which is mostly brought on by junk food and erratic lifestyle choices. The function of the ethanolic extract of the entire A. indica plant is examined in this study...
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EVALUATION OF PHYTOCHEMICALS AND ANTIOXIDANT POTENTIAL IN MILLETS
Millets are small-seeded grasses that have nutraceutical properties due to high content of proteins, dietary fibre, vitamins, antioxidants, and other valuable phytochemicals, important for health and wellbeing. The objective of the research was to analyse the phytochemical compounds and antioxidant properties of minor millet varieties viz., Kodo, Proso, Barnyard, Finger, Foxtail, and Little Millet...
1074
4917
ADVERSE DRUG REACTION MONITORING IN DRUG SENSITIVE TUBERCULOSIS PATIENTS: A CROSS-SECTIONAL STUDY IN A TERTIARY CARE HOSPITAL
Tuberculosis (TB) continues to rank among the world's most serious health problems despite the remarkable biomedical achievements. The objective of the study is to describe and characterize the adverse drug reactions associated with Anti Tubercular Therapy (ATT) in a tertiary care hospital. This was a cross sectional study done in the Department of Thoracic medicine, Government Medical College Kri...
1032
4907
CHARACTERIZATION AND EVALUATION FOR ANTIBACTERIAL ACTIVITY OF GREEN SYNTHESIZED NANOPARTICLES OF LEONOTIS NEPETIFOLIA
The current research is to develop an easy and eco-friendly method for synthesizing Flower silver nanoparticles [FAgNPs] and Stem silver nanoparticles [SagNPs] using an aqueous extract of flower and stem Leonotis nepetifolia, (L.) R. Br. (family: Lamiaceae), and to evaluate their antibacterial properties. The obtained sample of synthesized FAgNPs and SAgNPs were characterized by UV–vis spectroph...
1008
4937
ROLE OF COMPUTER ASSISTED LEARNING (CAL) AS AN EFFECTIVE TEACHING LEARNING METHOD AND AN ASSESSMENT TOOL IN PRACTICAL PHARMACOLOGY
Background: Pharmacology education has evolved with the introduction of competency-based medical education (CBME). Traditional live animal experiments in pharmacology practical face ethical, logistical, and regulatory challenges. Computer-assisted learning (CAL) using animal simulation software offers an alternative that aligns with CPCSEA guidelines, emphasizing the 4Rs (Reduction, Refinement, Re...
1025
4935
A CROSS-SECTIONAL STUDY TO ASSESS PREVALENCE OF PRE-DIABETES AND TYPE 2 DIABETES MELLITUS AND IT’S ASSOCIATED MODIFIED RISK FACTORS IN RURAL COMMUNITY OF GWALIOR DISTRICT
Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder marked by insulin resistance, impaired insulin secretion, and persistent hyperglycaemia. It accounts for over 90% of global diabetes cases and contributes to approximately 9% of global mortality, equating to nearly four million deaths annually. With a rising burden in rural areas, identifying the prevalence and risk factor...
1016
4905
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF VORTIOXETINE HBr
Vortioxetine, a well-established antidepressant for major depressive disorder, faces limitations in traditional formulations regarding patient compliance and rapid onset of action. Mouth dissolving tablets (MDTs) offer a patient-friendly alternative, particularly beneficial for drugs with narrow therapeutic windows. This study aimed to formulate and evaluate MDTs of vortioxetine using super disint...
1046
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FORMULATION AND IN-VITRO EVALUATION OF PULSATILE RELEASE TABLETS OF RITONAVIR
The objective of the present study was to develop a time-controlled floating pulsatile drug delivery system of Ritonavir (RIT), an antiviral drug with low oral bioavailability due to degradation by CYP3A4 enzymes, efflux by P-glycoprotein, and instability at alkaline pH. Ritonavir is primarily absorbed in the stomach; hence, a floating pulsatile release system was designed to enhance absorption an...
1024
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